Collection of regulogs for NiaR transcription factor

Transcription factor NiaR negatively controls NAD biosynthesis and salvage of niacin (vitamin B3) as a NAD precursor. It was originally investigated in Bacillus subtilis as a niacin-responsive YrxA repressor. NiaR regulators constitute a unique protein family. The comparative genomic approach was used to identify candidate DNA binding motifs of NiaR and reconstruct the NiaR regulons in various bacteria from the Bacillus/Clostridium group (Firmicutes) and the Thermotagales [18276644]. Representatives of two distinct types of candidate NiaR-binding motifs, characteristic of the Firmicutes (Bacillus subtilis) and Thermotogales (Thermotoga maritima), were verified by electophoretic mobility shift assay (EMSA). more

It was also shown that nicotinic acid (niacin) acts as a co-repressor for the NiaR regulator [18276644].