Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of Fur in Yersinia pestis KIM

Properties
Regulator type: Transcription factor
TF locus tag: y1208
Regulator family: FUR
Regulation mode: repressor (activator)
Biological process: Iron homeostasis
Effector: Iron ion, (Fe2+)
Regulog: Fur - Enterobacteriales
Statistics of regulated genes:
- Genes 72
- Operons 29
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 656 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -339
Score: 5
Sequence: GATAATGACAATCATTCTC
Position: -333
Score: 3.7
Sequence: GAcAATcATtcTCAaaAaa
Locus tag: y2023
Name: adhE
Funciton: iron-containing aldehyde-alcohol dehydrogenase
adhE
iron-containing aldehyde-alcohol dehydrogenase

Position: -108
Score: 4.8
Sequence: AACAATGATAATCATTTTT
Position: -102
Score: 4.7
Sequence: GATAATCATTTTTATTACC
Locus tag: y1526
Name: sfuA
Funciton: iron(III) ABC transporter, periplasmic protein
Locus tag: y1525
Name: sfuB
Funciton: iron(III) ABC transporter, permease protein
Locus tag: y1524
Name: sfuC
Funciton: iron(III) ABC transporter, ATP-binding protein
sfuA
iron(III) ABC transporter, periplasmic protein
sfuB
iron(III) ABC transporter, permease protein
sfuC
iron(III) ABC transporter, ATP-binding protein

Position: -93
Score: 4.4
Sequence: AATAATGTGAATGATTATC
Position: -87
Score: 4.1
Sequence: GTGAATGATTATCATGATG
Locus tag: y2524
Name: ftnA
Funciton: ferritin
ftnA
ferritin

Position: -45
Score: 4.3
Sequence: CTTATTGATAAGTATTATC
Position: -39
Score: 4.5
Sequence: GATAAGTATTATCATTTGC
Locus tag: y2875
Name: yiuA
Funciton: siderophore ABC transporter, substrate binding periplasmic protein
Locus tag: y2874
Name: yiuB
Funciton: ferric-enterobactin ABC-transporter, permease component
Locus tag: y2873
Name: yiuC
Funciton: ferric-enterobactin ABC transporter ATP-binding protein
yiuA
siderophore ABC transporter, substrate binding periplasmic protein
yiuB
ferric-enterobactin ABC-transporter, permease component
yiuC
ferric-enterobactin ABC transporter ATP-binding protein

Position: -118
Score: 4.1
Sequence: GAGCATGAAAATAATTCTC
Position: -112
Score: 4.4
Sequence: GAAAATAATTCTCAGTATT
Locus tag: y3912
Name: feoA
Funciton: ferrous iron transport protein A
Locus tag: y3911
Name: feoB
Funciton: ferrous iron transport protein B
Locus tag: y3910
Name: feoC
Funciton: ferrous iron transport protein C
feoA
ferrous iron transport protein A
feoB
ferrous iron transport protein B
feoC
ferrous iron transport protein C

Position: -157
Score: 4.4
Sequence: CGTTTTAATAATCATTATC
Position: -151
Score: 4.7
Sequence: AATAATCATTATCGTTACC
Locus tag: y0796
Name: fhuC
Funciton: iron-hydroxamate transporter ATP-binding subunit
Locus tag: y0797
Name: fhuD
Funciton: iron-hydroxamate transporter substrate-binding subunit
Locus tag: y0798
Name: fhuB
Funciton: iron-hydroxamate transporter permease subunit
fhuC
iron-hydroxamate transporter ATP-binding subunit
fhuD
iron-hydroxamate transporter substrate-binding subunit
fhuB
iron-hydroxamate transporter permease subunit

Position: -275
Score: 5
Sequence: gataatgataatcataacc
Position: -269
Score: 4.9
Sequence: gataatcataaccaatatc
Locus tag: y3756
Name: hmsT
Funciton: diguanylate cyclase, involved in hemin storage
hmsT
diguanylate cyclase, involved in hemin storage

Position: -67
Score: 4.9
Sequence: GCTATTGATAATCACTATC
Position: -61
Score: 4.4
Sequence: GATAATCACTATCATTCTG
Locus tag: y2642
Name: fhuF
Funciton: ferric iron reductase involved in ferric hydroximate transport
fhuF
ferric iron reductase involved in ferric hydroximate transport

Position: -39
Score: 5.2
Sequence: GGTATTGATAATCATTTTC
Position: -33
Score: 4.7
Sequence: GATAATCATTTTCATTTGT
Locus tag: y1897
Name: sitA
Funciton: iron ABC transporter, periplasmic substrate-binding protein
Locus tag: y1896
Name: sitB
Funciton: ATP-binding protein for iron and manganese ABC transporter
Locus tag: y1895
Name: sitC
Funciton: iron ABC transporter, membrane protein
Locus tag: y1894
Name: sitD
Funciton: iron ABC transporter, membrane protein
sitA
iron ABC transporter, periplasmic substrate-binding protein
sitB
ATP-binding protein for iron and manganese ABC transporter
sitC
iron ABC transporter, membrane protein
sitD
iron ABC transporter, membrane protein

Position: -103
Score: 5.3
Sequence: TATAATGATAATAATTATC
Position: -97
Score: 4.6
Sequence: GATAATAATTATCATTGAA
Locus tag: y3048
Name: gpmA
Funciton: phosphoglyceromutase 1
gpmA
phosphoglyceromutase 1

Position: -54
Score: 4.1
Sequence: TCGAATGCTTATGATTATC
Position: -48
Score: 4.4
Sequence: GCTTATGATTATCATTTAA
Locus tag: y0547
Name: hemN1
Funciton: coproporphyrinogen III oxidase
Locus tag: y0546
Name: hugX
Funciton: putative heme iron utilization protein
Locus tag: y0545
Name: null
Funciton: Flavin reductase
hemN1
coproporphyrinogen III oxidase
hugX
putative heme iron utilization protein
Flavin reductase

Position: -129
Score: 4.5
Sequence: TGAAGTGATAATTATTATC
Position: -123
Score: 4.8
Sequence: GATAATTATTATCACTACC
Locus tag: y1934
Name: sufA
Funciton: scaffold protein for iron-sulfur cluster assembly
Locus tag: y1935
Name: sufB
Funciton: FeS assembly protein
Locus tag: y1936
Name: sufC
Funciton: FeS assembly ATPase
Locus tag: y1937
Name: sufD
Funciton: FeS assembly protein
Locus tag: y1938
Name: sufS
Funciton: Selenocysteine lyase
Locus tag: y1939
Name: sufE
Funciton: cysteine desulfuration protein
sufA
scaffold protein for iron-sulfur cluster assembly
sufB
FeS assembly protein
sufC
FeS assembly ATPase
sufD
FeS assembly protein
sufS
Selenocysteine lyase
sufE
cysteine desulfuration protein

Position: -4
Score: 4.9
Sequence: GATATTGGTTATGATTATC
Position: 2
Score: 5.2
Sequence: GGTTATGATTATCATTATC
Locus tag: y3754
Name: yjjZ
Funciton: putative membrane protein
yjjZ
putative membrane protein

Position: -48
Score: 3.7
Sequence: GATAATGCTTATCACACTG
Position: -30
Score: 4.1
Sequence: GATAGTCGTTATCATTAAG
Locus tag: y0544
Name: hemP
Funciton: hemin uptake protein
Locus tag: y0543
Name: hemR
Funciton: TonB-dependent outer membrane hemin receptor
Locus tag: y0542
Name: hemS
Funciton: hemin transport protein
Locus tag: y0541
Name: hemT
Funciton: hemin ABC transporter, substrate-binding protein
Locus tag: y0540
Name: hemU
Funciton: hemin transport ABC permease protein
Locus tag: y0539
Name: hemV
Funciton: hemin transport system ATP-binding protein
hemP
hemin uptake protein
hemR
TonB-dependent outer membrane hemin receptor
hemS
hemin transport protein
hemT
hemin ABC transporter, substrate-binding protein
hemU
hemin transport ABC permease protein
hemV
hemin transport system ATP-binding protein

Position: -332
Score: 3.9
Sequence: tgaAATaAaAcTCATTcTt
Position: -326
Score: 3.6
Sequence: aAaAcTcATtcTtATTtaC
Locus tag: y3988
Name: bfr
Funciton: bacterioferrin
bfr
bacterioferrin

Position: -101
Score: 4.4
Sequence: GTTATTGATAATGGTTATT
Position: -95
Score: 4.7
Sequence: GATAATGGTTATTATTCAC
Locus tag: y2397
Name: ybtP
Funciton: yersiniabactin-iron ABC transporter, ATPase/permease components
Locus tag: y2396
Name: ybtQ
Funciton: yersiniabactin-iron ABC transporter, inner membrane and ATPase components
Locus tag: y2395
Name: ybtX
Funciton: MFS siderophore permease, RhtX/FptX family
Locus tag: y2394
Name: ybtS
Funciton: salicylate/anthranilate synthase
ybtP
yersiniabactin-iron ABC transporter, ATPase/permease components
ybtQ
yersiniabactin-iron ABC transporter, inner membrane and ATPase components
ybtX
MFS siderophore permease, RhtX/FptX family
ybtS
salicylate/anthranilate synthase

Position: -90
Score: 4.7
Sequence: GTGAATAATAACCATTATC
Position: -84
Score: 4.6
Sequence: AATAACCATTATCAATAAC
Locus tag: y2398
Name: ybtA
Funciton: AraC-type transcriptional regulator for yersiniabactin uptake and biosynthetic genes
ybtA
AraC-type transcriptional regulator for yersiniabactin uptake and biosynthetic genes

Position: -104
Score: 4.4
Sequence: AGGTTTGATAATCATTTTC
Position: -98
Score: 5
Sequence: GATAATCATTTTCAATATC
Locus tag: y4080
Name: sodA
Funciton: manganese/iron superoxide dismutase
sodA
manganese/iron superoxide dismutase

Position: -84
Score: 4.4
Sequence: CAGAATGATAATCACAATC
Position: -78
Score: 4.3
Sequence: GATAATCACAATCGTTTTA
Locus tag: y2452
Name: yijD
Funciton: iron permease FTR1
Locus tag: y2451
Name: ycdO
Funciton: Ferrous ion transport periplasmic protein
Locus tag: y2450
Name: ycdB
Funciton: Dyp-type peroxidase
yijD
iron permease FTR1
ycdO
Ferrous ion transport periplasmic protein
ycdB
Dyp-type peroxidase

Position: -47
Score: 4.1
Sequence: GTTAATGTTAATAAATCTC
Position: -41
Score: 4.5
Sequence: GTTAATAAATCTCATTATT
Locus tag: y2370
Name: yijD1
Funciton: putative iron permease FTR1
yijD1
putative iron permease FTR1

Position: -78
Score: 4
Sequence: GCGCTTGATAATTATTCTC
Position: -72
Score: 4.6
Sequence: GATAATTATTCTCATTTAA
Locus tag: y1500
Name: mntH
Funciton: Mn2+/Fe2+ transporter, NRAMP family
mntH
Mn2+/Fe2+ transporter, NRAMP family

Position: -74
Score: 4.6
Sequence: AGAAATAGTTATCATTTTC
Locus tag: y2404
Name: fyuA
Funciton: TonB-dependent siderophore receptor
fyuA
TonB-dependent siderophore receptor

Position: -103
Score: 4.6
Sequence: AGTAATGATAATTGATATC
Position: -97
Score: 4.4
Sequence: GATAATTGATATCATTTGC
Locus tag: y0850
Name: cfrA
Funciton: TonB-dependent outer membrane receptor
cfrA
TonB-dependent outer membrane receptor

Position: -71
Score: 4.8
Sequence: ACTAATGATAATTACTATC
Locus tag: y3495
Name: exbB
Funciton: TonB-dependent siderophore transporter component ExbB
Locus tag: y3494
Name: exbD
Funciton: TonB-dependent siderophore transporter component ExbD
exbB
TonB-dependent siderophore transporter component ExbB
exbD
TonB-dependent siderophore transporter component ExbD

Position: -63
Score: 5.1
Sequence: GTTAATAATTATTATTATC
Locus tag: y2399
Name: irp2
Funciton: non-ribosomal peptide synthase (siderophore synthase)
Locus tag: y2400
Name: nrpS
Funciton: non-ribosomal peptide synthase (siderophore synthase)
Locus tag: y2401
Name: nrpU
Funciton: thiazolinyl-S-HMWP1 reductase, siderophore synthesis
Locus tag: y2402
Name: nrpT
Funciton: siderophore biosynthetic protein (thioesterase)
Locus tag: y2403
Name: ybtE
Funciton: salicyl-AMP ligase
irp2
non-ribosomal peptide synthase (siderophore synthase)
nrpS
non-ribosomal peptide synthase (siderophore synthase)
nrpU
thiazolinyl-S-HMWP1 reductase, siderophore synthesis
nrpT
siderophore biosynthetic protein (thioesterase)
ybtE
salicyl-AMP ligase

Position: -41
Score: 4.2
Sequence: ACAAACGATTTTGATTATC
Position: -35
Score: 4.6
Sequence: GATTTTGATTATCATTCGC
Locus tag: y3342
Name: null
Funciton: iron(III) ABC transporter, periplasmic protein
Locus tag: y3343
Name: null
Funciton: TonB-dependent siderophore receptor
iron(III) ABC transporter, periplasmic protein
TonB-dependent siderophore receptor

Position: -63
Score: 4.8
Sequence: GATAATGATAACCACTATT
Locus tag: y3380
Name: iucA1
Funciton: aerobactin synthetase (subunit alpha)
Locus tag: y3381
Name: iucA2
Funciton: aerobactin synthetase (subunit alpha)
Locus tag: y3382
Name: iucB
Funciton: acetyl CoA:N6-hydroxylsyine acetyl transferase, siderophore biosynthesis
Locus tag: y3383
Name: iucC
Funciton: aerobactin synthetase (subunit beta)
Locus tag: y3384
Name: iucD
Funciton: L-lysine 6-monooxygenase (NADPH), siderophore biosynthesis
Locus tag: y3385
Name: iutA
Funciton: TonB-dependent siderophore receptor
iucA1
aerobactin synthetase (subunit alpha)
iucA2
aerobactin synthetase (subunit alpha)
iucB
acetyl CoA:N6-hydroxylsyine acetyl transferase, siderophore biosynthesis
iucC
aerobactin synthetase (subunit beta)
iucD
L-lysine 6-monooxygenase (NADPH), siderophore biosynthesis
iutA
TonB-dependent siderophore receptor

Position: -187
Score: 4.9
Sequence: GAAAATGATAATCGTTTGC
Locus tag: y3404
Name: null
Funciton: TonB-dependent receptor
Locus tag: y3406
Name: null
Funciton: siderophore synthetase/polyketide synthase
TonB-dependent receptor
siderophore synthetase/polyketide synthase

Position: -26
Score: 4.8
Sequence: GGTAATAAAAATCATTAGC
Position: -20
Score: 4.2
Sequence: AAAAATCATTAGCATTACT
Locus tag: y4043
Name: fatB
Funciton: iron ABC transporter, substrate-binding protein
Locus tag: y4044
Name: fatD
Funciton: iron ABC transporter, permease component
Locus tag: y4045
Name: fatC
Funciton: iron ABC transporter, permease component
Locus tag: y4046
Name: fecE
Funciton: iron ABC transporter, ATP-binding protein
fatB
iron ABC transporter, substrate-binding protein
fatD
iron ABC transporter, permease component
fatC
iron ABC transporter, permease component
fecE
iron ABC transporter, ATP-binding protein
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