Regulon of McbR in Corynebacterium aurimucosum ATCC 700975

Properties
Regulator type:	Transcription factor
TF locus tag:	cauri_2422
Regulator family:	TetR
Regulation mode:	repressor
Biological process:	Methionine biosynthesis
Effector:	S-adenosylmethionine; S-adenosylhomocysteine
Regulog:	McbR - Corynebacteriaceae
Statistics of regulated genes:
- Genes	28
- Operons	15
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 162 sites [see more]

Member of regulog collections

By taxonomy - Corynebacteriaceae
By TF family - TetR
By effector - S-adenosylmethionine
By effector - S-adenosylhomocysteine
By pathway - Methionine biosynthesis

Regulated operons
	Locus Tag	Name	Function
Position: -74 Score: 4.8 Sequence: TATACCACTCAGTCTA Locus tag: cauri_2144 Name: cysK Funciton: Cysteine synthase (EC 2.5.1.47) Locus tag: cauri_2145 Name: cysE Funciton: Serine acetyltransferase (EC 2.3.1.30)
	cauri_2144	cysK	Cysteine synthase (EC 2.5.1.47)
	cauri_2145	cysE	Serine acetyltransferase (EC 2.3.1.30)
Position: -65 Score: 4.4 Sequence: AAGACTGCTTTGTCTG Locus tag: cauri_0665 Name: cysI Funciton: Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
	cauri_0665	cysI	Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
Position: -92 Score: 4.2 Sequence: CCAACCGCTCGGTCTA Position: -27 Score: 4.8 Sequence: TGAACCGCTTGGTCTA Locus tag: cauri_0513 Name: metY Funciton: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) Locus tag: cauri_0512 Name: metX Funciton: Homoserine O-acetyltransferase (EC 2.3.1.31)
	cauri_0513	metY	O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
	cauri_0512	metX	Homoserine O-acetyltransferase (EC 2.3.1.31)
Position: -115 Score: 4.2 Sequence: TAGTCCGCTCGGTTCA Locus tag: cauri_2335 Name: cysH Funciton: Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10) Locus tag: cauri_2334 Name: cysD Funciton: Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) Locus tag: cauri_2333 Name: cysN Funciton: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)
	cauri_2335	cysH	Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
	cauri_2334	cysD	Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4)
	cauri_2333	cysN	Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4)
Position: -36 Score: 5 Sequence: TAGACAGCACAGTCTA Locus tag: cauri_2044 Name: cg2679 Funciton: Conserved hypothetical protein
	cauri_2044	cg2679	Conserved hypothetical protein
Position: -72 Score: 4.5 Sequence: TGAACCGATCGGTATA Position: -29 Score: 4.8 Sequence: TATACAACACTGTCTA Locus tag: cauri_0959 Name: gltT Funciton: Predicted sodium:dicarboxylate symporter
	cauri_0959	gltT	Predicted sodium:dicarboxylate symporter
Position: -36 Score: 5 Sequence: TAGACTGTGCTGTCTA Locus tag: cauri_2043 Name: cg2678 Funciton: Predicted ABC transporter, substrate-binding protein Locus tag: cauri_2042 Name: cg2677 Funciton: Predicted ABC transporter, permease protein 1 Locus tag: cauri_2041 Name: cg2676 Funciton: Predicted ABC transporter, permease protein 2 Locus tag: cauri_2040 Name: cg2675 Funciton: Predicted ABC transporter, ATP-binding protein Locus tag: cauri_2039 Name: cg2674 Funciton: Conserved hypothetical protein
	cauri_2043	cg2678	Predicted ABC transporter, substrate-binding protein
	cauri_2042	cg2677	Predicted ABC transporter, permease protein 1
	cauri_2041	cg2676	Predicted ABC transporter, permease protein 2
	cauri_2040	cg2675	Predicted ABC transporter, ATP-binding protein
	cauri_2039	cg2674	Conserved hypothetical protein
Position: -40 Score: 4.5 Sequence: TAGACCATGATGTCTA Position: -6 Score: 4.7 Sequence: TAGACAATGCGGTCTG Locus tag: cauri_0079 Name: cysR Funciton: Sulphur metabolism transcriptional regulator CysR, ROK family
	cauri_0079	cysR	Sulphur metabolism transcriptional regulator CysR, ROK family
Position: -57 Score: 4.4 Sequence: CATACCGGTTTGTCTA Locus tag: cauri_2422 Name: mcbR Funciton: Methionine biosynthesis transcriptional regulator McbR, TetR family
	cauri_2422	mcbR	Methionine biosynthesis transcriptional regulator McbR, TetR family
Position: -182 Score: 4.5 Sequence: TAGACAGCTTTGTACG Position: -70 Score: 4.3 Sequence: TGGACAGCTTGGTACG Locus tag: cauri_0019 Name: metF Funciton: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
	cauri_0019	metF	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Position: -70 Score: 4.6 Sequence: TAGACAGCTCGTTCTG Locus tag: cauri_1049 Name: hom Funciton: Homoserine dehydrogenase (EC 1.1.1.3) Locus tag: cauri_1050 Name: thrB Funciton: Homoserine kinase (EC 2.7.1.39)
	cauri_1049	hom	Homoserine dehydrogenase (EC 1.1.1.3)
	cauri_1050	thrB	Homoserine kinase (EC 2.7.1.39)
Position: -28 Score: 4.9 Sequence: TGAACAGCTTGGTCTA Locus tag: cauri_2045 Name: metB Funciton: Cystathionine gamma-synthase (EC 2.5.1.48)
	cauri_2045	metB	Cystathionine gamma-synthase (EC 2.5.1.48)
Position: -180 Score: 4.3 Sequence: CAGACAAAGCAGTCTT Locus tag: cauri_0664 Name: cysJ Funciton: Ferredoxin--NADP reductase (EC 1.18.1.2)
	cauri_0664	cysJ	Ferredoxin--NADP reductase (EC 1.18.1.2)
Position: -97 Score: 5.4 Sequence: TAGACCGCTTGGTCTA Locus tag: cauri_1185 Name: metK Funciton: S-adenosylmethionine synthetase (EC 2.5.1.6) Locus tag: cauri_1186 Name: priA Funciton: Helicase PriA essential for oriC/DnaA-independent DNA replication
	cauri_1185	metK	S-adenosylmethionine synthetase (EC 2.5.1.6)
	cauri_1186	priA	Helicase PriA essential for oriC/DnaA-independent DNA replication
Position: -101 Score: 4.8 Sequence: TAGACAAAGCGGTTCA Locus tag: cauri_0499 Name: metQ Funciton: Methionine ABC transporter substrate-binding protein Locus tag: cauri_0498 Name: metQ Funciton: Methionine ABC transporter substrate-binding protein Locus tag: cauri_0497 Name: metN Funciton: Methionine ABC transporter ATP-binding protein Locus tag: cauri_0496 Name: metI Funciton: Methionine ABC transporter permease protein
	cauri_0499	metQ	Methionine ABC transporter substrate-binding protein
	cauri_0498	metQ	Methionine ABC transporter substrate-binding protein
	cauri_0497	metN	Methionine ABC transporter ATP-binding protein
	cauri_0496	metI	Methionine ABC transporter permease protein

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of McbR in Corynebacterium aurimucosum ATCC 700975

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --