Regulon of IscR in Roseobacter sp. MED193

Properties
Regulator type:	Transcription factor
TF locus tag:	MED193_04321
Regulator family:	Rrf2
Regulation mode:	repressor (activator)
Biological process:	Iron-sulfur cluster biogenesis; Iron homeostasis
Effector:	Iron-sulfur cluster redox state; Iron ion, (Fe2+)
Regulog:	IscR - Rhodobacterales
Statistics of regulated genes:
- Genes	39
- Operons	8
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 125 sites [see more]

Member of regulog collections

By trascription factor - IscR
By taxonomy - Rhodobacterales
By TF family - Rrf2
By effector - Iron-sulfur cluster redox state
By effector - Iron ion, (Fe2+)
By pathway - Iron-sulfur cluster biogenesis
By pathway - Iron homeostasis

Regulated operons
	Locus Tag	Name	Function
Position: -355 Score: 4 Sequence: CTTGACAAAACCTGTAAGG Locus tag: MED193_22076 Name: fecB Funciton: ABC-type Fe3+-hydroxamate transport system, periplasmic component Locus tag: MED193_22071 Name: fecC Funciton: ABC-type Fe3+-siderophore transport system, permease component Locus tag: MED193_22066 Name: fecD Funciton: ABC-type Fe3+-siderophore transport system, permease component Locus tag: MED193_22061 Name: fecE Funciton: ABC Fe+3-siderophore transporter, ATPase subunit Locus tag: MED193_22056 Name: mxcB Funciton: Siderophore-interacting protein Locus tag: MED193_22051 Name: exbB Funciton: Ferric siderophore transport system, biopolymer transport protein ExbB Locus tag: MED193_22046 Name: exbD1 Funciton: Biopolymer transport protein ExbD/TolR Locus tag: MED193_22041 Name: exbD2 Funciton: Biopolymer transport protein ExbD/TolR Locus tag: MED193_22036 Name: tonB Funciton: Ferric siderophore transport system, periplasmic binding protein TonB
	MED193_22076	fecB	ABC-type Fe3+-hydroxamate transport system, periplasmic component
	MED193_22071	fecC	ABC-type Fe3+-siderophore transport system, permease component
	MED193_22066	fecD	ABC-type Fe3+-siderophore transport system, permease component
	MED193_22061	fecE	ABC Fe+3-siderophore transporter, ATPase subunit
	MED193_22056	mxcB	Siderophore-interacting protein
	MED193_22051	exbB	Ferric siderophore transport system, biopolymer transport protein ExbB
	MED193_22046	exbD1	Biopolymer transport protein ExbD/TolR
	MED193_22041	exbD2	Biopolymer transport protein ExbD/TolR
	MED193_22036	tonB	Ferric siderophore transport system, periplasmic binding protein TonB
Position: 69 Score: 4 Sequence: GTTGACTGTTTTTATCACC Locus tag: MED193_17504 Name: hmuR Funciton: TonB-dependent hemin , ferrichrome receptor Locus tag: MED193_17509 Name: Mlr1156 Funciton: Mlr1156 protein Locus tag: MED193_17514 Name: exbB Funciton: Ferric siderophore transport system, biopolymer transport protein ExbB Locus tag: MED193_17519 Name: exbD1 Funciton: Ferric siderophore transport system, periplasmic binding protein ExbD Locus tag: MED193_17524 Name: exbD2 Funciton: Ferric siderophore transport system, periplasmic binding protein ExbD Locus tag: MED193_17529 Name: tonB Funciton: Ferric siderophore transport system, periplasmic binding protein TonB
	MED193_17504	hmuR	TonB-dependent hemin , ferrichrome receptor
	MED193_17509	Mlr1156	Mlr1156 protein
	MED193_17514	exbB	Ferric siderophore transport system, biopolymer transport protein ExbB
	MED193_17519	exbD1	Ferric siderophore transport system, periplasmic binding protein ExbD
	MED193_17524	exbD2	Ferric siderophore transport system, periplasmic binding protein ExbD
	MED193_17529	tonB	Ferric siderophore transport system, periplasmic binding protein TonB
Position: -58 Score: 3.8 Sequence: TCCGACCAAAATGATCGCA Locus tag: MED193_12813 Name: fbpB Funciton: Ferric iron ABC transporter, permease protein
	MED193_12813	fbpB	Ferric iron ABC transporter, permease protein
Position: -139 Score: 5.3 Sequence: TCTGACTATTTTTGTCAGA Locus tag: MED193_15812 Name: TM1040_2633 Funciton: hypothetical protein
	MED193_15812	TM1040_2633	hypothetical protein
Position: -103 Score: 4.4 Sequence: CCTGACAAAAACAATAAGC Position: -72 Score: 4.5 Sequence: CCTTATTGTTTTTGTCAGA Locus tag: MED193_19654 Name: bfd Funciton: Bacterioferritin-associated ferredoxin Locus tag: MED193_19649 Name: bfr Funciton: Bacterioferritin (cytochrome b1) Locus tag: MED193_19644 Name: COG3488 Funciton: Probable thiol oxidoreductase with 2 cytochrome c heme-binding sites Locus tag: MED193_19639 Name: COG3489 Funciton: Predicted periplasmic lipoprotein Locus tag: MED193_19634 Name: COG3490 Funciton: Uncharacterised conserved protein UCP028101
	MED193_19654	bfd	Bacterioferritin-associated ferredoxin
	MED193_19649	bfr	Bacterioferritin (cytochrome b1)
	MED193_19644	COG3488	Probable thiol oxidoreductase with 2 cytochrome c heme-binding sites
	MED193_19639	COG3489	Predicted periplasmic lipoprotein
	MED193_19634	COG3490	Uncharacterised conserved protein UCP028101
Position: -118 Score: 5.3 Sequence: TCTGACAAAAATAGTCAGA Position: -91 Score: 4.7 Sequence: CTTGATTGTTTTAATCAGG Locus tag: MED193_19679 Name: MED193_19679 Funciton: hypothetical protein Locus tag: MED193_19674 Name: hemP Funciton: Hemin uptake protein HemP Locus tag: MED193_19669 Name: null Funciton: hypothetical protein Locus tag: MED193_19664 Name: irpA Funciton: Iron-regulated protein A precursor Locus tag: MED193_19659 Name: hmuX Funciton: hypothetical porin
	MED193_19679	MED193_19679	hypothetical protein
	MED193_19674	hemP	Hemin uptake protein HemP
	MED193_19669		hypothetical protein
	MED193_19664	irpA	Iron-regulated protein A precursor
	MED193_19659	hmuX	hypothetical porin
Position: -144 Score: 4 Sequence: CTTGACGAATTCCATCAGC Locus tag: MED193_04321 Name: iscR Funciton: Iron-sulfur cluster regulator IscR, Rrf2 family Locus tag: MED193_04316 Name: iscS Funciton: Cysteine desulfurase (EC 2.8.1.7) Locus tag: MED193_04311 Name: sufB Funciton: Iron-sulfur cluster assembly protein SufB Locus tag: MED193_04306 Name: null Funciton: hypothetical protein Locus tag: MED193_04301 Name: RSP_0439 Funciton: protein of unknown function DUF74 Locus tag: MED193_04296 Name: Jann_2361 Funciton: ExoV domain protein Locus tag: MED193_04291 Name: sufC Funciton: Iron-sulfur cluster assembly ATPase protein SufC Locus tag: MED193_04286 Name: sufD Funciton: Iron-sulfur cluster assembly protein SufD Locus tag: MED193_04281 Name: RSP_0433 Funciton: hypothetical protein Locus tag: MED193_04276 Name: null Funciton: hypothetical protein Locus tag: MED193_04271 Name: sufS Funciton: Cysteine desulfurase (EC 2.8.1.7), SufS subfamily
	MED193_04321	iscR	Iron-sulfur cluster regulator IscR, Rrf2 family
	MED193_04316	iscS	Cysteine desulfurase (EC 2.8.1.7)
	MED193_04311	sufB	Iron-sulfur cluster assembly protein SufB
	MED193_04306		hypothetical protein
	MED193_04301	RSP_0439	protein of unknown function DUF74
	MED193_04296	Jann_2361	ExoV domain protein
	MED193_04291	sufC	Iron-sulfur cluster assembly ATPase protein SufC
	MED193_04286	sufD	Iron-sulfur cluster assembly protein SufD
	MED193_04281	RSP_0433	hypothetical protein
	MED193_04276		hypothetical protein
	MED193_04271	sufS	Cysteine desulfurase (EC 2.8.1.7), SufS subfamily
Position: -65 Score: 4.2 Sequence: ACTGACAAAAGAAGTCGGA Locus tag: MED193_12793 Name: fbpA Funciton: Ferric iron ABC transporter, iron-binding protein
	MED193_12793	fbpA	Ferric iron ABC transporter, iron-binding protein

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of IscR in Roseobacter sp. MED193

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --