Regulog CadR-PbrR - Rhizobiales

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator
Biological process:	Lead resistance; Cadmium resistance
Effector:	Lead ion, (Pb2+); Cadmium, ion (Cd2+)
Phylum:	Proteobacteria/Alpha
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 19 sites [see more]

Member of regulog collections

By taxonomy - Rhizobiales
By trascription factor - CadR-PbrR
By TF family - MerR
By effector - Lead ion, (Pb2+)
By effector - Cadmium, ion (Cd2+)
By pathway - Lead resistance
By pathway - Cadmium resistance

Statistics of regulated genes
Genome	Genes	Operons
Sinorhizobium meliloti 1021	1	1
Rhizobium sp. NGR234	1	1
Rhizobium leguminosarum bv. viciae 3841	1	1
Rhizobium etli CFN 42	1	1
Agrobacterium tumefaciens str. C58 (Cereon)	4	2
Mesorhizobium sp. BNC1	7	4
Mesorhizobium loti MAFF303099	1	1
Brucella melitensis 16M	1	1
Bartonella quintana str. Toulouse
Rhodopseudomonas palustris CGA009	1	1
Bradyrhizobium japonicum USDA 110
Bradyrhizobium sp. BTAi1	1	1
Nitrobacter winogradskyi Nb-255	1	1
Azorhizobium caulinodans ORS 571	1	1
Xanthobacter autotrophicus Py2	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
cadA2	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	* Mesorhizobium sp. BNC1 Site: position = -57 score = 5.33082 sequence = ACCCTCTAGCTGCTATAGGTC Gene: Meso_4129: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)

CRON 2.
cadA	* Sinorhizobium meliloti 1021 Site: position = -54 score = 6.04897 sequence = AACCTCTAGCCGCTAGAGGAC Gene: SMc04128: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Rhizobium sp. NGR234 Site: position = -54 score = 6.01407 sequence = TAGCTCTAGTCGCTAGAGGTT Gene: NGR_c34490: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Rhizobium leguminosarum bv. viciae 3841 Site: position = -58 score = 6.30619 sequence = CACCTCTAGTCGCTAGAGGAT Gene: RL4262: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Rhizobium etli CFN 42 Site: position = -58 score = 6.30619 sequence = CACCTCTAGTCGCTAGAGGAT Gene: RHE_CH03719: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Agrobacterium tumefaciens str. C58 (Cereon) Site: position = -59 score = 5.82877 sequence = AAGCTCTAGTTGCTAGAGGTG Gene: Atu0843: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Mesorhizobium sp. BNC1 Site: position = -57 score = 6.17812 sequence = CTCCTATAGTCACTAGAGGAA Gene: Meso_2849: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Mesorhizobium loti MAFF303099 Site: position = -97 score = 6.06751 sequence = AAGCTCTAGTGACTAGAGCAA Gene: mll2475: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Brucella melitensis 16M Site: position = -63 score = 6.33603 sequence = CTCCTCTAGTTACTAGAGGAT Gene: BMEI0053: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Bartonella quintana str. Toulouse	* Rhodopseudomonas palustris CGA009 Site: position = -59 score = 4.64605 sequence = ACCCTGTAGCCGCTACAGGGT Gene: RPA3260: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Bradyrhizobium japonicum USDA 110	* Bradyrhizobium sp. BTAi1 Site: position = -46 score = 6.18954 sequence = CTCCTCTAGCGACTAGAGGAC Gene: BBta_7421: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Nitrobacter winogradskyi Nb-255 Site: position = -59 score = 5.11923 sequence = ACCCTATAGTTACTACAGGGT Gene: Nwi_3134: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Azorhizobium caulinodans ORS 571 Site: position = -55 score = 6.37302 sequence = CTCCTCTAGTGACTAGAGGAC Gene: AZC_1456: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	2 Xanthobacter autotrophicus Py2* Site: position = -28 score = 6.03519 sequence = CTCCTCTAGTGACTAGAGTAT Gene: Xaut_3978: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) Site: position = -28 score = 6.03519 sequence = CTCCTCTAGTGACTAGAGTAT Gene: Xaut_3338: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)

CRON 3.
cadR2	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	* Mesorhizobium sp. BNC1 Site: position = -34 score = 5.13025 sequence = ATGCTTTAGTCGCCAGAGGAT Gene: Meso_4426: Cadmium resistance transcriptional regulator, MerR family	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Cadmium resistance transcriptional regulator, MerR family
Meso_4425	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	Mesorhizobium sp. BNC1 Gene: Meso_4425: hypothetical protein	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	hypothetical protein
czcD	Sinorhizobium meliloti 1021 Gene: SMc04167: Co/Zn/Cd efflux protein	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841 Gene: RL1351: Co/Zn/Cd efflux protein	Rhizobium etli CFN 42 Gene: RHE_CH01219: Co/Zn/Cd efflux protein	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu0891: Co/Zn/Cd efflux protein	3 Mesorhizobium sp. BNC1 Gene: Meso_0755: Co/Zn/Cd efflux protein Gene: Meso_4214: Co/Zn/Cd efflux protein Gene: Meso_4424: Co/Zn/Cd efflux protein	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110 Gene: bll5050: Co/Zn/Cd efflux protein	Bradyrhizobium sp. BTAi1 Gene: BBta_4663: Co/Zn/Cd efflux protein	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Co/Zn/Cd efflux protein
Atu0889	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	* Agrobacterium tumefaciens str. C58 (Cereon) Site: position = -20 score = 5.23699 sequence = TATCTCCAGTCTCTAGAGATA Gene: Atu0889: hypothetical protein	Mesorhizobium sp. BNC1	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	hypothetical protein
PF02583	Sinorhizobium meliloti 1021 Gene: SMc04168: hypothetical protein	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841 Gene: RL1350: hypothetical protein	Rhizobium etli CFN 42 Gene: RHE_CH01218: hypothetical protein	Agrobacterium tumefaciens str. C58 (Cereon) Gene: Atu0890: hypothetical protein	Mesorhizobium sp. BNC1 Gene: Meso_0756: hypothetical protein	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	hypothetical protein
PF00501	Sinorhizobium meliloti 1021	Rhizobium sp. NGR234	Rhizobium leguminosarum bv. viciae 3841	Rhizobium etli CFN 42	Agrobacterium tumefaciens str. C58 (Cereon)	* Mesorhizobium sp. BNC1 Site: position = -64 score = 4.4297 sequence = ATTCTGTAGTGGCCACAGGAA Site: position = -280 score = 4.96872 sequence = ATTCTTTAGTGGCTACAGAAT Gene: Meso_4216: Coenzyme F390 synthetase	Mesorhizobium loti MAFF303099	Brucella melitensis 16M	Bartonella quintana str. Toulouse	Rhodopseudomonas palustris CGA009	Bradyrhizobium japonicum USDA 110	Bradyrhizobium sp. BTAi1	Nitrobacter winogradskyi Nb-255	Azorhizobium caulinodans ORS 571	Xanthobacter autotrophicus Py2	Coenzyme F390 synthetase

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CadR-PbrR - Rhizobiales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --