Collection of regulogs in Methanosarcinales taxonomic group

This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.

Studied genomes and reconstructed regulon statistics
	TF		RNA		Total
Genomes	Regulons	Sites	Regulons	Sites	Regulons	Sites
Methanocella paludicola SANAE	0	0	0	0	0	0
Methanococcoides burtonii DSM 6242	1	2	0	0	1	2
Methanohalophilus mahii DSM 5219	1	1	0	0	1	1
Methanosaeta thermophila PT	1	2	0	0	1	2
Methanosarcina acetivorans C2A	2	3	0	0	2	3
Methanosarcina barkeri str. fusaro	2	3	0	0	2	3
Methanosarcina mazei Goe1	2	3	0	0	2	3

Genomic distribution of regulons
Family	Type	Regulator								Function
ArsR	TF	Phr			1 Phr Methanosaeta thermophila PT	1 Phr Methanosarcina acetivorans C2A	1 Phr Methanosarcina barkeri str. fusaro	1 Phr Methanosarcina mazei Goe1		Heat shock response
[Other]	TF	RbkR	1 RbkR Methanococcoides burtonii DSM 6242	1 RbkR Methanohalophilus mahii DSM 5219		1 RbkR Methanosarcina acetivorans C2A	1 RbkR Methanosarcina barkeri str. fusaro	1 RbkR Methanosarcina mazei Goe1		Riboflavin biosynthesis