Regulog IolR - Frankineae/Propionibacterineae/Pseudonocardiaceae

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:
Biological process:	Inositol utilization
Effector:
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 30 sites [see more]

Member of regulog collections

By taxonomy - Frankineae/Propionibacterineae/Pseudonocardiaceae
By TF family - GntR/Others
By pathway - Inositol utilization

Statistics of regulated genes
Genome	Genes	Operons
Actinosynnema mirum DSM 43827
Saccharomonospora viridis DSM 43017
Saccharopolyspora erythraea NRRL 2338	19	7
Acidothermus cellulolyticus 11B	18	4
Frankia sp. CcI3
Frankia sp. EAN1pec
Nakamurella multipartita DSM 44233	15	7
Nocardioides sp. JS614
Propionibacterium acnes KPA171202	13	8

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes										Function

CRON 1.
iolG4	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -74 score = 4.85802 sequence = AGTTTGTCTTGACAAGTG Gene: Namu_1848: Inositol 2-dehydrogenase	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Inositol 2-dehydrogenase

CRON 2.
iolY	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -60 score = 4.6402 sequence = ATGATGTCAGGACATTTG Gene: Namu_5196: Inositol 2-dehydrogenase	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Inositol 2-dehydrogenase

CRON 3.
iolR2	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -121 score = 5.31475 sequence = AGCTTGTCCTGACAAAGT Gene: Namu_3354: Transcriptional regulator for inositol utilization, LacI family	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Transcriptional regulator for inositol utilization, LacI family

CRON 4.
iolR	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	* Saccharopolyspora erythraea NRRL 2338 Site: position = -97 score = 3.81628 sequence = AATACGTTCTGTCAAAGT Gene: SACE_4660: Inositol utilization transcriptional regulator, GntR family	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -159 score = 4.2298 sequence = CATATGTCAATACAATTG Gene: PPA0455: Inositol utilization transcriptional regulator, GntR family	Inositol utilization transcriptional regulator, GntR family

CRON 5.
tal	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614 Gene: Noca_1175: Transaldolase (EC 2.2.1.2)	* Propionibacterium acnes KPA171202 Site: position = -87 score = 4.40722 sequence = TATTTGACAGGACAAATT Gene: PPA0454: Transaldolase (EC 2.2.1.2)	Transaldolase (EC 2.2.1.2)

CRON 6.
iolR3	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	* Saccharopolyspora erythraea NRRL 2338 Site: position = -119 score = 5.42223 sequence = AGTTTGTCCGGACATGCT Gene: SACE_5191: Inositol utilization transcriptional regulator, GntR family	* Acidothermus cellulolyticus 11B Site: position = -99 score = 4.71605 sequence = ATTTTGTAAAGACATTCT Gene: Acel_1804: Inositol utilization transcriptional regulator, GntR family	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -79 score = 4.20949 sequence = ACTTTGATAGGACATATA Gene: Namu_4543: Inositol utilization transcriptional regulator, GntR family	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Inositol utilization transcriptional regulator, GntR family

CRON 7.
iolG	Actinosynnema mirum DSM 43827 Gene: Amir_6853: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Saccharomonospora viridis DSM 43017	2 Saccharopolyspora erythraea NRRL 2338 Gene: SACE_4657: Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Gene: SACE_5193: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	2 Acidothermus cellulolyticus 11B* Gene: Acel_1809: Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Site: position = -87 score = 3.77544 sequence = ACAAAGTCTTGACATGGC Site: position = -98 score = 4.22231 sequence = AAGATGTTATTACAAAGT Gene: Acel_1805: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4534: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Nocardioides sp. JS614	2 Propionibacterium acnes KPA171202* Site: position = -57 score = 4.07375 sequence = TATATGTCCTGTCAAATA Site: position = 7 score = 4.07533 sequence = GCTTTGTGCTAACATTAG Gene: PPA0469: Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Site: position = -65 score = 4.46119 sequence = TTTTTGACAGGACAAATG Gene: PPA0466: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
iolTA	Actinosynnema mirum DSM 43827 Gene: Amir_6851: Inositol ABC transport system sugar-binding protein	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B Gene: Acel_1806: Inositol ABC transport system sugar-binding protein	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -348 score = 5.08361 sequence = AGAATGTCAGAACAAAGT Gene: Namu_4537: Inositol ABC transport system sugar-binding protein	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Inositol ABC transport system sugar-binding protein
iolTB	Actinosynnema mirum DSM 43827 Gene: Amir_6850: Inositol ABC transport system permease protein	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B Gene: Acel_1807: Inositol ABC transport system permease protein	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4536: Inositol ABC transport system permease protein	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Inositol ABC transport system permease protein
iolTC	Actinosynnema mirum DSM 43827 Gene: Amir_6849: Inositol ABC transport system ATP-binding protein	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B Gene: Acel_1808: Inositol ABC transport system ATP-binding protein	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4535: Inositol ABC transport system ATP-binding protein	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Inositol ABC transport system ATP-binding protein
iolH	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	2 Saccharopolyspora erythraea NRRL 2338 Gene: SACE_2905: putative sugar-phosphate epimerase/isomerase IolH Gene: SACE_4656: putative sugar-phosphate epimerase/isomerase IolH	Acidothermus cellulolyticus 11B Gene: Acel_1810: putative sugar-phosphate epimerase/isomerase IolH	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	putative sugar-phosphate epimerase/isomerase IolH
iolG3	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	* Saccharopolyspora erythraea NRRL 2338 Site: position = -200 score = 4.91509 sequence = GCTATGTCTTGACATACG Gene: SACE_2908: Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)	Acidothermus cellulolyticus 11B Gene: Acel_1811: Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -100 score = 4.52279 sequence = TCCTTGACAGGACAAACT Gene: PPA0463: Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)	Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)
iolE	Actinosynnema mirum DSM 43827 Gene: Amir_6852: Inosose dehydratase (EC 4.2.1.44)	Saccharomonospora viridis DSM 43017	3 Saccharopolyspora erythraea NRRL 2338* Gene: SACE_2907: Inosose dehydratase (EC 4.2.1.44) Site: position = -124 score = 3.81628 sequence = ACTTTGACAGAACGTATT Gene: SACE_4659: Inosose dehydratase (EC 4.2.1.44) Site: position = -164 score = 4.91037 sequence = AGTATGTCAGGACCAAGT Gene: SACE_5192: Inosose dehydratase (EC 4.2.1.44)	2 Acidothermus cellulolyticus 11B* Gene: Acel_1812: Inosose dehydratase (EC 4.2.1.44) Site: position = -27 score = 4.21339 sequence = ATATTGTCAGGTCTAACT Gene: Acel_1816: Inosose dehydratase (EC 4.2.1.44)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_3352: Inosose dehydratase (EC 4.2.1.44)	Nocardioides sp. JS614	2 Propionibacterium acnes KPA171202* Site: position = -77 score = 4.07375 sequence = TATTTGACAGGACATATA Site: position = -141 score = 4.07533 sequence = CTAATGTTAGCACAAAGC Gene: PPA0468: Inosose dehydratase (EC 4.2.1.44) Gene: PPA0464: Inosose dehydratase (EC 4.2.1.44)	Inosose dehydratase (EC 4.2.1.44)
SACE_2906	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_2906: hypothetical protein	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	hypothetical protein
iolT	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	2 Saccharopolyspora erythraea NRRL 2338 Gene: SACE_2904: Myo-inositol transporter, MFS family Gene: SACE_4658: Myo-inositol transporter, MFS family	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Myo-inositol transporter, MFS family
iolC	Actinosynnema mirum DSM 43827 Gene: Amir_6848: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Saccharomonospora viridis DSM 43017	* Saccharopolyspora erythraea NRRL 2338 Site: position = -90 score = 5.42223 sequence = AGCATGTCCGGACAAACT Gene: SACE_5189: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	* Acidothermus cellulolyticus 11B Site: position = -83 score = 4.71605 sequence = AGAATGTCTTTACAAAAT Gene: Acel_1803: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -143 score = 4.20949 sequence = TATATGTCCTATCAAAGT Gene: Namu_4542: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -73 score = 4.2298 sequence = CAATTGTATTGACATATG Gene: PPA0456: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	5-keto-2-deoxygluconokinase (EC 2.7.1.92)
iolJ	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_5188: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Acidothermus cellulolyticus 11B Gene: Acel_1802: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4541: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Nocardioides sp. JS614	Propionibacterium acnes KPA171202 Gene: PPA0457: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
iolB	Actinosynnema mirum DSM 43827 Gene: Amir_6847: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_5187: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Acidothermus cellulolyticus 11B Gene: Acel_1801: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4540: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Nocardioides sp. JS614	Propionibacterium acnes KPA171202 Gene: PPA0458: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	5-deoxy-glucuronate isomerase (EC 5.3.1.-)
iolD	Actinosynnema mirum DSM 43827 Gene: Amir_6846: Epi-inositol hydrolase (EC 3.7.1.-)	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_5186: Epi-inositol hydrolase (EC 3.7.1.-)	Acidothermus cellulolyticus 11B Gene: Acel_1800: Epi-inositol hydrolase (EC 3.7.1.-)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4539: Epi-inositol hydrolase (EC 3.7.1.-)	Nocardioides sp. JS614	Propionibacterium acnes KPA171202 Gene: PPA0459: Epi-inositol hydrolase (EC 3.7.1.-)	Epi-inositol hydrolase (EC 3.7.1.-)
iolA	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_5185: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Acidothermus cellulolyticus 11B Gene: Acel_1799: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233 Gene: Namu_4538: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -101 score = 4.26004 sequence = TATTTGTTAGTACAAATT Site: position = -253 score = 3.79356 sequence = AACATGTTAGCACAATTG Gene: PPA0461: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
Acel_1815	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B Gene: Acel_1815: Oxidoreductase, short chain dehydrogenase/reductase family	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Oxidoreductase, short chain dehydrogenase/reductase family
iolG2	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B Gene: Acel_1814: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Frankia sp. CcI3	Frankia sp. EAN1pec	* Nakamurella multipartita DSM 44233 Site: position = -57 score = 5.31475 sequence = ACTTTGTCAGGACAAGCT Gene: Namu_3353: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
Acel_1813	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B Gene: Acel_1813: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
iolR1	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202 Gene: PPA0462: Inositol utilization transcriptional regulator, GntR family	Inositol utilization transcriptional regulator, GntR family

CRON 8.
yadN	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	* Saccharopolyspora erythraea NRRL 2338 Site: position = -113 score = 4.66865 sequence = CTAATGTACGGACATATT Gene: SACE_4661: Probable tautomerase (EC 5.3.2.-)	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Probable tautomerase (EC 5.3.2.-)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog IolR - Frankineae/Propionibacterineae/Pseudonocardiaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --