Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of MetJ in Enterobacter sp. 638

Properties
Regulator type: Transcription factor
TF locus tag: Ent638_4036
Regulator family: MetJ
Regulation mode: repressor
Biological process: Methionine metabolism; Methionine biosynthesis
Effector: S-adenosylmethionine
Regulog: MetJ - Enterobacteriales
Statistics of regulated genes:
- Genes 29
- Operons 19
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 167 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function
Position: -70
Score: 5.9
Sequence: AGAAGTCT-(0)-AAATATTC
Locus tag: Ent638_1987
Name: metE2
Funciton: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
Ent638_1987
metE2
Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
Position: -10
Score: 6.5
Sequence: GGATGTTT-(0)-AGATGTCC
Locus tag: Ent638_0827
Name: mmuP
Funciton: S-methylmethionine transporter
Locus tag: Ent638_0828
Name: mmuM
Funciton: Homocysteine S-methyltransferase (EC 2.1.1.10)
Ent638_0827
mmuP
S-methylmethionine transporter
Ent638_0828
mmuM
Homocysteine S-methyltransferase (EC 2.1.1.10)
Position: -76
Score: 7.1
Sequence: AGACATTT-(0)-AGACGTCT
Locus tag: Ent638_1140
Name: mtnA
Funciton: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
Ent638_1140
mtnA
Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
Position: -10
Score: 5.7
Sequence: GGAAGTAC-(0)-AGATGTCC
Locus tag: Ent638_1145
Name: ahpC
Funciton: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)
Ent638_1145
ahpC
Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)
Position: -200
Score: 5.9
Sequence: GGACATCT-(0)-AAACTTCT
Locus tag: Ent638_4036
Name: metJ
Funciton: S-adenosylmethionine-responsive transcriptional repressor MetJ
Ent638_4036
metJ
S-adenosylmethionine-responsive transcriptional repressor MetJ
Position: -57
Score: 6.8
Sequence: AGACGCTT-(0)-AGACGTCT
Locus tag: Ent638_1143
Name: mtnB
Funciton: Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
Locus tag: Ent638_1142
Name: mtnC
Funciton: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase (EC 3.1.3.77)
Locus tag: Ent638_1141
Name: mtnD
Funciton: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)
Ent638_1143
mtnB
Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
Ent638_1142
mtnC
2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase (EC 3.1.3.77)
Ent638_1141
mtnD
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)
Position: -176
Score: 6.3
Sequence: AAACATCT-(0)-GGACGTCC
Locus tag: Ent638_3967
Name: metE
Funciton: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Ent638_3967
metE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Position: -43
Score: 6.9
Sequence: GGATGTCT-(0)-AAACGTTT
Locus tag: Ent638_0217
Name: metA
Funciton: Homoserine O-succinyltransferase (EC 2.3.1.46)
Ent638_0217
metA
Homoserine O-succinyltransferase (EC 2.3.1.46)
Position: -44
Score: 7.4
Sequence: AGACGTCT-(0)-AAATGTCT
Locus tag: Ent638_1139
Name: mtnK
Funciton: 5-methylthioribose kinase (EC 2.7.1.100)
Ent638_1139
mtnK
5-methylthioribose kinase (EC 2.7.1.100)
Position: -100
Score: 6.6
Sequence: AGACGTCT-(0)-GGATGCCT
Locus tag: Ent638_0737
Name: metN
Funciton: Methionine ABC transporter ATP-binding protein
Locus tag: Ent638_0736
Name: metI
Funciton: Methionine ABC transporter permease protein
Locus tag: Ent638_0735
Name: metQ
Funciton: Methionine ABC transporter substrate-binding protein
Ent638_0737
metN
Methionine ABC transporter ATP-binding protein
Ent638_0736
metI
Methionine ABC transporter permease protein
Ent638_0735
metQ
Methionine ABC transporter substrate-binding protein
Position: -87
Score: 6.6
Sequence: GGACGTCC-(0)-AGATGTTT
Locus tag: Ent638_3968
Name: metR
Funciton: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
Ent638_3968
metR
Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
Position: -85
Score: 6.8
Sequence: AGATGTCC-(0)-AGATGTAT
Locus tag: Ent638_4035
Name: metB
Funciton: Cystathionine gamma-synthase (EC 2.5.1.48)
Locus tag: Ent638_4034
Name: metL
Funciton: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)
Ent638_4035
metB
Cystathionine gamma-synthase (EC 2.5.1.48)
Ent638_4034
metL
Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)
Position: -64
Score: 6.6
Sequence: AGACGTCT-(0)-AAATGGAT
Locus tag: Ent638_4033
Name: metF
Funciton: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Ent638_4033
metF
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Position: -34
Score: 6.1
Sequence: GGACGTCC-(0)-AGACGGAT
Locus tag: Ent638_3418
Name: metC
Funciton: Cystathionine beta-lyase (EC 4.4.1.8)
Ent638_3418
metC
Cystathionine beta-lyase (EC 4.4.1.8)
Position: -116
Score: 5.5
Sequence: GGACATCC-(0)-GGATGGCT
Locus tag: Ent638_1135
Name: mtnX
Funciton: Predicted methylthioribose ABC transporter, ATP-binding protein
Locus tag: Ent638_1136
Name: mtnY
Funciton: Predicted methylthioribose ABC transporter, permease protein
Locus tag: Ent638_1137
Name: mtnZ
Funciton: Predicted methylthioribose ABC transporter, substrate-binding protein
Locus tag: Ent638_1138
Name: COG5276
Funciton: Hypothetical protein, COG5276 family
Ent638_1135
mtnX
Predicted methylthioribose ABC transporter, ATP-binding protein
Ent638_1136
mtnY
Predicted methylthioribose ABC transporter, permease protein
Ent638_1137
mtnZ
Predicted methylthioribose ABC transporter, substrate-binding protein
Ent638_1138
COG5276
Hypothetical protein, COG5276 family
Position: -140
Score: 4.8
Sequence: AGCCAGCT-(0)-TAACGGCT
Locus tag: Ent638_1770
Name: mccA
Funciton: Cystathionine beta-synthase (EC 4.2.1.22)
Locus tag: Ent638_1769
Name: mccB
Funciton: Cystathionine gamma-lyase (EC 4.4.1.1)
Ent638_1770
mccA
Cystathionine beta-synthase (EC 4.2.1.22)
Ent638_1769
mccB
Cystathionine gamma-lyase (EC 4.4.1.1)
Position: -270
Score: 5.6
Sequence: AGCTGTCT-(0)-GGACATCC
Locus tag: Ent638_4020
Name: btuB
Funciton: TonB-dependent outer membrane transporter for vitamin B12
Ent638_4020
btuB
TonB-dependent outer membrane transporter for vitamin B12
Position: -144
Score: 5.9
Sequence: AGACGTCC-(0)-AGATGTTA
Locus tag: Ent638_3346
Name: metK
Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6)
Ent638_3346
metK
S-adenosylmethionine synthetase (EC 2.5.1.6)
Position: -83
Score: 6.8
Sequence: AGACGTCT-(0)-AAGCGTCT
Locus tag: Ent638_1144
Name: mtnE
Funciton: Methionine aminotransferase
Ent638_1144
mtnE
Methionine aminotransferase
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