Regulon of Fur in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Properties
Regulator type:	Transcription factor
TF locus tag:	KPN_00706
Regulator family:	FUR
Regulation mode:	repressor (activator)
Biological process:	Iron homeostasis
Effector:	Iron ion, (Fe2+)
Regulog:	Fur - Enterobacteriales
Statistics of regulated genes:
- Genes	71
- Operons	34
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 656 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - FUR
By TF family - FUR
By effector - Iron ion, (Fe2+)
By pathway - Iron homeostasis

Regulated operons
	Locus Tag	Name	Function
Position: -332 Score: 4 Sequence: TTTAATGCTAATCGTTTTT Position: -326 Score: 3.2 Sequence: GCTAATCGTTTTTTTAATT Locus tag: KPN_02199 Name: adhE Funciton: iron-containing aldehyde-alcohol dehydrogenase
	KPN_02199	adhE	iron-containing aldehyde-alcohol dehydrogenase
Position: -161 Score: 4 Sequence: ATAAATTAAAAGCATTCTC Position: -155 Score: 3.8 Sequence: TAAAAGCATTCTCATTTAT Locus tag: KPN_02402 Name: ftnA Funciton: ferritin
	KPN_02402	ftnA	ferritin
Position: -126 Score: 4.2 Sequence: GCAAATGATAACTATTCTT Position: -120 Score: 4.1 Sequence: GATAACTATTCTTTTTATC Locus tag: KPN_01250 Name: fiu Funciton: iron outer membrane transporter Locus tag: KPN_01249 Name: ybiX Funciton: 2OG-Fe(II) oxygenase
	KPN_01250	fiu	iron outer membrane transporter
	KPN_01249	ybiX	2OG-Fe(II) oxygenase
Position: -120 Score: 4.9 Sequence: GACAATAATAATCATTCTC Position: -114 Score: 4.7 Sequence: AATAATCATTCTCATTCGC Locus tag: KPN_03806 Name: yhhY Funciton: GCN5-related N-acetyltransferase
	KPN_03806	yhhY	GCN5-related N-acetyltransferase
Position: -101 Score: 4.6 Sequence: AATAATGAGTTTCATTTGC Locus tag: KPN_02149 Name: eitA Funciton: citrate-dependent iron(III) ABC transporter, peiplasmic component Locus tag: KPN_02150 Name: eitB Funciton: citrate-dependent iron(III) ABC transporter, permease component Locus tag: KPN_02151 Name: eitC Funciton: citrate-dependent iron(III) ABC transporter, ATPase component
	KPN_02149	eitA	citrate-dependent iron(III) ABC transporter, peiplasmic component
	KPN_02150	eitB	citrate-dependent iron(III) ABC transporter, permease component
	KPN_02151	eitC	citrate-dependent iron(III) ABC transporter, ATPase component
Position: -78 Score: 4.6 Sequence: ATTTATAATAATGATTATC Position: -72 Score: 4.4 Sequence: AATAATGATTATCAATCAG Locus tag: KPN_02414 Name: sdiA Funciton: transcriptional regulator of ftsQAZ gene cluster (LuxR/UhpA family)
	KPN_02414	sdiA	transcriptional regulator of ftsQAZ gene cluster (LuxR/UhpA family)
Position: -54 Score: 4.1 Sequence: GAGAATAATTCTCAGAATC Locus tag: KPN_00520 Name: yiuA Funciton: siderophore ABC transporter, substrate binding periplasmic protein Locus tag: KPN_00519 Name: yiuB Funciton: ferric-enterobactin ABC-transporter, permease component Locus tag: KPN_00518 Name: yiuC Funciton: ferric-enterobactin ABC transporter ATP-binding protein
	KPN_00520	yiuA	siderophore ABC transporter, substrate binding periplasmic protein
	KPN_00519	yiuB	ferric-enterobactin ABC-transporter, permease component
	KPN_00518	yiuC	ferric-enterobactin ABC transporter ATP-binding protein
Position: -103 Score: 4.5 Sequence: AATAATGATTACTATTCGC Locus tag: KPN_01908 Name: yncE Funciton: putative receptor, ATP binding
	KPN_01908	yncE	putative receptor, ATP binding
Position: -133 Score: 4.1 Sequence: GATGATAAAAACCATTCTC Position: -127 Score: 4.7 Sequence: AAAAACCATTCTCATTATC Locus tag: KPN_03778 Name: feoA Funciton: ferrous iron transport protein A Locus tag: KPN_03779 Name: feoB Funciton: ferrous iron transport protein B Locus tag: KPN_03780 Name: yhgG Funciton: ferrous iron transport protein C
	KPN_03778	feoA	ferrous iron transport protein A
	KPN_03779	feoB	ferrous iron transport protein B
	KPN_03780	yhgG	ferrous iron transport protein C
Position: -166 Score: 4.8 Sequence: GATATTAAGAATAATTATC Position: -160 Score: 4.6 Sequence: AAGAATAATTATCATTTAT Locus tag: KPN_00610 Name: fepB Funciton: ferric enterobactin (enterochelin) binding protein; periplasmic component
	KPN_00610	fepB	ferric enterobactin (enterochelin) binding protein; periplasmic component
Position: -43 Score: 4.8 Sequence: GATAACGATAATTACTATC Position: -37 Score: 5 Sequence: GATAATTACTATCATTATC Locus tag: KPN_00608 Name: fepD Funciton: iron-enterobactin (enterochelin) ABC transporter membrane protein Locus tag: KPN_00607 Name: fepG Funciton: iron-enterobactin (enterochelin) ABC transporter membrane protein Locus tag: KPN_00606 Name: fepC Funciton: iron-enterobactin (enterochelin) ABC transport ATPase
	KPN_00608	fepD	iron-enterobactin (enterochelin) ABC transporter membrane protein
	KPN_00607	fepG	iron-enterobactin (enterochelin) ABC transporter membrane protein
	KPN_00606	fepC	iron-enterobactin (enterochelin) ABC transport ATPase
Position: -56 Score: 4 Sequence: CGTCATAATAATAATTCTC Position: -50 Score: 4.5 Sequence: AATAATAATTCTCGTTTAC Locus tag: KPN_00165 Name: fhuA Funciton: TonB-dependent siderophore receptor Locus tag: KPN_00166 Name: fhuC Funciton: iron-hydroxamate transporter ATP-binding subunit Locus tag: KPN_00167 Name: fhuD Funciton: iron-hydroxamate transporter substrate-binding subunit Locus tag: KPN_00168 Name: fhuB Funciton: iron-hydroxamate transporter permease subunit
	KPN_00165	fhuA	TonB-dependent siderophore receptor
	KPN_00166	fhuC	iron-hydroxamate transporter ATP-binding subunit
	KPN_00167	fhuD	iron-hydroxamate transporter substrate-binding subunit
	KPN_00168	fhuB	iron-hydroxamate transporter permease subunit
Position: -94 Score: 4.9 Sequence: GATAATGATAGTAATTATC Position: -88 Score: 4.8 Sequence: GATAGTAATTATCGTTATC Locus tag: KPN_00609 Name: ybdA Funciton: enterobactin exporter EntS, MFS family
	KPN_00609	ybdA	enterobactin exporter EntS, MFS family
Position: -44 Score: 4.5 Sequence: AATATCAGTAATCATTATC Position: -38 Score: 4.4 Sequence: AGTAATCATTATCATTTAG Locus tag: KPN_04821 Name: fhuF Funciton: ferric iron reductase involved in ferric hydroximate transport
	KPN_04821	fhuF	ferric iron reductase involved in ferric hydroximate transport
Position: -99 Score: 4.5 Sequence: GCAAATAAGAATTATTTTC Position: -93 Score: 4.2 Sequence: AAGAATTATTTTCATTTAT Locus tag: KPN_03078 Name: sitA Funciton: iron ABC transporter, periplasmic substrate-binding protein Locus tag: KPN_03079 Name: sitB Funciton: ATP-binding protein for iron and manganese ABC transporter Locus tag: KPN_03080 Name: sitC Funciton: iron ABC transporter, membrane protein Locus tag: KPN_03081 Name: sitD Funciton: iron ABC transporter, membrane protein
	KPN_03078	sitA	iron ABC transporter, periplasmic substrate-binding protein
	KPN_03079	sitB	ATP-binding protein for iron and manganese ABC transporter
	KPN_03080	sitC	iron ABC transporter, membrane protein
	KPN_03081	sitD	iron ABC transporter, membrane protein
Position: -133 Score: 4 Sequence: GATAATACCTATCATTACC Locus tag: KPN_03087 Name: hmuR Funciton: TonB-dependent outer membrane receptor Locus tag: KPN_03088 Name: hemS Funciton: hemin transport protein Locus tag: KPN_03089 Name: hemT Funciton: hemin ABC transporter, substrate-binding protein Locus tag: KPN_03090 Name: hemU Funciton: hemin transport ABC permease protein Locus tag: KPN_03091 Name: hemV Funciton: hemin transport system ATP-binding protein
	KPN_03087	hmuR	TonB-dependent outer membrane receptor
	KPN_03088	hemS	hemin transport protein
	KPN_03089	hemT	hemin ABC transporter, substrate-binding protein
	KPN_03090	hemU	hemin transport ABC permease protein
	KPN_03091	hemV	hemin transport system ATP-binding protein
Position: -96 Score: 4.6 Sequence: TATAATGAGAATAGTTATC Locus tag: KPN_00768 Name: gpmA Funciton: phosphoglyceromutase 1
	KPN_00768	gpmA	phosphoglyceromutase 1
Position: -10 Score: 4.8 Sequence: ATTATTGATAATGATTATC Position: -4 Score: 5.1 Sequence: GATAATGATTATCATTGTT Locus tag: KPN_02163 Name: hemP Funciton: hemin uptake protein
	KPN_02163	hemP	hemin uptake protein
Position: -66 Score: 4.7 Sequence: TGAAGTGATAATCATTATC Position: -60 Score: 5.1 Sequence: GATAATCATTATCACTAAC Locus tag: KPN_02141 Name: sufA Funciton: scaffold protein for iron-sulfur cluster assembly Locus tag: KPN_02140 Name: sufB Funciton: FeS assembly protein Locus tag: KPN_02139 Name: sufC Funciton: FeS assembly ATPase Locus tag: KPN_02138 Name: sufD Funciton: FeS assembly protein Locus tag: KPN_02137 Name: sufS Funciton: Selenocysteine lyase Locus tag: KPN_02136 Name: sufE Funciton: cysteine desulfuration protein
	KPN_02141	sufA	scaffold protein for iron-sulfur cluster assembly
	KPN_02140	sufB	FeS assembly protein
	KPN_02139	sufC	FeS assembly ATPase
	KPN_02138	sufD	FeS assembly protein
	KPN_02137	sufS	Selenocysteine lyase
	KPN_02136	sufE	cysteine desulfuration protein
Position: -55 Score: 4.6 Sequence: TGTAATCATAACCATTCTC Position: -49 Score: 3.9 Sequence: cATAAccATtcTCATTtaa Locus tag: KPN_03723 Name: bfd Funciton: bacterioferritin-associated ferredoxin Locus tag: KPN_03722 Name: bfr Funciton: bacterioferrin
	KPN_03723	bfd	bacterioferritin-associated ferredoxin
	KPN_03722	bfr	bacterioferrin
Position: -173 Score: 4.5 Sequence: GCGAATAGTAATCATTATT Position: -167 Score: 4.1 Sequence: AGTAATCATTATTTATATC Locus tag: KPN_01909 Name: yncD Funciton: TonB-dependent siderophore outer membrane receptor
	KPN_01909	yncD	TonB-dependent siderophore outer membrane receptor
Position: -98 Score: 4.2 Sequence: AATAATAATTCGCATTACT Locus tag: KPN_02304 Name: foxR Funciton: TonB-dependent siderophore receptor
	KPN_02304	foxR	TonB-dependent siderophore receptor
Position: -216 Score: 4.4 Sequence: GCAAATGAGAATTATTTTT Locus tag: KPN_02197 Name: oppA Funciton: oligopeptide ABC transporter; periplasmic binding protein Locus tag: KPN_02196 Name: oppB Funciton: oligopeptide ABC transporter, permease protein Locus tag: KPN_02195 Name: oppC Funciton: oligopeptide ABC transporter, permease protein Locus tag: KPN_02194 Name: oppD Funciton: oligopeptide ABC transporter, ATP-binding protein Locus tag: KPN_02193 Name: oppF Funciton: oligopeptide ABC transporter, ATP-binding protein
	KPN_02197	oppA	oligopeptide ABC transporter; periplasmic binding protein
	KPN_02196	oppB	oligopeptide ABC transporter, permease protein
	KPN_02195	oppC	oligopeptide ABC transporter, permease protein
	KPN_02194	oppD	oligopeptide ABC transporter, ATP-binding protein
	KPN_02193	oppF	oligopeptide ABC transporter, ATP-binding protein
Position: -76 Score: 5 Sequence: TGTAATGATAATCACTATC Position: -70 Score: 4.2 Sequence: GATAATCACTATCATAAAT Locus tag: KPN_01045 Name: yijD Funciton: iron permease FTR1 Locus tag: KPN_01046 Name: ycdO Funciton: Ferrous ion transport periplasmic protein Locus tag: KPN_01047 Name: ycdB Funciton: Dyp-type peroxidase
	KPN_01045	yijD	iron permease FTR1
	KPN_01046	ycdO	Ferrous ion transport periplasmic protein
	KPN_01047	ycdB	Dyp-type peroxidase
Position: -47 Score: 4.5 Sequence: ATAAATGATAATTATTCTT Position: -41 Score: 4.8 Sequence: GATAATTATTCTTAATATC Locus tag: KPN_00611 Name: entC Funciton: isochorismate synthetase, siderophore biosynthesis Locus tag: KPN_00612 Name: entE Funciton: 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase complex Locus tag: KPN_00613 Name: entB Funciton: enterobactin synthetase component B (isochorismatase) Locus tag: KPN_00614 Name: entA Funciton: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis Locus tag: KPN_00615 Name: ybdB Funciton: putative protein PaaI, possibly involved in aromatic compounds catabolism
	KPN_00611	entC	isochorismate synthetase, siderophore biosynthesis
	KPN_00612	entE	2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase complex
	KPN_00613	entB	enterobactin synthetase component B (isochorismatase)
	KPN_00614	entA	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis
	KPN_00615	ybdB	putative protein PaaI, possibly involved in aromatic compounds catabolism
Position: -68 Score: 4.3 Sequence: GAACTTGATAATCATTCGC Position: -62 Score: 4.3 Sequence: GATAATCATTCGCATTTTG Locus tag: KPN_02743 Name: mntH Funciton: Mn2+/Fe2+ transporter, NRAMP family
	KPN_02743	mntH	Mn2+/Fe2+ transporter, NRAMP family
Position: -88 Score: 4.3 Sequence: GGCATTGATAAGCATTTTC Position: -82 Score: 4 Sequence: GATAAGCATTTTCAATACC Locus tag: KPN_04217 Name: sodA Funciton: manganese/iron superoxide dismutase
	KPN_04217	sodA	manganese/iron superoxide dismutase
Position: -197 Score: 4.1 Sequence: ATTATTGATAACTATTTGC Position: -191 Score: 4 Sequence: GATAACTATTTGCATTTGC Locus tag: KPN_00602 Name: fepA Funciton: TonB-dependent siderophore receptor FepA Locus tag: KPN_00601 Name: entD Funciton: enterochelin synthetase, component D (phoshpantetheinyltransferase)
	KPN_00602	fepA	TonB-dependent siderophore receptor FepA
	KPN_00601	entD	enterochelin synthetase, component D (phoshpantetheinyltransferase)
Position: -62 Score: 4.5 Sequence: GGCAATCATTATCATTTGC Locus tag: KPN_03499 Name: yqjH Funciton: FAD-binding 9, siderophore-interacting domain protein
	KPN_03499	yqjH	FAD-binding 9, siderophore-interacting domain protein
Position: -249 Score: 4.1 Sequence: CATTATCTTTATCATTTTC Locus tag: KPN_02593 Name: cirA Funciton: TonB-dependent ferric iron-catecholate receptor
	KPN_02593	cirA	TonB-dependent ferric iron-catecholate receptor
Position: -97 Score: 4.3 Sequence: ACTAATGAGAACCACTATC Locus tag: KPN_03426 Name: exbB Funciton: TonB-dependent siderophore transporter component ExbB Locus tag: KPN_03425 Name: exbD Funciton: TonB-dependent siderophore transporter component ExbD
	KPN_03426	exbB	TonB-dependent siderophore transporter component ExbB
	KPN_03425	exbD	TonB-dependent siderophore transporter component ExbD
Position: -93 Score: 4.6 Sequence: AGAAATGAGAACCATTATC Position: -87 Score: 4.1 Sequence: GAGAACCATTATCATAAAA Locus tag: KPN_01678 Name: null Funciton: putative oxidoreductase, Fe-S subunit
	KPN_01678		putative oxidoreductase, Fe-S subunit
Position: -210 Score: 4.1 Sequence: TTGAATGATTCTCAATTAC Locus tag: KPN_02105 Name: null Funciton: TonB-dependent siderophore receptor
	KPN_02105		TonB-dependent siderophore receptor
Position: -67 Score: 4.8 Sequence: TGTAATGATAATTGTTATC Position: -61 Score: 4.7 Sequence: GATAATTGTTATCATTAAT Locus tag: KPN_01244 Name: iroN Funciton: TonB-dependent siderophore receptor
	KPN_01244	iroN	TonB-dependent siderophore receptor

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of Fur in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --