Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of MetJ in Citrobacter koseri ATCC BAA-895

Properties
Regulator type: Transcription factor
TF locus tag: CKO_03057
Regulator family: MetJ
Regulation mode: repressor
Biological process: Methionine metabolism; Methionine biosynthesis
Effector: S-adenosylmethionine
Regulog: MetJ - Enterobacteriales
Statistics of regulated genes:
- Genes 26
- Operons 18
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 167 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -144
Score: 4.7
Sequence: AGCCATCC-(0)-AGATGTTA
Locus tag: CKO_04317
Name: metK
Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6)
metK
S-adenosylmethionine synthetase (EC 2.5.1.6)

Position: -10
Score: 4.7
Sequence: AGAAGAAT-(0)-AAATGTCA
Locus tag: CKO_00638
Name: folE
Funciton: GTP cyclohydrolase I (EC 3.5.4.16) type 1
folE
GTP cyclohydrolase I (EC 3.5.4.16) type 1

Position: -76
Score: 5.7
Sequence: AGCCATCC-(0)-AGAAGTCT
Locus tag: CKO_01563
Name: metE2
Funciton: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
metE2
Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

Position: -62
Score: 6.8
Sequence: AGACGCTT-(0)-AGACGTCT
Locus tag: CKO_02560
Name: ybdH
Funciton: Uncharacterized oxidoreductase YbdH
ybdH
Uncharacterized oxidoreductase YbdH

Position: -189
Score: 5.9
Sequence: GGACATCT-(0)-AAACTTCT
Locus tag: CKO_03057
Name: metJ
Funciton: S-adenosylmethionine-responsive transcriptional repressor MetJ
metJ
S-adenosylmethionine-responsive transcriptional repressor MetJ

Position: -76
Score: 6.8
Sequence: AGACATGT-(0)-AGACGTCT
Locus tag: CKO_03974
Name: mtnA
Funciton: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
mtnA
Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)

Position: -10
Score: 6.2
Sequence: GGAAGTAT-(0)-AGATGTCC
Locus tag: CKO_02554
Name: ahpC
Funciton: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)
ahpC
Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)

Position: -78
Score: 6.9
Sequence: AGATGTAT-(0)-TGACGTCT
Locus tag: CKO_03055
Name: metB
Funciton: Cystathionine gamma-synthase (EC 2.5.1.48)
Locus tag: CKO_03054
Name: metL
Funciton: Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)
metB
Cystathionine gamma-synthase (EC 2.5.1.48)
metL
Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)

Position: -43
Score: 6.9
Sequence: GGATGTCT-(0)-AAACGTTT
Locus tag: CKO_03907
Name: metA
Funciton: Homoserine O-succinyltransferase (EC 2.3.1.46)
metA
Homoserine O-succinyltransferase (EC 2.3.1.46)

Position: -35
Score: 7.4
Sequence: AGATGTAT-(0)-AGACGTCT
Locus tag: CKO_03975
Name: mtnK
Funciton: 5-methylthioribose kinase (EC 2.7.1.100)
mtnK
5-methylthioribose kinase (EC 2.7.1.100)

Position: -99
Score: 6.6
Sequence: AGACGTCT-(0)-GGATGCCT
Locus tag: CKO_03166
Name: metN
Funciton: Methionine ABC transporter ATP-binding protein
Locus tag: CKO_03167
Name: metI
Funciton: Methionine ABC transporter permease protein
Locus tag: CKO_03168
Name: metQ
Funciton: Methionine ABC transporter substrate-binding protein
metN
Methionine ABC transporter ATP-binding protein
metI
Methionine ABC transporter permease protein
metQ
Methionine ABC transporter substrate-binding protein

Position: -87
Score: 6.9
Sequence: AGACGTCC-(0)-AGATGTTT
Locus tag: CKO_00170
Name: metR
Funciton: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
metR
Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family

Position: -65
Score: 6.7
Sequence: AGACGTCT-(0)-AAACGGAT
Locus tag: CKO_03051
Name: metF
Funciton: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
metF
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)

Position: -177
Score: 6.8
Sequence: AAACATCT-(0)-GGACGTCT
Locus tag: CKO_00171
Name: metE
Funciton: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
metE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

Position: -56
Score: 6.7
Sequence: AGACGCTT-(0)-AGATGTCT
Locus tag: CKO_03971
Name: mtnB
Funciton: Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
Locus tag: CKO_03972
Name: mtnC
Funciton: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase (EC 3.1.3.77)
Locus tag: CKO_03973
Name: mtnD
Funciton: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)
mtnB
Methylthioribulose-1-phosphate dehydratase (EC 4.2.1.109)
mtnC
2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase (EC 3.1.3.77)
mtnD
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54)

Position: 44
Score: 6.6
Sequence: AGACATCC-(0)-AGACGTAT
Locus tag: CKO_04402
Name: metC
Funciton: Cystathionine beta-lyase (EC 4.4.1.8)
metC
Cystathionine beta-lyase (EC 4.4.1.8)

Position: -75
Score: 6.8
Sequence: AGACGTCT-(0)-AAGCGTCT
Locus tag: CKO_02559
Name: mtnE
Funciton: Methionine aminotransferase
mtnE
Methionine aminotransferase

Position: 11
Score: 6.3
Sequence: AGACATCT-(0)-GGATGGCT
Locus tag: CKO_03982
Name: CKO_03982
Funciton: hypothetical protein
Locus tag: CKO_03981
Name: mtnX
Funciton: Predicted methylthioribose ABC transporter, ATP-binding protein
Locus tag: CKO_03980
Name: mtnY
Funciton: Predicted methylthioribose ABC transporter, permease protein
Locus tag: CKO_03979
Name: mtnZ
Funciton: Predicted methylthioribose ABC transporter, substrate-binding protein
CKO_03982
hypothetical protein
mtnX
Predicted methylthioribose ABC transporter, ATP-binding protein
mtnY
Predicted methylthioribose ABC transporter, permease protein
mtnZ
Predicted methylthioribose ABC transporter, substrate-binding protein
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