Regulon of Fur in Yersinia pestis KIM

Properties
Regulator type:	Transcription factor
TF locus tag:	y1208
Regulator family:	FUR
Regulation mode:	repressor (activator)
Biological process:	Iron homeostasis
Effector:	Iron ion, (Fe2+)
Regulog:	Fur - Enterobacteriales
Statistics of regulated genes:
- Genes	72
- Operons	29
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 656 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - FUR
By TF family - FUR
By effector - Iron ion, (Fe2+)
By pathway - Iron homeostasis

Regulated operons
	Locus Tag	Name	Function
Position: -339 Score: 5 Sequence: GATAATGACAATCATTCTC Position: -333 Score: 3.7 Sequence: GAcAATcATtcTCAaaAaa Locus tag: y2023 Name: adhE Funciton: iron-containing aldehyde-alcohol dehydrogenase
	y2023	adhE	iron-containing aldehyde-alcohol dehydrogenase
Position: -108 Score: 4.8 Sequence: AACAATGATAATCATTTTT Position: -102 Score: 4.7 Sequence: GATAATCATTTTTATTACC Locus tag: y1526 Name: sfuA Funciton: iron(III) ABC transporter, periplasmic protein Locus tag: y1525 Name: sfuB Funciton: iron(III) ABC transporter, permease protein Locus tag: y1524 Name: sfuC Funciton: iron(III) ABC transporter, ATP-binding protein
	y1526	sfuA	iron(III) ABC transporter, periplasmic protein
	y1525	sfuB	iron(III) ABC transporter, permease protein
	y1524	sfuC	iron(III) ABC transporter, ATP-binding protein
Position: -93 Score: 4.4 Sequence: AATAATGTGAATGATTATC Position: -87 Score: 4.1 Sequence: GTGAATGATTATCATGATG Locus tag: y2524 Name: ftnA Funciton: ferritin
	y2524	ftnA	ferritin
Position: -45 Score: 4.3 Sequence: CTTATTGATAAGTATTATC Position: -39 Score: 4.5 Sequence: GATAAGTATTATCATTTGC Locus tag: y2875 Name: yiuA Funciton: siderophore ABC transporter, substrate binding periplasmic protein Locus tag: y2874 Name: yiuB Funciton: ferric-enterobactin ABC-transporter, permease component Locus tag: y2873 Name: yiuC Funciton: ferric-enterobactin ABC transporter ATP-binding protein
	y2875	yiuA	siderophore ABC transporter, substrate binding periplasmic protein
	y2874	yiuB	ferric-enterobactin ABC-transporter, permease component
	y2873	yiuC	ferric-enterobactin ABC transporter ATP-binding protein
Position: -118 Score: 4.1 Sequence: GAGCATGAAAATAATTCTC Position: -112 Score: 4.4 Sequence: GAAAATAATTCTCAGTATT Locus tag: y3912 Name: feoA Funciton: ferrous iron transport protein A Locus tag: y3911 Name: feoB Funciton: ferrous iron transport protein B Locus tag: y3910 Name: feoC Funciton: ferrous iron transport protein C
	y3912	feoA	ferrous iron transport protein A
	y3911	feoB	ferrous iron transport protein B
	y3910	feoC	ferrous iron transport protein C
Position: -157 Score: 4.4 Sequence: CGTTTTAATAATCATTATC Position: -151 Score: 4.7 Sequence: AATAATCATTATCGTTACC Locus tag: y0796 Name: fhuC Funciton: iron-hydroxamate transporter ATP-binding subunit Locus tag: y0797 Name: fhuD Funciton: iron-hydroxamate transporter substrate-binding subunit Locus tag: y0798 Name: fhuB Funciton: iron-hydroxamate transporter permease subunit
	y0796	fhuC	iron-hydroxamate transporter ATP-binding subunit
	y0797	fhuD	iron-hydroxamate transporter substrate-binding subunit
	y0798	fhuB	iron-hydroxamate transporter permease subunit
Position: -275 Score: 5 Sequence: gataatgataatcataacc Position: -269 Score: 4.9 Sequence: gataatcataaccaatatc Locus tag: y3756 Name: hmsT Funciton: diguanylate cyclase, involved in hemin storage
	y3756	hmsT	diguanylate cyclase, involved in hemin storage
Position: -67 Score: 4.9 Sequence: GCTATTGATAATCACTATC Position: -61 Score: 4.4 Sequence: GATAATCACTATCATTCTG Locus tag: y2642 Name: fhuF Funciton: ferric iron reductase involved in ferric hydroximate transport
	y2642	fhuF	ferric iron reductase involved in ferric hydroximate transport
Position: -39 Score: 5.2 Sequence: GGTATTGATAATCATTTTC Position: -33 Score: 4.7 Sequence: GATAATCATTTTCATTTGT Locus tag: y1897 Name: sitA Funciton: iron ABC transporter, periplasmic substrate-binding protein Locus tag: y1896 Name: sitB Funciton: ATP-binding protein for iron and manganese ABC transporter Locus tag: y1895 Name: sitC Funciton: iron ABC transporter, membrane protein Locus tag: y1894 Name: sitD Funciton: iron ABC transporter, membrane protein
	y1897	sitA	iron ABC transporter, periplasmic substrate-binding protein
	y1896	sitB	ATP-binding protein for iron and manganese ABC transporter
	y1895	sitC	iron ABC transporter, membrane protein
	y1894	sitD	iron ABC transporter, membrane protein
Position: -103 Score: 5.3 Sequence: TATAATGATAATAATTATC Position: -97 Score: 4.6 Sequence: GATAATAATTATCATTGAA Locus tag: y3048 Name: gpmA Funciton: phosphoglyceromutase 1
	y3048	gpmA	phosphoglyceromutase 1
Position: -54 Score: 4.1 Sequence: TCGAATGCTTATGATTATC Position: -48 Score: 4.4 Sequence: GCTTATGATTATCATTTAA Locus tag: y0547 Name: hemN1 Funciton: coproporphyrinogen III oxidase Locus tag: y0546 Name: hugX Funciton: putative heme iron utilization protein Locus tag: y0545 Name: null Funciton: Flavin reductase
	y0547	hemN1	coproporphyrinogen III oxidase
	y0546	hugX	putative heme iron utilization protein
	y0545		Flavin reductase
Position: -129 Score: 4.5 Sequence: TGAAGTGATAATTATTATC Position: -123 Score: 4.8 Sequence: GATAATTATTATCACTACC Locus tag: y1934 Name: sufA Funciton: scaffold protein for iron-sulfur cluster assembly Locus tag: y1935 Name: sufB Funciton: FeS assembly protein Locus tag: y1936 Name: sufC Funciton: FeS assembly ATPase Locus tag: y1937 Name: sufD Funciton: FeS assembly protein Locus tag: y1938 Name: sufS Funciton: Selenocysteine lyase Locus tag: y1939 Name: sufE Funciton: cysteine desulfuration protein
	y1934	sufA	scaffold protein for iron-sulfur cluster assembly
	y1935	sufB	FeS assembly protein
	y1936	sufC	FeS assembly ATPase
	y1937	sufD	FeS assembly protein
	y1938	sufS	Selenocysteine lyase
	y1939	sufE	cysteine desulfuration protein
Position: -4 Score: 4.9 Sequence: GATATTGGTTATGATTATC Position: 2 Score: 5.2 Sequence: GGTTATGATTATCATTATC Locus tag: y3754 Name: yjjZ Funciton: putative membrane protein
	y3754	yjjZ	putative membrane protein
Position: -48 Score: 3.7 Sequence: GATAATGCTTATCACACTG Position: -30 Score: 4.1 Sequence: GATAGTCGTTATCATTAAG Locus tag: y0544 Name: hemP Funciton: hemin uptake protein Locus tag: y0543 Name: hemR Funciton: TonB-dependent outer membrane hemin receptor Locus tag: y0542 Name: hemS Funciton: hemin transport protein Locus tag: y0541 Name: hemT Funciton: hemin ABC transporter, substrate-binding protein Locus tag: y0540 Name: hemU Funciton: hemin transport ABC permease protein Locus tag: y0539 Name: hemV Funciton: hemin transport system ATP-binding protein
	y0544	hemP	hemin uptake protein
	y0543	hemR	TonB-dependent outer membrane hemin receptor
	y0542	hemS	hemin transport protein
	y0541	hemT	hemin ABC transporter, substrate-binding protein
	y0540	hemU	hemin transport ABC permease protein
	y0539	hemV	hemin transport system ATP-binding protein
Position: -332 Score: 3.9 Sequence: tgaAATaAaAcTCATTcTt Position: -326 Score: 3.6 Sequence: aAaAcTcATtcTtATTtaC Locus tag: y3988 Name: bfr Funciton: bacterioferrin
	y3988	bfr	bacterioferrin
Position: -101 Score: 4.4 Sequence: GTTATTGATAATGGTTATT Position: -95 Score: 4.7 Sequence: GATAATGGTTATTATTCAC Locus tag: y2397 Name: ybtP Funciton: yersiniabactin-iron ABC transporter, ATPase/permease components Locus tag: y2396 Name: ybtQ Funciton: yersiniabactin-iron ABC transporter, inner membrane and ATPase components Locus tag: y2395 Name: ybtX Funciton: MFS siderophore permease, RhtX/FptX family Locus tag: y2394 Name: ybtS Funciton: salicylate/anthranilate synthase
	y2397	ybtP	yersiniabactin-iron ABC transporter, ATPase/permease components
	y2396	ybtQ	yersiniabactin-iron ABC transporter, inner membrane and ATPase components
	y2395	ybtX	MFS siderophore permease, RhtX/FptX family
	y2394	ybtS	salicylate/anthranilate synthase
Position: -90 Score: 4.7 Sequence: GTGAATAATAACCATTATC Position: -84 Score: 4.6 Sequence: AATAACCATTATCAATAAC Locus tag: y2398 Name: ybtA Funciton: AraC-type transcriptional regulator for yersiniabactin uptake and biosynthetic genes
	y2398	ybtA	AraC-type transcriptional regulator for yersiniabactin uptake and biosynthetic genes
Position: -104 Score: 4.4 Sequence: AGGTTTGATAATCATTTTC Position: -98 Score: 5 Sequence: GATAATCATTTTCAATATC Locus tag: y4080 Name: sodA Funciton: manganese/iron superoxide dismutase
	y4080	sodA	manganese/iron superoxide dismutase
Position: -84 Score: 4.4 Sequence: CAGAATGATAATCACAATC Position: -78 Score: 4.3 Sequence: GATAATCACAATCGTTTTA Locus tag: y2452 Name: yijD Funciton: iron permease FTR1 Locus tag: y2451 Name: ycdO Funciton: Ferrous ion transport periplasmic protein Locus tag: y2450 Name: ycdB Funciton: Dyp-type peroxidase
	y2452	yijD	iron permease FTR1
	y2451	ycdO	Ferrous ion transport periplasmic protein
	y2450	ycdB	Dyp-type peroxidase
Position: -47 Score: 4.1 Sequence: GTTAATGTTAATAAATCTC Position: -41 Score: 4.5 Sequence: GTTAATAAATCTCATTATT Locus tag: y2370 Name: yijD1 Funciton: putative iron permease FTR1
	y2370	yijD1	putative iron permease FTR1
Position: -78 Score: 4 Sequence: GCGCTTGATAATTATTCTC Position: -72 Score: 4.6 Sequence: GATAATTATTCTCATTTAA Locus tag: y1500 Name: mntH Funciton: Mn2+/Fe2+ transporter, NRAMP family
	y1500	mntH	Mn2+/Fe2+ transporter, NRAMP family
Position: -74 Score: 4.6 Sequence: AGAAATAGTTATCATTTTC Locus tag: y2404 Name: fyuA Funciton: TonB-dependent siderophore receptor
	y2404	fyuA	TonB-dependent siderophore receptor
Position: -103 Score: 4.6 Sequence: AGTAATGATAATTGATATC Position: -97 Score: 4.4 Sequence: GATAATTGATATCATTTGC Locus tag: y0850 Name: cfrA Funciton: TonB-dependent outer membrane receptor
	y0850	cfrA	TonB-dependent outer membrane receptor
Position: -71 Score: 4.8 Sequence: ACTAATGATAATTACTATC Locus tag: y3495 Name: exbB Funciton: TonB-dependent siderophore transporter component ExbB Locus tag: y3494 Name: exbD Funciton: TonB-dependent siderophore transporter component ExbD
	y3495	exbB	TonB-dependent siderophore transporter component ExbB
	y3494	exbD	TonB-dependent siderophore transporter component ExbD
Position: -63 Score: 5.1 Sequence: GTTAATAATTATTATTATC Locus tag: y2399 Name: irp2 Funciton: non-ribosomal peptide synthase (siderophore synthase) Locus tag: y2400 Name: nrpS Funciton: non-ribosomal peptide synthase (siderophore synthase) Locus tag: y2401 Name: nrpU Funciton: thiazolinyl-S-HMWP1 reductase, siderophore synthesis Locus tag: y2402 Name: nrpT Funciton: siderophore biosynthetic protein (thioesterase) Locus tag: y2403 Name: ybtE Funciton: salicyl-AMP ligase
	y2399	irp2	non-ribosomal peptide synthase (siderophore synthase)
	y2400	nrpS	non-ribosomal peptide synthase (siderophore synthase)
	y2401	nrpU	thiazolinyl-S-HMWP1 reductase, siderophore synthesis
	y2402	nrpT	siderophore biosynthetic protein (thioesterase)
	y2403	ybtE	salicyl-AMP ligase
Position: -41 Score: 4.2 Sequence: ACAAACGATTTTGATTATC Position: -35 Score: 4.6 Sequence: GATTTTGATTATCATTCGC Locus tag: y3342 Name: null Funciton: iron(III) ABC transporter, periplasmic protein Locus tag: y3343 Name: null Funciton: TonB-dependent siderophore receptor
	y3342		iron(III) ABC transporter, periplasmic protein
	y3343		TonB-dependent siderophore receptor
Position: -63 Score: 4.8 Sequence: GATAATGATAACCACTATT Locus tag: y3380 Name: iucA1 Funciton: aerobactin synthetase (subunit alpha) Locus tag: y3381 Name: iucA2 Funciton: aerobactin synthetase (subunit alpha) Locus tag: y3382 Name: iucB Funciton: acetyl CoA:N6-hydroxylsyine acetyl transferase, siderophore biosynthesis Locus tag: y3383 Name: iucC Funciton: aerobactin synthetase (subunit beta) Locus tag: y3384 Name: iucD Funciton: L-lysine 6-monooxygenase (NADPH), siderophore biosynthesis Locus tag: y3385 Name: iutA Funciton: TonB-dependent siderophore receptor
	y3380	iucA1	aerobactin synthetase (subunit alpha)
	y3381	iucA2	aerobactin synthetase (subunit alpha)
	y3382	iucB	acetyl CoA:N6-hydroxylsyine acetyl transferase, siderophore biosynthesis
	y3383	iucC	aerobactin synthetase (subunit beta)
	y3384	iucD	L-lysine 6-monooxygenase (NADPH), siderophore biosynthesis
	y3385	iutA	TonB-dependent siderophore receptor
Position: -187 Score: 4.9 Sequence: GAAAATGATAATCGTTTGC Locus tag: y3404 Name: null Funciton: TonB-dependent receptor Locus tag: y3406 Name: null Funciton: siderophore synthetase/polyketide synthase
	y3404		TonB-dependent receptor
	y3406		siderophore synthetase/polyketide synthase
Position: -26 Score: 4.8 Sequence: GGTAATAAAAATCATTAGC Position: -20 Score: 4.2 Sequence: AAAAATCATTAGCATTACT Locus tag: y4043 Name: fatB Funciton: iron ABC transporter, substrate-binding protein Locus tag: y4044 Name: fatD Funciton: iron ABC transporter, permease component Locus tag: y4045 Name: fatC Funciton: iron ABC transporter, permease component Locus tag: y4046 Name: fecE Funciton: iron ABC transporter, ATP-binding protein
	y4043	fatB	iron ABC transporter, substrate-binding protein
	y4044	fatD	iron ABC transporter, permease component
	y4045	fatC	iron ABC transporter, permease component
	y4046	fecE	iron ABC transporter, ATP-binding protein

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of Fur in Yersinia pestis KIM

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --