Regulog TPP - Clostridia-3
| Regulator type: | RNA regulatory element |
| Name: | TPP |
| RFAM: | RF00059 |
| Regulation mode: | |
| Biological process: | Thiamine biosynthesis |
| Effector: | Thiamine pyrophosphate |
| Phylum: | Firmicutes |
Member of regulog collections
- By taxonomy - Clostridia-3
- By RNA motif - TPP
- By effector - Thiamine pyrophosphate
- By pathway - Thiamine biosynthesis
| Genome | Genes | Operons |
|---|---|---|
| Clostridiales bacterium 1_7_47_FAA | 11 | 4 |
| Clostridium bolteae ATCC BAA-613 | 4 | 2 |
| Eubacterium eligens ATCC 27750 | 1 | 1 |
| Roseburia intestinalis L1-82 | 5 | 3 |
| Ruminococcus gnavus ATCC 29149 | 6 | 3 |
| Dorea longicatena DSM 13814 | 9 | 3 |
| Blautia hansenii DSM 20583 | 4 | 3 |
| Clostridium nexile DSM 1787 | 9 | 3 |
| Clostridium scindens ATCC 35704 | 7 | 3 |
| Eubacterium rectale ATCC 33656 | 2 | 1 |
| Ruminococcus lactaris ATCC 29176 | 3 | 1 |
| Dorea formicigenerans ATCC 27755 | 9 | 3 |
| Bryantella formatexigens DSM 14469 | 2 | 2 |
| Bacteroides pectinophilus ATCC 43243 | 2 | 1 |
| Genes | Function | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRON 1. | |||||||||||||||
| thiT |
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Gene: EUBELI_01236: Substrate-specific component ThiT of thiamin ECF transporter |
*
Roseburia intestinalis L1-82 Site: position = -550 score = 70.96 sequence = ACAAATGCTAGGGGT... Gene: ROSINTL182_02990: Substrate-specific component ThiT of thiamin ECF transporter |
*
Ruminococcus gnavus ATCC 29149 Site: position = -154 score = 61.48 sequence = TTGATAACAAGGGGA... Gene: RUMGNA_01568: Substrate-specific component ThiT of thiamin ECF transporter |
|
*
Blautia hansenii DSM 20583 Site: position = -141 score = 64.34 sequence = AGAATAAGAAGGGGA... Gene: BLAHAN_02691: Substrate-specific component ThiT of thiamin ECF transporter |
*
Clostridium nexile DSM 1787 Site: position = -38 score = 59.97 sequence = CAATTTGCTAGGGGA... Gene: CLONEX_00550: Substrate-specific component ThiT of thiamin ECF transporter |
*
Clostridium scindens ATCC 35704 Site: position = -188 score = 57.06 sequence = ATAAGACCCATATGG... Gene: CLOSCI_02958: Substrate-specific component ThiT of thiamin ECF transporter |
|
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|
*
Bryantella formatexigens DSM 14469 Site: position = -140 score = 67.74 sequence = ATTTTTATGCTAGGG... Gene: BRYFOR_01324: Substrate-specific component ThiT of thiamin ECF transporter |
|
Substrate-specific component ThiT of thiamin ECF transporter |
| CRON 2. | |||||||||||||||
| thiM |
Gene: Cbac1_010100012901: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
Gene: CLOBOL_04494: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
|
Gene: ROSINTL182_00600: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
*
Ruminococcus gnavus ATCC 29149 Site: position = -201 score = 47.58 sequence = AAATAAAAAACAAGG... Gene: RUMGNA_01198: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
*
Dorea longicatena DSM 13814 Site: position = -280 score = 36.42 sequence = GAAAAGGGGAGTCCG... Gene: DORLON_02556: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
|
Gene: CLONEX_00817: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
Gene: CLOSCI_03982: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
*
Eubacterium rectale ATCC 33656 Site: position = -163 score = 46.82 sequence = AAAAACACAACAGGG... Gene: EUBREC_2530: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
|
*
Dorea formicigenerans ATCC 27755 Site: position = -166 score = 48.84 sequence = ACAACAGGGGGCTTG... Gene: DORFOR_02060: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
Gene: BRYFOR_01349: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
Gene: BACPEC_00164: Hydroxyethylthiazole kinase (EC 2.7.1.50) |
Hydroxyethylthiazole kinase (EC 2.7.1.50) |
| thiE |
Gene: Cbac1_010100012896: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
|
|
Gene: ROSINTL182_00601: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: RUMGNA_01197: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: DORLON_02557: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
*
Blautia hansenii DSM 20583 Site: position = -151 score = 67.5 sequence = TTAAAGTCAGCAGGG... Gene: BLAHAN_02471: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
2
Clostridium nexile DSM 1787 Gene: CLONEX_00627: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: CLONEX_00818: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: CLOSCI_03983: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: EUBREC_2529: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: thiMED: Hydroxyethylthiazole kinase (EC 2.7.1.50) / Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) / Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: DORFOR_02061: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: BRYFOR_01348: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
|
Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
| COG0637 |
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Gene: ROSINTL182_00602: hypothetical phosphatase/hydrolase |
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Gene: CLOSCI_03984: hypothetical phosphatase/hydrolase |
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Gene: DORFOR_02062: hypothetical phosphatase/hydrolase |
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hypothetical phosphatase/hydrolase |
| thiD |
*
Clostridiales bacterium 1_7_47_FAA Site: position = -255 score = 51.06 sequence = TAAATAGACAACGGG... Gene: Cbac1_010100007113: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
*
Clostridium bolteae ATCC BAA-613 Site: position = -253 score = 51.79 sequence = TTGTAAATAAACGGG... Gene: CLOBOL_02869: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: EUBELI_01399: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
*
Roseburia intestinalis L1-82 Site: position = -250 score = 51.57 sequence = AACAAAAAATGGGGT... Gene: ROSINTL182_02417: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: RUMGNA_01195: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: DORLON_02558: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: BLAHAN_02470: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
2
Clostridium nexile DSM 1787 Gene: CLONEX_00626: Phosphomethylpyrimidine kinase (EC 2.7.4.7) Gene: CLONEX_00819: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: CLOSCI_03985: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: EUBREC_2528: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
|
Gene: DORFOR_02063: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: BRYFOR_01347: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Gene: BACPEC_01111: Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
Phosphomethylpyrimidine kinase (EC 2.7.4.7) |
| cytX |
Gene: Cbac1_010100007108: Predicted hydroxymethylpyrimidine transporter CytX |
Gene: CLOBOL_02868: Predicted hydroxymethylpyrimidine transporter CytX |
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Gene: ROSINTL182_02416: Predicted hydroxymethylpyrimidine transporter CytX |
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Gene: DORLON_02128: Predicted hydroxymethylpyrimidine transporter CytX |
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Gene: CLOSCI_03986: Predicted hydroxymethylpyrimidine transporter CytX |
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Gene: DORFOR_02064: Predicted hydroxymethylpyrimidine transporter CytX |
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Predicted hydroxymethylpyrimidine transporter CytX |
| thiW |
*
Clostridiales bacterium 1_7_47_FAA Site: position = -179 score = 59.65 sequence = CTAAGTAACAGCAGG... Gene: Cbac1_010100012906: Substrate-specific component ThiW of predicted thiazole ECF transporter |
*
Clostridium bolteae ATCC BAA-613 Site: position = -118 score = 60.62 sequence = CTAAATGACAACAGG... Gene: CLOBOL_04495: Substrate-specific component ThiW of predicted thiazole ECF transporter |
|
Gene: ROSINTL182_02415: Substrate-specific component ThiW of predicted thiazole ECF transporter |
|
*
Dorea longicatena DSM 13814 Site: position = -445 score = 55.29 sequence = TATAAACAGGGGGGA... Gene: DORLON_00841: Substrate-specific component ThiW of predicted thiazole ECF transporter |
|
*
Clostridium nexile DSM 1787 Site: position = -166 score = 66.31 sequence = CAAAAACATAGGGGA... Gene: CLONEX_00816: Substrate-specific component ThiW of predicted thiazole ECF transporter |
|
Gene: EUBREC_2526: Substrate-specific component ThiW of predicted thiazole ECF transporter |
*
Ruminococcus lactaris ATCC 29176 Site: position = -183 score = 44.44 sequence = CGATGAAGAAGGGGA... Gene: RUMLAC_00295: Substrate-specific component ThiW of predicted thiazole ECF transporter |
|
|
Gene: BACPEC_00165: Substrate-specific component ThiW of predicted thiazole ECF transporter |
Substrate-specific component ThiW of predicted thiazole ECF transporter |
| thiC |
*
Clostridiales bacterium 1_7_47_FAA Site: position = -220 score = 59.95 sequence = TACAACTACAACAGG... Gene: Cbac1_010100002944: Thiamin biosynthesis protein ThiC |
|
*
Eubacterium eligens ATCC 27750 Site: position = -159 score = 48.77 sequence = TATATTTGCAGGGGA... Gene: EUBELI_00711: Thiamin biosynthesis protein ThiC |
*
Roseburia intestinalis L1-82 Site: position = -121 score = 59.75 sequence = GAAAACAACGCAGAG... Gene: ROSINTL182_02889: Thiamin biosynthesis protein ThiC |
*
Ruminococcus gnavus ATCC 29149 Site: position = -194 score = 50.3 sequence = AGAAACAAAAAAGGG... Gene: RUMGNA_03567: Thiamin biosynthesis protein ThiC |
2
Dorea longicatena DSM 13814 Gene: DORLON_03029: Thiamin biosynthesis protein ThiC Gene: DORLON_00843: Thiamin biosynthesis protein ThiC |
*
Blautia hansenii DSM 20583 Site: position = -175 score = 68.71 sequence = AAAAACAACCAGGGA... Gene: BLAHAN_01030: Thiamin biosynthesis protein ThiC |
Gene: CLONEX_00820: Thiamin biosynthesis protein ThiC |
*
Clostridium scindens ATCC 35704 Site: position = -234 score = 57.85 sequence = AGGAACAACAGGGGT... Gene: CLOSCI_03456: Thiamin biosynthesis protein ThiC |
Gene: EUBREC_2527: Thiamin biosynthesis protein ThiC |
Gene: RUMLAC_00297: Thiamin biosynthesis protein ThiC |
*
Dorea formicigenerans ATCC 27755 Site: position = -220 score = 58.25 sequence = AATTACATACGGGGA... Gene: DORFOR_01676: Thiamin biosynthesis protein ThiC |
*
Bryantella formatexigens DSM 14469 Site: position = -258 score = 72.29 sequence = AACATAGATACAGGG... Gene: BRYFOR_01350: Thiamin biosynthesis protein ThiC |
*
Bacteroides pectinophilus ATCC 43243 Site: position = -226 score = 65.85 sequence = TATACAGAATTTGGG... Gene: BACPEC_01112: Thiamin biosynthesis protein ThiC |
Thiamin biosynthesis protein ThiC |
| PF00702 |
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Gene: RUMGNA_01196: Haloacid dehalogenase-like hydrolase |
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Haloacid dehalogenase-like hydrolase |
| tenA |
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*
Clostridium nexile DSM 1787 Site: position = -163 score = 49.66 sequence = TGTGTTTGCGAGGGA... Site: position = -323 score = 70.88 sequence = TACTCAAGCAGGGGG... Gene: CLONEX_00625: Thiaminase II (EC 3.5.99.2) |
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Thiaminase II (EC 3.5.99.2) |
| CRON 3. | |||||||||||||||
| thiS |
*
Clostridiales bacterium 1_7_47_FAA Site: position = -301 score = 57.32 sequence = CCATAAATAGGGGAG... Gene: Cbac1_010100017419: Thiamine biosynthesis protein ThiS |
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Gene: ROSINTL182_02079: Thiamine biosynthesis protein ThiS |
|
*
Dorea longicatena DSM 13814 Site: position = -327 score = 67.35 sequence = TAGATAAAACACGGG... Gene: DORLON_01209: Thiamine biosynthesis protein ThiS |
Gene: BLAHAN_00600: Thiamine biosynthesis protein ThiS |
|
*
Clostridium scindens ATCC 35704 Site: position = -319 score = 58.83 sequence = AAATTGAACAGGGGA... Gene: CLOSCI_02950: Thiamine biosynthesis protein ThiS |
Gene: EUBREC_0225: Thiamine biosynthesis protein ThiS |
|
*
Dorea formicigenerans ATCC 27755 Site: position = -346 score = 57.06 sequence = TTGTAAATAAAAGGG... Gene: DORFOR_02215: Thiamine biosynthesis protein ThiS |
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Thiamine biosynthesis protein ThiS |
| thiF |
Gene: Cbac1_010100017414: Sulfur carrier protein adenylyltransferase ThiF |
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Gene: DORLON_01208: Sulfur carrier protein adenylyltransferase ThiF |
Gene: BLAHAN_00599: Sulfur carrier protein adenylyltransferase ThiF |
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Gene: CLOSCI_02951: Sulfur carrier protein adenylyltransferase ThiF |
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Sulfur carrier protein adenylyltransferase ThiF |
| thiG |
Gene: Cbac1_010100017409: Thiazole biosynthesis protein ThiG |
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Gene: EUBELI_00477: Thiazole biosynthesis protein ThiG |
Gene: ROSINTL182_02081: Thiazole biosynthesis protein ThiG |
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Gene: DORLON_01207: Thiazole biosynthesis protein ThiG |
Gene: BLAHAN_00598: Thiazole biosynthesis protein ThiG |
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Gene: CLOSCI_02952: Thiazole biosynthesis protein ThiG |
Gene: EUBREC_0224: Thiazole biosynthesis protein ThiG |
Gene: RUMLAC_02758: Thiazole biosynthesis protein ThiG |
Gene: DORFOR_02214: Thiazole biosynthesis protein ThiG |
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Thiazole biosynthesis protein ThiG |
| thiH |
Gene: Cbac1_010100017404: Thiazole biosynthesis protein ThiH |
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Gene: EUBELI_00478: Thiazole biosynthesis protein ThiH |
Gene: ROSINTL182_02082: Thiazole biosynthesis protein ThiH |
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Gene: DORLON_01206: Thiazole biosynthesis protein ThiH |
Gene: BLAHAN_00597: Thiazole biosynthesis protein ThiH |
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Gene: CLOSCI_02953: Thiazole biosynthesis protein ThiH |
Gene: EUBREC_0223: Thiazole biosynthesis protein ThiH |
Gene: RUMLAC_02757: Thiazole biosynthesis protein ThiH |
Gene: DORFOR_02213: Thiazole biosynthesis protein ThiH |
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Thiazole biosynthesis protein ThiH |
| thiE |
Gene: Cbac1_010100017399: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
|
Gene: EUBELI_00479: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: ROSINTL182_02083: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
|
Gene: DORLON_01205: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: BLAHAN_00596: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
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Gene: CLOSCI_02954: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: EUBREC_0222: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: RUMLAC_02756: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Gene: DORFOR_03140: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
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Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) |
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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Regulated Genes | [ Tab delimited format ] | DOWNLOAD |
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Regulatory Sites | [ FASTA format ] | DOWNLOAD |