Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of PurR regulog to Lactococcus lactis subsp. cremoris SK11

Reference regulog properties
Source regulog: PurR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: PurR
Regulation mode: repressor
Biological process: Purine metabolism
Effector: 5-phosphoribosyl 1-pyrophosphate
Phylum: Firmicutes
Propagated regulon:
Target genome Lactococcus lactis subsp. cremoris SK11
Orthologous TF(s) LACR_2590
Regulated genes 15
Built upon 100 sites [see more]
Predicted regulatory interactions in Lactococcus lactis subsp. cremoris SK11
Locus tag Position Score Sequence
Position: -205
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_0617
LACR_0617 -205 4.8 ATTTCCGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: glyA
Ortholog function: Serine hydroxymethyltransferase (EC 2.1.2.1)
Lactococcus lactis subsp. cremoris SK11 LACR_0617 -205 4.8 ATTTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L0082 -203 4.8 ATTTCCGAACATT
Position: -53
Score: 4.9
Sequence: AATTACGAACAAT
Locus tag: LACR_0921
LACR_0921 -53 4.9 AATTACGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: folD
Ortholog function: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
Lactococcus lactis subsp. cremoris SK11 LACR_0921 -53 4.9 AATTACGAACAAT
Lactococcus lactis subsp. lactis Il1403 L76582 -53 4.9 AATTACGAACAAT
Position: -134
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_1007
LACR_1007 -134 4.8 ATTTCCGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: fhs
Ortholog function: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
Lactococcus lactis subsp. cremoris SK11 LACR_1007 -134 4.8 ATTTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L159505 -131 4.8 ATTTCCGAACAAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1033 -93 5.2 AAAAACGAACATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0945 -94 4.9 AAAAGCGAACGTT
Streptococcus gallolyticus UCN34 GALLO_1115 -100 4.8 AAACACGAACATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1210 -95 4.8 AAACACGAACAAT
Streptococcus mitis B6 smi_1192 -90 4.2 TTTTACGAACGTT
Streptococcus mutans UA159 SMU.1073 -90 5.1 AAATCCGAACATT
Streptococcus pneumoniae TIGR4 SP_1229 -172 4.6 AAAAACGAAGATT
-89 4.7 ATTTACGAACGTT
Streptococcus pyogenes M1 GAS SPy1213 -93 5.1 AAAAACGAACAAT
Streptococcus sanguinis SK36 SSA_1200 -93 4.1 TTTCCCGAACATT
Streptococcus suis 05ZYH33 SSU05_0690 -97 4.1 AATTCCGTACGTT
Streptococcus thermophilus CNRZ1066 str0791 -94 5.2 AAAACCGAACATT
Position: -232
Score: 4.7
Sequence: ATTTCCGAACGTT
Locus tag: LACR_1256
LACR_1256 -232 4.7 ATTTCCGAACGTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: guaC
Ortholog function: GMP reductase (EC 1.7.1.7)
Lactococcus lactis subsp. cremoris SK11 LACR_1256 -232 4.7 ATTTCCGAACGTT
Lactococcus lactis subsp. lactis Il1403 L158186 -227 3.9 ATTTCCGAATGAT
Streptococcus agalactiae 2603V/R SAG1087 -149 5.2 AAAAACGAACATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0894 -205 5.2 AAAACCGAACATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1036 -209 5 AAAAACGAACGTT
Streptococcus gallolyticus UCN34 GALLO_1025 -260 5.2 AAAAACGAACATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1159 -146 4.7 ATTTCCGAACGTT
Streptococcus mitis B6 smi_1212 -141 4.9 AAATCCGAACGAT
Streptococcus pneumoniae TIGR4 SP_1249 -141 4.6 AAACCCGAACGAT
Streptococcus pyogenes M1 GAS SPy1135 -205 4.7 AAAACCGAACTTT
Streptococcus suis 05ZYH33 SSU05_0815 -87 4.3 AATTCTGAACATT
Streptococcus uberis 0140J SUB0865 -187 4.6 AAATCCGAACAAA
Position: -124
Score: 4.7
Sequence: ATTTCCGAACGTT
Locus tag: LACR_1527
LACR_1527 -124 4.7 ATTTCCGAACGTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: bmpA
Ortholog function: Predicted nucleoside ABC transporter, substrate-binding protein
Lactococcus lactis subsp. cremoris SK11 LACR_1527 -124 4.7 ATTTCCGAACGTT
Lactococcus lactis subsp. lactis Il1403 L61620 -124 4.8 ATTTCCGAACATT
Position: -291
Score: 3.9
Sequence: AAAAACGAGAATT
Position: -266
Score: 4.9
Sequence: AATTCCGAACAAT
Locus tag: LACR_1601
LACR_1601 -291 3.9 AAAAACGAGAATT
-266 4.9 AATTCCGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purD
Ortholog function: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
Lactococcus lactis subsp. cremoris SK11 LACR_1601 -266 4.9 AATTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L153005 -224 5 AATACCGAACAAT
Streptococcus agalactiae 2603V/R SAG0043 -88 4.5 AAAAGCGAACAAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0051 -108 4.9 ATTAACGAACATT
-57 4.5 ATAAACGAACAAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0030 -14 5 ATAAACGAACAAT
Streptococcus gallolyticus UCN34 GALLO_0032 -116 4.3 ATTTCCGAACAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_2092 -121 4.5 TAAAACGAACGAT
Streptococcus mitis B6 smi_0073 -56 4.6 TAAAACGAACGTT
Streptococcus mutans UA159 SMU.48 -122 3.5 ACTCCCGAACAAA
Streptococcus pneumoniae TIGR4 SP_0051 -56 4.2 TAAAACGAACTTT
Streptococcus pyogenes M1 GAS SPy0032 -55 4.9 AAAAGCGAACGTT
Streptococcus sanguinis SK36 SSA_0037 -121 4.5 TAAAACGAACGAT
Streptococcus suis 05ZYH33 SSU05_0033 -88 4.5 ATTCCCGAACATT
Streptococcus thermophilus CNRZ1066 str0040 -121 3.8 ATCTCCGAACAAA
Streptococcus uberis 0140J SUB0053 -57 4 ATTCACGAACAAA
Position: -171
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_1605
LACR_1605 -171 4.8 ATTTCCGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purH
Ortholog function: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
Lactococcus lactis subsp. cremoris SK11 LACR_1605 -171 4.8 ATTTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L158710 -170 4.8 ATTTCCGAACAAT
Streptococcus agalactiae 2603V/R SAG0030 -108 4.9 AAATACGAACGTT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0049 -106 5.2 AAAAACGAACATT
-13 4.2 AAAGACGAATATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0028 -110 5.2 AAAAACGAACATT
-16 4.3 AAAGGCGAACAAA
Streptococcus gallolyticus UCN34 GALLO_0031 -109 4.3 AATTTCGAACGTT
-16 4.3 AAAGGCGAACAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0040 -16 4.8 AAAGGCGAACATT
Streptococcus mitis B6 smi_0072 155 4.3 AAAGGCGAACTTT
Streptococcus mutans UA159 SMU.37 -109 4.8 AAATGCGAACGAT
-16 4.7 AAAGGCGAACAAT
Streptococcus pneumoniae TIGR4 SP_0050 -16 4.3 AAAGGCGAACTTT
Streptococcus sanguinis SK36 SSA_0035 -16 4.1 AAAGGCGAATATT
Streptococcus suis 05ZYH33 SSU05_0032 -16 4.8 AAAGGCGAACATT
Streptococcus thermophilus CNRZ1066 str0035 -109 4.9 AAATCCGAACGTT
-16 4.6 AAAGGCGAACGAT
Streptococcus uberis 0140J SUB0030 -108 5.2 AAAAACGAACATT
-15 4.7 AAAGGCGAACAAT
Position: -109
Score: 4.7
Sequence: ATTTCCGAACGTT
Locus tag: LACR_1606
LACR_1606 -109 4.7 ATTTCCGAACGTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: hprT
Ortholog function: Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)
Lactococcus lactis subsp. cremoris SK11 LACR_1606 -109 4.7 ATTTCCGAACGTT
Lactococcus lactis subsp. lactis Il1403 L160442 -110 4.7 ATTTCCGAACGTT
Position: -115
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_1611
LACR_1611 -115 4.8 ATTTCCGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purM
Ortholog function: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
Lactococcus lactis subsp. cremoris SK11 LACR_1611 -115 4.8 ATTTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L165202 -115 4.6 ATTTCCGAACGAT
Streptococcus agalactiae 2603V/R SAG0027 -108 4.9 AAATACGAACGTT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0046 -106 5.2 AAAAACGAACATT
-13 4.2 AAAGACGAATATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0026 -110 5.2 AAAAACGAACATT
-16 4.3 AAAGGCGAACAAA
Streptococcus gallolyticus UCN34 GALLO_0028 -109 4.3 AATTTCGAACGTT
-16 4.3 AAAGGCGAACAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0037 -16 4.8 AAAGGCGAACATT
Streptococcus mitis B6 smi_0069 155 4.3 AAAGGCGAACTTT
Streptococcus mutans UA159 SMU.34 -109 4.8 AAATGCGAACGAT
-16 4.7 AAAGGCGAACAAT
Streptococcus pneumoniae TIGR4 SP_0047 -16 4.3 AAAGGCGAACTTT
Streptococcus pyogenes M1 GAS SPy0027 -78 4.7 AAAAACGAACCTT
Streptococcus sanguinis SK36 SSA_0032 -16 4.1 AAAGGCGAATATT
Streptococcus suis 05ZYH33 SSU05_0029 -16 4.8 AAAGGCGAACATT
Streptococcus thermophilus CNRZ1066 str0033 -109 4.9 AAATCCGAACGTT
-16 4.6 AAAGGCGAACGAT
Streptococcus uberis 0140J SUB0028 -108 5.2 AAAAACGAACATT
-15 4.7 AAAGGCGAACAAT
Position: -132
Score: 4.8
Sequence: ATTTCCGAACATT
Position: -115
Score: 5.1
Sequence: AAAACCGAACAAT
Locus tag: LACR_1622
LACR_1622 -132 4.8 ATTTCCGAACATT
-115 5.1 AAAACCGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purC
Ortholog function: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
Lactococcus lactis subsp. cremoris SK11 LACR_1622 -132 4.8 ATTTCCGAACATT
-115 5.1 AAAACCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L177350 -132 4.8 ATTTCCGAACATT
-115 5.1 AAAACCGAACAAT
Streptococcus agalactiae 2603V/R SAG0024 -108 4.9 AAATACGAACGTT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0043 -106 5.2 AAAAACGAACATT
-13 4.2 AAAGACGAATATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0023 -110 5.2 AAAAACGAACATT
-16 4.3 AAAGGCGAACAAA
Streptococcus gallolyticus UCN34 GALLO_0025 -109 4.3 AATTTCGAACGTT
-16 4.3 AAAGGCGAACAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0034 -16 4.8 AAAGGCGAACATT
Streptococcus mitis B6 smi_0066 155 4.3 AAAGGCGAACTTT
Streptococcus mutans UA159 SMU.29 -109 4.8 AAATGCGAACGAT
-16 4.7 AAAGGCGAACAAT
Streptococcus pneumoniae TIGR4 SP_0044 -16 4.3 AAAGGCGAACTTT
Streptococcus pyogenes M1 GAS SPy0024 -78 4.7 AAAAACGAACCTT
Streptococcus sanguinis SK36 SSA_0028 -16 4.1 AAAGGCGAATATT
Streptococcus suis 05ZYH33 SSU05_0026 -16 4.8 AAAGGCGAACATT
Streptococcus thermophilus CNRZ1066 str0030 -109 4.9 AAATCCGAACGTT
-16 4.6 AAAGGCGAACGAT
Streptococcus uberis 0140J SUB0025 -108 5.2 AAAAACGAACATT
-15 4.7 AAAGGCGAACAAT
Position: -184
Score: 4.7
Sequence: ATTACCGAACGAT
Locus tag: LACR_1894
LACR_1894 -184 4.7 ATTACCGAACGAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: pbuO
Ortholog function: Guanine/hypoxanthine permease
Lactococcus lactis subsp. cremoris SK11 LACR_1894 -184 4.7 ATTACCGAACGAT
Lactococcus lactis subsp. lactis Il1403 L171588 -184 4.9 ATTACCGAACAAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1804 -143 4.3 AAATAAGAACAAT
-100 5 AAATACGAACAAT
Streptococcus gallolyticus UCN34 GALLO_0354 -96 4.3 AAAAGTGAACAAT
Streptococcus pyogenes M1 GAS SPy1736 -102 5 AATACCGAACAAT
Streptococcus uberis 0140J SUB1480 -166 4.9 AAAAGCGAACGTT
Position: -157
Score: 4.5
Sequence: ATAACCGAACAAA
Locus tag: LACR_1998
LACR_1998 -157 4.5 ATAACCGAACAAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ppa
Ortholog function: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)
Lactococcus lactis subsp. cremoris SK11 LACR_1998 -157 4.5 ATAACCGAACAAA
Lactococcus lactis subsp. lactis Il1403 L62663 -158 4.4 CAAAACGAACAAT
Position: -335
Score: 4.6
Sequence: ATTTCCGAACGAT
Locus tag: LACR_2207
LACR_2207 -335 4.6 ATTTCCGAACGAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purA
Ortholog function: Adenylosuccinate synthetase (EC 6.3.4.4)
Lactococcus lactis subsp. lactis Il1403 L12179 -242 4.6 ATTTCCGAACGAT
Streptococcus mitis B6 smi_0022 -216 4.3 ATTTCCGAACAAA
Streptococcus sanguinis SK36 SSA_2185 -218 4.5 AATTCCGAACTTT
Position: 6
Score: 4.4
Sequence: AGAAACGAACGTT
Locus tag: LACR_2590
LACR_2590 6 4.4 AGAAACGAACGTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purR
Ortholog function: Purine metabolism transcriptional regulator PurR, PurR family
Lactococcus lactis subsp. cremoris SK11 LACR_2590 6 4.4 AGAAACGAACGTT
Lactococcus lactis subsp. lactis Il1403 L134453 6 4.4 AGAAACGAACGTT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1941 -85 4.6 AAAAACGGACATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0264 -109 5.2 AAAAACGAACATT
Streptococcus gallolyticus UCN34 GALLO_2000 -87 3.9 AAAAATGGACATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0202 -85 4.6 AAAAACGAGCATT
Streptococcus sanguinis SK36 SSA_2114 -56 3.9 AAAAATGGACATT
Streptococcus uberis 0140J SUB1636 -88 4.2 AAAGATGAACAAT
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