Regulog HisR - Thermoanaerobacterales

Properties
Regulator type:	Transcription factor
Regulator family:	TrpR
Regulation mode:	repressor
Biological process:	Histidine biosynthesis
Effector:	Histidine
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 8 sites [see more]

Member of regulog collections

By taxonomy - Thermoanaerobacterales
By trascription factor - HisR
By TF family - TrpR
By effector - Histidine
By pathway - Histidine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Anaerocellum thermophilum DSM 6725	9	1
Caldicellulosiruptor saccharolyticus DSM 8903	9	1
Carboxydothermus hydrogenoformans Z-2901	10	2
Moorella thermoacetica ATCC 39073	8	1
Thermoanaerobacter ethanolicus X514	9	1
Thermoanaerobacter italicus Ab9	9	1
Thermoanaerobacter tengcongensis MB4	9	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
hisZ	* Anaerocellum thermophilum DSM 6725 Site: position = -36 score = 5.80169 sequence = CACTTCATTATGATAAAGTA Gene: Athe_1480: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Caldicellulosiruptor saccharolyticus DSM 8903 Site: position = -37 score = 5.56306 sequence = CACTTCATCATGATAAAGCA Gene: Csac_2027: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1083: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Moorella thermoacetica ATCC 39073 Site: position = -32 score = 5.39704 sequence = TACGTTAACATAGTAAAGTA Gene: Moth_2037: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Thermoanaerobacter ethanolicus X514 Site: position = -45 score = 5.32759 sequence = TACTTTATCACGTTACAAAG Gene: Teth514_0999: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Thermoanaerobacter italicus Ab9 Site: position = -45 score = 5.32759 sequence = TACTTTATCACGTTACAAAG Gene: Thit_1821: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Thermoanaerobacter tengcongensis MB4 Site: position = -43 score = 5.32759 sequence = TACTTTATCACGTTACAAAG Gene: TTE2140: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)
hisG	Anaerocellum thermophilum DSM 6725 Gene: Athe_1479: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2026: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	* Carboxydothermus hydrogenoformans Z-2901 Site: position = -31 score = 5.65222 sequence = CACTTTAACAAAATAAAGTG Gene: CHY_1084: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Moorella thermoacetica ATCC 39073 Gene: Moth_2036: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1000: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Thermoanaerobacter italicus Ab9 Gene: Thit_1820: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2139: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)
hisD	Anaerocellum thermophilum DSM 6725 Gene: Athe_1478: Histidinol dehydrogenase (EC 1.1.1.23)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2025: Histidinol dehydrogenase (EC 1.1.1.23)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1085: Histidinol dehydrogenase (EC 1.1.1.23)	Moorella thermoacetica ATCC 39073 Gene: Moth_2035: Histidinol dehydrogenase (EC 1.1.1.23)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1001: Histidinol dehydrogenase (EC 1.1.1.23)	Thermoanaerobacter italicus Ab9 Gene: Thit_1819: Histidinol dehydrogenase (EC 1.1.1.23)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2138: Histidinol dehydrogenase (EC 1.1.1.23)	Histidinol dehydrogenase (EC 1.1.1.23)
hisC	Anaerocellum thermophilum DSM 6725 Gene: Athe_1477: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2024: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1086: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Moorella thermoacetica ATCC 39073	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1002: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Thermoanaerobacter italicus Ab9 Gene: Thit_1818: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2137: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisB	Anaerocellum thermophilum DSM 6725 Gene: Athe_1476: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2023: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1087: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Moorella thermoacetica ATCC 39073 Gene: Moth_2034: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1003: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Thermoanaerobacter italicus Ab9 Gene: Thit_1817: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2136: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
hisH	Anaerocellum thermophilum DSM 6725 Gene: Athe_1475: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2022: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1088: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Moorella thermoacetica ATCC 39073 Gene: Moth_2033: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1004: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Thermoanaerobacter italicus Ab9 Gene: Thit_1816: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2135: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisA	Anaerocellum thermophilum DSM 6725 Gene: Athe_1474: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2021: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1089: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Moorella thermoacetica ATCC 39073 Gene: Moth_2032: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1005: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Thermoanaerobacter italicus Ab9 Gene: Thit_1815: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2134: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisF	Anaerocellum thermophilum DSM 6725 Gene: Athe_1473: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2020: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1090: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Moorella thermoacetica ATCC 39073 Gene: Moth_2031: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1006: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Thermoanaerobacter italicus Ab9 Gene: Thit_1814: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2133: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
hisIE	Anaerocellum thermophilum DSM 6725 Gene: Athe_1472: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2019: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_1091: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Moorella thermoacetica ATCC 39073 Gene: Moth_2030: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1007: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Thermoanaerobacter italicus Ab9 Gene: Thit_1813: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Thermoanaerobacter tengcongensis MB4 Gene: TTE2132: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
hisR	Anaerocellum thermophilum DSM 6725 Gene: Athe_1764: Predicted histidine repressor, TrpR family	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2311: Predicted histidine repressor, TrpR family	* Carboxydothermus hydrogenoformans Z-2901 Site: position = -50 score = 5.49378 sequence = TATTTTAGTATATTAAAGTA Gene: CHY_1082: Predicted histidine repressor, TrpR family	Moorella thermoacetica ATCC 39073 Gene: Moth_2038: Predicted histidine repressor, TrpR family	Thermoanaerobacter ethanolicus X514 Gene: Teth514_0536: Predicted histidine repressor, TrpR family	Thermoanaerobacter italicus Ab9 Gene: Thit_0588: Predicted histidine repressor, TrpR family	Thermoanaerobacter tengcongensis MB4 Gene: TTE0603: Predicted histidine repressor, TrpR family	Predicted histidine repressor, TrpR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HisR - Thermoanaerobacterales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --