Regulog CadR-PbrR - Rhodobacterales

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator
Biological process:	Lead resistance; Cadmium resistance
Effector:	Lead ion, (Pb2+); Cadmium, ion (Cd2+)
Phylum:	Proteobacteria/Alpha
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 33 sites [see more]

Member of regulog collections

By taxonomy - Rhodobacterales
By trascription factor - CadR-PbrR
By TF family - MerR
By effector - Lead ion, (Pb2+)
By effector - Cadmium, ion (Cd2+)
By pathway - Lead resistance
By pathway - Cadmium resistance

Statistics of regulated genes
Genome	Genes	Operons
Rhodobacter sphaeroides 2.4.1	1	1
Paracoccus denitrificans PD1222	2	2
Jannaschia sp. CCS1
Rhodobacterales bacterium HTCC2654	8	5
Oceanicola granulosus HTCC2516	1	1
Loktanella vestfoldensis SKA53
Oceanicola batsensis HTCC2597	13	6
Roseovarius nubinhibens ISM	6	4
Roseovarius sp. 217	6	5
Sulfitobacter sp. EE-36	3	1
Silicibacter TM1040	1	1
Silicibacter pomeroyi DSS-3
Roseobacter sp. MED193	9	5
Hyphomonas neptunium ATCC 15444	2	1
Oceanicaulis alexandrii HTCC2633

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
PF01841	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	* Rhodobacterales bacterium HTCC2654 Site: position = -78 score = 5.12465 sequence = AAGCTACAGTGACTGTAGCAA Gene: RB2654_22408: Transglutaminase-like protein	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	* Oceanicola batsensis HTCC2597 Site: position = -57 score = 5.12465 sequence = AAGCTACAGTGACTGTAGCAA Gene: OB2597_16652: Transglutaminase-like protein	* Roseovarius nubinhibens ISM Site: position = -64 score = 5.59608 sequence = AAGCTATAGTGACTATAGCAA Gene: ISM_17525: Transglutaminase-like protein	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	* Roseobacter sp. MED193 Site: position = -57 score = 4.87793 sequence = AAGCTACAGTAACTATAGAGA Gene: MED193_02255: Transglutaminase-like protein	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Transglutaminase-like protein
czcD2	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	2 Rhodobacterales bacterium HTCC2654* Gene: RB2654_22413: Co/Zn/Cd efflux protein Site: position = -50 score = 6.27327 sequence = AACCTCTAGTCGCTAGAGGAA Gene: RB2654_10329: Co/Zn/Cd efflux protein	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_16657: Co/Zn/Cd efflux protein	Roseovarius nubinhibens ISM Gene: ISM_17520: Co/Zn/Cd efflux protein	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_02260: Co/Zn/Cd efflux protein	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Co/Zn/Cd efflux protein
PF11964	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654 Gene: RB2654_22418: hypothetical protein	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_16662: hypothetical protein	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein

CRON 2.
cadR	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	* Rhodobacterales bacterium HTCC2654 Site: position = -119 score = 5.72403 sequence = ATCCTCTAGCTACTGTAGGTT Gene: RB2654_22398: Cadmium resistance transcriptional regulator, MerR family	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	* Oceanicola batsensis HTCC2597 Site: position = -134 score = 5.72403 sequence = ATCCTCTAGCTACTGTAGGTT Gene: OB2597_16642: Cadmium resistance transcriptional regulator, MerR family	* Roseovarius nubinhibens ISM Site: position = -129 score = 6.01198 sequence = ATCCTCTAGCAGCTAGAGGTT Gene: ISM_17535: Cadmium resistance transcriptional regulator, MerR family	* Roseovarius sp. 217 Site: position = -135 score = 5.72403 sequence = ATCCTCTAGCTACTGTAGGTT Gene: ROS217_02950: Cadmium resistance transcriptional regulator, MerR family	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	* Roseobacter sp. MED193 Site: position = -117 score = 6.19546 sequence = ATCCTCTAGCTACTAGAGGTT Gene: MED193_02240: Cadmium resistance transcriptional regulator, MerR family	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cadmium resistance transcriptional regulator, MerR family
PF02694	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_02245: Protein of unknown function UPF0060	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Protein of unknown function UPF0060
czcD	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654 Gene: RB2654_22403: Co/Zn/Cd efflux protein	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	2 Oceanicola batsensis HTCC2597 Gene: OB2597_16707: Co/Zn/Cd efflux protein Gene: OB2597_16647: Co/Zn/Cd efflux protein	Roseovarius nubinhibens ISM Gene: ISM_17530: Co/Zn/Cd efflux protein	2 Roseovarius sp. 217* Site: position = -128 score = 5.80329 sequence = AAGCTCTAGTCACTAGAGAGA Gene: ROS217_13921: Co/Zn/Cd efflux protein Gene: ROS217_02945: Co/Zn/Cd efflux protein	Sulfitobacter sp. EE-36	* Silicibacter TM1040 Site: position = -71 score = 6.26213 sequence = AACCTCTAGTCACTAGAGCAA Gene: TM1040_2930: Co/Zn/Cd efflux protein	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_02250: Co/Zn/Cd efflux protein	* Hyphomonas neptunium ATCC 15444 Site: position = -53 score = 5.88338 sequence = ATCCTCTAGTTACTTGAGGAT Gene: HNE_1727: Co/Zn/Cd efflux protein	Oceanicaulis alexandrii HTCC2633	Co/Zn/Cd efflux protein
lspA	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_16702: Lipoprotein signal peptidase (EC 3.4.23.36)	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444 Gene: HNE_1728: Lipoprotein signal peptidase (EC 3.4.23.36)	Oceanicaulis alexandrii HTCC2633	Lipoprotein signal peptidase (EC 3.4.23.36)

CRON 3.
cadR2	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	* Oceanicola batsensis HTCC2597 Site: position = -124 score = 5.08982 sequence = AAGCTACAGTGGGTAGAGGTT Gene: OB2597_05245: Cadmium resistance transcriptional regulator, MerR family	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cadmium resistance transcriptional regulator, MerR family
PF02694	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_05250: Protein of unknown function UPF0060	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Protein of unknown function UPF0060
PF01841	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	* Oceanicola batsensis HTCC2597 Site: position = -45 score = 4.94116 sequence = AAGCTACAGTCGCTGTAGCAA Gene: OB2597_05255: Transglutaminase-like protein	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Transglutaminase-like protein
czcD3	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_05260: Co/Zn/Cd efflux protein	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Co/Zn/Cd efflux protein

CRON 4.
EE36_00940	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	* Sulfitobacter sp. EE-36 Site: position = -61 score = 4.81219 sequence = AAGCTACAGTTGCTGTAGGTC Gene: EE36_00940: cation-transporting P-type ATPase	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	cation-transporting P-type ATPase
cadA	* Rhodobacter sphaeroides 2.4.1 Site: position = -70 score = 5.13063 sequence = AACCTATAGTTGCTAGAGACA Gene: RSP_1791: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	2 Paracoccus denitrificans PD1222* Site: position = -37 score = 5.75504 sequence = AACCTCTAGTTGCTAGAGATC Gene: Pden_0212: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -75 score = 6.07865 sequence = AAGCTCTAGTCGCTAGAGGAA Gene: Pden_2344: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Jannaschia sp. CCS1	* Rhodobacterales bacterium HTCC2654 Site: position = -228 score = 5.34119 sequence = AAGCTCTAGTTACTGTAGGGG Gene: RB2654_22328: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Oceanicola granulosus HTCC2516 Site: position = -63 score = 5.10322 sequence = AACCTACAGTCGGTAGAGGTC Gene: OG2516_17805: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Loktanella vestfoldensis SKA53	2 Oceanicola batsensis HTCC2597* Site: position = -228 score = 5.34119 sequence = AAGCTCTAGTTACTGTAGGGG Gene: OB2597_16572: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -62 score = 5.00681 sequence = AACCTACAGTTGCTGTAGGTC Gene: OB2597_05215: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Roseovarius nubinhibens ISM Site: position = -201 score = 5.1577 sequence = AAGCTCTAGCTACTGTAGGGG Gene: ISM_17615: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Roseovarius sp. 217 Site: position = -271 score = 5.34119 sequence = AAGCTCTAGTTACTGTAGGGG Gene: ROS217_03080: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Sulfitobacter sp. EE-36 Gene: EE36_00945: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	2 Roseobacter sp. MED193* Site: position = -60 score = 5.1577 sequence = AAGCTCTAGCTACTGTAGGGG Gene: MED193_02180: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -58 score = 5.87994 sequence = AACCTCTAGTCACTGTAGGTC Gene: MED193_15017: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)
copG	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597 Gene: OB2597_05210: Predicted metal binding protein	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36 Gene: EE36_00950: Predicted metal binding protein	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Predicted metal binding protein
cadR2	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	Rhodobacterales bacterium HTCC2654	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	Oceanicola batsensis HTCC2597	Roseovarius nubinhibens ISM	Roseovarius sp. 217	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	Roseobacter sp. MED193 Gene: MED193_15022: Cadmium resistance transcriptional regulator, MerR family	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	Cadmium resistance transcriptional regulator, MerR family

CRON 5.
PF03734	Rhodobacter sphaeroides 2.4.1	Paracoccus denitrificans PD1222	Jannaschia sp. CCS1	* Rhodobacterales bacterium HTCC2654 Site: position = -150 score = 5.29212 sequence = AACCTCTAGTAGCTTTAGGAG Gene: RB2654_22323: hypothetical protein	Oceanicola granulosus HTCC2516	Loktanella vestfoldensis SKA53	* Oceanicola batsensis HTCC2597 Site: position = -150 score = 5.29212 sequence = AACCTCTAGTAGCTTTAGGAG Gene: OB2597_16567: hypothetical protein	* Roseovarius nubinhibens ISM Site: position = -152 score = 5.57465 sequence = AACCTCTAGCCACTAGAAGTC Gene: ISM_17625: hypothetical protein	3 Roseovarius sp. 217* Site: position = -111 score = 5.34303 sequence = AAGCTCTAGTTGGTAGAGGTT Gene: ROS217_02920: hypothetical protein Gene: ROS217_03090: hypothetical protein Site: position = -60 score = 5.14431 sequence = AAGCTCTAGTGGGTGGAGGTC Gene: ROS217_02925: hypothetical protein	Sulfitobacter sp. EE-36	Silicibacter TM1040	Silicibacter pomeroyi DSS-3	* Roseobacter sp. MED193 Site: position = -88 score = 5.57465 sequence = AACCTCTAGCCACTAGAAGTC Gene: MED193_02170: hypothetical protein	Hyphomonas neptunium ATCC 15444	Oceanicaulis alexandrii HTCC2633	hypothetical protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CadR-PbrR - Rhodobacterales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --