Regulog PerR - Staphylococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	FUR
Regulation mode:	repressor
Biological process:	Oxidative stress response
Effector:	Hydrogen peroxide; Manganese ion, (Mn2+); Iron ion, (Fe2+)
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 69 sites [see more]

Member of regulog collections

By taxonomy - Staphylococcaceae
By TF family - FUR
By effector - Hydrogen peroxide
By effector - Manganese ion, (Mn2+)
By effector - Iron ion, (Fe2+)
By pathway - Oxidative stress response

Statistics of regulated genes
Genome	Genes	Operons
Staphylococcus aureus subsp. aureus N315	17	10
Staphylococcus capitis SK14	15	8
Staphylococcus epidermidis ATCC 12228	11	6
Staphylococcus carnosus subsp. carnosus TM300	14	7
Staphylococcus haemolyticus JCSC1435	17	9
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	14	7
Macrococcus caseolyticus JCSC5402	14	7

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
sufC	* Staphylococcus aureus subsp. aureus N315 Site: position = -56 score = 5.67115 sequence = TTAAAATTATTATAA Gene: SA0774: hypothetical protein	* Staphylococcus capitis SK14 Site: position = -55 score = 5.67115 sequence = TTAAAATTATTATAA Gene: STACA0001_0212: FeS assembly ATPase SufC	* Staphylococcus epidermidis ATCC 12228 Site: position = -55 score = 5.67115 sequence = TTAAAATTATTATAA Gene: SE0606: ABC transporter (ATP-binding protein)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -58 score = 5.67115 sequence = TTAAAATTATTATAA Gene: Sca_0458: putative ABC transporter ATP-binding protein	* Staphylococcus haemolyticus JCSC1435 Site: position = -55 score = 5.67115 sequence = TTAAAATTATTATAA Gene: SH2039: ABC transporter ATP-binding protein	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -57 score = 5.67115 sequence = TTAAAATTATTATAA Gene: SSP1861: putative Iron-regulated ABC transporter ATPase component	* Macrococcus caseolyticus JCSC5402 Site: position = -57 score = 5.67115 sequence = TTAAAATTATTATAA Gene: MCCL_0542: ABC transporter, ATP-binding protein involved in Fe-S cluster formation YurY	hypothetical protein
sufD	Staphylococcus aureus subsp. aureus N315 Gene: SA0775: hypothetical protein	Staphylococcus capitis SK14 Gene: STACA0001_0211: FeS assembly protein SufD	Staphylococcus epidermidis ATCC 12228 Gene: SE0607: conserved hypothetical protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0459: hypothetical protein	Staphylococcus haemolyticus JCSC1435 Gene: SH2038: hypothetical protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1860: hypothetical protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0543: hypothetical protein	hypothetical protein
sufS	Staphylococcus aureus subsp. aureus N315 Gene: SA0776: hypothetical protein	Staphylococcus capitis SK14 Gene: STACA0001_0210: cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL)	Staphylococcus epidermidis ATCC 12228 Gene: SE0608: aminotransferase NifS-like protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0460: putative selenocysteine lyase	Staphylococcus haemolyticus JCSC1435 Gene: SH2037: hypothetical protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1859: putative selenocysteine lyase	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0544: hypothetical protein	hypothetical protein
nifU	Staphylococcus aureus subsp. aureus N315 Gene: SA0777: hypothetical protein	Staphylococcus capitis SK14 Gene: STACA0001_0209: SUF system FeS assembly protein, NifU family	Staphylococcus epidermidis ATCC 12228 Gene: SE0609: nitrogen fixation protein NifU	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0461: NifU-like protein	Staphylococcus haemolyticus JCSC1435 Gene: SH2036: hypothetical protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1858: NifU homolog involved in Fe-S cluster formation	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0545: nitrogen fixation protein NifU	hypothetical protein
sufB	* Staphylococcus aureus subsp. aureus N315 Site: position = -104 score = 4.825 sequence = TAAAAATTTTTATAA Gene: SA0778: hypothetical protein	Staphylococcus capitis SK14 Gene: STACA0001_0208: FeS assembly protein SufB	Staphylococcus epidermidis ATCC 12228 Gene: SE0610: conserved hypothetical protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0462: putative FeS assembly protein SufB	Staphylococcus haemolyticus JCSC1435 Gene: SH2035: hypothetical protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1857: hypothetical protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0546: FeS assembly protein SufB	hypothetical protein

CRON 2.
perR	* Staphylococcus aureus subsp. aureus N315 Site: position = -37 score = 5.62786 sequence = TAATAATAATTATTA Gene: SA1678: peroxide-responsive repressor PerR	* Staphylococcus capitis SK14 Site: position = -36 score = 5.62786 sequence = TAATAATTATTATTA Gene: STACA0001_1914: peroxide-responsive repressor PerR	* Staphylococcus epidermidis ATCC 12228 Site: position = -36 score = 5.62786 sequence = TAATAATAATTATTA Gene: SE1545: peroxide-responsive repressor PerR	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -36 score = 5.62786 sequence = TAATAATTATTATTA Gene: Sca_1434: peroxide-responsive repressor PerR	* Staphylococcus haemolyticus JCSC1435 Site: position = -35 score = 5.62786 sequence = TAATAATTATTATTA Gene: SH1102: peroxide-responsive repressor PerR	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -36 score = 5.47011 sequence = TAATAATAATTCTTA Gene: SSP0932: peroxide-responsive repressor PerR	* Macrococcus caseolyticus JCSC5402 Site: position = -33 score = 4.81383 sequence = ATAGAATTACTATAA Gene: MCCL_1591: peroxide-responsive repressor PerR	peroxide-responsive repressor PerR

CRON 3.
katA	* Staphylococcus aureus subsp. aureus N315 Site: position = -26 score = 5.98145 sequence = TTATAATTATTATAA Gene: SA1170: catalase	* Staphylococcus capitis SK14 Site: position = -42 score = 5.46321 sequence = TTATAATTATTACAA Gene: STACA0001_1577: catalase	Staphylococcus epidermidis ATCC 12228 Gene: SE1016: catalase	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -33 score = 5.82369 sequence = TTATAATTATTCTAA Gene: Sca_2336: catalase	* Staphylococcus haemolyticus JCSC1435 Site: position = -37 score = 5.98145 sequence = TTATAATTATTATAA Gene: SH1573: catalase	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -41 score = 5.62786 sequence = TAATAATTATTATTA Gene: SSP1432: catalase	* Macrococcus caseolyticus JCSC5402 Site: position = -29 score = 5.36849 sequence = AAATAATTATTATAA Site: position = -46 score = 5.35669 sequence = TTATAATAATTATCA Gene: MCCL_0056: catalase	catalase

CRON 4.
hemE	* Staphylococcus aureus subsp. aureus N315 Site: position = -29 score = 5.12515 sequence = TAAGAATGATTTTAA Site: position = -191 score = 5.09745 sequence = TTAAAATTACTATAA Gene: SA1652: uroporphyrinogen-III decarboxylase	* Staphylococcus capitis SK14 Site: position = -32 score = 5.12515 sequence = TAAGAATGATTTTAA Gene: STACA0001_0695: uroporphyrinogen-III decarboxylase	Staphylococcus epidermidis ATCC 12228 Gene: SE1513: uroporphyrinogen-III decarboxylase	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -32 score = 4.86577 sequence = TTAGAATGATTTTAT Gene: Sca_1408: uroporphyrinogen-III decarboxylase	* Staphylococcus haemolyticus JCSC1435 Site: position = -32 score = 5.12515 sequence = TAAGAATGATTTTAA Gene: SH1128: uroporphyrinogen-III decarboxylase	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -32 score = 4.86584 sequence = CAAGAATGATTATAA Gene: SSP0965: uroporphyrinogen-III decarboxylase	* Macrococcus caseolyticus JCSC5402 Site: position = -138 score = 5.0732 sequence = TAATAGTTATTCTAA Gene: MCCL_1550: uroporphyrinogen-III decarboxylase	uroporphyrinogen-III decarboxylase
hemH	Staphylococcus aureus subsp. aureus N315 Gene: SA1651: ferrochelatase	Staphylococcus capitis SK14 Gene: STACA0001_0694: ferrochelatase	Staphylococcus epidermidis ATCC 12228 Gene: SE1512: ferrochelatase	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1407: ferrochelatase	Staphylococcus haemolyticus JCSC1435 Gene: SH1129: ferrochelatase	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0966: protoheme ferro-lyase	Macrococcus caseolyticus JCSC5402 Gene: MCCL_1549: ferrochelatase	ferrochelatase
hemY	Staphylococcus aureus subsp. aureus N315 Gene: SA1650: protoporphyrinogen oxidase	Staphylococcus capitis SK14 Gene: STACA0001_0693: protoporphyrinogen oxidase	Staphylococcus epidermidis ATCC 12228 Gene: SE1511: protoporphyrinogen oxidase	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1406: protoporphyrinogen oxidase	Staphylococcus haemolyticus JCSC1435 Gene: SH1130: protoporphyrinogen oxidase	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0967: protoporphyrinogen oxidase	Macrococcus caseolyticus JCSC5402 Gene: MCCL_1548: protoporphyrinogen oxidase	protoporphyrinogen oxidase

CRON 5.
fur	* Staphylococcus aureus subsp. aureus N315 Site: position = -122 score = 5.61223 sequence = TTATAATcATTcTAA Gene: SA1329: iron uptake regulatory protein Fur	* Staphylococcus capitis SK14 Site: position = -40 score = 5.45969 sequence = TTAAAATGATTATAA Gene: STACA0001_1739: iron uptake regulatory protein Fur	* Staphylococcus epidermidis ATCC 12228 Site: position = -40 score = 5.45969 sequence = TTAAAATGATTATAA Gene: SE1182: iron uptake regulatory protein Fur	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -40 score = 5.45969 sequence = TTAAAATGATTATAA Gene: Sca_1124: iron uptake regulatory protein Fur	* Staphylococcus haemolyticus JCSC1435 Site: position = -40 score = 5.45969 sequence = TTAAAATGATTATAA Gene: SH1418: iron uptake regulatory protein Fur	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -40 score = 5.45969 sequence = TTAAAATGATTATAA Gene: SSP1254: iron uptake regulatory protein Fur	* Macrococcus caseolyticus JCSC5402 Site: position = -95 score = 5.6469 sequence = TAATAATTATTCTAA Gene: MCCL_1147: iron uptake regulatory protein Fur	iron uptake regulatory protein Fur

CRON 6.
ftnA	* Staphylococcus aureus subsp. aureus N315 Site: position = -92 score = 5.80465 sequence = TTATAATTATTATTA Gene: SA1709: ferritin	* Staphylococcus capitis SK14 Site: position = -89 score = 5.6469 sequence = TTAGAATAATTATTA Site: position = -132 score = 5.5134 sequence = TTAGAATAATTTTAA Gene: STACA0001_1946: ferritin	* Staphylococcus epidermidis ATCC 12228 Site: position = -84 score = 5.6469 sequence = TTAGAATAATTATTA Site: position = -126 score = 5.6469 sequence = TTAGAATAATTATTA Gene: SE1578: ferritin	Staphylococcus carnosus subsp. carnosus TM300	* Staphylococcus haemolyticus JCSC1435 Site: position = -99 score = 5.80465 sequence = TTATAATAATTATTA Gene: SH1060: ferritin	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0898: ferritin	Macrococcus caseolyticus JCSC5402 Gene: MCCL_1624: ferritin	ferritin

CRON 7.
dps	* Staphylococcus aureus subsp. aureus N315 Site: position = -71 score = 5.61223 sequence = TTAGAATCATTATAA Site: position = -54 score = 5.23096 sequence = TAATAATTAATATAA Site: position = -112 score = 5.82369 sequence = TTAGAATAATTATAA Gene: SA1941: metalloregulation DNA-binding stress protein	* Staphylococcus capitis SK14 Site: position = -54 score = 4.79889 sequence = ATATAATAATTATTG Site: position = -109 score = 5.15292 sequence = TTGAAATAATTATAA Site: position = -68 score = 5.82369 sequence = TTAGAATTATTATAA Gene: STACA0001_0845: metalloregulation DNA-binding stress protein	* Staphylococcus epidermidis ATCC 12228 Site: position = -58 score = 5.82369 sequence = TTAGAATTATTATAA Gene: SE1738: metalloregulation DNA-binding stress protein	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -111 score = 5.5134 sequence = TTAGAATTATTTTAA Site: position = -70 score = 5.82369 sequence = TTAGAATTATTATAA Site: position = -53 score = 5.23096 sequence = TAATAGTTATTATAA Gene: Sca_1644: metalloregulation DNA-binding stress protein	* Staphylococcus haemolyticus JCSC1435 Site: position = -71 score = 5.76999 sequence = TTATAATCATTATAA Site: position = -54 score = 5.19894 sequence = TAATAATAATTGTAA Gene: SH0895: metalloregulation DNA-binding stress protein	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -71 score = 5.19894 sequence = TAATAATTATTGTAA Site: position = -129 score = 5.30194 sequence = TTAAAATGATTCTAA Site: position = -88 score = 5.82369 sequence = TTAGAATTATTATAA Gene: SSP0745: metalloregulation DNA-binding stress protein	* Macrococcus caseolyticus JCSC5402 Site: position = -38 score = 5.23096 sequence = TAATAATTAATATAA Site: position = -55 score = 5.61223 sequence = TTAGAATGATTATAA Gene: MCCL_1798: metalloregulation DNA-binding stress protein	metalloregulation DNA-binding stress protein

CRON 8.
bcp	* Staphylococcus aureus subsp. aureus N315 Site: position = -34 score = 5.23499 sequence = ATAAAATTATTATAA Gene: SA1680: bacterioferritin comigratory protein	Staphylococcus capitis SK14 Gene: STACA0001_1916: bacterioferritin comigratory protein	Staphylococcus epidermidis ATCC 12228 Gene: SE1547: bacterioferritin comigratory protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1436: bacterioferritin comigratory protein	* Staphylococcus haemolyticus JCSC1435 Site: position = -34 score = 4.97158 sequence = ATATAATTAATATAA Gene: SH1098: bacterioferritin comigratory protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0930: bacterioferritin comigratory protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_1593: bacterioferritin comigratory protein	bacterioferritin comigratory protein
SA1679	Staphylococcus aureus subsp. aureus N315 Gene: SA1679: putative phosphoglycerate dehydrogenase	Staphylococcus capitis SK14 Gene: STACA0001_1915: putative phosphoglycerate dehydrogenase	Staphylococcus epidermidis ATCC 12228 Gene: SE1546: putative phosphoglycerate dehydrogenase	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1435: putative phosphoglycerate dehydrogenase	Staphylococcus haemolyticus JCSC1435 Gene: SH1099: putative phosphoglycerate dehydrogenase	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0931: putative phosphoglycerate dehydrogenase	Macrococcus caseolyticus JCSC5402 Gene: MCCL_1592: putative phosphoglycerate dehydrogenase	putative phosphoglycerate dehydrogenase

CRON 9.
ahpC	* Staphylococcus aureus subsp. aureus N315 Site: position = -74 score = 5.82369 sequence = TTAGAATTATTATAA Gene: SA0366: alkyl hydroperoxide reductase subunit C	* Staphylococcus capitis SK14 Site: position = -76 score = 5.82369 sequence = TTAGAATTATTATAA Gene: STACA0001_1447: alkyl hydroperoxide reductase subunit C	* Staphylococcus epidermidis ATCC 12228 Site: position = -75 score = 5.82369 sequence = TTAGAATTATTATAA Gene: SE2357: alkyl hydroperoxide reductase subunit C	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -95 score = 5.82369 sequence = TTAGAATTATTATAA Gene: Sca_0039: alkyl hydroperoxide reductase subunit C	* Staphylococcus haemolyticus JCSC1435 Site: position = -77 score = 5.82369 sequence = TTAGAATTATTATAA Gene: SH2592: alkyl hydroperoxide reductase subunit C	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -86 score = 5.82369 sequence = TTAGAATTATTATAA Gene: SSP2333: alkyl hydroperoxide reductase subunit C	* Macrococcus caseolyticus JCSC5402 Site: position = -52 score = 5.66593 sequence = TTAGAATTATTCTAA Site: position = -125 score = 5.15292 sequence = TTGAAATAATTATAA Gene: MCCL_0098: alkyl hydroperoxide reductase subunit C	alkyl hydroperoxide reductase subunit C
ahpF	Staphylococcus aureus subsp. aureus N315 Gene: SA0365: alkyl hydroperoxide reductase subunit F	Staphylococcus capitis SK14 Gene: STACA0001_1446: alkyl hydroperoxide reductase subunit F	Staphylococcus epidermidis ATCC 12228 Gene: SE2358: alkyl hydroperoxide reductase subunit F	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0038: alkyl hydroperoxide reductase subunit F	Staphylococcus haemolyticus JCSC1435 Gene: SH2593: alkyl hydroperoxide reductase subunit F	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2334: alkyl hydroperoxide reductase subunit F	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0099: alkyl hydroperoxide reductase subunit F	alkyl hydroperoxide reductase subunit F

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog PerR - Staphylococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --