Regulon of MetJ in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Properties
Regulator type:	Transcription factor
TF locus tag:	KPN_04232
Regulator family:	MetJ
Regulation mode:	repressor
Biological process:	Methionine metabolism; Methionine biosynthesis
Effector:	S-adenosylmethionine
Regulog:	MetJ - Enterobacteriales
Statistics of regulated genes:
- Genes	29
- Operons	20
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 167 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - MetJ
By TF family - MetJ
By effector - S-adenosylmethionine
By pathway - Methionine metabolism
By pathway - Methionine biosynthesis

Regulated operons
	Locus Tag	Name	Function
Position: -10 Score: 4.6 Sequence: AGAAACAT-(0)-AAATGTCA Locus tag: KPN_02591 Name: folE Funciton: GTP cyclohydrolase I (EC 3.5.4.16) type 1
	KPN_02591	folE	GTP cyclohydrolase I (EC 3.5.4.16) type 1
Position: -78 Score: 5.7 Sequence: AGCCATCC-(0)-AGAAGTCT Locus tag: KPN_01615 Name: metE2 Funciton: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
	KPN_01615	metE2	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
Position: -189 Score: 5.9 Sequence: GGACATCT-(0)-AAACTTCT Locus tag: KPN_04232 Name: metJ Funciton: S-adenosylmethionine-responsive transcriptional repressor MetJ
	KPN_04232	metJ	S-adenosylmethionine-responsive transcriptional repressor MetJ
Position: -69 Score: 7 Sequence: GGATGTTT-(0)-AGATGTCT Locus tag: KPN_00309 Name: mmuP Funciton: S-methylmethionine transporter Locus tag: KPN_00310 Name: mmuM Funciton: Homocysteine S-methyltransferase (EC 2.1.1.10)
	KPN_00309	mmuP	S-methylmethionine transporter
	KPN_00310	mmuM	Homocysteine S-methyltransferase (EC 2.1.1.10)
Position: -76 Score: 6.3 Sequence: AGCCGTTC-(0)-AGACGTCT Locus tag: KPN_00627 Name: mtnA Funciton: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
	KPN_00627	mtnA	Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
Position: -10 Score: 6.2 Sequence: GGAAGTAT-(0)-AGATGTCC Locus tag: KPN_00650 Name: ahpC Funciton: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Locus tag: KPN_00651 Name: ahpF Funciton: Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)
	KPN_00650	ahpC	Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)
	KPN_00651	ahpF	Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)
Position: -47 Score: 5.8 Sequence: AGCCATTT-(0)-AGACGGCT Locus tag: KPN_00634 Name: mtnB Funciton: Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
	KPN_00634	mtnB	Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
Position: -43 Score: 6.9 Sequence: GGATGTCT-(0)-AAACGTTT Locus tag: KPN_04394 Name: metA Funciton: Homoserine O-succinyltransferase (EC 2.3.1.46)
	KPN_04394	metA	Homoserine O-succinyltransferase (EC 2.3.1.46)
Position: -49 Score: 7.2 Sequence: AGAAGTAT-(0)-AGACGTCT Locus tag: KPN_00626 Name: mtnK Funciton: 5-methylthioribose kinase (EC 2.7.1.100)
	KPN_00626	mtnK	5-methylthioribose kinase (EC 2.7.1.100)
Position: -100 Score: 6.6 Sequence: AGACGTCT-(0)-GGATGCCT Locus tag: KPN_00213 Name: metN Funciton: Methionine ABC transporter ATP-binding protein Locus tag: KPN_00212 Name: metI Funciton: Methionine ABC transporter permease protein Locus tag: KPN_00211 Name: metQ Funciton: Methionine ABC transporter substrate-binding protein
	KPN_00213	metN	Methionine ABC transporter ATP-binding protein
	KPN_00212	metI	Methionine ABC transporter permease protein
	KPN_00211	metQ	Methionine ABC transporter substrate-binding protein
Position: -87 Score: 6.9 Sequence: AGACGTCC-(0)-AGATGTTT Locus tag: KPN_04324 Name: metR Funciton: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
	KPN_04324	metR	Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
Position: -78 Score: 6.9 Sequence: AGATGTAT-(0)-TGACGTCT Locus tag: KPN_04233 Name: metB Funciton: Cystathionine gamma-synthase (EC 2.5.1.48) Locus tag: KPN_04234 Name: metL Funciton: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)
	KPN_04233	metB	Cystathionine gamma-synthase (EC 2.5.1.48)
	KPN_04234	metL	Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)
Position: -64 Score: 7 Sequence: GGACGTCT-(0)-AAACGTAT Locus tag: KPN_04239 Name: metF Funciton: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
	KPN_04239	metF	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Position: -176 Score: 6.8 Sequence: AAACATCT-(0)-GGACGTCT Locus tag: KPN_04325 Name: metE Funciton: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
	KPN_04325	metE	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Position: -59 Score: 6.8 Sequence: AGACGCTT-(0)-AGACGTCT Locus tag: KPN_00644 Name: mtnC Funciton: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase (EC 3.1.3.77) Locus tag: KPN_00643 Name: mtnD Funciton: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)
	KPN_00644	mtnC	2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase (EC 3.1.3.77)
	KPN_00643	mtnD	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)
Position: -34 Score: 7 Sequence: AGACGTCC-(0)-AGACGTAT Locus tag: KPN_03428 Name: metC Funciton: Cystathionine beta-lyase (EC 4.4.1.8)
	KPN_03428	metC	Cystathionine beta-lyase (EC 4.4.1.8)
Position: -83 Score: 6.8 Sequence: AGACGTCT-(0)-AAGCGTCT Locus tag: KPN_00645 Name: mtnE Funciton: Methionine aminotransferase
	KPN_00645	mtnE	Methionine aminotransferase
Position: -119 Score: 5.8 Sequence: GGACATCC-(0)-AGATGGCT Locus tag: KPN_00622 Name: mtnX Funciton: Predicted methylthioribose ABC transporter, ATP-binding protein Locus tag: KPN_00623 Name: mtnY Funciton: Predicted methylthioribose ABC transporter, permease protein Locus tag: KPN_00624 Name: mtnZ Funciton: Predicted methylthioribose ABC transporter, substrate-binding protein Locus tag: KPN_00625 Name: COG5276 Funciton: Hypothetical protein, COG5276 family
	KPN_00622	mtnX	Predicted methylthioribose ABC transporter, ATP-binding protein
	KPN_00623	mtnY	Predicted methylthioribose ABC transporter, permease protein
	KPN_00624	mtnZ	Predicted methylthioribose ABC transporter, substrate-binding protein
	KPN_00625	COG5276	Hypothetical protein, COG5276 family
Position: -280 Score: 5.9 Sequence: AGCAGTCT-(0)-GGACATCT Locus tag: KPN_04255 Name: btuB Funciton: TonB-dependent outer membrane transporter for vitamin B12
	KPN_04255	btuB	TonB-dependent outer membrane transporter for vitamin B12
Position: -136 Score: 4.7 Sequence: AGAAGTTA-(0)-ATCCGTCT Locus tag: KPN_03375 Name: metK Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6)
	KPN_03375	metK	S-adenosylmethionine synthetase (EC 2.5.1.6)

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of MetJ in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --