Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog MetR - Various betaproteobacteria

Properties
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Methionine biosynthesis
Effector: Homocysteine
Phylum: Proteobacteria/beta
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 19 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Azoarcus sp. EbN1
Thauera sp. MZ1T
Dechloromonas aromatica RCB
Nitrosomonas europaea ATCC 19718 2 2
Nitrosospira multiformis ATCC 25196 2 2
Thiobacillus denitrificans 2 2
Chromobacterium violaceum ATCC 12472 2 2
Neisseria meningitidis MC58 3 2
Laribacter hongkongensis HLHK9 2 2
Methylobacillus flagellatus KT 2 2
Methylotenera mobilis JLW8 2 2
Methylophilales bacterium HTCC2181
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
metR
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
*
Nitrosomonas europaea ATCC 19718

Site:
position = -17
score = 5.35694
sequence = ATGAATAATTTTCAT

Gene: NE1435: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Nitrosospira multiformis ATCC 25196

Site:
position = -31
score = 5.8124
sequence = ATGAATAAAATTCAT

Gene: Nmul_A2635: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Thiobacillus denitrificans

Site:
position = -23
score = 5.19237
sequence = ATGAATAACACTCAT

Gene: Tbd_2285: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Chromobacterium violaceum ATCC 12472

Site:
position = -47
score = 4.77053
sequence = ATGATTCAAACTCAT

Gene: CV3603: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Neisseria meningitidis MC58

Site:
position = -47
score = 4.90149
sequence = ATGAATTATTTTAAT

Gene: NMB2055: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Laribacter hongkongensis HLHK9

Site:
position = 10
score = 4.2641
sequence = ATGGTTTTATTTCAT

Site:
position = 31
score = 5.8124
sequence = ATGAATTTTATTCAT

Gene: LHK_00468: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Methylobacillus flagellatus KT

Site:
position = -19
score = 5.8124
sequence = ATGAATTAAATTCAT

Gene: Mfla_2570: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Methylotenera mobilis JLW8

Site:
position = -22
score = 5.35694
sequence = ATTAATTTTATTCAT

Gene: Mmol_0965: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
Methylophilales bacterium HTCC2181
Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
CRON 2.
metF
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
*
Neisseria meningitidis MC58

Site:
position = -110
score = 4.12849
sequence = ATTAGAAATTTTCAT

Site:
position = -79
score = 4.08205
sequence = TTGAAATTGACTCAT

Gene: NMB0943: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
metE
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
*
Nitrosomonas europaea ATCC 19718

Site:
position = -98
score = 5.35694
sequence = ATGAAAATTATTCAT

Gene: NE1436: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Nitrosospira multiformis ATCC 25196

Site:
position = -125
score = 5.8124
sequence = ATGAATTTTATTCAT

Gene: Nmul_A2634: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Thiobacillus denitrificans

Site:
position = -98
score = 5.19237
sequence = ATGAGTGTTATTCAT

Gene: Tbd_2286: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Chromobacterium violaceum ATCC 12472

Site:
position = -67
score = 4.77053
sequence = ATGAGTTTGAATCAT

Gene: CV3604: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Neisseria meningitidis MC58

Gene: NMB0944: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Laribacter hongkongensis HLHK9

Site:
position = -97
score = 5.8124
sequence = ATGAATAAAATTCAT

Site:
position = -76
score = 4.2641
sequence = ATGAAATAAAACCAT

Gene: LHK_00469: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Methylobacillus flagellatus KT

Site:
position = -92
score = 5.8124
sequence = ATGAATTTAATTCAT

Gene: Mfla_2571: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Methylotenera mobilis JLW8

Site:
position = -96
score = 5.35694
sequence = ATGAATAAAATTAAT

Gene: Mmol_0966: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Methylophilales bacterium HTCC2181
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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