Regulog ThiR - Halobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	[Other]
Regulation mode:	repressor
Biological process:	Thiamine transport; Thiamine biosynthesis
Effector:	Thiamine phosphate
Phylum:	Euryarchaeota
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 40 sites [see more]

Member of regulog collections

By trascription factor - ThiR
By taxonomy - Halobacteriales
By TF family - [Other]
By effector - Thiamine phosphate
By pathway - Thiamine transport
By pathway - Thiamine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Haloarcula marismortui ATCC 43049	6	4
Halobacterium salinarum R1	3	2
Halobacterium sp. NRC-1	3	2
Haloferax volcanii DS2	2	2
Halomicrobium mukohataei DSM 12286	2	2
Haloquadratum walsbyi DSM 16790	3	2
Halorhabdus utahensis DSM 12940	5	3
Halorubrum lacusprofundi ATCC 49239	1	1
Haloterrigena turkmenica DSM 5511	2	2
Natrialba magadii ATCC 43099	3	3
Natronomonas pharaonis DSM 2160	4	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
thi4	* Haloarcula marismortui ATCC 43049 Site: position = 2 score = 4.67383 sequence = GTACCACCAAGAGATAT Gene: rrnAC1782: Thiazole biosynthetic enzyme Thi4	* Halobacterium salinarum R1 Site: position = -28 score = 4.22469 sequence = TAATTATCTAGTTGTAC Site: position = -15 score = 4.6386 sequence = GTACCATGTAGTGGTAT Gene: OE4651F: Thiazole biosynthetic enzyme Thi4	* Halobacterium sp. NRC-1 Site: position = -28 score = 4.22469 sequence = TAATTATCTAGTTGTAC Site: position = -15 score = 4.6386 sequence = GTACCATGTAGTGGTAT Gene: VNG2604Gm: Thiazole biosynthetic enzyme Thi4	* Haloferax volcanii DS2 Site: position = -28 score = 5.0469 sequence = TTACTACTAGGTAGTAT Site: position = -15 score = 5.28335 sequence = GTATCACTAAGTAGTAT Gene: HVO_0665: Thiazole biosynthetic enzyme Thi4	* Halomicrobium mukohataei DSM 12286 Site: position = -15 score = 5.29479 sequence = GTACCACTAGGTTGTAT Gene: Hmuk_0002: Thiazole biosynthetic enzyme Thi4	* Haloquadratum walsbyi DSM 16790 Site: position = -15 score = 4.82031 sequence = ATAACACCAAGTAATAT Gene: HQ1276A: Thiazole biosynthetic enzyme Thi4	* Halorhabdus utahensis DSM 12940 Site: position = -15 score = 5.37323 sequence = GTACCACTAAGTGGTAT Gene: Huta_2718: Thiazole biosynthetic enzyme Thi4	* Halorubrum lacusprofundi ATCC 49239 Site: position = -28 score = 4.24518 sequence = GTACCACCGGGAGATAT Site: position = -15 score = 5.45364 sequence = ATATCACTAAGTGGTAT Gene: Hlac_2980: Thiazole biosynthetic enzyme Thi4	* Haloterrigena turkmenica DSM 5511 Site: position = -15 score = 5.0629 sequence = CTACCACCAAGTTGTAT Gene: Htur_1462: Thiazole biosynthetic enzyme Thi4	* Natrialba magadii ATCC 43099 Site: position = -15 score = 5.39728 sequence = ATACCACCTAGTTGTAT Gene: Nmag_2419: Thiazole biosynthetic enzyme Thi4	* Natronomonas pharaonis DSM 2160 Site: position = -15 score = 5.10342 sequence = ATATAACTGAGTTGTAT Gene: NP5174A: Thiazole biosynthetic enzyme Thi4	Thiazole biosynthetic enzyme Thi4
thiDN	Haloarcula marismortui ATCC 43049	Halobacterium salinarum R1 Gene: OE4654F: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)	Halobacterium sp. NRC-1 Gene: VNG2606G: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160	Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)

CRON 2.
thiC	* Haloarcula marismortui ATCC 43049 Site: position = -29 score = 5.09262 sequence = TTATAACTTGGTAGTAT Site: position = -16 score = 4.56026 sequence = GTATAACCTAGTGATTA Gene: rrnAC1182: Thiamin biosynthesis protein ThiC	* Halobacterium salinarum R1 Site: position = -30 score = 4.80278 sequence = TTATTATCTAGTGGTAT Site: position = -17 score = 4.45129 sequence = GTATCACTAAGTAATTG Gene: OE2057F: Thiamin biosynthesis protein ThiC	* Halobacterium sp. NRC-1 Site: position = -30 score = 4.80278 sequence = TTATTATCTAGTGGTAT Site: position = -17 score = 4.45129 sequence = GTATCACTAAGTAATTG Gene: VNG0715G: Thiamin biosynthesis protein ThiC	* Haloferax volcanii DS2 Site: position = -30 score = 4.53047 sequence = TTATTAACTAGTTGTAT Gene: HVO_2154: Thiamin biosynthesis protein ThiC	* Halomicrobium mukohataei DSM 12286 Site: position = -30 score = 4.8485 sequence = TTATAATCTAGTGATAT Site: position = -17 score = 4.31537 sequence = ATATAACTAGCTTATCT Gene: Hmuk_2297: Thiamin biosynthesis protein ThiC	Haloquadratum walsbyi DSM 16790	* Halorhabdus utahensis DSM 12940 Site: position = -43 score = 5.25063 sequence = GTATCACTAGGTTATAT Site: position = -30 score = 4.91507 sequence = ATATAATCTAGTAGTAC Gene: Huta_2472: Thiamin biosynthesis protein ThiC	Halorubrum lacusprofundi ATCC 49239	* Haloterrigena turkmenica DSM 5511 Site: position = -17 score = 4.45043 sequence = ATACAACCTAGTTATCG Site: position = -30 score = 4.61058 sequence = ATATAACTCGATGATAC Gene: Htur_1332: Thiamin biosynthesis protein ThiC	* Natrialba magadii ATCC 43099 Site: position = -17 score = 4.68232 sequence = ATACAACCTAGTTATCC Site: position = -30 score = 4.67821 sequence = TTATAATCTAGTAATAC Gene: Nmag_2593: Thiamin biosynthesis protein ThiC	* Natronomonas pharaonis DSM 2160 Site: position = -17 score = 4.10509 sequence = GTATTACTAGATTGTTG Site: position = -30 score = 4.56683 sequence = TTATTAGCTGGTTGTAT Gene: NP2210A: Thiamin biosynthesis protein ThiC	Thiamin biosynthesis protein ThiC

CRON 3.
tenA1	* Haloarcula marismortui ATCC 43049 Site: position = -59 score = 5.39728 sequence = ATACAACCAAGTTGTAT Gene: rrnAC1765: Thiaminase II (EC 3.5.99.2)	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2 Gene: HVO_B0381: Thiaminase II (EC 3.5.99.2)	Halomicrobium mukohataei DSM 12286	* Haloquadratum walsbyi DSM 16790 Site: position = -61 score = 4.83599 sequence = GTATTAGTTAGTTGTAT Gene: HQ2369A: Thiaminase II (EC 3.5.99.2)	* Halorhabdus utahensis DSM 12940 Site: position = -55 score = 4.91507 sequence = GTATAATTTGGTAGTAT Site: position = -42 score = 4.24892 sequence = GTATTAGTGAGTTATAA Gene: Huta_0684: Thiaminase II (EC 3.5.99.2)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_2987: Thiaminase II (EC 3.5.99.2)	Haloterrigena turkmenica DSM 5511 Gene: Htur_2707: Thiaminase II (EC 3.5.99.2)	* Natrialba magadii ATCC 43099 Site: position = -55 score = 4.10061 sequence = GTATAAGCAGATTATAG Site: position = -42 score = 4.44075 sequence = ATAGCACTAGCTTATAT Gene: Nmag_0869: Thiaminase II (EC 3.5.99.2)	* Natronomonas pharaonis DSM 2160 Site: position = -41 score = 4.24518 sequence = GTACCACCCGGATATAT Gene: NP4082A: Thiaminase II (EC 3.5.99.2)	Thiaminase II (EC 3.5.99.2)
tenA2	Haloarcula marismortui ATCC 43049 Gene: rrnAC1767: Thiaminase II (EC 3.5.99.2)	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2 Gene: HVO_B0380: Thiaminase II (EC 3.5.99.2)	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940 Gene: Huta_0685: Thiaminase II (EC 3.5.99.2)	Halorubrum lacusprofundi ATCC 49239 Gene: Hlac_2986: Thiaminase II (EC 3.5.99.2)	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160 Gene: NP4080A: Thiaminase II (EC 3.5.99.2)	Thiaminase II (EC 3.5.99.2)
thiV	Haloarcula marismortui ATCC 43049 Gene: rrnAC1769: Predicted thiamin transporter ThiV, SSS family	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2 Gene: HVO_B0379: Predicted thiamin transporter ThiV, SSS family	Halomicrobium mukohataei DSM 12286	Haloquadratum walsbyi DSM 16790 Gene: HQ2370A: Predicted thiamin transporter ThiV, SSS family	Halorhabdus utahensis DSM 12940 Gene: Huta_0686: Predicted thiamin transporter ThiV, SSS family	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511	Natrialba magadii ATCC 43099	Natronomonas pharaonis DSM 2160	Predicted thiamin transporter ThiV, SSS family

CRON 4.
thiR2	* Haloarcula marismortui ATCC 43049 Site: position = -77 score = 5.39728 sequence = ATACAACTTGGTTGTAT Gene: rrnAC1764: Predicted thiamin repressor ThiR, Xre family	Halobacterium salinarum R1	Halobacterium sp. NRC-1	Haloferax volcanii DS2	Halomicrobium mukohataei DSM 12286 Gene: Hmuk_1352: Predicted thiamin repressor ThiR, Xre family	Haloquadratum walsbyi DSM 16790	Halorhabdus utahensis DSM 12940 Gene: Huta_2411: Predicted thiamin repressor ThiR, Xre family	Halorubrum lacusprofundi ATCC 49239	Haloterrigena turkmenica DSM 5511 Gene: Htur_2542: Predicted thiamin repressor ThiR, Xre family	Natrialba magadii ATCC 43099 Gene: Nmag_0434: Predicted thiamin repressor ThiR, Xre family	Natronomonas pharaonis DSM 2160	Predicted thiamin repressor ThiR, Xre family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog ThiR - Halobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --