Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of McbR in Corynebacterium glutamicum ATCC 13032

Properties
Regulator type: Transcription factor
TF locus tag: cg3253
Regulator family: TetR
Regulation mode: repressor
Biological process: Methionine biosynthesis
Effector: S-adenosylmethionine; S-adenosylhomocysteine
Regulog: McbR - Corynebacteriaceae
Statistics of regulated genes:
- Genes 47
- Operons 25
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 162 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -69
Score: 5.2
Sequence: TAGACAGCATGGTCTA
Locus tag: cg3372
Name: cg3372
Funciton: Hypothetical protein
cg3372
Hypothetical protein

Position: -272
Score: 4.9
Sequence: CAGACCGAGCAGTCTA
Locus tag: cg1290
Name: metE
Funciton: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)
metE
5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)

Position: -95
Score: 4.2
Sequence: CGTACTAAGCTGTCTA
Locus tag: cg1701
Name: metH
Funciton: 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13)
metH
5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13)

Position: -72
Score: 5
Sequence: TAGACTGATCGGTATA
Position: -50
Score: 4.4
Sequence: CAGACCAACCTGTCTA
Locus tag: cg2679
Name: cg2679
Funciton: Conserved hypothetical protein
cg2679
Conserved hypothetical protein

Position: -112
Score: 4.8
Sequence: TAGACAGGTTGGTCTG
Position: -90
Score: 4.9
Sequence: TATACCGATCAGTCTA
Locus tag: cg2678
Name: cg2678
Funciton: Predicted ABC transporter, substrate-binding protein
Locus tag: cg2677
Name: cg2677
Funciton: Predicted ABC transporter, permease protein 1
Locus tag: cg2676
Name: cg2676
Funciton: Predicted ABC transporter, permease protein 2
Locus tag: cg2675
Name: cg2675
Funciton: Predicted ABC transporter, ATP-binding protein
Locus tag: cg2674
Name: cg2674
Funciton: Conserved hypothetical protein
cg2678
Predicted ABC transporter, substrate-binding protein
cg2677
Predicted ABC transporter, permease protein 1
cg2676
Predicted ABC transporter, permease protein 2
cg2675
Predicted ABC transporter, ATP-binding protein
cg2674
Conserved hypothetical protein

Position: -13
Score: 4.4
Sequence: TAGACTAAGCGGTATG
Locus tag: cg1739
Name: cg1739
Funciton: GMP synthase-Glutamine amidotransferase domain (EC 6.3.5.2)
cg1739
GMP synthase-Glutamine amidotransferase domain (EC 6.3.5.2)

Position: -175
Score: 4.3
Sequence: TAGACTTATGGGTCTA
Position: -118
Score: 5.2
Sequence: TAGACAGATCTGTTTA
Locus tag: cg2810
Name: gltT
Funciton: Predicted sodium:dicarboxylate symporter
gltT
Predicted sodium:dicarboxylate symporter

Position: -69
Score: 5.2
Sequence: TAGACAGAGCTGTCCA
Locus tag: cg0754
Name: metX
Funciton: Homoserine O-acetyltransferase (EC 2.3.1.31)
metX
Homoserine O-acetyltransferase (EC 2.3.1.31)

Position: -90
Score: 4.5
Sequence: TATACCACACAGTCTA
Position: -68
Score: 4.7
Sequence: TAGACCAAGCTGTTCA
Locus tag: cg0755
Name: metY
Funciton: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
metY
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)

Position: -286
Score: 5.1
Sequence: TAGACCGCTTGGTCTG
Position: -201
Score: 5.6
Sequence: TAGACAGATCGGTCTA
Position: -83
Score: 4.5
Sequence: TAGACAGAGCGGTACG
Locus tag: cg3118
Name: cysI
Funciton: Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
Locus tag: cg3117
Name: cysX
Funciton: Ferredoxin-like protein involved in electron transfer
Locus tag: cg3116
Name: cysH
Funciton: Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
Locus tag: cg3115
Name: cysD
Funciton: Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)
Locus tag: cg3114
Name: cysN
Funciton: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)
Locus tag: cg3113
Name: cysY
Funciton: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
Locus tag: cg3112
Name: cysZ
Funciton: Sulfate transporter, CysZ-type
cysI
Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
cysX
Ferredoxin-like protein involved in electron transfer
cysH
Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
cysD
Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)
cysN
Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)
cysY
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
cysZ
Sulfate transporter, CysZ-type

Position: -69
Score: 4.8
Sequence: CAGACAATGCGGTCTA
Position: -36
Score: 5.4
Sequence: TAGACAGCGTTGTCTA
Locus tag: cg0156
Name: cysR
Funciton: Sulphur metabolism transcriptional regulator CysR, ROK family
cysR
Sulphur metabolism transcriptional regulator CysR, ROK family

Position: -85
Score: 5.1
Sequence: TAGACTGAACGGTCTA
Position: -20
Score: 4.8
Sequence: TAGACCATACGGTCTA
Locus tag: cg0012
Name: ssuR
Funciton: Sulphonate sulphur utilization transcriptional regulator SsuR, ROK family
ssuR
Sulphonate sulphur utilization transcriptional regulator SsuR, ROK family

Position: -79
Score: 5
Sequence: TAGACTGAATTGTCTA
Position: -24
Score: 4.3
Sequence: TAGACTGAATGGCCTA
Locus tag: cg1147
Name: ssuI
Funciton: Predicted flavin reductase
ssuI
Predicted flavin reductase

Position: -182
Score: 4.6
Sequence: TAGACCGCTTAGTCTT
Position: -117
Score: 5
Sequence: TAGACATCTCGGTCTA
Position: -30
Score: 4.4
Sequence: TAGACGAAGCGGTCTG
Locus tag: cg1376
Name: ssuD
Funciton: Alkanesulfonate monooxygenase
Locus tag: cg1377
Name: ssuC
Funciton: Sulfonate ABC transporter, permease protein
Locus tag: cg1379
Name: ssuB
Funciton: Sulfonate ABC transporter, ATP-binding protein
Locus tag: cg1380
Name: ssuA
Funciton: Sulfonate ABC transporter, substrate-binding protein
ssuD
Alkanesulfonate monooxygenase
ssuC
Sulfonate ABC transporter, permease protein
ssuB
Sulfonate ABC transporter, ATP-binding protein
ssuA
Sulfonate ABC transporter, substrate-binding protein

Position: -74
Score: 5.5
Sequence: TAGACAGCTTGGTCTA
Locus tag: cg1806
Name: metK
Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6)
Locus tag: cg1805
Name: priA
Funciton: Helicase PriA essential for oriC/DnaA-independent DNA replication
metK
S-adenosylmethionine synthetase (EC 2.5.1.6)
priA
Helicase PriA essential for oriC/DnaA-independent DNA replication

Position: -24
Score: 5.1
Sequence: TAGACCGTGTGGTCTA
Locus tag: cg1156
Name: ssuD
Funciton: Alkanesulfonate monooxygenase
ssuD
Alkanesulfonate monooxygenase

Position: -197
Score: 5.4
Sequence: TAGACCGATCTGTCTA
Position: -112
Score: 5
Sequence: CAGACCAAGCGGTCTA
Locus tag: cg3119
Name: cysJ
Funciton: Ferredoxin--NADP reductase (EC 1.18.1.2)
cysJ
Ferredoxin--NADP reductase (EC 1.18.1.2)

Position: -78
Score: 4.1
Sequence: CGAACCGGTTTGTCTA
Locus tag: cg3253
Name: mcbR
Funciton: Methionine biosynthesis transcriptional regulator McbR, TetR family
mcbR
Methionine biosynthesis transcriptional regulator McbR, TetR family

Position: -113
Score: 4.9
Sequence: TGAACAGCTTGGTCTA
Locus tag: cg1337
Name: hom
Funciton: Homoserine dehydrogenase (EC 1.1.1.3)
Locus tag: cg1338
Name: thrB
Funciton: Homoserine kinase (EC 2.7.1.39)
hom
Homoserine dehydrogenase (EC 1.1.1.3)
thrB
Homoserine kinase (EC 2.7.1.39)

Position: -109
Score: 4.6
Sequence: TAGACCAAGCTGTACA
Locus tag: cg0737
Name: metQ
Funciton: Methionine ABC transporter substrate-binding protein
Locus tag: cg0736
Name: metN
Funciton: Methionine ABC transporter ATP-binding protein
Locus tag: cg0735
Name: metI
Funciton: Methionine ABC transporter permease protein
metQ
Methionine ABC transporter substrate-binding protein
metN
Methionine ABC transporter ATP-binding protein
metI
Methionine ABC transporter permease protein

Position: -150
Score: 4.6
Sequence: TGAACAGAACTGTCTA
Locus tag: cg2833
Name: cysK
Funciton: Cysteine synthase (EC 2.5.1.47)
Locus tag: cg2834
Name: cysE
Funciton: Serine acetyltransferase (EC 2.3.1.30)
cysK
Cysteine synthase (EC 2.5.1.47)
cysE
Serine acetyltransferase (EC 2.3.1.30)

Position: -36
Score: 4.9
Sequence: TAGACAAAGATGTCTA
Locus tag: cg1151
Name: seuA
Funciton: coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase
Locus tag: cg1152
Name: seuB
Funciton: Flavine mononucleotide dependent monooxygenase, subunit B
Locus tag: cg1153
Name: seuC
Funciton: Flavine mononucleotide dependent monooxygenase, subunit C
seuA
coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase
seuB
Flavine mononucleotide dependent monooxygenase, subunit B
seuC
Flavine mononucleotide dependent monooxygenase, subunit C

Position: -224
Score: 4.6
Sequence: TAGACTATGCAGTCTA
Locus tag: cg3132
Name: cg3132
Funciton: Conserved hypothetical protein
cg3132
Conserved hypothetical protein

Position: -78
Score: 5.3
Sequence: TGGACAGCTTGGTCTA
Locus tag: cg2687
Name: metB
Funciton: Cystathionine gamma-synthase (EC 2.5.1.48)
metB
Cystathionine gamma-synthase (EC 2.5.1.48)

Position: -158
Score: 4.5
Sequence: TAGACTGGTTTGTCTG
Locus tag: cg1386
Name: fixB
Funciton: Electron transfer flavoprotein, beta subunit
Locus tag: cg1387
Name: fixA
Funciton: Electron transfer flavoprotein, alpha subunit
Locus tag: cg1388
Name: iscS
Funciton: Cysteine desulfurase (EC 2.8.1.7)
fixB
Electron transfer flavoprotein, beta subunit
fixA
Electron transfer flavoprotein, alpha subunit
iscS
Cysteine desulfurase (EC 2.8.1.7)
Export
Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD