Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of TyrR in Shewanella sp MR-7

Properties
Regulator type: Transcription factor
TF locus tag: Shewmr7_2672
Regulator family: TyrR
Regulation mode: activator
Biological process: Amino acid utilization
Effector: Tyrosine; Phenylalanine
Regulog: TyrR - Shewanellaceae
Statistics of regulated genes:
- Genes 37
- Operons 18
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 312 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -180
Score: 4.5
Sequence: GTGTAAATAAAAAGTGGCAT
Locus tag: Shewmr7_3725
Name: tdo
Funciton: tryptophan 2,3-dioxygenase
Locus tag: Shewmr7_3724
Name: kyn
Funciton: kynureninase (tryptophan degradation)
tdo
tryptophan 2,3-dioxygenase
kyn
kynureninase (tryptophan degradation)

Position: -218
Score: 4
Sequence: GTGGCAATTAATTTTACCAG
Position: -152
Score: 4.6
Sequence: GTGTAAGCTAAATTTTACAG
Locus tag: Shewmr7_2040
Name: emrD
Funciton: multidrug resistance protein D
emrD
multidrug resistance protein D

Position: -172
Score: 4.2
Sequence: ATGGTAATTTTTAGTTACAA
Locus tag: Shewmr7_0787
Name: pep3
Funciton: peptidase, M13 family
pep3
peptidase, M13 family

Position: -298
Score: 3.9
Sequence: CTGGCAAAAAAGCCTGCCAA
Position: -101
Score: 4.5
Sequence: TTGTAATCTTAACTTGACGC
Locus tag: Shewmr7_2056
Name: aroA
Funciton: 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)
aroA
5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)

Position: -319
Score: 3.8
Sequence: ATGTAACAGTATCGTTCCAC
Position: -235
Score: 4.4
Sequence: ACGTAATGATTAGTTTACAA
Locus tag: Shewmr7_2671
Name: hmgC
Funciton: Fumarylacetoacetase (EC 3.7.1.2)
Locus tag: Shewmr7_2670
Name: hmgB
Funciton: Maleylacetoacetate isomerase (EC 5.2.1.2)
hmgC
Fumarylacetoacetase (EC 3.7.1.2)
hmgB
Maleylacetoacetate isomerase (EC 5.2.1.2)

Position: -106
Score: 5.1
Sequence: GTGTAAACATAGATTTGCAC
Locus tag: Shewmr7_3229
Name: brnQ
Funciton: Branched-chain amino acid transport system carrier protein
brnQ
Branched-chain amino acid transport system carrier protein

Position: -105
Score: 4.6
Sequence: GTGGCAACAAGAATTGACAA
Locus tag: Shewmr7_2393
Name: liuR
Funciton: Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family
Locus tag: Shewmr7_2394
Name: liuA
Funciton: Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)
Locus tag: Shewmr7_2395
Name: liuB
Funciton: Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)
Locus tag: Shewmr7_2396
Name: liuC
Funciton: Methylglutaconyl-CoA hydratase (EC 4.2.1.18)
Locus tag: Shewmr7_2397
Name: liuD
Funciton: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)
Locus tag: Shewmr7_2398
Name: liuE
Funciton: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
Locus tag: Shewmr7_2399
Name: liuF
Funciton: Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5)
Locus tag: Shewmr7_2400
Name: liuG
Funciton: Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5)
liuR
Predicted transcriptional regulator LiuR of leucine degradation pathway, MerR family
liuA
Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)
liuB
Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)
liuC
Methylglutaconyl-CoA hydratase (EC 4.2.1.18)
liuD
Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)
liuE
Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
liuF
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5)
liuG
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5)

Position: -197
Score: 4.6
Sequence: TTGTCAATTGAGCGTTACAT
Locus tag: Shewmr7_0850
Name: putA
Funciton: Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)
putA
Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)

Position: -205
Score: 4.7
Sequence: CTGTAAACTAGACTTGCCAC
Locus tag: Shewmr7_2672
Name: tyrR
Funciton: Transcriptional regulator of aromatic amino acid biosynthesis
tyrR
Transcriptional regulator of aromatic amino acid biosynthesis

Position: -372
Score: 3.8
Sequence: CTGTACATTTAAATTTTCAG
Locus tag: Shewmr7_2845
Name: aceB
Funciton: Malate synthase (EC 2.3.3.9)
Locus tag: Shewmr7_2844
Name: aceA
Funciton: Isocitrate lyase (EC 4.1.3.1)
aceB
Malate synthase (EC 2.3.3.9)
aceA
Isocitrate lyase (EC 4.1.3.1)

Position: -189
Score: 4.6
Sequence: TTGTCATTCTTTGTTTACAG
Locus tag: Shewmr7_2637
Name: aprE2
Funciton: Cold-active alkaline serine protease (EC 3.4.21.62)
aprE2
Cold-active alkaline serine protease (EC 3.4.21.62)

Position: -154
Score: 5.2
Sequence: GTGGAAAGCTAGATTGCCAC
Locus tag: Shewmr7_1673
Name: ldh
Funciton: Leucine dehydrogenase (EC 1.4.1.9)
ldh
Leucine dehydrogenase (EC 1.4.1.9)

Position: -357
Score: 3.9
Sequence: TTTGAAATTAATCATTCCAA
Locus tag: Shewmr7_1455
Name: aprE
Funciton: Alkaline serine protease
aprE
Alkaline serine protease

Position: -208
Score: 3.9
Sequence: ATGTAACAACTTAGTTACAG
Locus tag: Shewmr7_2545
Name: mdeA
Funciton: Methionine gamma-lyase (EC 4.4.1.11)
mdeA
Methionine gamma-lyase (EC 4.4.1.11)

Position: -122
Score: 4.4
Sequence: TTGTAATATTTGCTTTACGT
Locus tag: Shewmr7_2674
Name: phhA
Funciton: Phenylalanine-4-hydroxylase (EC 1.14.16.1)
Locus tag: Shewmr7_2673
Name: phhB
Funciton: Pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96)
phhA
Phenylalanine-4-hydroxylase (EC 1.14.16.1)
phhB
Pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96)

Position: -159
Score: 4.4
Sequence: CTGTAAATCCTGACTGACAA
Locus tag: Shewmr7_2664
Name: ivdA
Funciton: 3-ketoacyl-CoA thiolase [isoleucine degradation] (EC 2.3.1.16)
Locus tag: Shewmr7_2663
Name: ivdB
Funciton: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
Locus tag: Shewmr7_2662
Name: ivdC
Funciton: Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)
Locus tag: Shewmr7_2661
Name: ivdD
Funciton: Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) / Enoyl-CoA hydratase [isoleucine degradation] (EC 4.2.1.17)
Locus tag: Shewmr7_2660
Name: ivdE
Funciton: 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)
Locus tag: Shewmr7_2659
Name: ivdF
Funciton: 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)
Locus tag: Shewmr7_2658
Name: ivdG
Funciton: 3-hydroxyacyl-CoA dehydrogenase [isoleucine degradation] (EC 1.1.1.35)
ivdA
3-ketoacyl-CoA thiolase [isoleucine degradation] (EC 2.3.1.16)
ivdB
Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
ivdC
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)
ivdD
Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) / Enoyl-CoA hydratase [isoleucine degradation] (EC 4.2.1.17)
ivdE
3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)
ivdF
3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)
ivdG
3-hydroxyacyl-CoA dehydrogenase [isoleucine degradation] (EC 1.1.1.35)

Position: -160
Score: 4.8
Sequence: TTGTAAAGCATTATATACAT
Locus tag: Shewmr7_1947
Name: bkdA1
Funciton: Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)
Locus tag: Shewmr7_1948
Name: bkdA2
Funciton: Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)
Locus tag: Shewmr7_1949
Name: bkdB
Funciton: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)
bkdA1
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)
bkdA2
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)
bkdB
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)

Position: -155
Score: 3.9
Sequence: TTGGCAGGCTTTTTTGCCAG
Locus tag: Shewmr7_2057
Name: tyrB
Funciton: Tyrosine aminotransferase (EC 2.6.1.42)
tyrB
Tyrosine aminotransferase (EC 2.6.1.42)
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