Regulog ArgR - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	ArgR
Regulation mode:	repressor
Biological process:	Arginine biosynthesis
Effector:	Arginine
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 75 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-1
By trascription factor - ArgR
By TF family - ArgR
By effector - Arginine
By pathway - Arginine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824	16	8
Clostridium beijerincki NCIMB 8052	3	2
Clostridium botulinum A str. ATCC 3502	7	3
Clostridium butyricum 5521	5	3
Clostridium kluyveri DSM 555	13	3
Clostridium novyi NT	15	6
Clostridium perfringens ATCC 13124	6	3
Clostridium tetani E88	7	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
artP2	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	2 Clostridium kluyveri DSM 555* Site: position = -222 score = 4.86438 sequence = ATGTATATGTATAAAT Site: position = -122 score = 4.59811 sequence = ATGTATAATTATAAGG Gene: CKL_2377: Arginine ABC transporter, substrate-binding protein Site: position = -88 score = 4.84682 sequence = TTGCATAATTATAATA Site: position = -68 score = 5.12392 sequence = ATGTATAATTATTTAT Gene: CKL_0978: Arginine ABC transporter, substrate-binding protein	* Clostridium novyi NT Site: position = -254 score = 5.09167 sequence = ATATATAATTATAAAA Site: position = -232 score = 4.52639 sequence = ATGTATAATAATACTG Site: position = -158 score = 4.80749 sequence = TTGTATATGTATAAAA Site: position = -138 score = 5.28929 sequence = TTGAATAAATATTCAT Site: position = -115 score = 4.84682 sequence = TTGCATAATTATAATA Site: position = -95 score = 5.12392 sequence = ATGTATAATTATTTAT Site: position = -10 score = 4.85953 sequence = GTGTATAAATATGAAA Gene: NT01CX_0138: Arginine ABC transporter, substrate-binding protein	Clostridium perfringens ATCC 13124	2 Clostridium tetani E88* Gene: CTC00558: Arginine ABC transporter, substrate-binding protein Site: position = -226 score = 4.78003 sequence = ATGTATAAATATTCGA Site: position = -73 score = 5.26697 sequence = TTGCATAAATATAAAT Gene: CTC00557: Arginine ABC transporter, substrate-binding protein	Arginine ABC transporter, substrate-binding protein
artQ2	2 Clostridium acetobutylicum ATCC 824 Gene: CAC0377: Arginine ABC transporter, permease protein Gene: CAC3619: Arginine ABC transporter, permease protein	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0979: Arginine ABC transporter, permease protein	Clostridium novyi NT Gene: NT01CX_0137: Arginine ABC transporter, permease protein	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC00559: Arginine ABC transporter, permease protein	Arginine ABC transporter, permease protein
artM2	2 Clostridium acetobutylicum ATCC 824 Gene: CAC0378: Arginine ABC transporter, ATP-binding protein Gene: CAC3618: Arginine ABC transporter, ATP-binding protein	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO0420: Arginine ABC transporter, ATP-binding protein	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0980: Arginine ABC transporter, ATP-binding protein	Clostridium novyi NT Gene: NT01CX_0136: Arginine ABC transporter, ATP-binding protein	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC00560: Arginine ABC transporter, ATP-binding protein	Arginine ABC transporter, ATP-binding protein
argG	* Clostridium acetobutylicum ATCC 824 Site: position = -123 score = 5.28548 sequence = ATGAATATTTATAAAA Site: position = -103 score = 4.71903 sequence = TTGCATAATTATAAGA Site: position = -83 score = 4.56267 sequence = ATTTATAATAATACCA Gene: CAC0973: Argininosuccinate synthase (EC 6.3.4.5)	* Clostridium beijerincki NCIMB 8052 Site: position = -165 score = 4.66577 sequence = ATGAATATTTTTTCAT Site: position = -122 score = 4.83811 sequence = CTGTATAATTATAAAC Site: position = -46 score = 4.80433 sequence = ATGTATGTTTATGCAT Gene: Cbei_4515: Argininosuccinate synthase (EC 6.3.4.5)	* Clostridium botulinum A str. ATCC 3502 Site: position = -256 score = 4.68143 sequence = GTGCATAATTATAAAG Site: position = -139 score = 4.60916 sequence = TTGCATATTTATTATT Site: position = -119 score = 5.55159 sequence = ATGTATAATTATAAAA Gene: CBO2670: Argininosuccinate synthase (EC 6.3.4.5)	* Clostridium butyricum 5521 Site: position = -87 score = 5.55159 sequence = ATGTATAATTATAAAA Gene: CBY_1679: Argininosuccinate synthase (EC 6.3.4.5)	Clostridium kluyveri DSM 555 Gene: CKL_0981: Argininosuccinate synthase (EC 6.3.4.5)	Clostridium novyi NT Gene: NT01CX_0135: Argininosuccinate synthase (EC 6.3.4.5)	* Clostridium perfringens ATCC 13124 Site: position = -72 score = 4.88931 sequence = TTGCATAAATATACTT Site: position = -52 score = 5.03443 sequence = ATGTATAATTATTAAC Gene: CPF_0683: Argininosuccinate synthase (EC 6.3.4.5)	Clostridium tetani E88 Gene: CTC00561: Argininosuccinate synthase (EC 6.3.4.5)	Argininosuccinate synthase (EC 6.3.4.5)
argH	Clostridium acetobutylicum ATCC 824 Gene: CAC0974: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4516: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2669: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium butyricum 5521 Gene: CBY_1678: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium kluyveri DSM 555 Gene: CKL_0982: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium novyi NT Gene: NT01CX_0134: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium perfringens ATCC 13124 Gene: CPF_0682: Argininosuccinate lyase (EC 4.3.2.1)	Clostridium tetani E88 Gene: CTC00562: Argininosuccinate lyase (EC 4.3.2.1)	Argininosuccinate lyase (EC 4.3.2.1)
argC	* Clostridium acetobutylicum ATCC 824 Site: position = -117 score = 5.17641 sequence = ATGAATAATTATACAC Site: position = -97 score = 4.95099 sequence = CTTTATAAATATTCAA Site: position = -63 score = 5.03576 sequence = TTGAATAATTATACTT Gene: CAC2390: N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4517: N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1677: N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)	* Clostridium kluyveri DSM 555 Site: position = -257 score = 4.74324 sequence = TTGTACATTTATAAAA Site: position = -224 score = 4.56952 sequence = TTGTATATTTATAATG Site: position = -123 score = 4.80201 sequence = ATTAATTTTTATAAAA Site: position = -102 score = 4.81086 sequence = TTGCATATTTATTTAT Gene: CKL_1553: N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)	* Clostridium novyi NT Site: position = -132 score = 5.00731 sequence = TTGAATAATTATACTA Site: position = -59 score = 4.87908 sequence = TTGAATAATTATGCTT Gene: NT01CX_2379: N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)
argJ	2 Clostridium acetobutylicum ATCC 824* Site: position = -88 score = 5.29542 sequence = ATGCATAAATATAAAT Site: position = -68 score = 5.38497 sequence = TTGAATAATTATAAAA Gene: CAC3020: Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1) Gene: CAC2391: Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4518: Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1675: Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)	Clostridium kluyveri DSM 555 Gene: CKL_1554: Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)	Clostridium novyi NT Gene: NT01CX_2378: Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)
argB	* Clostridium acetobutylicum ATCC 824 Site: position = -98 score = 5.03576 sequence = AAGTATAATTATTCAA Site: position = -64 score = 4.95099 sequence = TTGAATATTTATAAAG Site: position = -44 score = 5.17641 sequence = GTGTATAATTATTCAT Gene: CAC2389: Acetylglutamate kinase (EC 2.7.2.8)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4519: Acetylglutamate kinase (EC 2.7.2.8)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1674: Acetylglutamate kinase (EC 2.7.2.8)	Clostridium kluyveri DSM 555 Gene: CKL_1555: Acetylglutamate kinase (EC 2.7.2.8)	* Clostridium novyi NT Site: position = -102 score = 4.87908 sequence = AAGCATAATTATTCAA Site: position = -29 score = 5.00731 sequence = TAGTATAATTATTCAA Gene: NT01CX_2380: Acetylglutamate kinase (EC 2.7.2.8)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Acetylglutamate kinase (EC 2.7.2.8)
argD	Clostridium acetobutylicum ATCC 824 Gene: CAC2388: Acetylornithine aminotransferase (EC 2.6.1.11)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4520: Acetylornithine aminotransferase (EC 2.6.1.11)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1673: Acetylornithine aminotransferase (EC 2.6.1.11)	Clostridium kluyveri DSM 555 Gene: CKL_1556: Acetylornithine aminotransferase (EC 2.6.1.11)	Clostridium novyi NT Gene: NT01CX_2381: Acetylornithine aminotransferase (EC 2.6.1.11)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Acetylornithine aminotransferase (EC 2.6.1.11)
argF	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4521: Ornithine carbamoyltransferase (EC 2.1.3.3)	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1672: Ornithine carbamoyltransferase (EC 2.1.3.3)	Clostridium kluyveri DSM 555 Gene: CKL_2376: Ornithine carbamoyltransferase (EC 2.1.3.3)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Ornithine carbamoyltransferase (EC 2.1.3.3)
carA	* Clostridium acetobutylicum ATCC 824 Site: position = -182 score = 5.29542 sequence = ATGCATAAATATAAAT Site: position = -81 score = 5.42365 sequence = ATGTATAAATATAAAA Gene: CAC2645: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_2375: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	* Clostridium novyi NT Site: position = -77 score = 5.26697 sequence = ATGTATAAATATGAAA Site: position = -57 score = 5.08597 sequence = ATGTATAAAAATTCAA Gene: NT01CX_0383: Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Carbamoyl-phosphate synthase small chain (EC 6.3.5.5)
carB	Clostridium acetobutylicum ATCC 824 Gene: CAC2644: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_2374: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Clostridium novyi NT Gene: NT01CX_0382: Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)
CAC0376	* Clostridium acetobutylicum ATCC 824 Site: position = -65 score = 4.6096 sequence = TCGTATAAATATTAAA Site: position = -44 score = 4.60797 sequence = TTGTATACAAATACAA Gene: CAC0376: NG,NG-dimethylarginine dimethylaminohydrolase 1 (EC 3.5.3.18)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	NG,NG-dimethylarginine dimethylaminohydrolase 1 (EC 3.5.3.18)
CAC3620	2 Clostridium acetobutylicum ATCC 824* Site: position = -188 score = 4.53889 sequence = ATTAATGAATATAAAT Site: position = -131 score = 4.64186 sequence = TTGAATAAATATTCGT Site: position = -31 score = 4.9478 sequence = ATGAATAAAAATTCAA Gene: CAC0380: Periplasmic amino acid-binding protein Site: position = -195 score = 5.15725 sequence = ATGCATAAATATTAAT Site: position = -70 score = 4.89627 sequence = GTTAATAATTATTCAT Gene: CAC3620: Amino acid (probably glutamine) ABC transporter, periplasmic binding protein component	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Amino acid (probably glutamine) ABC transporter, periplasmic binding protein component

CRON 2.
argT	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	* Clostridium botulinum A str. ATCC 3502 Site: position = -62 score = 5.42365 sequence = TTTTATATTTATACAT Gene: CBO1788: Predicted arginine uptake transporter	* Clostridium butyricum 5521 Site: position = -31 score = 5.08916 sequence = TTGTATATTTATAAAG Site: position = 0 score = 5.07574 sequence = ATGAATAATAATTCAA Gene: CBY_2294: Predicted arginine uptake transporter	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -92 score = 5.2101 sequence = TTGTATTATTATAAAT Site: position = -72 score = 5.26697 sequence = ATGCATAAATATAAAA Gene: NT01CX_1828: Predicted arginine uptake transporter	* Clostridium perfringens ATCC 13124 Site: position = -117 score = 5.42746 sequence = TTGAATATTTATACAT Gene: CPF_2910: Predicted arginine uptake transporter	* Clostridium tetani E88 Site: position = -64 score = 4.74981 sequence = ATTAATATTTATGCAC Site: position = -34 score = 5.1288 sequence = TTGCATAAATATTAAT Gene: CTC00841: Predicted arginine uptake transporter	Predicted arginine uptake transporter

CRON 3.
artP	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -240 score = 4.7292 sequence = TTTTATAATTTTAAAA Site: position = -104 score = 4.93376 sequence = ATGAATAATAATTAAA Site: position = -70 score = 4.60507 sequence = TTGAGTAAATATAAAA Site: position = -50 score = 4.60981 sequence = GTGTATAATTATGCTA Gene: Cbei_4781: Arginine ABC transporter, substrate-binding protein	* Clostridium botulinum A str. ATCC 3502 Site: position = -43 score = 5.23084 sequence = ATGCATAATTATACAG Gene: CBO2018: Arginine ABC transporter, substrate-binding protein	* Clostridium butyricum 5521 Site: position = -110 score = 4.68739 sequence = TTTAATATTTATTTAT Site: position = -76 score = 5.38497 sequence = TTGAATAATTATAAAA Site: position = -56 score = 5.17393 sequence = ATGTATAATTATACTA Gene: CBY_1781: Arginine ABC transporter, substrate-binding protein	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -267 score = 4.58655 sequence = TTTTAAAAATATGCAA Site: position = -115 score = 5.04466 sequence = GTGTATAAATATAAAT Site: position = -84 score = 4.8393 sequence = ATACATAAATATTCAT Site: position = -61 score = 5.39491 sequence = TTGCATAATTATAAAT Gene: NT01CX_0932: Arginine ABC transporter, substrate-binding protein	* Clostridium perfringens ATCC 13124 Site: position = -261 score = 4.57217 sequence = ATGTATAAAAACACAA Site: position = -77 score = 4.92928 sequence = TTGCATTTTTATTCAT Site: position = -56 score = 5.5554 sequence = ATGTATAATTATTCAA Gene: CPF_0581: Arginine ABC transporter, substrate-binding protein	Clostridium tetani E88	Arginine ABC transporter, substrate-binding protein
artQ	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4780: Arginine ABC transporter, permease protein	Clostridium botulinum A str. ATCC 3502 Gene: CBO2017: Arginine ABC transporter, permease protein	Clostridium butyricum 5521 Gene: CBY_1780: Arginine ABC transporter, permease protein	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0933: Arginine ABC transporter, permease protein	Clostridium perfringens ATCC 13124 Gene: CPF_0582: Arginine ABC transporter, permease protein	Clostridium tetani E88	Arginine ABC transporter, permease protein
artM	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4779: Arginine ABC transporter, ATP-binding protein	Clostridium botulinum A str. ATCC 3502 Gene: CBO2016: Arginine ABC transporter, ATP-binding protein	Clostridium butyricum 5521 Gene: CBY_1779: Arginine ABC transporter, ATP-binding protein	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0934: Arginine ABC transporter, ATP-binding protein	Clostridium perfringens ATCC 13124 Gene: CPF_0583: Arginine ABC transporter, ATP-binding protein	Clostridium tetani E88	Arginine ABC transporter, ATP-binding protein
CBO2015	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO2015: Aspartate aminotransferase (EC 2.6.1.1)	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Aspartate aminotransferase (EC 2.6.1.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog ArgR - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --