Regulog HypR - Rhizobiales

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	activator (repressor)
Biological process:	Proline and 4-hydrohyproline utilization
Effector:	Proline
Phylum:	Proteobacteria/alpha
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 18 sites [see more]

Member of regulog collections

By taxonomy - Rhizobiales
By trascription factor - HypR
By TF family - GntR/Others
By effector - Proline
By pathway - Proline and 4-hydrohyproline utilization

Statistics of regulated genes
Genome	Genes	Operons
Sinorhizobium meliloti 1021	14	5
Rhizobium sp. NGR234
Rhizobium leguminosarum bv. viciae 3841	2	2
Rhizobium etli CFN 42	2	2
Agrobacterium tumefaciens str. C58 (Cereon)	10	4
Mesorhizobium sp. BNC1	2	2
Mesorhizobium loti MAFF303099
Brucella melitensis 16M	1	1
Bartonella quintana str. Toulouse
Rhodopseudomonas palustris CGA009
Bradyrhizobium japonicum USDA 110
Bradyrhizobium sp. BTAi1
Nitrobacter winogradskyi Nb-255
Azorhizobium caulinodans ORS 571
Xanthobacter autotrophicus Py2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
hypS	* Sinorhizobium meliloti 1021 Site: position = -71 score = 3.81704 sequence = GTTTGTATACTCTA Gene: SMb20261: Putative L-lactate/Malate dehydrogenase	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	* Agrobacterium tumefaciens str. C58 (Cereon) Site: position = -52 score = 3.46455 sequence = CTTTGTATACTTTA Site: position = -232 score = 4.18237 sequence = ATGAGTATACAAAA Site: position = -41 score = 3.72489 sequence = TTATGTATTCAAAA Gene: Atu4676: Putative L-lactate/Malate dehydrogenase	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M Gene: BMEII1005: Putative L-lactate/Malate dehydrogenase	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Putative L-lactate/Malate dehydrogenase
hypT	Sinorhizobium meliloti 1021 Gene: SMb20260: Putative hydroxyproline transporter	Rhizobium sp. NGR234 Gene: NGR_b14200: Putative hydroxyproline transporter	Rhizobium leguminosarum bv. viciae 3841 Gene: RL1805: Putative hydroxyproline transporter	Rhizobium etli CFN 42 Gene: RHE_CH01706: Putative hydroxyproline transporter	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1 Gene: Meso_0754: Putative hydroxyproline transporter	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Putative hydroxyproline transporter

CRON 2.
hypD	2 Sinorhizobium meliloti 1021* Gene: SMc03259: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted Site: position = -108 score = 5.12511 sequence = TTTTGTCGACAAAT Gene: SMb20259: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	Rhizobium sp. NGR234 Gene: NGR_c13110: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	* Rhizobium leguminosarum bv. viciae 3841 Site: position = -51 score = 4.56911 sequence = TCTTGTCGACAGTT Gene: pRL100268: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	* Rhizobium etli CFN 42 Site: position = -51 score = 4.56911 sequence = TCTTGTCGACAGTT Gene: RHE_PC00042: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	* Agrobacterium tumefaciens str. C58 (Cereon) Site: position = -99 score = 5.09177 sequence = TCTTGTCGACAAAT Gene: Atu4675: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	* Mesorhizobium sp. BNC1 Site: position = -71 score = 4.60882 sequence = TTGTGTCGACAAAC Gene: Meso_2568: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	3 Mesorhizobium loti MAFF303099 Gene: mlr6292: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted Gene: mll3981: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted Gene: mll6811: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	* Brucella melitensis 16M Site: position = -89 score = 5.23266 sequence = TCTTGTCGACAAGA Gene: BMEII1006: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bll4423: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2 Gene: Xaut_2517: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted

CRON 3.
hypM	* Sinorhizobium meliloti 1021 Site: position = -101 score = 4.50138 sequence = TTTTGTATACTAAT Gene: SMb20263: Predicted hydroxyproline ABC transporter, substrate-binding protein	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	* Agrobacterium tumefaciens str. C58 (Cereon) Site: position = -100 score = 4.18237 sequence = TTTTGTATACTCAT Gene: Atu4678: Predicted hydroxyproline ABC transporter, substrate-binding protein	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Predicted hydroxyproline ABC transporter, substrate-binding protein
hypN	Sinorhizobium meliloti 1021 Gene: SMb20264: Predicted hydroxyproline ABC transporter, permease protein	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu4679: Predicted hydroxyproline ABC transporter, permease protein	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Predicted hydroxyproline ABC transporter, permease protein
hypP	Sinorhizobium meliloti 1021 Gene: SMb20265: Predicted hydroxyproline ABC transporter, permease protein	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu4680: Predicted hydroxyproline ABC transporter, permease protein	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Predicted hydroxyproline ABC transporter, permease protein
hypQ	Sinorhizobium meliloti 1021 Gene: SMb20266: Predicted hydroxyproline ABC transporter, ATP-binding protein	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu4681: Predicted hydroxyproline ABC transporter, ATP-binding protein	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Predicted hydroxyproline ABC transporter, ATP-binding protein
hypO	Sinorhizobium meliloti 1021 Gene: SMb20267: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	2 Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu3364: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster Gene: Atu4682: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Mesorhizobium sp. BNC1 Gene: Meso_3322: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Mesorhizobium loti MAFF303099 Gene: mll3980: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Brucella melitensis 16M Gene: BMEI0256: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
hypE	Sinorhizobium meliloti 1021 Gene: SMb20268: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841 Gene: pRL120535: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Rhizobium etli CFN 42 Gene: RHE_PF00391: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu3953: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099 Gene: mll3979: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Brucella melitensis 16M Gene: BMEI0257: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
hypX	Sinorhizobium meliloti 1021 Gene: SMb20269: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu4683: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
hypY	Sinorhizobium meliloti 1021 Gene: SMb20270: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive	Rhizobium sp. NGR234 Gene: NGR_c20530: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu4684: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099 Gene: mlr6810: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive	Brucella melitensis 16M Gene: BMEI1586: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
hypZ	Sinorhizobium meliloti 1021 Gene: SMb20271: OsmC/Ohr family protein	Rhizobium sp. NGR234 Gene: NGR_b08950: OsmC/Ohr family protein	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099 Gene: mll0741: OsmC/Ohr family protein	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	OsmC/Ohr family protein

CRON 4.
hypH	* Sinorhizobium meliloti 1021 Site: position = -185 score = 3.81704 sequence = TAGAGTATACAAAC Gene: SMb20262: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841 Gene: pRL120235: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible

CRON 5.
hypR	* Sinorhizobium meliloti 1021 Site: position = -24 score = 5.266 sequence = TTTTGTCGACAAGA Gene: SMb20258: Predicted regulator for proline and hydrohyproline utilization, GntR family	Rhizobium sp. NGR234	* Rhizobium leguminosarum bv. viciae 3841 Site: position = -113 score = 4.56911 sequence = AACTGTCGACAAGA Gene: pRL100269: Predicted regulator for proline and hydrohyproline utilization, GntR family	* Rhizobium etli CFN 42 Site: position = -93 score = 4.56911 sequence = AACTGTCGACAAGA Gene: RHE_PC00043: Predicted regulator for proline and hydrohyproline utilization, GntR family	* Agrobacterium tumefaciens str. C58 (Cereon) Site: position = -25 score = 4.73111 sequence = TTATGTCGACAAGA Gene: Atu4674: Predicted regulator for proline and hydrohyproline utilization, GntR family	* Mesorhizobium sp. BNC1 Site: position = -143 score = 3.41635 sequence = ACGTGTTTACAATC Gene: Meso_2569: Predicted regulator for proline and hydrohyproline utilization, GntR family	Mesorhizobium loti MAFF303099	Brucella melitensis 16M Gene: BMEII1007: Predicted regulator for proline and hydrohyproline utilization, GntR family	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Predicted regulator for proline and hydrohyproline utilization, GntR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HypR - Rhizobiales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --