Regulog CadR-PbrR - Ralstonia

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator
Biological process:	Lead resistance; Cadmium resistance
Effector:	Lead ion, (Pb2+); Cadmium, ion (Cd2+)
Phylum:	Proteobacteria/Beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 21 sites [see more]

Member of regulog collections

By taxonomy - Ralstonia
By trascription factor - CadR-PbrR
By TF family - MerR
By effector - Lead ion, (Pb2+)
By effector - Cadmium, ion (Cd2+)
By pathway - Lead resistance
By pathway - Cadmium resistance

Statistics of regulated genes
Genome	Genes	Operons
Ralstonia solanacearum GMI1000	1	1
Ralstonia pickettii 12J	10	6
Ralstonia metallidurans CH34	14	8
Ralstonia eutropha JMP134	2	2
Ralstonia eutropha H16	2	2
Cupriavidus taiwanensis	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes							Function

CRON 1.
cadR	Ralstonia solanacearum GMI1000	Ralstonia pickettii 12J	* Ralstonia metallidurans CH34 Site: position = -30 score = 5.8573 sequence = ACCCTGTAATTACTACAGGGA Gene: Rmet_3456: Cadmium resistance transcriptional regulator, MerR family	* Ralstonia eutropha JMP134 Site: position = -31 score = 5.68202 sequence = ACCCCGTAGTCACTACAGAGA Gene: Reut_A3299: Cadmium resistance transcriptional regulator, MerR family	* Ralstonia eutropha H16 Site: position = -42 score = 6.14485 sequence = ACCCTGTAGTAGTTACAGGGT Gene: H16_A3607: Cadmium resistance transcriptional regulator, MerR family	* Cupriavidus taiwanensis Site: position = -39 score = 6.12231 sequence = ACCCTGTAGTCGTTACAGGGT Gene: RALTA_A3062: Cadmium resistance transcriptional regulator, MerR family	Cadmium resistance transcriptional regulator, MerR family

CRON 2.
pbrA	Ralstonia solanacearum GMI1000	2 Ralstonia pickettii 12J* Site: position = -63 score = 6.15292 sequence = ACTCTATAGTAGCTATAGAGT Gene: Rpic_1815: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -65 score = 6.15292 sequence = ACTCTATAGTAGCTATAGAGT Gene: Rpic_1643: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	3 Ralstonia metallidurans CH34* Site: position = -26 score = 4.85391 sequence = ACTCTATATCTACTAGAGGTT Gene: Rmet_2303: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -63 score = 6.1543 sequence = ACTCTATAGTAACTAGAGGGT Gene: Rmet_5947: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -63 score = 6.1543 sequence = ACTCTATAGTAACTAGAGGGT Gene: pMOL30_091: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)
lspA	Ralstonia solanacearum GMI1000	2 Ralstonia pickettii 12J Gene: Rpic_1814: Lipoprotein signal peptidase (EC 3.4.23.36) Gene: Rpic_1644: Lipoprotein signal peptidase (EC 3.4.23.36)	3 Ralstonia metallidurans CH34 Gene: Rmet_5948: Lipoprotein signal peptidase (EC 3.4.23.36) Gene: Rmet_2304: Lipoprotein signal peptidase (EC 3.4.23.36) Gene: pMOL30_090: Lipoprotein signal peptidase (EC 3.4.23.36)	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	Lipoprotein signal peptidase (EC 3.4.23.36)
pbrD	Ralstonia solanacearum GMI1000	Ralstonia pickettii 12J	Ralstonia metallidurans CH34 Gene: Rmet_5949: Pb(II) binding protein	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	Pb(II) binding protein

CRON 3.
pbrR	Ralstonia solanacearum GMI1000	2 Ralstonia pickettii 12J* Site: position = -43 score = 6.15292 sequence = ACTCTATAGCTACTATAGAGT Gene: Rpic_1642: Lead resistance transcriptional regulator, MerR family Site: position = -43 score = 6.15292 sequence = ACTCTATAGCTACTATAGAGT Gene: Rpic_1816: Lead resistance transcriptional regulator, MerR family	2 Ralstonia metallidurans CH34* Site: position = -44 score = 6.1543 sequence = ACCCTCTAGTTACTATAGAGT Gene: pMOL30_092: Lead resistance transcriptional regulator, MerR family Site: position = -44 score = 6.1543 sequence = ACCCTCTAGTTACTATAGAGT Gene: Rmet_5946: Lead resistance transcriptional regulator, MerR family	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	Lead resistance transcriptional regulator, MerR family
pbrT	Ralstonia solanacearum GMI1000	2 Ralstonia pickettii 12J Gene: Rpic_1817: Pb(II) uptake protein, ILT family Gene: Rpic_1641: Pb(II) uptake protein, ILT family	2 Ralstonia metallidurans CH34 Gene: pMOL30_093: Pb(II) uptake protein, ILT family Gene: Rmet_5945: Pb(II) uptake protein, ILT family	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	Pb(II) uptake protein, ILT family

CRON 4.
Rpic_1752	Ralstonia solanacearum GMI1000	* Ralstonia pickettii 12J Site: position = -115 score = 5.97091 sequence = ACCCTGTAGTCACTACAGACT Gene: Rpic_1752: hypothetical protein	* Ralstonia metallidurans CH34 Site: position = -115 score = 5.97091 sequence = ACCCTGTAGTCACTACAGACT Gene: Rmet_5969: hypothetical protein	Ralstonia eutropha JMP134	Ralstonia eutropha H16	Cupriavidus taiwanensis	hypothetical protein

CRON 5.
cadA	* Ralstonia solanacearum GMI1000 Site: position = -57 score = 5.64595 sequence = ACCCTGGAGTTCCTTCAGGGT Gene: RS05448: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Ralstonia pickettii 12J Site: position = -34 score = 5.63839 sequence = ACCCTGGAGCTTCTTCAGGGT Gene: Rpic_4809: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Ralstonia metallidurans CH34 Site: position = -46 score = 6.06593 sequence = ACCCTGTAGCGACTAAAGGGT Gene: Rmet_4594: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Ralstonia eutropha JMP134 Site: position = -61 score = 6.2636 sequence = ACTCTGTAGCGGCTACAGGGT Gene: Reut_B3972: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Ralstonia eutropha H16 Site: position = -61 score = 6.40785 sequence = ACTCTGTAGTCGCTACAGGGT Gene: H16_B1644: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Cupriavidus taiwanensis Site: position = -61 score = 6.40785 sequence = ACTCTGTAGCCACTACAGGGT Gene: RALTA_B1454: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CadR-PbrR - Ralstonia

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --