Regulog CzrA - Clostridia-3

Properties
Regulator type:	Transcription factor
Regulator family:	ArsR
Regulation mode:	repressor
Biological process:	Zinc resistance; Nickel resistance; Copper resistance; Cobalt resistance; Cadmium resistance
Effector:	Zinc ion, (Zn2+); Silver ion, (Ag+); Nickel ion, (Ni2+); Copper ion, (Cu2+); Cobalt ion, (Co2+); Cadmium, ion (Cd2+)
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 13 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-3
By trascription factor - CzrA
By TF family - ArsR
By effector - Zinc ion, (Zn2+)
By effector - Silver ion, (Ag+)
By effector - Nickel ion, (Ni2+)
By effector - Copper ion, (Cu2+)
By effector - Cobalt ion, (Co2+)
By effector - Cadmium, ion (Cd2+)
By pathway - Zinc resistance
By pathway - Nickel resistance
By pathway - Copper resistance
By pathway - Cobalt resistance
By pathway - Cadmium resistance

Statistics of regulated genes
Genome	Genes	Operons
Bacteroides pectinophilus ATCC 43243	3	1
Blautia hansenii DSM 20583
Bryantella formatexigens DSM 14469	3	1
Clostridiales bacterium 1_7_47_FAA	3	1
Clostridium bolteae ATCC BAA-613	3	1
Clostridium nexile DSM 1787	1	1
Clostridium scindens ATCC 35704	2	1
Dorea formicigenerans ATCC 27755
Dorea longicatena DSM 13814	3	1
Eubacterium eligens ATCC 27750	3	1
Eubacterium rectale ATCC 33656	2	1
Roseburia intestinalis L1-82	3	2
Ruminococcus gnavus ATCC 29149	2	1
Ruminococcus lactaris ATCC 29176

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
PF00403	* Bacteroides pectinophilus ATCC 43243 Site: position = -87 score = 6.94351 sequence = CATATGAATGATTGTTCATATG Gene: BACPEC_01957: Heavy-metal-associated domain	Blautia hansenii DSM 20583	* Bryantella formatexigens DSM 14469 Site: position = -41 score = 7.59281 sequence = CATATGAATAAATGTTCATATG Gene: BRYFOR_04019: Heavy-metal-associated domain	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100022157: Heavy-metal-associated domain	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01423: Heavy-metal-associated domain	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	* Dorea longicatena DSM 13814 Site: position = -62 score = 7.34499 sequence = CATATGAATAACTGTTCATATA Gene: DORLON_02327: Heavy-metal-associated domain	* Eubacterium eligens ATCC 27750 Site: position = -63 score = 7.34499 sequence = CATATGAATGAATGTTCATATG Gene: EUBELI_01434: Heavy-metal-associated domain	* Eubacterium rectale ATCC 33656 Site: position = -78 score = 6.17876 sequence = CATATGAACAATCATTCATATG Gene: EUBREC_2969: Heavy-metal-associated domain	Roseburia intestinalis L1-82 Gene: ROSINTL182_01064: Heavy-metal-associated domain	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Heavy-metal-associated domain
cadA	Bacteroides pectinophilus ATCC 43243 Gene: BACPEC_01958: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469 Gene: BRYFOR_04020: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100022162: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_01422: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	* Clostridium nexile DSM 1787 Site: position = -51 score = 5.09777 sequence = AATATGGTTATATGAACATATG Site: position = -35 score = 5.69279 sequence = CATATGAACAATCACTCATATG Gene: CLONEX_04065: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	* Clostridium scindens ATCC 35704 Site: position = -63 score = 7.59281 sequence = CATATGAATAACTGTTCATATG Gene: CLOSCI_04034: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	2 Dorea formicigenerans ATCC 27755 Gene: DORFOR_02523: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4) Gene: DORFOR_02521: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Dorea longicatena DSM 13814 Gene: DORLON_02326: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Eubacterium eligens ATCC 27750 Gene: EUBELI_01433: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Eubacterium rectale ATCC 33656 Gene: EUBREC_2968: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	* Roseburia intestinalis L1-82 Site: position = -28 score = 6.88673 sequence = CATATGAATACATGAACATATG Gene: ROSINTL182_01062: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	* Ruminococcus gnavus ATCC 29149 Site: position = -28 score = 6.63892 sequence = CATATGAACAGCTATTCATGTG Gene: RUMGNA_00975: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)	Ruminococcus lactaris ATCC 29176	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)
czrA	Bacteroides pectinophilus ATCC 43243 Gene: BACPEC_01959: Cadmium-dependent transcriptuin regulator, ArsR family	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469 Gene: BRYFOR_04021: Cadmium-dependent transcriptuin regulator, ArsR family	* Clostridiales bacterium 1_7_47_FAA Site: position = -54 score = 6.17876 sequence = CATATGAACAATCATTCATATG Gene: Cbac1_010100022152: Cadmium-dependent transcriptuin regulator, ArsR family	* Clostridium bolteae ATCC BAA-613 Site: position = -55 score = 6.17876 sequence = CATATGAACAATCATTCATATG Gene: CLOBOL_01424: Cadmium-dependent transcriptuin regulator, ArsR family	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704 Gene: CLOSCI_04035: Cadmium-dependent transcriptuin regulator, ArsR family	Dorea formicigenerans ATCC 27755 Gene: DORFOR_02522: Cadmium-dependent transcriptuin regulator, ArsR family	Dorea longicatena DSM 13814 Gene: DORLON_02325: Cadmium-dependent transcriptuin regulator, ArsR family	Eubacterium eligens ATCC 27750 Gene: EUBELI_01432: Cadmium-dependent transcriptuin regulator, ArsR family	Eubacterium rectale ATCC 33656	* Roseburia intestinalis L1-82 Site: position = -58 score = 5.63602 sequence = CATATGAACAGATAAGAATATG Gene: ROSINTL182_01065: Cadmium-dependent transcriptuin regulator, ArsR family	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_00977: Cadmium-dependent transcriptuin regulator, ArsR family	Ruminococcus lactaris ATCC 29176	Cadmium-dependent transcriptuin regulator, ArsR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CzrA - Clostridia-3

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --