Regulog CblR - Sulfolobales

Properties
Regulator type:	Transcription factor
Regulator family:
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:
Phylum:	Crenarchaeota
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 28 sites [see more]

Member of regulog collections

By taxonomy - Sulfolobales
By trascription factor - CblR
By pathway - Cobalamin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Metallosphaera sedula DSM 5348	11	6
Sulfolobus tokodaii str. 7	10	6
Sulfolobus solfataricus P2	13	4
Sulfolobus islandicus Y.N.15.51	13	4
Sulfolobus acidocaldarius DSM 639	11	5

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes						Function

CRON 1.
btuF	* Metallosphaera sedula DSM 5348 Site: position = -1 score = 6.4987 sequence = TATGGATAGCCTATCCATC Gene: Msed_0807: Vitamin B12 ABC transporter, B12-binding component BtuF	* Sulfolobus tokodaii str. 7 Site: position = -64 score = 4.94422 sequence = TTAGGATAACTTAACCATA Site: position = -1 score = 5.71788 sequence = TATGGATGACTTATCCATA Gene: ST0840: Vitamin B12 ABC transporter, B12-binding component BtuF	* Sulfolobus solfataricus P2 Site: position = -23 score = 6.50944 sequence = TTTGGATAGTCTATCCAGA Gene: SSO0485: Vitamin B12 ABC transporter, B12-binding component BtuF	* Sulfolobus islandicus Y.N.15.51 Site: position = -23 score = 6.50944 sequence = TTTGGATAGTCTATCCAGA Gene: YN1551_1191: Vitamin B12 ABC transporter, B12-binding component BtuF	* Sulfolobus acidocaldarius DSM 639 Site: position = -24 score = 5.78266 sequence = TATGGATAGCCTATCCTAC Gene: Saci_1220: Vitamin B12 ABC transporter, B12-binding component BtuF	Vitamin B12 ABC transporter, B12-binding component BtuF
btuC	Metallosphaera sedula DSM 5348 Gene: Msed_0806: Vitamin B12 ABC transporter, permease component BtuC	* Sulfolobus tokodaii str. 7 Site: position = -85 score = 5.71788 sequence = TATGGATAAGTCATCCATA Site: position = -22 score = 4.94422 sequence = TATGGTTAAGTTATCCTAA Gene: ST0841: Vitamin B12 ABC transporter, permease component BtuC	Sulfolobus solfataricus P2 Gene: SSO0486: Vitamin B12 ABC transporter, permease component BtuC	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_1192: Vitamin B12 ABC transporter, permease component BtuC	* Sulfolobus acidocaldarius DSM 639 Site: position = -24 score = 6.16447 sequence = TATGGATAAGCTATCCACA Gene: Saci_1221: Vitamin B12 ABC transporter, permease component BtuC	Vitamin B12 ABC transporter, permease component BtuC
btuD	Metallosphaera sedula DSM 5348 Gene: Msed_0805: Vitamin B12 ABC transporter, ATPase component BtuD	Sulfolobus tokodaii str. 7 Gene: ST0842: Vitamin B12 ABC transporter, ATPase component BtuD	Sulfolobus solfataricus P2 Gene: SSO0487: Vitamin B12 ABC transporter, ATPase component BtuD	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_1193: Vitamin B12 ABC transporter, ATPase component BtuD	Sulfolobus acidocaldarius DSM 639 Gene: Saci_1222: Vitamin B12 ABC transporter, ATPase component BtuD	Vitamin B12 ABC transporter, ATPase component BtuD

CRON 2.
cobN	* Metallosphaera sedula DSM 5348 Site: position = -20 score = 5.81713 sequence = TATGGATAGGCTAACCAGG Gene: Msed_2089: CobN component of cobalt chelatase involved in B12 biosynthesis	Sulfolobus tokodaii str. 7	Sulfolobus solfataricus P2	Sulfolobus islandicus Y.N.15.51	Sulfolobus acidocaldarius DSM 639	CobN component of cobalt chelatase involved in B12 biosynthesis
chlID	Metallosphaera sedula DSM 5348 Gene: Msed_2088: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis	Sulfolobus tokodaii str. 7	Sulfolobus solfataricus P2	Sulfolobus islandicus Y.N.15.51	Sulfolobus acidocaldarius DSM 639	ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis

CRON 3.
hoxN	* Metallosphaera sedula DSM 5348 Site: position = -23 score = 6.42953 sequence = TATGGATAGCCTATCCAAC Gene: Msed_1305: HoxN/HupN/NixA family cobalt transporter	* Sulfolobus tokodaii str. 7 Site: position = 20 score = 6.06065 sequence = TATGGATAACTTATCCAAA Site: position = 49 score = 5.79414 sequence = TGTGGATAACTTATCCAAA Gene: ST2443: HoxN/HupN/NixA family cobalt transporter	* Sulfolobus solfataricus P2 Site: position = 29 score = 6.09849 sequence = GATGGATAGACAATCCATA Gene: SSO1018: HoxN/HupN/NixA family cobalt transporter	* Sulfolobus islandicus Y.N.15.51 Site: position = 2 score = 6.09849 sequence = GATGGATAGACAATCCATA Gene: YN1551_1651: HoxN/HupN/NixA family cobalt transporter	* Sulfolobus acidocaldarius DSM 639 Site: position = -23 score = 6.31821 sequence = ATTGGATAGGCTATCCATA Gene: Saci_2028: HoxN/HupN/NixA family cobalt transporter	HoxN/HupN/NixA family cobalt transporter

CRON 4.
potE	* Metallosphaera sedula DSM 5348 Site: position = -1 score = 6.19342 sequence = TATGGCTAGCCTATCCAAA Gene: Msed_0588: Amino acid permease related protein	* Sulfolobus tokodaii str. 7 Site: position = 5 score = 5.71588 sequence = TATGGATAACTTATCCAAG Gene: ST2455: Amino acid permease related protein	Sulfolobus solfataricus P2	Sulfolobus islandicus Y.N.15.51	Sulfolobus acidocaldarius DSM 639	Amino acid permease related protein

CRON 5.
cbiC	Metallosphaera sedula DSM 5348	* Sulfolobus tokodaii str. 7 Site: position = -22 score = 5.94788 sequence = TTTGGATAAGCTATCCAAT Gene: ST1824: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	* Sulfolobus solfataricus P2 Site: position = -1 score = 5.65151 sequence = TGTGGATAGACAATCCAAT Gene: SSO2308: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	* Sulfolobus islandicus Y.N.15.51 Site: position = -1 score = 5.65151 sequence = TGTGGATAGACAATCCAAT Gene: YN1551_0113: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	* Sulfolobus acidocaldarius DSM 639 Site: position = -1 score = 5.90954 sequence = TTTGGATACCCTATCCATC Gene: Saci_0399: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiH	Metallosphaera sedula DSM 5348 Gene: Msed_2092: Cobalt-precorrin-3b C17-methyltransferase	Sulfolobus tokodaii str. 7 Gene: ST1823: Cobalt-precorrin-3b C17-methyltransferase	Sulfolobus solfataricus P2 Gene: SSO2306: Cobalt-precorrin-3b C17-methyltransferase	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0112: Cobalt-precorrin-3b C17-methyltransferase	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0398: Cobalt-precorrin-3b C17-methyltransferase	Cobalt-precorrin-3b C17-methyltransferase
cbiD	Metallosphaera sedula DSM 5348	Sulfolobus tokodaii str. 7 Gene: ST1821: Cobalt-precorrin-6 synthase, anaerobic	Sulfolobus solfataricus P2 Gene: SSO2305: Cobalt-precorrin-6 synthase, anaerobic	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0111: Cobalt-precorrin-6 synthase, anaerobic	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0397: Cobalt-precorrin-6 synthase, anaerobic	Cobalt-precorrin-6 synthase, anaerobic
cbiT	Metallosphaera sedula DSM 5348 Gene: Msed_2108: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Sulfolobus tokodaii str. 7 Gene: ST1819: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Sulfolobus solfataricus P2 Gene: SSO2303: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0110: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0396: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)	Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
cbiL	Metallosphaera sedula DSM 5348 Gene: Msed_0693: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Sulfolobus tokodaii str. 7 Gene: ST1817: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Sulfolobus solfataricus P2 Gene: SSO2301: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0109: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0395: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiF	Metallosphaera sedula DSM 5348 Gene: Msed_0694: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Sulfolobus tokodaii str. 7 Gene: ST1816: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Sulfolobus solfataricus P2 Gene: SSO2299: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0108: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0394: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)	Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
cbiG	Metallosphaera sedula DSM 5348 Gene: Msed_2091: Cobalamin biosynthesis protein CbiG	Sulfolobus tokodaii str. 7 Gene: ST1826: Cobalamin biosynthesis protein CbiG	2 Sulfolobus solfataricus P2 Gene: SSO2297: Cobalamin biosynthesis protein CbiG Gene: SSO0129: Cobalamin biosynthesis protein CbiG	2 Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0798: Cobalamin biosynthesis protein CbiG Gene: YN1551_0107: Cobalamin biosynthesis protein CbiG	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0401: Cobalamin biosynthesis protein CbiG	Cobalamin biosynthesis protein CbiG
cbiE	Metallosphaera sedula DSM 5348	Sulfolobus tokodaii str. 7 Gene: ST1825: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Sulfolobus solfataricus P2 Gene: SSO2296: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Sulfolobus islandicus Y.N.15.51 Gene: YN1551_0106: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Sulfolobus acidocaldarius DSM 639 Gene: Saci_0400: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
Msed_2090	* Metallosphaera sedula DSM 5348 Site: position = -119 score = 5.81713 sequence = CCTGGTTAGCCTATCCATA Gene: Msed_2090: Signal peptidase, type IV - prepilin/preflagellin	Sulfolobus tokodaii str. 7 Gene: ST2258: Signal peptidase, type IV - prepilin/preflagellin	Sulfolobus solfataricus P2 Gene: SSO0131: Signal peptidase, type IV - prepilin/preflagellin	Sulfolobus islandicus Y.N.15.51	Sulfolobus acidocaldarius DSM 639	Signal peptidase, type IV - prepilin/preflagellin

CRON 6.
bluB	* Metallosphaera sedula DSM 5348 Site: position = -18 score = 5.71385 sequence = CCTGGATACTCTATCCATA Gene: Msed_1226: Cob(II)yrinic acid a,c-diamide reductase	* Sulfolobus tokodaii str. 7 Site: position = -1 score = 6.08621 sequence = TATGGATAACCTATCCATG Gene: ST0601: Cob(II)yrinic acid a,c-diamide reductase	* Sulfolobus solfataricus P2 Site: position = -22 score = 6.398 sequence = GCTGGATAGCCTATCCATA Gene: SSO2560: Cob(II)yrinic acid a,c-diamide reductase	* Sulfolobus islandicus Y.N.15.51 Site: position = -22 score = 6.5786 sequence = TCTGGATAGTCTATCCATA Gene: YN1551_3111: Cob(II)yrinic acid a,c-diamide reductase	* Sulfolobus acidocaldarius DSM 639 Site: position = -18 score = 6.14469 sequence = GATGGATAATCTATCCATA Gene: Saci_0250: Cob(II)yrinic acid a,c-diamide reductase	Cob(II)yrinic acid a,c-diamide reductase

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CblR - Sulfolobales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --