Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog LtbR - Corynebacteriaceae

Properties
Regulator type: Transcription factor
Regulator family: IclR
Regulation mode: repressor
Biological process: Tryptophan biosynthesis; Leucine biosynthesis
Effector:
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 52 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Corynebacterium amycolatum SK46 3 2
Corynebacterium aurimucosum ATCC 700975 5 5
Corynebacterium diphtheriae NCTC 13129 6 5
Corynebacterium efficiens YS-314 11 5
Corynebacterium glutamicum ATCC 13032 6 5
Corynebacterium jeikeium K411 5 4
Corynebacterium kroppenstedtii DSM 44385 3 3
Corynebacterium urealyticum DSM 7109 5 4
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
leuC
*
Corynebacterium amycolatum SK46

Site:
position = -52
score = 4.77639
sequence = CATCTCATTCCTTGAGATA

Site:
position = -73
score = 4.12965
sequence = TGTCCCATGTCATGATATT

Gene: CORAM0001_0736: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
*
Corynebacterium aurimucosum ATCC 700975

Site:
position = -35
score = 5.00319
sequence = CGTCCCATTAATTGAGATT

Site:
position = -56
score = 4.17871
sequence = TCTCCCATATAATGAAATC

Gene: cauri_1155: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
*
Corynebacterium diphtheriae NCTC 13129

Site:
position = -75
score = 4.54804
sequence = CATTCCATTGCGCGGGATT

Gene: DIP1127: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
*
Corynebacterium efficiens YS-314

Site:
position = -170
score = 4.31147
sequence = TATCCCATGAAGCGAAACG

Site:
position = -149
score = 4.703
sequence = TGTCCCAAAGAGTGGGATT

Gene: CE1427: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
*
Corynebacterium glutamicum ATCC 13032

Site:
position = -167
score = 4.93457
sequence = CATTTCACCCAATGAGACG

Site:
position = -47
score = 5.3143
sequence = AATCTCATATAGTGAGATT

Gene: cg1487: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
*
Corynebacterium jeikeium K411

Site:
position = -44
score = 4.85536
sequence = CATTCCATCCAGTGGAACT

Site:
position = -66
score = 3.94585
sequence = TGTCCCATGATTTGATACT

Gene: jk1221: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
 
Corynebacterium kroppenstedtii DSM 44385

Gene: ckrop_1211: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
*
Corynebacterium urealyticum DSM 7109

Site:
position = -99
score = 4.03001
sequence = TATCCCATGATTTGATACT

Site:
position = -77
score = 4.8289
sequence = CATTCCATCAAGTGGAACT

Gene: cur_0774: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33)
leuD
 
Corynebacterium amycolatum SK46

Gene: CORAM0001_0737: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_1156: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium diphtheriae NCTC 13129

Gene: DIP1128: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium efficiens YS-314

Gene: CE1428: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg1488: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium jeikeium K411

Gene: jk1220: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium kroppenstedtii DSM 44385

Gene: ckrop_1210: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
Corynebacterium urealyticum DSM 7109

Gene: cur_0775: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33)
 
CRON 2.
leuB
 
Corynebacterium amycolatum SK46

Gene: CORAM0001_0706: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium aurimucosum ATCC 700975

Site:
position = -11
score = 5.13285
sequence = AATCCCACAAAATGAAACT

Gene: cauri_1136: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium diphtheriae NCTC 13129

Site:
position = -33
score = 4.01606
sequence = AAGTTCACATAGTGGGAAG

Site:
position = -11
score = 4.67079
sequence = GGTTCCATAATATGAAACT

Gene: DIP1105: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium efficiens YS-314

Site:
position = 13
score = 4.71379
sequence = AATCCCGCAAAATGAAACT

Gene: CE1383: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium glutamicum ATCC 13032

Site:
position = -11
score = 4.92135
sequence = AATCCCACAACATGAAACT

Site:
position = -32
score = 4.07253
sequence = AAGTCCATATAGTGAGAAG

Gene: cg1453: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium jeikeium K411

Site:
position = -11
score = 4.41554
sequence = GAGTTCATACAGTGAAACT

Gene: jk1288: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium kroppenstedtii DSM 44385

Site:
position = -11
score = 4.42
sequence = TATCTCAGGATATGAAACT

Gene: ckrop_1234: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
*
Corynebacterium urealyticum DSM 7109

Site:
position = -11
score = 4.38784
sequence = GGGTTCATTCTATGAAACT

Gene: cur_0764: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
3-isopropylmalate dehydrogenase (EC 1.1.1.85)
 
CRON 3.
ltbR
*
Corynebacterium amycolatum SK46

Site:
position = -32
score = 4.77639
sequence = TATCTCAAGGAATGAGATG

Site:
position = -11
score = 4.12965
sequence = AATATCATGACATGGGACA

Gene: CORAM0001_0735: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_1154: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
*
Corynebacterium diphtheriae NCTC 13129

Site:
position = -33
score = 4.54804
sequence = AATCCCGCGCAATGGAATG

Gene: DIP1126: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
*
Corynebacterium efficiens YS-314

Site:
position = -189
score = 4.703
sequence = AATCCCACTCTTTGGGACA

Site:
position = -168
score = 4.31147
sequence = CGTTTCGCTTCATGGGATA

Site:
position = -32
score = 4.27796
sequence = TGTCCCACACAGTGGACTG

Gene: CE1426: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
*
Corynebacterium glutamicum ATCC 13032

Site:
position = -152
score = 5.3143
sequence = AATCTCACTATATGAGATT

Site:
position = -32
score = 4.93457
sequence = CGTCTCATTGGGTGAAATG

Site:
position = -11
score = 3.93356
sequence = AAATTCAAGGTATGGGACA

Gene: cg1486: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
*
Corynebacterium jeikeium K411

Site:
position = -33
score = 4.85536
sequence = AGTTCCACTGGATGGAATG

Site:
position = -11
score = 3.94585
sequence = AGTATCAAATCATGGGACA

Gene: jk1222: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
 
Corynebacterium kroppenstedtii DSM 44385

Gene: ckrop_1212: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
*
Corynebacterium urealyticum DSM 7109

Site:
position = -33
score = 4.8289
sequence = AGTTCCACTTGATGGAATG

Site:
position = -11
score = 4.03001
sequence = AGTATCAAATCATGGGATA

Gene: cur_0773: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family
 
CRON 4.
ilvC
 
Corynebacterium amycolatum SK46

Gene: CORAM0001_0699: Ketol-acid reductoisomerase (EC 1.1.1.86)
*
Corynebacterium aurimucosum ATCC 700975

Site:
position = -88
score = 3.94694
sequence = CGTCCCAAAGTGTGATACA

Gene: cauri_1132: Ketol-acid reductoisomerase (EC 1.1.1.86)
*
Corynebacterium diphtheriae NCTC 13129

Site:
position = -90
score = 5.09578
sequence = CGTCTCATTTAATGAGATA

Site:
position = -59
score = 4.14328
sequence = TATCTCAATATGTGATATA

Gene: DIP1100: Ketol-acid reductoisomerase (EC 1.1.1.86)
 
Corynebacterium efficiens YS-314

Gene: CE1367: Ketol-acid reductoisomerase (EC 1.1.1.86)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg1437: Ketol-acid reductoisomerase (EC 1.1.1.86)
*
Corynebacterium jeikeium K411

Site:
position = -62
score = 4.9722
sequence = AATCTCACCAAATGAAATA

Gene: jk1298: Ketol-acid reductoisomerase (EC 1.1.1.86)
*
Corynebacterium kroppenstedtii DSM 44385

Site:
position = -56
score = 4.48028
sequence = AATCTCACCCTATGATATG

Gene: ckrop_1237: Ketol-acid reductoisomerase (EC 1.1.1.86)
*
Corynebacterium urealyticum DSM 7109

Site:
position = -93
score = 5.00688
sequence = CATCTCAAAGAGTGAAATT

Gene: cur_0755: Ketol-acid reductoisomerase (EC 1.1.1.86)
Ketol-acid reductoisomerase (EC 1.1.1.86)
 
CRON 5.
cg1658
 
Corynebacterium amycolatum SK46
*
Corynebacterium aurimucosum ATCC 700975

Site:
position = -99
score = 4.11102
sequence = TTTTTCACCCATTGAGACT

Site:
position = -78
score = 4.83839
sequence = CATTTCATTACGTGGGACG

Gene: cauri_1287: Putative leucine permease
 
Corynebacterium diphtheriae NCTC 13129
*
Corynebacterium efficiens YS-314

Site:
position = -128
score = 4.45557
sequence = CTTCCCATTAAATGGGATA

Site:
position = -98
score = 4.89002
sequence = CGTTTCATATCATGGGATT

Gene: CE1595: Putative leucine permease
*
Corynebacterium glutamicum ATCC 13032

Site:
position = -122
score = 4.72633
sequence = AATCTCAATATATGAAACC

Site:
position = -92
score = 5.23973
sequence = CATCTCATTGTATGGGATT

Gene: cg1658: Putative leucine permease
 
Corynebacterium jeikeium K411
*
Corynebacterium kroppenstedtii DSM 44385

Site:
position = -199
score = 5.18932
sequence = AATTCCATTATATGAGACT

Gene: ckrop_0883: Putative leucine permease
 
Corynebacterium urealyticum DSM 7109
Putative leucine permease
 
CRON 6.
leuA
 
Corynebacterium amycolatum SK46
*
Corynebacterium aurimucosum ATCC 700975

Site:
position = -268
score = 4.51236
sequence = CGTCCCAATATGTGAAATC

Gene: cauri_0182: 2-isopropylmalate synthase
*
Corynebacterium diphtheriae NCTC 13129

Site:
position = -296
score = 4.61538
sequence = TGTTCCACATAGTGGGATA

Gene: DIP0266: 2-isopropylmalate synthase
 
Corynebacterium efficiens YS-314

Gene: CE0216: 2-isopropylmalate synthase
 
Corynebacterium glutamicum ATCC 13032

Gene: cg0303: 2-isopropylmalate synthase
 
Corynebacterium jeikeium K411

Gene: jk2002: 2-isopropylmalate synthase
 
Corynebacterium kroppenstedtii DSM 44385

Gene: ckrop_0180: 2-isopropylmalate synthase
 
Corynebacterium urealyticum DSM 7109

Gene: cur_1901: 2-isopropylmalate synthase
2-isopropylmalate synthase
 
CRON 7.
trpE
 
Corynebacterium amycolatum SK46
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_2507: Anthranilate synthase, aminase component (EC 4.1.3.27)
 
Corynebacterium diphtheriae NCTC 13129

Gene: DIP2352: Anthranilate synthase, aminase component (EC 4.1.3.27)
*
Corynebacterium efficiens YS-314

Site:
position = -16
score = 3.30622
sequence = AAGCCCCATTAATGAGTTG

Gene: CE2868: Anthranilate synthase, aminase component (EC 4.1.3.27)
*
Corynebacterium glutamicum ATCC 13032

Site:
position = -263
score = 3.6957
sequence = AGTCCCATTTTGTGAATAA

Gene: cg3359: Anthranilate synthase, aminase component (EC 4.1.3.27)
 
Corynebacterium jeikeium K411
 
Corynebacterium kroppenstedtii DSM 44385
 
Corynebacterium urealyticum DSM 7109
Anthranilate synthase, aminase component (EC 4.1.3.27)
trpG
 
Corynebacterium amycolatum SK46
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_2508: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)
 
Corynebacterium diphtheriae NCTC 13129

Gene: DIP2353: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)
 
Corynebacterium efficiens YS-314

Gene: CE2869: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg3360: Anthranilate synthase, amidotransferase component (EC 4.1.3.27)
 
Corynebacterium jeikeium K411
 
Corynebacterium kroppenstedtii DSM 44385
 
Corynebacterium urealyticum DSM 7109
Anthranilate synthase, amidotransferase component (EC 4.1.3.27)
trpD
 
Corynebacterium amycolatum SK46
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_2509: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)
 
Corynebacterium diphtheriae NCTC 13129

Gene: DIP2354: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)
 
Corynebacterium efficiens YS-314

Gene: CE2870: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg3361: Anthranilate phosphoribosyltransferase (EC 2.4.2.18)
 
Corynebacterium jeikeium K411
 
Corynebacterium kroppenstedtii DSM 44385
 
Corynebacterium urealyticum DSM 7109
Anthranilate phosphoribosyltransferase (EC 2.4.2.18)
trpCF
 
Corynebacterium amycolatum SK46
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_2510: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)
 
Corynebacterium diphtheriae NCTC 13129

Gene: DIP2355: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)
 
Corynebacterium efficiens YS-314

Gene: CE2871: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg3362: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)
 
Corynebacterium jeikeium K411
 
Corynebacterium kroppenstedtii DSM 44385
 
Corynebacterium urealyticum DSM 7109
Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)
trpB
 
Corynebacterium amycolatum SK46
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_2511: Tryptophan synthase beta chain (EC 4.2.1.20)
 
Corynebacterium diphtheriae NCTC 13129

Gene: DIP2351: Tryptophan synthase beta chain (EC 4.2.1.20)
 
Corynebacterium efficiens YS-314

Gene: CE2872: Tryptophan synthase beta chain (EC 4.2.1.20)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg3363: Tryptophan synthase beta chain (EC 4.2.1.20)
 
Corynebacterium jeikeium K411
 
Corynebacterium kroppenstedtii DSM 44385
 
Corynebacterium urealyticum DSM 7109
Tryptophan synthase beta chain (EC 4.2.1.20)
trpA
 
Corynebacterium amycolatum SK46
 
Corynebacterium aurimucosum ATCC 700975

Gene: cauri_2512: Tryptophan synthase alpha chain (EC 4.2.1.20)
 
Corynebacterium diphtheriae NCTC 13129
 
Corynebacterium efficiens YS-314

Gene: CE2873: Tryptophan synthase alpha chain (EC 4.2.1.20)
 
Corynebacterium glutamicum ATCC 13032

Gene: cg3364: Tryptophan synthase alpha chain (EC 4.2.1.20)
 
Corynebacterium jeikeium K411
 
Corynebacterium kroppenstedtii DSM 44385
 
Corynebacterium urealyticum DSM 7109
Tryptophan synthase alpha chain (EC 4.2.1.20)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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