Regulog T-box(Met) - Lactobacillaceae

Properties
Regulator type:	RNA regulatory element
Name:	T-box
RFAM:	RF00230
Regulation mode:
Biological process:	Amino acid metabolism
Effector:	Met-tRNA
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Lactobacillaceae
By RNA motif - T-box
By effector - Met-tRNA
By pathway - Amino acid metabolism

Statistics of regulated genes
Genome	Genes	Operons
Oenococcus oeni PSU-1	9	2
Lactobacillus reuteri JCM 1112	12	6
Lactobacillus helveticus DPC 4571	6	3
Lactobacillus fermentum IFO 3956	13	6
Lactobacillus salivarius subsp. salivarius UCC118	5	1
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	6	3
Lactobacillus acidophilus NCFM	7	4
Lactobacillus johnsonii NCC 533	5	2
Lactobacillus plantarum WCFS1	16	7
Lactobacillus casei ATCC 334	8	4
Lactobacillus brevis ATCC 367	5	3
Lactobacillus sakei subsp. sakei 23K	3	1
Pediococcus pentosaceus ATCC 25745	4	2
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	20	6
Lactobacillus rhamnosus GG	7	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
metQ2	Oenococcus oeni PSU-1	* Lactobacillus reuteri JCM 1112 Site: position = -304 score = 71.35 sequence = TAAAATTACGTTAGA... Gene: LAR_1132: Methionine ABC transporter substrate-binding protein	Lactobacillus helveticus DPC 4571	* Lactobacillus fermentum IFO 3956 Site: position = -284 score = 72.81 sequence = GAAAAGTTAGAAAGA... Gene: LAF_0793: Methionine ABC transporter substrate-binding protein	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Methionine ABC transporter substrate-binding protein
msrA	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112 Gene: LAR_1131: Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956 Gene: LAF_0794: Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)

CRON 2.
metQ	2 Oenococcus oeni PSU-1* Gene: OEOE_1054: Methionine ABC transporter substrate-binding protein Site: position = -233 score = 91.25 sequence = CAAACGAATTGATCC... Gene: OEOE_1717: Methionine ABC transporter substrate-binding protein	2 Lactobacillus reuteri JCM 1112* Site: position = -335 score = 97.97 sequence = TTAAAACATATCGAA... Gene: LAR_0184: Methionine ABC transporter substrate-binding protein Gene: LAR_1485: Methionine ABC transporter substrate-binding protein	* Lactobacillus helveticus DPC 4571 Site: position = -287 score = 90.49 sequence = CAAACATCTTGAAGA... Gene: lhv_0960: Methionine ABC transporter substrate-binding protein	2 Lactobacillus fermentum IFO 3956* Site: position = -317 score = 90.31 sequence = AAAACATATCGAAAA... Gene: LAF_0053: Methionine ABC transporter substrate-binding protein Gene: LAF_0177: Methionine ABC transporter substrate-binding protein	2 Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0141: Methionine ABC transporter substrate-binding protein Gene: LSL_0130: Methionine ABC transporter substrate-binding protein	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365* Site: position = -330 score = 90.29 sequence = AAGTTATCTCGAAAA... Gene: LBUL_0723: Methionine ABC transporter substrate-binding protein Gene: LBUL_0087: Methionine ABC transporter substrate-binding protein	2 Lactobacillus acidophilus NCFM* Site: position = -287 score = 91.63 sequence = TAAACATCTTGAAGA... Gene: LBA0904: Methionine ABC transporter substrate-binding protein Site: position = -270 score = 91.97 sequence = AAAAAATCTTGATGA... Gene: LBA1395: Methionine ABC transporter substrate-binding protein	* Lactobacillus johnsonii NCC 533 Site: position = -295 score = 71.38 sequence = AACTTAAACATTTTG... Gene: LJ1408: Methionine ABC transporter substrate-binding protein	2 Lactobacillus plantarum WCFS1 Gene: lp_2350: Methionine ABC transporter substrate-binding protein Gene: lp_1746: Methionine ABC transporter substrate-binding protein	2 Lactobacillus casei ATCC 334* Site: position = -351 score = 74.32 sequence = ACAACACTTTGAGAA... Gene: LSEI_0411: Methionine ABC transporter substrate-binding protein Site: position = -312 score = 76.28 sequence = GAAACGAATGACGTG... Gene: LSEI_1177: Methionine ABC transporter substrate-binding protein	* Lactobacillus brevis ATCC 367 Site: position = -346 score = 82.41 sequence = TGAAAACAATGTGAT... Gene: LVIS_1957: Methionine ABC transporter substrate-binding protein	Lactobacillus sakei subsp. sakei 23K Gene: LSA1114: Methionine ABC transporter substrate-binding protein	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1309: Methionine ABC transporter substrate-binding protein	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293* Site: position = -388 score = 76.42 sequence = CGAAAACAAATTGAA... Gene: LEUM_0431: Methionine ABC transporter substrate-binding protein Gene: LEUM_0430: Methionine ABC transporter substrate-binding protein	3 Lactobacillus rhamnosus GG* Site: position = -313 score = 81.96 sequence = GAAACGAATGATATG... Gene: LGG_01196: Methionine ABC transporter substrate-binding protein Site: position = -342 score = 73.29 sequence = AACGGACTGAGTGAG... Gene: LGG_01195: Methionine ABC transporter substrate-binding protein Site: position = -313 score = 62.49 sequence = TCAACACTTCGAGAA... Gene: LGG_00500: Methionine ABC transporter substrate-binding protein	Methionine ABC transporter substrate-binding protein
hmrB	2 Oenococcus oeni PSU-1 Gene: OEOE_1719: N-acyl-L-amino acid amidohydrolase Gene: OEOE_1063: N-acyl-L-amino acid amidohydrolase	Lactobacillus reuteri JCM 1112 Gene: LAR_0181: N-acyl-L-amino acid amidohydrolase	Lactobacillus helveticus DPC 4571	2 Lactobacillus fermentum IFO 3956 Gene: LAF_0056: N-acyl-L-amino acid amidohydrolase Gene: LAF_0788: N-acyl-L-amino acid amidohydrolase	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0133: N-acyl-L-amino acid amidohydrolase	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0429: N-acyl-L-amino acid amidohydrolase	Lactobacillus rhamnosus GG	N-acyl-L-amino acid amidohydrolase
metN	2 Oenococcus oeni PSU-1 Gene: OEOE_1056: Methionine ABC transporter ATP-binding protein Gene: OEOE_1720: Methionine ABC transporter ATP-binding protein	Lactobacillus reuteri JCM 1112 Gene: LAR_0183: Methionine ABC transporter ATP-binding protein	Lactobacillus helveticus DPC 4571 Gene: lhv_0961: Methionine ABC transporter ATP-binding protein	Lactobacillus fermentum IFO 3956 Gene: LAF_0054: Methionine ABC transporter ATP-binding protein	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0131: Methionine ABC transporter ATP-binding protein	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0724: Methionine ABC transporter ATP-binding protein	Lactobacillus acidophilus NCFM Gene: LBA0905: Methionine ABC transporter ATP-binding protein	Lactobacillus johnsonii NCC 533 Gene: LJ1407: Methionine ABC transporter ATP-binding protein	2 Lactobacillus plantarum WCFS1* Site: position = -303 score = 75.41 sequence = AGTTATCATTTTGAA... Gene: lp_2352: Methionine ABC transporter ATP-binding protein Site: position = -318 score = 72.73 sequence = AATAAATACGTCTAA... Gene: lp_1744: Methionine ABC transporter ATP-binding protein	Lactobacillus casei ATCC 334 Gene: LSEI_1178: Methionine ABC transporter ATP-binding protein	Lactobacillus brevis ATCC 367 Gene: LVIS_1956: Methionine ABC transporter ATP-binding protein	* Lactobacillus sakei subsp. sakei 23K Site: position = -309 score = 80.31 sequence = AATACAAGCGATGAA... Gene: LSA1116: Methionine ABC transporter ATP-binding protein	* Pediococcus pentosaceus ATCC 25745 Site: position = -300 score = 96.23 sequence = AACAAAGTATTAGAG... Gene: PEPE_1311: Methionine ABC transporter ATP-binding protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0428: Methionine ABC transporter ATP-binding protein	Lactobacillus rhamnosus GG Gene: LGG_01197: Methionine ABC transporter ATP-binding protein	Methionine ABC transporter ATP-binding protein
metP	2 Oenococcus oeni PSU-1 Gene: OEOE_1055: Methionine ABC transporter permease protein Gene: OEOE_1721: Methionine ABC transporter permease protein	Lactobacillus reuteri JCM 1112 Gene: LAR_0182: Methionine ABC transporter permease protein	Lactobacillus helveticus DPC 4571 Gene: lhv_0962: Methionine ABC transporter permease protein	Lactobacillus fermentum IFO 3956 Gene: LAF_0055: Methionine ABC transporter permease protein	2 Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0140: Methionine ABC transporter permease protein Gene: LSL_0132: Methionine ABC transporter permease protein	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0725: Methionine ABC transporter permease protein	Lactobacillus acidophilus NCFM Gene: LBA0906: Methionine ABC transporter permease protein	Lactobacillus johnsonii NCC 533 Gene: LJ1406: Methionine ABC transporter permease protein	2 Lactobacillus plantarum WCFS1 Gene: lp_2351: Methionine ABC transporter permease protein Gene: lp_1745: Methionine ABC transporter permease protein	Lactobacillus casei ATCC 334 Gene: LSEI_1179: Methionine ABC transporter permease protein	Lactobacillus brevis ATCC 367 Gene: LVIS_1955: Methionine ABC transporter permease protein	Lactobacillus sakei subsp. sakei 23K Gene: LSA1115: Methionine ABC transporter permease protein	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1310: Methionine ABC transporter permease protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0427: Methionine ABC transporter permease protein	Lactobacillus rhamnosus GG Gene: LGG_01198: Methionine ABC transporter permease protein	Methionine ABC transporter permease protein
metE2	Oenococcus oeni PSU-1 Gene: OEOE_1718: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	2 Lactobacillus reuteri JCM 1112* Site: position = -312 score = 78.65 sequence = TAACCGCAATGAAAA... Gene: LAR_1028: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14) Site: position = -345 score = 87.12 sequence = AAACAGCTTAGAAAA... Gene: LAR_1752: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Lactobacillus helveticus DPC 4571	2 Lactobacillus fermentum IFO 3956* Site: position = -316 score = 72.06 sequence = AGAAACAGCTGAGAA... Gene: LAF_1601: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14) Site: position = -328 score = 81.71 sequence = ATAAGTTGCTGAGAA... Gene: LAF_0302: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -319 score = 73.85 sequence = AAATAGCTAAGAAAA... Gene: LSL_0129: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0096: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Lactobacillus acidophilus NCFM Site: position = -308 score = 75.51 sequence = AAGCGACGAAGAAAA... Gene: LBA1080: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Lactobacillus johnsonii NCC 533 Site: position = -459 score = 93.32 sequence = TTAAAGCTTAGAAAA... Gene: LJ0632: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Lactobacillus plantarum WCFS1 Site: position = -335 score = 77.68 sequence = AAAGAACGATTAAAA... Gene: lp_3283: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Lactobacillus casei ATCC 334 Site: position = -486 score = 66.84 sequence = CAGATTGCTTTGCGG... Gene: LSEI_0764: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Lactobacillus brevis ATCC 367 Site: position = -312 score = 56.47 sequence = ATAAATAAAGCTCGG... Gene: LVIS_0258: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Lactobacillus sakei subsp. sakei 23K	* Pediococcus pentosaceus ATCC 25745 Site: position = -337 score = 80.23 sequence = AATGAAAGCAATGAG... Gene: PEPE_0496: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293* Site: position = -378 score = 71.51 sequence = TATTTTAACAAAGAA... Gene: LEUM_1801: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14) Gene: LEUM_1803: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Lactobacillus rhamnosus GG Gene: LGG_00749: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
metA	Oenococcus oeni PSU-1 Gene: OEOE_0767: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus reuteri JCM 1112 Gene: LAR_1676: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus helveticus DPC 4571 Gene: lhv_1326: Homoserine O-succinyltransferase (EC 2.3.1.46)	2 Lactobacillus fermentum IFO 3956* Site: position = -274 score = 80.52 sequence = ATAAATTTCGTTGAT... Gene: LAF_0826: Homoserine O-succinyltransferase (EC 2.3.1.46) Gene: LAF_0345: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1717: Homoserine O-succinyltransferase (EC 2.3.1.46)	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1353: Homoserine O-succinyltransferase (EC 2.3.1.46) Gene: LBUL_0089: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus acidophilus NCFM Gene: LBA1237: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -315 score = 70.56 sequence = GATTAAGACGTTGAA... Gene: lp_2537: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus casei ATCC 334 Gene: LSEI_0479: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -354 score = 88.87 sequence = AATATAAACGTTGAA... Gene: LEUM_1806: Homoserine O-succinyltransferase (EC 2.3.1.46)	Lactobacillus rhamnosus GG Gene: LGG_00567: Homoserine O-succinyltransferase (EC 2.3.1.46)	Homoserine O-succinyltransferase (EC 2.3.1.46)
metI	Oenococcus oeni PSU-1 Gene: OEOE_0766: Cystathionine gamma-synthase (EC 2.5.1.48)	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956 Gene: LAF_0815: Cystathionine gamma-synthase (EC 2.5.1.48)	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -319 score = 68.78 sequence = AAATAACATGTTGAT... Gene: lp_2634: Cystathionine gamma-synthase (EC 2.5.1.48)	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1805: Cystathionine gamma-synthase (EC 2.5.1.48)	Lactobacillus rhamnosus GG	Cystathionine gamma-synthase (EC 2.5.1.48)
metC	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1804: Cystathionine beta-lyase	Lactobacillus rhamnosus GG	Cystathionine beta-lyase
yebR	* Oenococcus oeni PSU-1 Site: position = -235 score = 83.03 sequence = TTCAAACGAATTGAT... Gene: OEOE_1057: GAF domain-containing protein	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	GAF domain-containing protein
LEUM_1800	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1800: hypothetical protein	Lactobacillus rhamnosus GG	hypothetical protein
metY	Oenococcus oeni PSU-1 Gene: OEOE_0239: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_2536: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1799: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	Lactobacillus rhamnosus GG	O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
hom	Oenococcus oeni PSU-1 Gene: OEOE_1546: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	2 Lactobacillus fermentum IFO 3956 Gene: LAF_1145: Homoserine dehydrogenase (EC 1.1.1.3) Gene: LAF_0825: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1519: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1259: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus acidophilus NCFM Gene: LBA1212: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus johnsonii NCC 533	2 Lactobacillus plantarum WCFS1 Gene: lp_0571: Homoserine dehydrogenase (EC 1.1.1.3) Gene: lp_2535: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus casei ATCC 334 Gene: LSEI_2151: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0786: Homoserine dehydrogenase (EC 1.1.1.3)	Lactobacillus rhamnosus GG Gene: LGG_02155: Homoserine dehydrogenase (EC 1.1.1.3)	Homoserine dehydrogenase (EC 1.1.1.3)
rhc	Oenococcus oeni PSU-1 Gene: OEOE_1562: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Lactobacillus reuteri JCM 1112 Site: position = -329 score = 82.17 sequence = AGATATTGCTTAGAA... Gene: LAR_1486: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	* Lactobacillus helveticus DPC 4571 Site: position = -373 score = 67.22 sequence = GAAAAGCTCTGAAGA... Gene: lhv_1913: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus fermentum IFO 3956 Gene: LAF_1600: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1173: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	2 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365* Site: position = -375 score = 67.24 sequence = GGGAAAAGCTCTGAA... Gene: LBUL_1233: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS Gene: LBUL_0088: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus acidophilus NCFM Gene: LBA1081: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus johnsonii NCC 533 Gene: LJ0631: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus plantarum WCFS1 Gene: lp_0774: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus casei ATCC 334 Gene: LSEI_0765: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus brevis ATCC 367 Gene: LVIS_0340: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1638: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1802: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	Lactobacillus rhamnosus GG Gene: LGG_00750: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS	S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS
metE	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571 Gene: lhv_1914: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1232: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	2 Lactobacillus plantarum WCFS1* Site: position = -303 score = 94.33 sequence = TGTAAACGTCCTGAA... Gene: lp_1375: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Gene: lp_2718: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Lactobacillus casei ATCC 334 Site: position = -423 score = 79.17 sequence = TTGAAATGCGGAAAG... Gene: LSEI_0625: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1794: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Lactobacillus rhamnosus GG Site: position = -457 score = 81.14 sequence = TTGAAATGCGGAAAG... Gene: LGG_00597: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
metF	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571 Gene: lhv_1915: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1231: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_1374: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Lactobacillus casei ATCC 334 Gene: LSEI_0624: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -500 score = 84.19 sequence = GTTTTATACGAAGAA... Gene: LEUM_1795: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Lactobacillus rhamnosus GG Gene: LGG_00596: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
mdh	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112 Gene: LAR_1029: Predicted metal-dependent hydrolase	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293* Site: position = -320 score = 92.37 sequence = CAAAAACTTTGAAAA... Gene: LEUM_0115: Predicted metal-dependent hydrolase Gene: LEUM_1523: Predicted metal-dependent hydrolase	Lactobacillus rhamnosus GG	Predicted metal-dependent hydrolase
LEUM_0116	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0116: Amino acid transporter	Lactobacillus rhamnosus GG	Amino acid transporter
metB	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	* Lactobacillus fermentum IFO 3956 Site: position = -280 score = 76.1 sequence = TGTTCACGTTGATGA... Gene: LAF_0814: Cystathionine gamma-lyase (EC 4.4.1.1)	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Cystathionine gamma-lyase (EC 4.4.1.1)

CRON 3.
hcp	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1585: hypothetical protein	Lactobacillus acidophilus NCFM	Lactobacillus johnsonii NCC 533 Gene: LJ1702: hypothetical protein	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -283 score = 75.05 sequence = ATTAAAATCGTTGAA... Gene: LEUM_1975: hypothetical protein	Lactobacillus rhamnosus GG Gene: LGG_00428: hypothetical protein	hypothetical protein
mtsA	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571 Gene: lhv_0999: Substrate-specific component MtsA of methionine-regulated ECF transporter	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1584: Substrate-specific component MtsA of methionine-regulated ECF transporter	Lactobacillus acidophilus NCFM Gene: LBA0922: Substrate-specific component MtsA of methionine-regulated ECF transporter	Lactobacillus johnsonii NCC 533 Gene: LJ1703: Substrate-specific component MtsA of methionine-regulated ECF transporter	* Lactobacillus plantarum WCFS1 Site: position = -315 score = 63.62 sequence = AGAAAAAGCTGTGAC... Gene: lp_0150: Substrate-specific component MtsA of methionine-regulated ECF transporter	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1974: Substrate-specific component MtsA of methionine-regulated ECF transporter	Lactobacillus rhamnosus GG Gene: LGG_00429: Substrate-specific component MtsA of methionine-regulated ECF transporter	Substrate-specific component MtsA of methionine-regulated ECF transporter
mtsB	Oenococcus oeni PSU-1 Gene: OEOE_1540: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571 Gene: lhv_0998: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1583: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus acidophilus NCFM Gene: LBA0921: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus johnsonii NCC 533 Gene: LJ1704: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus plantarum WCFS1 Gene: lp_0149: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1973: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactobacillus rhamnosus GG Gene: LGG_00430: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
mtsC	Oenococcus oeni PSU-1 Gene: OEOE_1539: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571 Gene: lhv_0997: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1582: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus acidophilus NCFM Gene: LBA0920: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus johnsonii NCC 533 Gene: LJ1705: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus plantarum WCFS1 Gene: lp_0148: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1972: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactobacillus rhamnosus GG Gene: LGG_00431: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter

CRON 4.
mmuM	Oenococcus oeni PSU-1	* Lactobacillus reuteri JCM 1112 Site: position = -296 score = 85.71 sequence = AGAATTCGCTGAGAT... Gene: LAR_0993: Homocysteine S-methyltransferase (EC 2.1.1.10)	* Lactobacillus helveticus DPC 4571 Site: position = -194 score = 76.14 sequence = TGAAAAATTTGAAAA... Gene: lhv_1172: Homocysteine S-methyltransferase (EC 2.1.1.10)	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0268: Homocysteine S-methyltransferase (EC 2.1.1.10)	Lactobacillus acidophilus NCFM Gene: LBA1003: Homocysteine S-methyltransferase (EC 2.1.1.10)	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	Lactobacillus brevis ATCC 367	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	Homocysteine S-methyltransferase (EC 2.1.1.10)

CRON 5.
oppA	Oenococcus oeni PSU-1	Lactobacillus reuteri JCM 1112	Lactobacillus helveticus DPC 4571	Lactobacillus fermentum IFO 3956	Lactobacillus salivarius subsp. salivarius UCC118	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -426 score = 56.98 sequence = AGCAAAGCTTAAGAA... Gene: LBUL_0325: ABC-type oligopeptide transport system, periplasmic component	* Lactobacillus acidophilus NCFM Site: position = -309 score = 76.92 sequence = ATTAAGCAATGACAA... Gene: LBA1961: ABC-type oligopeptide transport system, periplasmic component	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus casei ATCC 334	* Lactobacillus brevis ATCC 367 Site: position = -280 score = 91.08 sequence = TGAACGCATGACTAG... Gene: LVIS_2175: ABC-type oligopeptide transport system, periplasmic component	Lactobacillus sakei subsp. sakei 23K	Pediococcus pentosaceus ATCC 25745	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Lactobacillus rhamnosus GG	ABC-type oligopeptide transport system, periplasmic component

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog T-box(Met) - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --