Regulog NihR - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	CRP
Regulation mode:	activator
Biological process:	Nickel homeostasis
Effector:
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 10 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - CRP
By pathway - Nickel homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM
Lactobacillus brevis ATCC 367	7	2
Lactobacillus casei ATCC 334
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
Lactobacillus fermentum IFO 3956	7	2
Lactobacillus helveticus DPC 4571
Lactobacillus johnsonii NCC 533
Lactobacillus plantarum WCFS1	6	2
Lactobacillus reuteri JCM 1112
Lactobacillus rhamnosus GG
Lactobacillus sakei subsp. sakei 23K	11	2
Lactobacillus salivarius subsp. salivarius UCC118
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Oenococcus oeni PSU-1
Pediococcus pentosaceus ATCC 25745	7	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
PF09861	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -134 score = 4.67889 sequence = CTTAACATTTGGTAAT Gene: LVIS_1849: Conserved hypothetical protein, PF09861 family	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -127 score = 4.3771 sequence = TTTTCCTTATGTAACA Gene: LAF_1733: Conserved hypothetical protein, PF09861 family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -120 score = 4.77519 sequence = GTATACATTTGTTAAC Gene: lp_0104: Conserved hypothetical protein, PF09861 family	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	* Lactobacillus sakei subsp. sakei 23K Site: position = -148 score = 5.02565 sequence = TTGAACATTTGTTAAC Gene: LSA0784: Conserved hypothetical protein, PF09861 family	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	* Pediococcus pentosaceus ATCC 25745 Site: position = -95 score = 4.91674 sequence = TGTAACAAATGTTATA Gene: PEPE_1694: Conserved hypothetical protein, PF09861 family	Conserved hypothetical protein, PF09861 family
PF00731	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1850: Predicted enzyme, PF00731 family	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1732: Predicted enzyme, PF00731 family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0105: Predicted enzyme, PF00731 family	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0785: Predicted enzyme, PF00731 family	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1693: Predicted enzyme, PF00731 family	Predicted enzyme, PF00731 family
PF01969	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1851: Conserved hypothetical protein, PF01969 family	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1731: Conserved hypothetical protein, PF01969 family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	2 Lactobacillus sakei subsp. sakei 23K Gene: LSA0786: Conserved hypothetical protein, PF01969 family Gene: LSA0787: Conserved hypothetical protein, PF01969 family	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1692: Conserved hypothetical protein, PF01969 family	Conserved hypothetical protein, PF01969 family
LSA0788	Lactobacillus acidophilus NCFM Gene: LBA1595: Predicted glycerol uptake facilitator protein	Lactobacillus brevis ATCC 367 Gene: LVIS_1853: Predicted glycerol uptake facilitator protein	Lactobacillus casei ATCC 334 Gene: LSEI_0801: Predicted glycerol uptake facilitator protein	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0058: Predicted glycerol uptake facilitator protein	Lactobacillus fermentum IFO 3956 Gene: LAF_1730: Predicted glycerol uptake facilitator protein	Lactobacillus helveticus DPC 4571 Gene: lhv_1671: Predicted glycerol uptake facilitator protein	Lactobacillus johnsonii NCC 533 Gene: LJ0700: Predicted glycerol uptake facilitator protein	3 Lactobacillus plantarum WCFS1 Gene: lp_0108: Predicted glycerol uptake facilitator protein Gene: lp_3436: Predicted glycerol uptake facilitator protein Gene: lp_1175: Predicted glycerol uptake facilitator protein	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_00784: Predicted glycerol uptake facilitator protein	2 Lactobacillus sakei subsp. sakei 23K Gene: LSA0788: Predicted glycerol uptake facilitator protein Gene: LSA1170: Predicted glycerol uptake facilitator protein	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0466: Predicted glycerol uptake facilitator protein	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1392: Predicted glycerol uptake facilitator protein	Oenococcus oeni PSU-1 Gene: OEOE_0349: Predicted glycerol uptake facilitator protein	2 Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1691: Predicted glycerol uptake facilitator protein Gene: PEPE_1249: Predicted glycerol uptake facilitator protein	Predicted glycerol uptake facilitator protein
LSA0789	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0789: Hypothetical protein	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Hypothetical protein
LSA0790	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1852: ATP-utilizing enzyme of the PP-loop superfamily	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1729: ATP-utilizing enzyme of the PP-loop superfamily	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0109: ATP-utilizing enzyme of the PP-loop superfamily	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0790: ATP-utilizing enzyme of the PP-loop superfamily	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1690: ATP-utilizing enzyme of the PP-loop superfamily	ATP-utilizing enzyme of the PP-loop superfamily
nixA	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1854: High-affinity nickel permease	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1728: High-affinity nickel permease	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_2023: High-affinity nickel permease	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1696: High-affinity nickel permease	High-affinity nickel permease
nihR	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -87 score = 4.67889 sequence = ATTACCAAATGTTAAG Gene: LVIS_1848: Predicted transcriptional regulator for nickel homeostasis, Crp family	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -129 score = 4.3771 sequence = TGTTACATAAGGAAAA Gene: LAF_1734: Predicted transcriptional regulator for nickel homeostasis, Crp family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -148 score = 4.77519 sequence = GTTAACAAATGTATAC Gene: lp_0103: Predicted transcriptional regulator for nickel homeostasis, Crp family	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	* Lactobacillus sakei subsp. sakei 23K Site: position = -101 score = 5.02565 sequence = GTTAACAAATGTTCAA Gene: LSA0783: Predicted transcriptional regulator for nickel homeostasis, Crp family	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	* Pediococcus pentosaceus ATCC 25745 Site: position = -91 score = 4.91674 sequence = TATAACATTTGTTACA Gene: PEPE_1695: Predicted transcriptional regulator for nickel homeostasis, Crp family	Predicted transcriptional regulator for nickel homeostasis, Crp family
nikM	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0102: Nickel ECF transporter, substrate-binding protein	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0782: Nickel ECF transporter, substrate-binding protein	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Nickel ECF transporter, substrate-binding protein
nikQ	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0101: Nickel ECF transporter, transmembrane component	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0781: Nickel ECF transporter, transmembrane component	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Nickel ECF transporter, transmembrane component
nikO	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0100: Nickel ECF transporter, ATP-binding protein	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0780: Nickel ECF transporter, ATP-binding protein	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Nickel ECF transporter, ATP-binding protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NihR - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --