Regulog HexR - Pseudomonadaceae

Properties
Regulator type:	Transcription factor
Regulator family:	RpiR
Regulation mode:	repressor (activator)
Biological process:	Central carbohydrate metabolism
Effector:	2-keto-3-deoxy-6-phosphogluconate
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 44 sites [see more]

Member of regulog collections

By trascription factor - HexR
By taxonomy - Pseudomonadaceae
By TF family - RpiR
By effector - 2-keto-3-deoxy-6-phosphogluconate
By pathway - Central carbohydrate metabolism

Statistics of regulated genes
Genome	Genes	Operons
Azotobacter vinelandii AvOP	12	5
Pseudomonas aeruginosa PAO1	9	4
Pseudomonas entomophila L48	9	4
Pseudomonas fluorescens Pf-5	9	4
Pseudomonas mendocina ymp	9	5
Pseudomonas putida KT2440	9	4
Pseudomonas stutzeri A1501	12	4
Pseudomonas syringae pv. tomato str. DC3000	9	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
zwf	3 Azotobacter vinelandii AvOP* Site: position = -84 score = 6.94492 sequence = TTGTTTT-(4)-ACAACAT Gene: Avin_17630: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Site: position = -84 score = 5.52106 sequence = ATGTaGT-(6)-ACgcaAT Gene: Avin_27260: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Gene: Avin_16620: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Pseudomonas aeruginosa PAO1 Site: position = -81 score = 7.76461 sequence = ATGTTGT-(6)-ACTACAT Gene: PA3183: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Pseudomonas entomophila L48 Site: position = -85 score = 7.76461 sequence = ATGTTGT-(7)-ACTACAT Gene: PSEEN4405: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Pseudomonas fluorescens Pf-5 Site: position = -85 score = 7.76461 sequence = ATGTTGT-(7)-ACTACAT Gene: PFL_4610: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Pseudomonas mendocina ymp Site: position = -85 score = 8.10947 sequence = ATGTTGT-(7)-ACAACAT Gene: Pmen_3143: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Pseudomonas putida KT2440 Site: position = -85 score = 7.76461 sequence = ATGTTGT-(7)-ACTACAT Gene: PP1022: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	2 Pseudomonas stutzeri A1501* Site: position = -85 score = 7.76461 sequence = ATGTTGT-(7)-ACTACAT Gene: PST_3497: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Gene: PST_2329: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -85 score = 7.76461 sequence = ATGTTGT-(7)-ACTACAT Gene: PSPTO1300: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
eda	3 Azotobacter vinelandii AvOP Gene: Avin_27250: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) Gene: Avin_15720: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) Gene: Avin_27250: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Pseudomonas aeruginosa PAO1 Gene: PA3181: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Pseudomonas entomophila L48 Gene: PSEEN4403: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Pseudomonas fluorescens Pf-5 Gene: PFL_4608: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Pseudomonas mendocina ymp Gene: Pmen_3141: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Pseudomonas putida KT2440 Gene: PP1024: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	2 Pseudomonas stutzeri A1501 Gene: PST_3495: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) Gene: PST_2327: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO1302: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
pykA	Azotobacter vinelandii AvOP Gene: Avin_27240: Pyruvate kinase	Pseudomonas aeruginosa PAO1	Pseudomonas entomophila L48	Pseudomonas fluorescens Pf-5	Pseudomonas mendocina ymp	Pseudomonas putida KT2440	Pseudomonas stutzeri A1501	Pseudomonas syringae pv. tomato str. DC3000	Pyruvate kinase
Avin_45750	Azotobacter vinelandii AvOP Gene: Avin_27230: hypothetical protein	Pseudomonas aeruginosa PAO1	Pseudomonas entomophila L48	Pseudomonas fluorescens Pf-5	Pseudomonas mendocina ymp	Pseudomonas putida KT2440	Pseudomonas stutzeri A1501	Pseudomonas syringae pv. tomato str. DC3000	hypothetical protein
eno	Azotobacter vinelandii AvOP Gene: Avin_27220: Enolase	Pseudomonas aeruginosa PAO1	Pseudomonas entomophila L48	Pseudomonas fluorescens Pf-5	Pseudomonas mendocina ymp	Pseudomonas putida KT2440	Pseudomonas stutzeri A1501	Pseudomonas syringae pv. tomato str. DC3000	Enolase
gapN	2 Azotobacter vinelandii AvOP Gene: Avin_27210: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9) Gene: Avin_45780: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)	Pseudomonas aeruginosa PAO1 Gene: PA2323: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)	Pseudomonas entomophila L48 Gene: PSEEN2956: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)	Pseudomonas fluorescens Pf-5	Pseudomonas mendocina ymp	Pseudomonas putida KT2440 Gene: PP3443: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)	Pseudomonas stutzeri A1501 Gene: PST_3494: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)	Pseudomonas syringae pv. tomato str. DC3000	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
pgl	2 Azotobacter vinelandii AvOP* Gene: Avin_17640: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type Site: position = -127 score = 7.03484 sequence = TCGTAGT-(6)-ACAACAT Gene: Avin_15710: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Pseudomonas aeruginosa PAO1 Gene: PA3182: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Pseudomonas entomophila L48 Gene: PSEEN4404: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Pseudomonas fluorescens Pf-5 Gene: PFL_4609: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Pseudomonas mendocina ymp Gene: Pmen_3142: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Pseudomonas putida KT2440 Gene: PP1023: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	2 Pseudomonas stutzeri A1501 Gene: PST_2328: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type Gene: PST_3496: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO1301: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
PST_3493	Azotobacter vinelandii AvOP	Pseudomonas aeruginosa PAO1	Pseudomonas entomophila L48	Pseudomonas fluorescens Pf-5	Pseudomonas mendocina ymp	Pseudomonas putida KT2440	Pseudomonas stutzeri A1501 Gene: PST_3493: Aldo/keto reductase	Pseudomonas syringae pv. tomato str. DC3000	Aldo/keto reductase

CRON 2.
hexR	2 Azotobacter vinelandii AvOP* Site: position = -66 score = 7.03484 sequence = ATGTTGT-(6)-ACtACga Gene: Avin_15700: Central carbohydrate metabolism transcription regulator HexR, RpiR family Site: position = -111 score = 5.52106 sequence = ATtgcGT-(6)-ACtACAT Gene: Avin_27270: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas aeruginosa PAO1 Site: position = -125 score = 7.76461 sequence = ATGTAGT-(6)-ACAACAT Gene: PA3184: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas entomophila L48 Site: position = -138 score = 7.76461 sequence = ATGTAGT-(7)-ACAACAT Gene: PSEEN4406: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas fluorescens Pf-5 Site: position = -239 score = 7.76461 sequence = ATGTAGT-(7)-ACAACAT Gene: PFL_4611: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas mendocina ymp Site: position = -138 score = 8.10947 sequence = ATGTTGT-(7)-ACAACAT Gene: Pmen_3144: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas putida KT2440 Site: position = -138 score = 7.76461 sequence = ATGTAGT-(7)-ACAACAT Gene: PP_1021: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas stutzeri A1501 Site: position = -178 score = 7.76461 sequence = ATGTAGT-(7)-ACAACAT Gene: PST_3498: Central carbohydrate metabolism transcription regulator HexR, RpiR family	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -154 score = 7.76461 sequence = ATGTAGT-(7)-ACAACAT Gene: PSPTO1299: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Central carbohydrate metabolism transcription regulator HexR, RpiR family

CRON 3.
edd	2 Azotobacter vinelandii AvOP Gene: Avin_15680: Phosphogluconate dehydratase (EC 4.2.1.12) Gene: Avin_27280: Phosphogluconate dehydratase (EC 4.2.1.12)	* Pseudomonas aeruginosa PAO1 Site: position = -43 score = 7.91839 sequence = ATGTTGT-(4)-ACAACAA Gene: PA3194: Phosphogluconate dehydratase (EC 4.2.1.12)	* Pseudomonas entomophila L48 Site: position = -141 score = 7.03565 sequence = ATTTTGT-(8)-ACAACGA Site: position = -204 score = 7.51083 sequence = TTGTTGT-(7)-ACAAGAT Gene: PSEEN4417: Phosphogluconate dehydratase (EC 4.2.1.12)	* Pseudomonas fluorescens Pf-5 Site: position = -138 score = 7.03565 sequence = ATtTTGT-(7)-ACAACga Site: position = -201 score = 7.51083 sequence = TTGTTGT-(7)-ACAAGAT Gene: PFL_4622: Phosphogluconate dehydratase (EC 4.2.1.12)	* Pseudomonas mendocina ymp Site: position = -50 score = 6.46186 sequence = ATtTTGT-(7)-ACAAaca Site: position = -111 score = 7.51083 sequence = TTGTTGT-(7)-ACAAGAT Gene: Pmen_1312: Phosphogluconate dehydratase (EC 4.2.1.12)	* Pseudomonas putida KT2440 Site: position = -142 score = 7.03565 sequence = ATtTTGT-(8)-ACAACga Site: position = -203 score = 7.51083 sequence = TTGTTGT-(7)-ACAAGAT Gene: PP1010: Phosphogluconate dehydratase (EC 4.2.1.12)	2 Pseudomonas stutzeri A1501* Site: position = -38 score = 6.80592 sequence = tgGTTGT-(6)-ACAAaAT Gene: PST_2444: Phosphogluconate dehydratase (EC 4.2.1.12) Site: position = -31 score = 6.58015 sequence = TTGTTAT-(4)-ACTACAA Gene: PST_3500: Phosphogluconate dehydratase (EC 4.2.1.12)	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -140 score = 6.90724 sequence = ATtTTGT-(7)-ACAACta Site: position = -201 score = 7.51083 sequence = TTGTTGT-(7)-ACAAGAT Gene: PSPTO1288: Phosphogluconate dehydratase (EC 4.2.1.12)	Phosphogluconate dehydratase (EC 4.2.1.12)
glk	2 Azotobacter vinelandii AvOP Gene: Avin_04130: Glucokinase (EC 2.7.1.2) Gene: Avin_15690: Glucokinase (EC 2.7.1.2)	Pseudomonas aeruginosa PAO1 Gene: PA3193: Glucokinase (EC 2.7.1.2)	Pseudomonas entomophila L48 Gene: PSEEN4416: Glucokinase (EC 2.7.1.2)	Pseudomonas fluorescens Pf-5 Gene: PFL_4621: Glucokinase (EC 2.7.1.2)	* Pseudomonas mendocina ymp Site: position = -193 score = 7.72731 sequence = TTGTTGT-(8)-ACAACAA Gene: Pmen_1147: Glucokinase (EC 2.7.1.2)	Pseudomonas putida KT2440 Gene: PP1011: Glucokinase (EC 2.7.1.2)	2 Pseudomonas stutzeri A1501 Gene: PST_2443: Glucokinase (EC 2.7.1.2) Gene: PST_3499: Glucokinase (EC 2.7.1.2)	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO1289: Glucokinase (EC 2.7.1.2)	Glucokinase (EC 2.7.1.2)
gltR	Azotobacter vinelandii AvOP	Pseudomonas aeruginosa PAO1 Gene: PA3192: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	Pseudomonas entomophila L48 Gene: PSEEN4415: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	Pseudomonas fluorescens Pf-5 Gene: PFL_4620: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	Pseudomonas mendocina ymp Gene: Pmen_1148: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	Pseudomonas putida KT2440 Gene: PP1012: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	Pseudomonas stutzeri A1501 Gene: PST_2442: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO1290: DNA-binding response regulator GltR, controls specific porins for the entry of glucose	DNA-binding response regulator GltR, controls specific porins for the entry of glucose
gltS	Azotobacter vinelandii AvOP	Pseudomonas aeruginosa PAO1 Gene: PA3191: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Pseudomonas entomophila L48 Gene: PSEEN4414: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Pseudomonas fluorescens Pf-5 Gene: PFL_4619: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Pseudomonas mendocina ymp Gene: Pmen_1149: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Pseudomonas putida KT2440 Gene: PP1013: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Pseudomonas stutzeri A1501 Gene: PST_2441: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Pseudomonas syringae pv. tomato str. DC3000 Gene: PSPTO1291: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster	Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster

CRON 4.
gapA	Azotobacter vinelandii AvOP	* Pseudomonas aeruginosa PAO1 Site: position = -104 score = 7.91839 sequence = TTGTTGT-(4)-ACAACAT Gene: PA3195: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Pseudomonas entomophila L48 Site: position = -146 score = 7.03565 sequence = TCGTTGT-(8)-ACAAAAT Site: position = -83 score = 7.51083 sequence = ATCTTGT-(7)-ACAACAA Gene: PSEEN4418: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Pseudomonas fluorescens Pf-5 Site: position = -105 score = 7.03565 sequence = TCGTTGT-(7)-ACAAAAT Site: position = -43 score = 7.51083 sequence = ATCTTGT-(7)-ACAACAA Gene: PFL_4623: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Pseudomonas mendocina ymp Site: position = -97 score = 6.256 sequence = TTGTATT-(4)-ACAAAAT Site: position = -38 score = 7.51083 sequence = ATCTTGT-(7)-ACAACAA Gene: Pmen_1311: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Pseudomonas putida KT2440 Site: position = -145 score = 7.03565 sequence = TCGTTGT-(8)-ACAAAAT Site: position = -82 score = 7.51083 sequence = ATCTTGT-(7)-ACAACAA Gene: PP1009: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Pseudomonas stutzeri A1501	* Pseudomonas syringae pv. tomato str. DC3000 Site: position = -98 score = 6.25077 sequence = TTGTAGA-(4)-ACAAAAT Site: position = -39 score = 7.51083 sequence = ATCTTGT-(7)-ACAACAA Gene: PSPTO1287: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HexR - Pseudomonadaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --