Regulog CueR - Ralstonia

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator (repressor)
Biological process:	Copper resistance
Effector:	Copper ion, (Cu+)
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 18 sites [see more]

Member of regulog collections

By taxonomy - Ralstonia
By trascription factor - CueR
By TF family - MerR
By effector - Copper ion, (Cu+)
By pathway - Copper resistance

Statistics of regulated genes
Genome	Genes	Operons
Ralstonia solanacearum GMI1000	3	2
Ralstonia pickettii 12J	13	5
Ralstonia metallidurans CH34	11	4
Ralstonia eutropha JMP134	3	2
Ralstonia eutropha H16	4	3
Cupriavidus taiwanensis	3	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes							Function

CRON 1.
copZ	* Ralstonia solanacearum GMI1000 Site: position = -69 score = 4.94927 sequence = CGTTTCCCATGGTGGGAAGGT Gene: RS02624: Copper chaperone	* Ralstonia pickettii 12J Site: position = -66 score = 5.12843 sequence = CACTTCCCACGATGGGAAGGT Gene: Rpic_3544: Copper chaperone	Ralstonia metallidurans CH34 Gene: Rmet_3525: Copper chaperone	* Ralstonia eutropha JMP134 Site: position = -82 score = 5.48199 sequence = CGCTTCCCACCATGGGAAGGT Gene: Reut_A3377: Copper chaperone	* Ralstonia eutropha H16 Site: position = -81 score = 5.48199 sequence = CGCTTCCCACCATGGGAAGGT Gene: H16_A3669: Copper chaperone	* Cupriavidus taiwanensis Site: position = -80 score = 5.32726 sequence = CGCTTCCCATGGTGGCAAGGT Gene: RALTA_A3125: Copper chaperone	Copper chaperone

CRON 2.
copA	* Ralstonia solanacearum GMI1000 Site: position = -61 score = 5.33146 sequence = ACCTTCCTAATATGGGAAGGT Gene: RS02623: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Ralstonia pickettii 12J Site: position = -100 score = 5.12843 sequence = ACCTTCCCATCGTGGGAAGTG Gene: Rpic_3543: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Ralstonia metallidurans CH34 Site: position = -67 score = 5.90649 sequence = ACCTTCCAATGGTGGTAAGGT Gene: Rmet_3524: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Ralstonia eutropha JMP134 Site: position = -59 score = 5.64498 sequence = ACCTTCCTATGATGGTAAGGT Gene: Reut_A3376: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Ralstonia eutropha H16 Site: position = -61 score = 5.99144 sequence = ACCTTCCAATGATGGTAAGGT Gene: H16_A3668: Copper-translocating P-type ATPase (EC 3.6.3.4)	* Cupriavidus taiwanensis Site: position = -60 score = 5.99144 sequence = ACCTTCCAATGATGGTAAGGT Gene: RALTA_A3123: Copper-translocating P-type ATPase (EC 3.6.3.4)	Copper-translocating P-type ATPase (EC 3.6.3.4)
cueR	Ralstonia solanacearum GMI1000 Gene: RS02622: Copper-responsive transcriptional regulator, MerR family	Ralstonia pickettii 12J Gene: Rpic_3542: Copper-responsive transcriptional regulator, MerR family	Ralstonia metallidurans CH34 Gene: Rmet_3523: Copper-responsive transcriptional regulator, MerR family	Ralstonia eutropha JMP134 Gene: Reut_A3375: Copper-responsive transcriptional regulator, MerR family	Ralstonia eutropha H16 Gene: H16_A3667: Copper-responsive transcriptional regulator, MerR family	Cupriavidus taiwanensis Gene: RALTA_A3122: Copper-responsive transcriptional regulator, MerR family	Copper-responsive transcriptional regulator, MerR family

CRON 3.
copA2	Ralstonia solanacearum GMI1000	2 Ralstonia pickettii 12J* Gene: Rpic_1804: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -156 score = 5.34053 sequence = ACCTTCCCTCCGTGGAAAGGT Gene: Rpic_4609: Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Ralstonia metallidurans CH34* Site: position = -349 score = 5.75672 sequence = ACCTTCCCATGGCGGGAAGGA Gene: pMOL30_143: Copper-translocating P-type ATPase (EC 3.6.3.4) Site: position = -349 score = 5.75672 sequence = ACCTTCCCATGGCGGGAAGGA Gene: Rmet_6119: Copper-translocating P-type ATPase (EC 3.6.3.4)	Ralstonia eutropha JMP134	* Ralstonia eutropha H16 Site: position = -358 score = 5.38399 sequence = ACCTTCCAACGATGGGAACCT Gene: H16_A2173: Copper-translocating P-type ATPase (EC 3.6.3.4)	Cupriavidus taiwanensis	Copper-translocating P-type ATPase (EC 3.6.3.4)
copG	Ralstonia solanacearum GMI1000	Ralstonia pickettii 12J	2 Ralstonia metallidurans CH34 Gene: pMOL30_144: CopG protein Gene: Rmet_6118: CopG protein	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	CopG protein
cueR2	Ralstonia solanacearum GMI1000	* Ralstonia pickettii 12J Site: position = -125 score = 4.89448 sequence = ACCTTCCCACGTGGGCAGGCT Gene: Rpic_1805: Copper-responsive transcriptional regulator, MerR family	Ralstonia metallidurans CH34	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	Copper-responsive transcriptional regulator, MerR family

CRON 4.
Rpic_1651	Ralstonia solanacearum GMI1000	* Ralstonia pickettii 12J Site: position = -116 score = 5.65875 sequence = ACGTTGCCATTGTGGGAAGGT Gene: Rpic_1651: hypothetical protein	Ralstonia metallidurans CH34	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	hypothetical protein
Rpic_1650	Ralstonia solanacearum GMI1000	Ralstonia pickettii 12J Gene: Rpic_1650: hypothetical protein	Ralstonia metallidurans CH34	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	hypothetical protein
cusD	Ralstonia solanacearum GMI1000 Gene: RS05408: Heavy metal efflux RND transmembrane protein	Ralstonia pickettii 12J Gene: Rpic_1649: Heavy metal efflux RND transmembrane protein	2 Ralstonia metallidurans CH34* Site: position = -110 score = 4.5961 sequence = ACGTTCCTGCCGTGGGAACGT Gene: Rmet_5030: Heavy metal efflux RND transmembrane protein Gene: Rmet_6133: Heavy metal efflux RND transmembrane protein	Ralstonia eutropha JMP134	Ralstonia eutropha H16 Gene: H16_A2184: Heavy metal efflux RND transmembrane protein	Cupriavidus taiwanensis	Heavy metal efflux RND transmembrane protein
cusC	Ralstonia solanacearum GMI1000 Gene: RS05407: Heavy metal efflux RND outer membrane protein, CzcC family	Ralstonia pickettii 12J Gene: Rpic_1648: Heavy metal efflux RND outer membrane protein, CzcC family	3 Ralstonia metallidurans CH34 Gene: Rmet_5031: Heavy metal efflux RND outer membrane protein, CzcC family Gene: pMOL30_135: Heavy metal efflux RND outer membrane protein, CzcC family Gene: Rmet_6134: Heavy metal efflux RND outer membrane protein, CzcC family	Ralstonia eutropha JMP134	Ralstonia eutropha H16 Gene: H16_A2185: Heavy metal efflux RND outer membrane protein, CzcC family	Cupriavidus taiwanensis	Heavy metal efflux RND outer membrane protein, CzcC family
cusB	Ralstonia solanacearum GMI1000 Gene: RS05406: Heavy metal efflux RND transporter, membrane fusion protein, CzcB family	Ralstonia pickettii 12J Gene: Rpic_1647: Heavy metal efflux RND transporter, membrane fusion protein, CzcB family	3 Ralstonia metallidurans CH34 Gene: pMOL30_134: Heavy metal efflux RND transporter, membrane fusion protein, CzcB family Gene: Rmet_6135: Heavy metal efflux RND transporter, membrane fusion protein, CzcB family Gene: Rmet_5032: Heavy metal efflux RND transporter, membrane fusion protein, CzcB family	Ralstonia eutropha JMP134	Ralstonia eutropha H16 Gene: H16_A2186: Heavy metal efflux RND transporter, membrane fusion protein, CzcB family	Cupriavidus taiwanensis	Heavy metal efflux RND transporter, membrane fusion protein, CzcB family
cusA	Ralstonia solanacearum GMI1000 Gene: RS05405: Heavy metal efflux RND transmembrane protein, CzcA family	Ralstonia pickettii 12J Gene: Rpic_1646: Heavy metal efflux RND transmembrane protein, CzcA family	3 Ralstonia metallidurans CH34 Gene: pMOL30_133: Heavy metal efflux RND transmembrane protein, CzcA family Gene: Rmet_6136: Heavy metal efflux RND transmembrane protein, CzcA family Gene: Rmet_5033: Heavy metal efflux RND transmembrane protein, CzcA family	Ralstonia eutropha JMP134	Ralstonia eutropha H16 Gene: H16_A2187: Heavy metal efflux RND transmembrane protein, CzcA family	Cupriavidus taiwanensis	Heavy metal efflux RND transmembrane protein, CzcA family
cusF	Ralstonia solanacearum GMI1000 Gene: RS05404: Heavy metal efflux RND periplasmic protein	Ralstonia pickettii 12J Gene: Rpic_1645: Heavy metal efflux RND periplasmic protein	Ralstonia metallidurans CH34 Gene: Rmet_5034: Heavy metal efflux RND periplasmic protein	Ralstonia eutropha JMP134	Ralstonia eutropha H16 Gene: H16_A2188: Heavy metal efflux RND periplasmic protein	Cupriavidus taiwanensis	Heavy metal efflux RND periplasmic protein
Rmet_6706	Ralstonia solanacearum GMI1000	Ralstonia pickettii 12J	Ralstonia metallidurans CH34 Gene: Rmet_6706: hypothetical protein	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	hypothetical protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CueR - Ralstonia

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --