CitB family of transcription factors consists of response regulators of two-component systems controlling transport and catabolism of tricarboxylates or dicarboxylates such as citrate, malate etc. [9973351, 19376865]. [22101843, 18997424]. Members of CitB family of response regulators and their cognate sensor kinases were found both in Gram-positive and Gram-negative bacteria [19376865]. Activity of two-component response regulators is controlled via phosphorylation with phosphoryl group donated by cognate histidine kinase (e.g. CitA). Histidine kinases of CitB-family regulators, in their turn, undergo autophosphorylation process in response to binding of citrate [19376865], succinate, fumarate, malate, aspartate, and L- and D-tartrate [19661178].
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CitB-family response regulators (COG4565) are composed of an N-terminal receiver domain and a characteristic C-terminal winged HTH DNA binding domain (SSF46785).
