Regulog CueR - Rhizobiales

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator (repressor)
Biological process:	Copper resistance
Effector:	Copper ion, (Cu+)
Phylum:	Proteobacteria/alpha
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 22 sites [see more]

Member of regulog collections

By taxonomy - Rhizobiales
By trascription factor - CueR
By TF family - MerR
By effector - Copper ion, (Cu+)
By pathway - Copper resistance

Statistics of regulated genes
Genome	Genes	Operons
Sinorhizobium meliloti 1021	12	5
Rhizobium sp. NGR234	14	5
Rhizobium leguminosarum bv. viciae 3841	4	2
Rhizobium etli CFN 42	2	1
Agrobacterium tumefaciens str. C58 (Cereon)	5	2
Mesorhizobium sp. BNC1	5	3
Mesorhizobium loti MAFF303099	1	1
Brucella melitensis 16M	2	2
Bartonella quintana str. Toulouse
Rhodopseudomonas palustris CGA009
Bradyrhizobium japonicum USDA 110
Bradyrhizobium sp. BTAi1
Nitrobacter winogradskyi Nb-255
Azorhizobium caulinodans ORS 571
Xanthobacter autotrophicus Py2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
copA	2 Sinorhizobium meliloti 1021* Site: position = -55 score = 5.86085 sequence = ACCTTCCCATTATTGGAAGGA Gene: SMb21578: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -57 score = 5.57237 sequence = ACCTTACCATTGTTGGAAGGA Gene: SMa1013: Copper-translocating P-type ATPase (EC 3.6.3.4)	3 Rhizobium sp. NGR234* Site: position = -57 score = 5.57237 sequence = ACCTTACCATTGTTGGAAGGA Gene: NGR_b08430: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -58 score = 4.52683 sequence = ACCTTCCGACCGTTGTAAGCC Gene: NGR_b07400: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -58 score = 5.30739 sequence = ACCTTCCCACCGTTGGAAGCC Gene: NGR_b12440: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Rhizobium leguminosarum bv. viciae 3841* Site: position = -64 score = 5.71226 sequence = ACCTTCCAGTCGCTGGAAGGT Gene: pRL110010: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -56 score = 5.47744 sequence = ACCTTCCCATCATAGGAAGGA Gene: pRL110331: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Rhizobium etli CFN 42 Site: position = -63 score = 5.74921 sequence = ACCTTCCAGTTGCTGGAAGGT Gene: RHE_PE00007: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Agrobacterium tumefaciens str. C58 (Cereon)* Site: position = -54 score = 5.38205 sequence = ACCTTGCCACGATGGGAAGCC Gene: Atu1195: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -110 score = 5.62174 sequence = ACCTTCCCATCATGGGAAGCC Gene: Atu0937: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Mesorhizobium sp. BNC1* Site: position = -49 score = 5.4631 sequence = ACCTTCCAGTAACTGGAAGGA Gene: Meso_2667: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -66 score = 5.39235 sequence = ACCTTCCCATCGTTGGAAGCC Site: position = -115 score = 5.30739 sequence = GGCTTCCCACCGTTGGAAGGT Gene: Meso_3893: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Mesorhizobium loti MAFF303099 Site: position = -62 score = 5.215 sequence = ACCTTCCAGTTACTGGAAGCA Gene: mlr5325: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Brucella melitensis 16M Site: position = -77 score = 5.35626 sequence = ACCTTCCAACGGTTGGAAGGG Gene: BMEI1730: Copper-translocating P-type ATPase (EC 3.6.3.4)	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Copper-translocating P-type ATPase (EC 3.6.3.4)
COG2871	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234 Gene: NGR_b07390: Putative oxidoreductase	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu1196: Putative oxidoreductase	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Putative oxidoreductase
cueR	2 Sinorhizobium meliloti 1021 Gene: SMb21579: Copper-responsive transcriptional regulator, MerR family Gene: SMa1014: Copper-responsive transcriptional regulator, MerR family	3 Rhizobium sp. NGR234 Gene: NGR_b07380: Copper-responsive transcriptional regulator, MerR family Gene: NGR_b12430: Copper-responsive transcriptional regulator, MerR family Gene: NGR_b08420: Copper-responsive transcriptional regulator, MerR family	2 Rhizobium leguminosarum bv. viciae 3841 Gene: pRL110009: Copper-responsive transcriptional regulator, MerR family Gene: pRL110330: Copper-responsive transcriptional regulator, MerR family	Rhizobium etli CFN 42 Gene: RHE_PE00006: Copper-responsive transcriptional regulator, MerR family	2 Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu1197: Copper-responsive transcriptional regulator, MerR family Gene: Atu0938: Copper-responsive transcriptional regulator, MerR family	Mesorhizobium sp. BNC1 Gene: Meso_3892: Copper-responsive transcriptional regulator, MerR family	Mesorhizobium loti MAFF303099	Brucella melitensis 16M Gene: BMEI1729: Copper-responsive transcriptional regulator, MerR family	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Copper-responsive transcriptional regulator, MerR family
cueO	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234 Gene: NGR_b07370: Multicopper oxidase	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Multicopper oxidase
copG	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1 Gene: Meso_3891: Predicted metal binding protein	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Predicted metal binding protein

CRON 2.
PF11162	* Sinorhizobium meliloti 1021 Site: position = -147 score = 5.03409 sequence = ACCTTGCCATCGTTGTAAGCC Gene: SMc02279: Hypothetical protein	* Rhizobium sp. NGR234 Site: position = -135 score = 4.75459 sequence = ACCTTACCATCGTTGGAAACA Gene: NGR_b08300: Hypothetical protein	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Hypothetical protein
SMc02280	Sinorhizobium meliloti 1021 Gene: SMc02280: Hypothetical protein	Rhizobium sp. NGR234 Gene: NGR_b08290: Hypothetical protein	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bsl2212: Hypothetical protein	Bradyrhizobium sp. BTAi1 Gene: BBta_6517: Hypothetical protein	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Hypothetical protein
copB	Sinorhizobium meliloti 1021 Gene: SMc02281: Copper tolerance outer membrane protein	Rhizobium sp. NGR234 Gene: NGR_b08280: Copper tolerance outer membrane protein	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu3992: Copper tolerance outer membrane protein	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bll2211: Copper tolerance outer membrane protein	Bradyrhizobium sp. BTAi1 Gene: BBta_6518: Copper tolerance outer membrane protein	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Copper tolerance outer membrane protein
cueO	Sinorhizobium meliloti 1021 Gene: SMc02282: Multicopper oxidase	Rhizobium sp. NGR234 Gene: NGR_b08270: Multicopper oxidase	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu3991: Multicopper oxidase	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bll2210: Multicopper oxidase	Bradyrhizobium sp. BTAi1 Gene: BBta_6519: Multicopper oxidase	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Multicopper oxidase
copC	Sinorhizobium meliloti 1021 Gene: SMc02283: Cupredoxin	Rhizobium sp. NGR234 Gene: NGR_b08260: Cupredoxin	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu3990: Cupredoxin	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bll2209: Cupredoxin	Bradyrhizobium sp. BTAi1 Gene: BBta_6520: Cupredoxin	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Cupredoxin
cusF	Sinorhizobium meliloti 1021 Gene: SMc02284: Heavy metal efflux RND periplasmic protein	Rhizobium sp. NGR234 Gene: NGR_b08250: Heavy metal efflux RND periplasmic protein	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bll2208: Heavy metal efflux RND periplasmic protein	Bradyrhizobium sp. BTAi1 Gene: BBta_6521: Heavy metal efflux RND periplasmic protein	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Heavy metal efflux RND periplasmic protein

CRON 3.
copZ	2 Sinorhizobium meliloti 1021* Site: position = -57 score = 5.70718 sequence = ACCTTGCCATCGTTGGAAGCT Gene: SMb20560: Copper chaperone Site: position = -59 score = 4.6501 sequence = ACCTTGCCATCGTTGGAAACG Gene: SMa1009: Copper chaperone	* Rhizobium sp. NGR234 Site: position = -57 score = 4.9065 sequence = ACCCTGCCATCGTTGGAAGCC Gene: NGR_b08480: Copper chaperone	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	* Mesorhizobium sp. BNC1 Site: position = -35 score = 5.30739 sequence = ACCTTCCAACGGTGGGAAGCC Gene: Meso_3894: Copper chaperone	Mesorhizobium loti MAFF303099	* Brucella melitensis 16M Site: position = -59 score = 5.85162 sequence = ACCTTGCCACGATGGGAAGCT Gene: BMEI1032: Copper chaperone	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Copper chaperone

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CueR - Rhizobiales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --