Regulog LtbR - Corynebacteriaceae
| Regulator type: | Transcription factor |
| Regulator family: | IclR |
| Regulation mode: | repressor |
| Biological process: | Tryptophan biosynthesis; Leucine biosynthesis |
| Effector: | |
| Phylum: | Actinobacteria |
| Visualization: | |
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Allows to visualize regulog content in the context of metabolic pathways |
Member of regulog collections
- By taxonomy - Corynebacteriaceae
- By trascription factor - LtbR
- By TF family - IclR
- By pathway - Tryptophan biosynthesis
- By pathway - Leucine biosynthesis
| Genome | Genes | Operons |
|---|---|---|
| Corynebacterium amycolatum SK46 | 3 | 2 |
| Corynebacterium aurimucosum ATCC 700975 | 5 | 5 |
| Corynebacterium diphtheriae NCTC 13129 | 6 | 5 |
| Corynebacterium efficiens YS-314 | 11 | 5 |
| Corynebacterium glutamicum ATCC 13032 | 6 | 5 |
| Corynebacterium jeikeium K411 | 5 | 4 |
| Corynebacterium kroppenstedtii DSM 44385 | 3 | 3 |
| Corynebacterium urealyticum DSM 7109 | 5 | 4 |
| Genes | Function | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CRON 1. | |||||||||
| leuC |
*
Corynebacterium amycolatum SK46 Site: position = -52 score = 4.77639 sequence = CATCTCATTCCTTGAGATA Site: position = -73 score = 4.12965 sequence = TGTCCCATGTCATGATATT Gene: CORAM0001_0736: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
*
Corynebacterium aurimucosum ATCC 700975 Site: position = -35 score = 5.00319 sequence = CGTCCCATTAATTGAGATT Site: position = -56 score = 4.17871 sequence = TCTCCCATATAATGAAATC Gene: cauri_1155: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
*
Corynebacterium diphtheriae NCTC 13129 Site: position = -75 score = 4.54804 sequence = CATTCCATTGCGCGGGATT Gene: DIP1127: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
*
Corynebacterium efficiens YS-314 Site: position = -170 score = 4.31147 sequence = TATCCCATGAAGCGAAACG Site: position = -149 score = 4.703 sequence = TGTCCCAAAGAGTGGGATT Gene: CE1427: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
*
Corynebacterium glutamicum ATCC 13032 Site: position = -167 score = 4.93457 sequence = CATTTCACCCAATGAGACG Site: position = -47 score = 5.3143 sequence = AATCTCATATAGTGAGATT Gene: cg1487: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
*
Corynebacterium jeikeium K411 Site: position = -44 score = 4.85536 sequence = CATTCCATCCAGTGGAACT Site: position = -66 score = 3.94585 sequence = TGTCCCATGATTTGATACT Gene: jk1221: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
Gene: ckrop_1211: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
*
Corynebacterium urealyticum DSM 7109 Site: position = -99 score = 4.03001 sequence = TATCCCATGATTTGATACT Site: position = -77 score = 4.8289 sequence = CATTCCATCAAGTGGAACT Gene: cur_0774: 3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
3-isopropylmalate dehydratase large, subunit (EC 4.2.1.33) |
| leuD |
Gene: CORAM0001_0737: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: cauri_1156: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: DIP1128: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: CE1428: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: cg1488: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: jk1220: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: ckrop_1210: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
Gene: cur_0775: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) |
| CRON 2. | |||||||||
| leuB |
Gene: CORAM0001_0706: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium aurimucosum ATCC 700975 Site: position = -11 score = 5.13285 sequence = AATCCCACAAAATGAAACT Gene: cauri_1136: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium diphtheriae NCTC 13129 Site: position = -33 score = 4.01606 sequence = AAGTTCACATAGTGGGAAG Site: position = -11 score = 4.67079 sequence = GGTTCCATAATATGAAACT Gene: DIP1105: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium efficiens YS-314 Site: position = 13 score = 4.71379 sequence = AATCCCGCAAAATGAAACT Gene: CE1383: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium glutamicum ATCC 13032 Site: position = -11 score = 4.92135 sequence = AATCCCACAACATGAAACT Site: position = -32 score = 4.07253 sequence = AAGTCCATATAGTGAGAAG Gene: cg1453: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium jeikeium K411 Site: position = -11 score = 4.41554 sequence = GAGTTCATACAGTGAAACT Gene: jk1288: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium kroppenstedtii DSM 44385 Site: position = -11 score = 4.42 sequence = TATCTCAGGATATGAAACT Gene: ckrop_1234: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
*
Corynebacterium urealyticum DSM 7109 Site: position = -11 score = 4.38784 sequence = GGGTTCATTCTATGAAACT Gene: cur_0764: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
3-isopropylmalate dehydrogenase (EC 1.1.1.85) |
| CRON 3. | |||||||||
| ltbR |
*
Corynebacterium amycolatum SK46 Site: position = -32 score = 4.77639 sequence = TATCTCAAGGAATGAGATG Site: position = -11 score = 4.12965 sequence = AATATCATGACATGGGACA Gene: CORAM0001_0735: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
Gene: cauri_1154: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
*
Corynebacterium diphtheriae NCTC 13129 Site: position = -33 score = 4.54804 sequence = AATCCCGCGCAATGGAATG Gene: DIP1126: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
*
Corynebacterium efficiens YS-314 Site: position = -189 score = 4.703 sequence = AATCCCACTCTTTGGGACA Site: position = -168 score = 4.31147 sequence = CGTTTCGCTTCATGGGATA Site: position = -32 score = 4.27796 sequence = TGTCCCACACAGTGGACTG Gene: CE1426: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
*
Corynebacterium glutamicum ATCC 13032 Site: position = -152 score = 5.3143 sequence = AATCTCACTATATGAGATT Site: position = -32 score = 4.93457 sequence = CGTCTCATTGGGTGAAATG Site: position = -11 score = 3.93356 sequence = AAATTCAAGGTATGGGACA Gene: cg1486: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
*
Corynebacterium jeikeium K411 Site: position = -33 score = 4.85536 sequence = AGTTCCACTGGATGGAATG Site: position = -11 score = 3.94585 sequence = AGTATCAAATCATGGGACA Gene: jk1222: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
Gene: ckrop_1212: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
*
Corynebacterium urealyticum DSM 7109 Site: position = -33 score = 4.8289 sequence = AGTTCCACTTGATGGAATG Site: position = -11 score = 4.03001 sequence = AGTATCAAATCATGGGATA Gene: cur_0773: Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
Leucine and tryptophan biosynthesis transcriptional regulator LtbR, IclR family |
| CRON 4. | |||||||||
| ilvC |
Gene: CORAM0001_0699: Ketol-acid reductoisomerase (EC 1.1.1.86) |
*
Corynebacterium aurimucosum ATCC 700975 Site: position = -88 score = 3.94694 sequence = CGTCCCAAAGTGTGATACA Gene: cauri_1132: Ketol-acid reductoisomerase (EC 1.1.1.86) |
*
Corynebacterium diphtheriae NCTC 13129 Site: position = -90 score = 5.09578 sequence = CGTCTCATTTAATGAGATA Site: position = -59 score = 4.14328 sequence = TATCTCAATATGTGATATA Gene: DIP1100: Ketol-acid reductoisomerase (EC 1.1.1.86) |
Gene: CE1367: Ketol-acid reductoisomerase (EC 1.1.1.86) |
Gene: cg1437: Ketol-acid reductoisomerase (EC 1.1.1.86) |
*
Corynebacterium jeikeium K411 Site: position = -62 score = 4.9722 sequence = AATCTCACCAAATGAAATA Gene: jk1298: Ketol-acid reductoisomerase (EC 1.1.1.86) |
*
Corynebacterium kroppenstedtii DSM 44385 Site: position = -56 score = 4.48028 sequence = AATCTCACCCTATGATATG Gene: ckrop_1237: Ketol-acid reductoisomerase (EC 1.1.1.86) |
*
Corynebacterium urealyticum DSM 7109 Site: position = -93 score = 5.00688 sequence = CATCTCAAAGAGTGAAATT Gene: cur_0755: Ketol-acid reductoisomerase (EC 1.1.1.86) |
Ketol-acid reductoisomerase (EC 1.1.1.86) |
| CRON 5. | |||||||||
| cg1658 |
|
*
Corynebacterium aurimucosum ATCC 700975 Site: position = -99 score = 4.11102 sequence = TTTTTCACCCATTGAGACT Site: position = -78 score = 4.83839 sequence = CATTTCATTACGTGGGACG Gene: cauri_1287: Putative leucine permease |
|
*
Corynebacterium efficiens YS-314 Site: position = -128 score = 4.45557 sequence = CTTCCCATTAAATGGGATA Site: position = -98 score = 4.89002 sequence = CGTTTCATATCATGGGATT Gene: CE1595: Putative leucine permease |
*
Corynebacterium glutamicum ATCC 13032 Site: position = -122 score = 4.72633 sequence = AATCTCAATATATGAAACC Site: position = -92 score = 5.23973 sequence = CATCTCATTGTATGGGATT Gene: cg1658: Putative leucine permease |
|
*
Corynebacterium kroppenstedtii DSM 44385 Site: position = -199 score = 5.18932 sequence = AATTCCATTATATGAGACT Gene: ckrop_0883: Putative leucine permease |
|
Putative leucine permease |
| CRON 6. | |||||||||
| leuA |
|
*
Corynebacterium aurimucosum ATCC 700975 Site: position = -268 score = 4.51236 sequence = CGTCCCAATATGTGAAATC Gene: cauri_0182: 2-isopropylmalate synthase |
*
Corynebacterium diphtheriae NCTC 13129 Site: position = -296 score = 4.61538 sequence = TGTTCCACATAGTGGGATA Gene: DIP0266: 2-isopropylmalate synthase |
Gene: CE0216: 2-isopropylmalate synthase |
Gene: cg0303: 2-isopropylmalate synthase |
Gene: jk2002: 2-isopropylmalate synthase |
Gene: ckrop_0180: 2-isopropylmalate synthase |
Gene: cur_1901: 2-isopropylmalate synthase |
2-isopropylmalate synthase |
| CRON 7. | |||||||||
| trpE |
|
Gene: cauri_2507: Anthranilate synthase, aminase component (EC 4.1.3.27) |
Gene: DIP2352: Anthranilate synthase, aminase component (EC 4.1.3.27) |
*
Corynebacterium efficiens YS-314 Site: position = -16 score = 3.30622 sequence = AAGCCCCATTAATGAGTTG Gene: CE2868: Anthranilate synthase, aminase component (EC 4.1.3.27) |
*
Corynebacterium glutamicum ATCC 13032 Site: position = -263 score = 3.6957 sequence = AGTCCCATTTTGTGAATAA Gene: cg3359: Anthranilate synthase, aminase component (EC 4.1.3.27) |
|
|
|
Anthranilate synthase, aminase component (EC 4.1.3.27) |
| trpG |
|
Gene: cauri_2508: Anthranilate synthase, amidotransferase component (EC 4.1.3.27) |
Gene: DIP2353: Anthranilate synthase, amidotransferase component (EC 4.1.3.27) |
Gene: CE2869: Anthranilate synthase, amidotransferase component (EC 4.1.3.27) |
Gene: cg3360: Anthranilate synthase, amidotransferase component (EC 4.1.3.27) |
|
|
|
Anthranilate synthase, amidotransferase component (EC 4.1.3.27) |
| trpD |
|
Gene: cauri_2509: Anthranilate phosphoribosyltransferase (EC 2.4.2.18) |
Gene: DIP2354: Anthranilate phosphoribosyltransferase (EC 2.4.2.18) |
Gene: CE2870: Anthranilate phosphoribosyltransferase (EC 2.4.2.18) |
Gene: cg3361: Anthranilate phosphoribosyltransferase (EC 2.4.2.18) |
|
|
|
Anthranilate phosphoribosyltransferase (EC 2.4.2.18) |
| trpCF |
|
Gene: cauri_2510: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |
Gene: DIP2355: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |
Gene: CE2871: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |
Gene: cg3362: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |
|
|
|
Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24) |
| trpB |
|
Gene: cauri_2511: Tryptophan synthase beta chain (EC 4.2.1.20) |
Gene: DIP2351: Tryptophan synthase beta chain (EC 4.2.1.20) |
Gene: CE2872: Tryptophan synthase beta chain (EC 4.2.1.20) |
Gene: cg3363: Tryptophan synthase beta chain (EC 4.2.1.20) |
|
|
|
Tryptophan synthase beta chain (EC 4.2.1.20) |
| trpA |
|
Gene: cauri_2512: Tryptophan synthase alpha chain (EC 4.2.1.20) |
|
Gene: CE2873: Tryptophan synthase alpha chain (EC 4.2.1.20) |
Gene: cg3364: Tryptophan synthase alpha chain (EC 4.2.1.20) |
|
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Tryptophan synthase alpha chain (EC 4.2.1.20) |
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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Regulated Genes | [ Tab delimited format ] | DOWNLOAD |
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Regulatory Sites | [ FASTA format ] | DOWNLOAD |