Regulog HypR - Enterobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	activator (repressor)
Biological process:	Proline and 4-hydrohyproline utilization
Effector:	Proline; 4-hydroxyproline
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

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Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - HypR
By TF family - GntR/Others
By effector - Proline
By effector - 4-hydroxyproline
By pathway - Proline and 4-hydrohyproline utilization

Statistics of regulated genes
Genome	Genes	Operons
Escherichia coli str. K-12 substr. MG1655
Salmonella typhimurium LT2
Citrobacter koseri ATCC BAA-895
Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Enterobacter sp. 638
Erwinia amylovora ATCC 49946	9	1
Yersinia pestis KIM
Serratia proteamaculans 568
Erwinia carotovora subsp. atroseptica SCRI1043
Edwardsiella tarda EIB202
Proteus mirabilis HI4320
Photorhabdus luminescens subsp. laumondii TTO1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
COG531 (PotE)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	* Erwinia amylovora ATCC 49946 Site: position = -81 score = 3.93499 sequence = ATCGTATACGAT Gene: EAM_2489: Putative proline/hydroxyproline permease, PotE family	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1836: Putative proline/hydroxyproline permease, PotE family	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2247: Putative proline/hydroxyproline permease, PotE family	Putative proline/hydroxyproline permease, PotE family
hypD	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2488: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1838: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2245: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted	1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
hypR	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2487: Predicted regulator for proline and hydrohyproline utilization, GntR family	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Predicted regulator for proline and hydrohyproline utilization, GntR family
hypE	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2486: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1840: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2243: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)	Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
hypO	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2485: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1841: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2242: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster	D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
EAM_2484	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2484: Oxidase	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1842: Oxidase	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2241: Oxidase	Oxidase
COG446 (HcaD)	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2483: Putative oxidoreductase in 4-hydroxyproline catabolic gene cluster	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1843: Putative oxidoreductase in 4-hydroxyproline catabolic gene cluster	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2240: Putative oxidoreductase in 4-hydroxyproline catabolic gene cluster	Putative oxidoreductase in 4-hydroxyproline catabolic gene cluster
hypH	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2482: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1837: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu2246: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible	Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
hypS	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946 Gene: EAM_2481: Putative L-lactate/Malate dehydrogenase	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_1835: Putative L-lactate/Malate dehydrogenase	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Putative L-lactate/Malate dehydrogenase

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HypR - Enterobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --