Regulog HisR - Staphylococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	TrpR
Regulation mode:	repressor
Biological process:	Histidine biosynthesis
Effector:	Histidine
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 24 sites [see more]

Member of regulog collections

By taxonomy - Staphylococcaceae
By trascription factor - HisR
By TF family - TrpR
By effector - Histidine
By pathway - Histidine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Staphylococcus aureus subsp. aureus N315	13	4
Staphylococcus capitis SK14	4	3
Staphylococcus epidermidis ATCC 12228	12	4
Staphylococcus carnosus subsp. carnosus TM300	13	4
Staphylococcus haemolyticus JCSC1435	4	3
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	13	4
Macrococcus caseolyticus JCSC5402	3	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
hisR	* Staphylococcus aureus subsp. aureus N315 Site: position = -62 score = 5.16946 sequence = CACTTTAATAGATTAATGCG Gene: SA1723: Predicted histidine repressor, TrpR family	* Staphylococcus capitis SK14 Site: position = -60 score = 5.07424 sequence = CACTTTAACTAATTAGTACG Gene: STACA0001_1960: Predicted histidine repressor, TrpR family	* Staphylococcus epidermidis ATCC 12228 Site: position = -60 score = 5.03122 sequence = CACTTTAACGAATTAGTAAG Gene: SE1592: Predicted histidine repressor, TrpR family	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -60 score = 5.08992 sequence = CACTTTAACGTATTAGTACG Gene: Sca_1481: Predicted histidine repressor, TrpR family	* Staphylococcus haemolyticus JCSC1435 Site: position = -65 score = 5.43956 sequence = CACTTTAACTATTTAATGCG Gene: SH1044: Predicted histidine repressor, TrpR family	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -61 score = 5.06836 sequence = CACTTTAATGTACTAATACG Gene: SSP0883: Predicted histidine repressor, TrpR family	Macrococcus caseolyticus JCSC5402	Predicted histidine repressor, TrpR family

CRON 2.
yuiF	* Staphylococcus aureus subsp. aureus N315 Site: position = -38 score = 5.04842 sequence = CGCTTTAGTTCGATAGAGCG Gene: SA0804: Histidine permease	* Staphylococcus capitis SK14 Site: position = -39 score = 4.87058 sequence = TACTTTAGTTCGATAGAGTG Gene: STACA0001_0183: Histidine permease	* Staphylococcus epidermidis ATCC 12228 Site: position = -37 score = 4.87058 sequence = TACTTTAGTTCGATAGAGTG Gene: SE0637: Histidine permease	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -37 score = 4.22076 sequence = TGCTTTAGTTCGATAACGTA Gene: Sca_0548: Histidine permease	* Staphylococcus haemolyticus JCSC1435 Site: position = -37 score = 4.86297 sequence = TACTTTAGTTCGGTAGAGAG Gene: SH2008: Histidine permease	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -38 score = 4.46835 sequence = TACTTTAGTTCGATAACGTG Gene: SSP1832: Histidine permease	* Macrococcus caseolyticus JCSC5402 Site: position = -47 score = 4.22627 sequence = TACTTTAGTATGCTAATATA Gene: MCCL_0570: Histidine permease	Histidine permease
SA0805	Staphylococcus aureus subsp. aureus N315 Gene: SA0805: putative esterase	Staphylococcus capitis SK14 Gene: STACA0001_0182: putative esterase	Staphylococcus epidermidis ATCC 12228 Gene: SE0638: putative esterase	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0549: putative esterase	Staphylococcus haemolyticus JCSC1435 Gene: SH2007: putative esterase	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1831: putative esterase	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0571: putative esterase	putative esterase

CRON 3.
SA0417	* Staphylococcus aureus subsp. aureus N315 Site: position = -27 score = 5.5165 sequence = CGCTTTAACGCTTTAAAGGA Gene: SA0417: putative sodium-dependent transporter	* Staphylococcus capitis SK14 Site: position = -30 score = 5.57261 sequence = CACTTTAGCGCTTTAAAGGG Gene: STACA0001_1477: putative sodium-dependent transporter	* Staphylococcus epidermidis ATCC 12228 Site: position = -108 score = 5.57261 sequence = CACTTTAGCGCTTTAAAGGG Gene: SE2326: putative sodium-dependent transporter	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -143 score = 5.72011 sequence = CGCTTTAACGCTTTAAAGTA Gene: Sca_0085: putative sodium-dependent transporter	* Staphylococcus haemolyticus JCSC1435 Site: position = -108 score = 5.87238 sequence = CGCTTTAACGCGTTAAAGGG Gene: SH2552: putative sodium-dependent transporter	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -47 score = 5.11013 sequence = CGCTTTAACGCAATAAAGCT Gene: SSP2298: putative sodium-dependent transporter	* Macrococcus caseolyticus JCSC5402 Site: position = -33 score = 5.44315 sequence = CACTTTACAGCGTTAAAACG Gene: MCCL_0041: putative sodium-dependent transporter	putative sodium-dependent transporter

CRON 4.
hisZ	* Staphylococcus aureus subsp. aureus N315 Site: position = -84 score = 4.74132 sequence = CACTTTAGTGTGGTAGAGAA Gene: SA2472: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	Staphylococcus capitis SK14	* Staphylococcus epidermidis ATCC 12228 Site: position = -56 score = 3.91433 sequence = TACTTTAATGTATTATCGAA Gene: SE0270: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -50 score = 4.86297 sequence = TACTTTAGTTCGGTAGAGAG Gene: Sca_0637: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	Staphylococcus haemolyticus JCSC1435	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -49 score = 4.63863 sequence = TACTTTAGTTCGGTAGAGAA Gene: SSP0431: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	Macrococcus caseolyticus JCSC5402	ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)
hisG	Staphylococcus aureus subsp. aureus N315 Gene: SA2471: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0271: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0636: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0430: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Macrococcus caseolyticus JCSC5402	ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)
hisD	Staphylococcus aureus subsp. aureus N315 Gene: SA2470: Histidinol dehydrogenase (EC 1.1.1.23)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0272: Histidinol dehydrogenase (EC 1.1.1.23)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0635: Histidinol dehydrogenase (EC 1.1.1.23)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0429: Histidinol dehydrogenase (EC 1.1.1.23)	Macrococcus caseolyticus JCSC5402	Histidinol dehydrogenase (EC 1.1.1.23)
hisC	Staphylococcus aureus subsp. aureus N315 Gene: SA2469: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0634: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0428: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Macrococcus caseolyticus JCSC5402	Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisB	Staphylococcus aureus subsp. aureus N315 Gene: SA2468: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0273: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0633: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0427: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Macrococcus caseolyticus JCSC5402	Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
hisH	Staphylococcus aureus subsp. aureus N315 Gene: SA2467: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0274: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0632: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0426: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Macrococcus caseolyticus JCSC5402	Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisA	Staphylococcus aureus subsp. aureus N315 Gene: SA2466: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0275: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0631: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0425: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Macrococcus caseolyticus JCSC5402	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisF	Staphylococcus aureus subsp. aureus N315 Gene: SA2465: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0276: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0630: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0424: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Macrococcus caseolyticus JCSC5402	Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
hisIE	Staphylococcus aureus subsp. aureus N315 Gene: SA2464: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0277: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0629: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0423: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Macrococcus caseolyticus JCSC5402	Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HisR - Staphylococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --