Collection of regulogs for NmlR transcription factor

Transcription factor NmlR from the MerR protein family regulates carbonyl stress response in Proteobacteria. It was first identified in Neisseria gonorrhoeae as it lacks the conserved cysteines known to bind metal ions in characterized proteins of this family [16135233]. NmlR regulates itself and three other genes in N. gonorrhoeae encoding a glutathione-dependent dehydrogenase (AdhC), a CPx-type ATPase (CopA) and a thioredoxin reductase (TrxB). An nmlR mutant lacked the ability to survive oxidative stress induced by diamide and cumene hydroperoxide. NmlR bind to the promoter regions of genes and is responsible for their high expression in the presence of diamide.