Regulon of McbR in Corynebacterium glutamicum ATCC 13032

Properties
Regulator type:	Transcription factor
TF locus tag:	cg3253
Regulator family:	TetR
Regulation mode:	repressor
Biological process:	Methionine biosynthesis
Effector:	S-adenosylmethionine; S-adenosylhomocysteine
Regulog:	McbR - Corynebacteriaceae
Statistics of regulated genes:
- Genes	47
- Operons	25
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 162 sites [see more]

Member of regulog collections

By taxonomy - Corynebacteriaceae
By TF family - TetR
By effector - S-adenosylmethionine
By effector - S-adenosylhomocysteine
By pathway - Methionine biosynthesis

Regulated operons
	Locus Tag	Name	Function
Position: -69 Score: 5.2 Sequence: TAGACAGCATGGTCTA Locus tag: cg3372 Name: cg3372 Funciton: Hypothetical protein
	cg3372	cg3372	Hypothetical protein
Position: -272 Score: 4.9 Sequence: CAGACCGAGCAGTCTA Locus tag: cg1290 Name: metE Funciton: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)
	cg1290	metE	5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)
Position: -95 Score: 4.2 Sequence: CGTACTAAGCTGTCTA Locus tag: cg1701 Name: metH Funciton: 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13)
	cg1701	metH	5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13)
Position: -72 Score: 5 Sequence: TAGACTGATCGGTATA Position: -50 Score: 4.4 Sequence: CAGACCAACCTGTCTA Locus tag: cg2679 Name: cg2679 Funciton: Conserved hypothetical protein
	cg2679	cg2679	Conserved hypothetical protein
Position: -112 Score: 4.8 Sequence: TAGACAGGTTGGTCTG Position: -90 Score: 4.9 Sequence: TATACCGATCAGTCTA Locus tag: cg2678 Name: cg2678 Funciton: Predicted ABC transporter, substrate-binding protein Locus tag: cg2677 Name: cg2677 Funciton: Predicted ABC transporter, permease protein 1 Locus tag: cg2676 Name: cg2676 Funciton: Predicted ABC transporter, permease protein 2 Locus tag: cg2675 Name: cg2675 Funciton: Predicted ABC transporter, ATP-binding protein Locus tag: cg2674 Name: cg2674 Funciton: Conserved hypothetical protein
	cg2678	cg2678	Predicted ABC transporter, substrate-binding protein
	cg2677	cg2677	Predicted ABC transporter, permease protein 1
	cg2676	cg2676	Predicted ABC transporter, permease protein 2
	cg2675	cg2675	Predicted ABC transporter, ATP-binding protein
	cg2674	cg2674	Conserved hypothetical protein
Position: -13 Score: 4.4 Sequence: TAGACTAAGCGGTATG Locus tag: cg1739 Name: cg1739 Funciton: GMP synthase-Glutamine amidotransferase domain (EC 6.3.5.2)
	cg1739	cg1739	GMP synthase-Glutamine amidotransferase domain (EC 6.3.5.2)
Position: -175 Score: 4.3 Sequence: TAGACTTATGGGTCTA Position: -118 Score: 5.2 Sequence: TAGACAGATCTGTTTA Locus tag: cg2810 Name: gltT Funciton: Predicted sodium:dicarboxylate symporter
	cg2810	gltT	Predicted sodium:dicarboxylate symporter
Position: -69 Score: 5.2 Sequence: TAGACAGAGCTGTCCA Locus tag: cg0754 Name: metX Funciton: Homoserine O-acetyltransferase (EC 2.3.1.31)
	cg0754	metX	Homoserine O-acetyltransferase (EC 2.3.1.31)
Position: -90 Score: 4.5 Sequence: TATACCACACAGTCTA Position: -68 Score: 4.7 Sequence: TAGACCAAGCTGTTCA Locus tag: cg0755 Name: metY Funciton: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
	cg0755	metY	O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
Position: -286 Score: 5.1 Sequence: TAGACCGCTTGGTCTG Position: -201 Score: 5.6 Sequence: TAGACAGATCGGTCTA Position: -83 Score: 4.5 Sequence: TAGACAGAGCGGTACG Locus tag: cg3118 Name: cysI Funciton: Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1) Locus tag: cg3117 Name: cysX Funciton: Ferredoxin-like protein involved in electron transfer Locus tag: cg3116 Name: cysH Funciton: Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10) Locus tag: cg3115 Name: cysD Funciton: Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) Locus tag: cg3114 Name: cysN Funciton: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) Locus tag: cg3113 Name: cysY Funciton: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) Locus tag: cg3112 Name: cysZ Funciton: Sulfate transporter, CysZ-type
	cg3118	cysI	Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
	cg3117	cysX	Ferredoxin-like protein involved in electron transfer
	cg3116	cysH	Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
	cg3115	cysD	Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)
	cg3114	cysN	Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)
	cg3113	cysY	Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
	cg3112	cysZ	Sulfate transporter, CysZ-type
Position: -69 Score: 4.8 Sequence: CAGACAATGCGGTCTA Position: -36 Score: 5.4 Sequence: TAGACAGCGTTGTCTA Locus tag: cg0156 Name: cysR Funciton: Sulphur metabolism transcriptional regulator CysR, ROK family
	cg0156	cysR	Sulphur metabolism transcriptional regulator CysR, ROK family
Position: -85 Score: 5.1 Sequence: TAGACTGAACGGTCTA Position: -20 Score: 4.8 Sequence: TAGACCATACGGTCTA Locus tag: cg0012 Name: ssuR Funciton: Sulphonate sulphur utilization transcriptional regulator SsuR, ROK family
	cg0012	ssuR	Sulphonate sulphur utilization transcriptional regulator SsuR, ROK family
Position: -79 Score: 5 Sequence: TAGACTGAATTGTCTA Position: -24 Score: 4.3 Sequence: TAGACTGAATGGCCTA Locus tag: cg1147 Name: ssuI Funciton: Predicted flavin reductase
	cg1147	ssuI	Predicted flavin reductase
Position: -182 Score: 4.6 Sequence: TAGACCGCTTAGTCTT Position: -117 Score: 5 Sequence: TAGACATCTCGGTCTA Position: -30 Score: 4.4 Sequence: TAGACGAAGCGGTCTG Locus tag: cg1376 Name: ssuD Funciton: Alkanesulfonate monooxygenase Locus tag: cg1377 Name: ssuC Funciton: Sulfonate ABC transporter, permease protein Locus tag: cg1379 Name: ssuB Funciton: Sulfonate ABC transporter, ATP-binding protein Locus tag: cg1380 Name: ssuA Funciton: Sulfonate ABC transporter, substrate-binding protein
	cg1376	ssuD	Alkanesulfonate monooxygenase
	cg1377	ssuC	Sulfonate ABC transporter, permease protein
	cg1379	ssuB	Sulfonate ABC transporter, ATP-binding protein
	cg1380	ssuA	Sulfonate ABC transporter, substrate-binding protein
Position: -74 Score: 5.5 Sequence: TAGACAGCTTGGTCTA Locus tag: cg1806 Name: metK Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6) Locus tag: cg1805 Name: priA Funciton: Helicase PriA essential for oriC/DnaA-independent DNA replication
	cg1806	metK	S-adenosylmethionine synthetase (EC 2.5.1.6)
	cg1805	priA	Helicase PriA essential for oriC/DnaA-independent DNA replication
Position: -24 Score: 5.1 Sequence: TAGACCGTGTGGTCTA Locus tag: cg1156 Name: ssuD Funciton: Alkanesulfonate monooxygenase
	cg1156	ssuD	Alkanesulfonate monooxygenase
Position: -197 Score: 5.4 Sequence: TAGACCGATCTGTCTA Position: -112 Score: 5 Sequence: CAGACCAAGCGGTCTA Locus tag: cg3119 Name: cysJ Funciton: Ferredoxin--NADP reductase (EC 1.18.1.2)
	cg3119	cysJ	Ferredoxin--NADP reductase (EC 1.18.1.2)
Position: -78 Score: 4.1 Sequence: CGAACCGGTTTGTCTA Locus tag: cg3253 Name: mcbR Funciton: Methionine biosynthesis transcriptional regulator McbR, TetR family
	cg3253	mcbR	Methionine biosynthesis transcriptional regulator McbR, TetR family
Position: -113 Score: 4.9 Sequence: TGAACAGCTTGGTCTA Locus tag: cg1337 Name: hom Funciton: Homoserine dehydrogenase (EC 1.1.1.3) Locus tag: cg1338 Name: thrB Funciton: Homoserine kinase (EC 2.7.1.39)
	cg1337	hom	Homoserine dehydrogenase (EC 1.1.1.3)
	cg1338	thrB	Homoserine kinase (EC 2.7.1.39)
Position: -109 Score: 4.6 Sequence: TAGACCAAGCTGTACA Locus tag: cg0737 Name: metQ Funciton: Methionine ABC transporter substrate-binding protein Locus tag: cg0736 Name: metN Funciton: Methionine ABC transporter ATP-binding protein Locus tag: cg0735 Name: metI Funciton: Methionine ABC transporter permease protein
	cg0737	metQ	Methionine ABC transporter substrate-binding protein
	cg0736	metN	Methionine ABC transporter ATP-binding protein
	cg0735	metI	Methionine ABC transporter permease protein
Position: -150 Score: 4.6 Sequence: TGAACAGAACTGTCTA Locus tag: cg2833 Name: cysK Funciton: Cysteine synthase (EC 2.5.1.47) Locus tag: cg2834 Name: cysE Funciton: Serine acetyltransferase (EC 2.3.1.30)
	cg2833	cysK	Cysteine synthase (EC 2.5.1.47)
	cg2834	cysE	Serine acetyltransferase (EC 2.3.1.30)
Position: -36 Score: 4.9 Sequence: TAGACAAAGATGTCTA Locus tag: cg1151 Name: seuA Funciton: coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase Locus tag: cg1152 Name: seuB Funciton: Flavine mononucleotide dependent monooxygenase, subunit B Locus tag: cg1153 Name: seuC Funciton: Flavine mononucleotide dependent monooxygenase, subunit C
	cg1151	seuA	coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase
	cg1152	seuB	Flavine mononucleotide dependent monooxygenase, subunit B
	cg1153	seuC	Flavine mononucleotide dependent monooxygenase, subunit C
Position: -224 Score: 4.6 Sequence: TAGACTATGCAGTCTA Locus tag: cg3132 Name: cg3132 Funciton: Conserved hypothetical protein
	cg3132	cg3132	Conserved hypothetical protein
Position: -78 Score: 5.3 Sequence: TGGACAGCTTGGTCTA Locus tag: cg2687 Name: metB Funciton: Cystathionine gamma-synthase (EC 2.5.1.48)
	cg2687	metB	Cystathionine gamma-synthase (EC 2.5.1.48)
Position: -158 Score: 4.5 Sequence: TAGACTGGTTTGTCTG Locus tag: cg1386 Name: fixB Funciton: Electron transfer flavoprotein, beta subunit Locus tag: cg1387 Name: fixA Funciton: Electron transfer flavoprotein, alpha subunit Locus tag: cg1388 Name: iscS Funciton: Cysteine desulfurase (EC 2.8.1.7)
	cg1386	fixB	Electron transfer flavoprotein, beta subunit
	cg1387	fixA	Electron transfer flavoprotein, alpha subunit
	cg1388	iscS	Cysteine desulfurase (EC 2.8.1.7)

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of McbR in Corynebacterium glutamicum ATCC 13032

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --