Regulog CueR - Vibrionales

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator (repressor)
Biological process:	Copper resistance
Effector:	Copper ion, (Cu+)
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 25 sites [see more]

Member of regulog collections

By taxonomy - Vibrionales
By trascription factor - CueR
By TF family - MerR
By effector - Copper ion, (Cu+)
By pathway - Copper resistance

Statistics of regulated genes
Genome	Genes	Operons
Vibrio cholerae O1 biovar eltor str. N16961	3	2
Vibrio vulnificus CMCP6	8	3
Vibrio harveyi ATCC BAA-1116	8	3
Vibrio parahaemolyticus RIMD 2210633	9	3
Vibrio shilonii AK1	7	2
Vibrio splendidus LGP32	5	1
Vibrio fischeri ES114	8	3
Vibrio salmonicida LFI1238	8	3
Vibrio angustum S14	2	2
Photobacterium profundum SS9	7	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes											Function

CRON 1.
cueR	Vibrio cholerae O1 biovar eltor str. N16961 Gene: VC0974: Copper-responsive transcriptional regulator, MerR family	Vibrio vulnificus CMCP6 Gene: VV20113: Copper-responsive transcriptional regulator, MerR family	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_06131: Copper-responsive transcriptional regulator, MerR family	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA0662: Copper-responsive transcriptional regulator, MerR family	Vibrio shilonii AK1 Gene: VSAK1_08833: Copper-responsive transcriptional regulator, MerR family	Vibrio splendidus LGP32 Gene: VS_2283: Copper-responsive transcriptional regulator, MerR family	* Vibrio fischeri ES114 Site: position = -46 score = 5.48541 sequence = ACCTTACAGTTAATGGAAGGT Gene: VF_0782: Copper-responsive transcriptional regulator, MerR family	* Vibrio salmonicida LFI1238 Site: position = -47 score = 5.48541 sequence = ACCTTACAGTAAATGGAAGGT Gene: VSAL_I0803: Copper-responsive transcriptional regulator, MerR family	* Vibrio angustum S14 Site: position = -73 score = 5.21019 sequence = ACCTTCTAGTTACTGTAAGGT Gene: VAS14_16481: Copper-responsive transcriptional regulator, MerR family	* Photobacterium profundum SS9 Site: position = -82 score = 4.74729 sequence = ACCTTCTGGTTGGTGTAAGGT Gene: PBPRA2823: Copper-responsive transcriptional regulator, MerR family	Copper-responsive transcriptional regulator, MerR family

CRON 2.
PF00034	Vibrio cholerae O1 biovar eltor str. N16961	* Vibrio vulnificus CMCP6 Site: position = -58 score = 5.73614 sequence = AGCTTCCCCTTAGGGGAAGCT Gene: VV20052: Cytochrome c553	* Vibrio harveyi ATCC BAA-1116 Site: position = -64 score = 5.73614 sequence = AGCTTCCCCTAAGGGGAAGCT Gene: VIBHAR_05667: Cytochrome c553	* Vibrio parahaemolyticus RIMD 2210633 Site: position = 3 score = 5.73614 sequence = AGCTTCCCCTTAGGGGAAGCT Gene: VPA1012: Cytochrome c553	Vibrio shilonii AK1	Vibrio splendidus LGP32	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	Vibrio angustum S14	Photobacterium profundum SS9	Cytochrome c553

CRON 3.
VCA0262	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -57 score = 4.52231 sequence = ACCTTCCCCTAGGGTAAAACT Gene: VCA0262: Conserved hypothetical protein	* Vibrio vulnificus CMCP6 Site: position = -102 score = 4.8515 sequence = ACCTTACCCTAGGGTAAAGCT Gene: VV20849: Conserved hypothetical protein	* Vibrio harveyi ATCC BAA-1116 Site: position = -58 score = 5.01562 sequence = ACCTTCCCCTAAGGTTAACCT Gene: VIBHAR_06363: Conserved hypothetical protein	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -72 score = 4.68512 sequence = ACTTTCCCCCTAGGGTAACCT Gene: VPA0484: Conserved hypothetical protein	3 Vibrio shilonii AK1* Gene: VSAK1_07509: Conserved hypothetical protein Gene: VSAK1_07549: Conserved hypothetical protein Site: position = -56 score = 5.90122 sequence = ACCTTCCCCTTAGGGGAGGGT Gene: VSAK1_10308: Conserved hypothetical protein	* Vibrio splendidus LGP32 Site: position = -53 score = 5.55089 sequence = ACCTTACCCTAAGGGGAACGT Gene: VS_II0513: Conserved hypothetical protein	* Vibrio fischeri ES114 Site: position = -50 score = 5.50869 sequence = ACCTTCCCCTAAGTGGAGGCT Gene: VF_A0442: Conserved hypothetical protein	* Vibrio salmonicida LFI1238 Site: position = -59 score = 5.41482 sequence = ACCTTACCCTAAGTGGAAGGC Gene: VSAL_II0717: Conserved hypothetical protein	Vibrio angustum S14	* Photobacterium profundum SS9 Site: position = -201 score = 5.47173 sequence = ACCTTACCCTTAGGGAAAGGT Gene: PBPRA1006: Conserved hypothetical protein	Conserved hypothetical protein
VPA0483	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6	Vibrio harveyi ATCC BAA-1116	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA0483: unknown	Vibrio shilonii AK1	Vibrio splendidus LGP32	Vibrio fischeri ES114	Vibrio salmonicida LFI1238	Vibrio angustum S14	Photobacterium profundum SS9	unknown
cusC	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6 Gene: VV20850: Heavy metal RND efflux outer membrane protein, CzcC family	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_06364: Heavy metal RND efflux outer membrane protein, CzcC family	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA0482: Heavy metal RND efflux outer membrane protein, CzcC family	2 Vibrio shilonii AK1 Gene: VSAK1_07514: Heavy metal RND efflux outer membrane protein, CzcC family Gene: VSAK1_10303: Heavy metal RND efflux outer membrane protein, CzcC family	Vibrio splendidus LGP32 Gene: VS_II0514: Heavy metal RND efflux outer membrane protein, CzcC family	Vibrio fischeri ES114 Gene: VF_A0443: Heavy metal RND efflux outer membrane protein, CzcC family	Vibrio salmonicida LFI1238 Gene: VSAL_II0716: Heavy metal RND efflux outer membrane protein, CzcC family	Vibrio angustum S14	Photobacterium profundum SS9 Gene: PBPRA1005: Heavy metal RND efflux outer membrane protein, CzcC family	Heavy metal RND efflux outer membrane protein, CzcC family
cusB	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6 Gene: VV20851: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_06365: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA0481: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	2 Vibrio shilonii AK1 Gene: VSAK1_07519: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family Gene: VSAK1_10298: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Vibrio splendidus LGP32 Gene: VS_II0515: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Vibrio fischeri ES114 Gene: VF_A0444: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Vibrio salmonicida LFI1238 Gene: VSAL_II0715: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Vibrio angustum S14	Photobacterium profundum SS9 Gene: PBPRA1004: Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family	Cobalt/zinc/cadmium efflux RND transporter, membrane fusion protein, CzcB family
cusA	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6 Gene: VV20852: Cation efflux system protein CusA, transmembrane protein	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_06366: Cation efflux system protein CusA, transmembrane protein	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA0480: Cation efflux system protein CusA, transmembrane protein	2 Vibrio shilonii AK1 Gene: VSAK1_07524: Cation efflux system protein CusA, transmembrane protein Gene: VSAK1_10293: Cation efflux system protein CusA, transmembrane protein	Vibrio splendidus LGP32 Gene: VS_II0516: Cation efflux system protein CusA, transmembrane protein	Vibrio fischeri ES114 Gene: VF_A0445: Cation efflux system protein CusA, transmembrane protein	Vibrio salmonicida LFI1238 Gene: VSAL_II0714: Cation efflux system protein CusA, transmembrane protein	Vibrio angustum S14	Photobacterium profundum SS9 Gene: PBPRA1003: Cation efflux system protein CusA, transmembrane protein	Cation efflux system protein CusA, transmembrane protein
cusF	Vibrio cholerae O1 biovar eltor str. N16961	Vibrio vulnificus CMCP6 Gene: VV20853: putative blue copper protein	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_06367: putative blue copper protein	Vibrio parahaemolyticus RIMD 2210633 Gene: VPA0479: putative blue copper protein	2 Vibrio shilonii AK1 Gene: VSAK1_07529: putative blue copper protein Gene: VSAK1_10288: putative blue copper protein	Vibrio splendidus LGP32 Gene: VS_II0517: putative blue copper protein	Vibrio fischeri ES114 Gene: VF_A0446: putative blue copper protein	Vibrio salmonicida LFI1238 Gene: VSAL_II0713: putative blue copper protein	Vibrio angustum S14	Photobacterium profundum SS9 Gene: PBPRA1002: putative blue copper protein	putative blue copper protein

CRON 4.
copA	* Vibrio cholerae O1 biovar eltor str. N16961 Site: position = -29 score = 5.33823 sequence = ACCTTACCTTAAGGTTAAGGT Gene: VC2215: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio vulnificus CMCP6 Site: position = -60 score = 5.8161 sequence = ACCTTCCCCCGGCGGCAAGGT Gene: VV1_0239: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio harveyi ATCC BAA-1116 Site: position = -57 score = 5.60184 sequence = ACCTTCCCCTTGCAGGAAGGT Gene: VIBHAR_01268: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio parahaemolyticus RIMD 2210633 Site: position = -58 score = 5.59954 sequence = ACCTTCCCCTTGATGTAAGGT Gene: VP0758: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio shilonii AK1 Site: position = -100 score = 5.68568 sequence = ACCTTACCCTTGCGGTAAGGT Gene: VSAK1_08868: Copper-translocating P-type ATPase (EC 3.6.3.4)	Vibrio splendidus LGP32 Gene: VS_0768: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio fischeri ES114 Site: position = -60 score = 5.48541 sequence = ACCTTCCATTAACTGTAAGGT Gene: VF_0781: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio salmonicida LFI1238 Site: position = -61 score = 5.48541 sequence = ACCTTCCATTTACTGTAAGGT Gene: VSAL_I0802: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Vibrio angustum S14 Site: position = -107 score = 5.21019 sequence = ACCTTACAGTAACTAGAAGGT Gene: VAS14_16476: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Photobacterium profundum SS9 Site: position = -92 score = 4.74729 sequence = ACCTTACACCAACCAGAAGGT Gene: PBPRA2824: Copper-translocating P-type ATPase (EC 3.6.3.4)	Copper-translocating P-type ATPase (EC 3.6.3.4)
copG	Vibrio cholerae O1 biovar eltor str. N16961 Gene: VC2216: Predicted metal-binding protein	Vibrio vulnificus CMCP6 Gene: VV1_0240: Predicted metal-binding protein	Vibrio harveyi ATCC BAA-1116 Gene: VIBHAR_01267: Predicted metal-binding protein	Vibrio parahaemolyticus RIMD 2210633 Gene: VP0757: Predicted metal-binding protein	Vibrio shilonii AK1 Gene: VSAK1_08863: Predicted metal-binding protein	Vibrio splendidus LGP32 Gene: VS_0767: Predicted metal-binding protein	Vibrio fischeri ES114 Gene: VF_0780: Predicted metal-binding protein	Vibrio salmonicida LFI1238 Gene: VSAL_I0801: Predicted metal-binding protein	Vibrio angustum S14 Gene: VAS14_02436: Predicted metal-binding protein	Photobacterium profundum SS9 Gene: PBPRA1905: Predicted metal-binding protein	Predicted metal-binding protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CueR - Vibrionales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --