Regulog MtlR - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	BglG
Regulation mode:	activator
Biological process:	Mannitol utilization
Effector:	HPr, phosphocarrier protein; MtlA, mannitol-specific enzyme IICB PTS component
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 4 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - BglG
By effector - HPr, phosphocarrier protein
By effector - MtlA, mannitol-specific enzyme IICB PTS component
By pathway - Mannitol utilization

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM
Lactobacillus brevis ATCC 367
Lactobacillus casei ATCC 334	4	1
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
Lactobacillus fermentum IFO 3956
Lactobacillus helveticus DPC 4571
Lactobacillus johnsonii NCC 533
Lactobacillus plantarum WCFS1	4	1
Lactobacillus reuteri JCM 1112
Lactobacillus rhamnosus GG	4	1
Lactobacillus sakei subsp. sakei 23K
Lactobacillus salivarius subsp. salivarius UCC118	3	1
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Oenococcus oeni PSU-1
Pediococcus pentosaceus ATCC 25745

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
mtlA	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	* Lactobacillus casei ATCC 334 Site: position = -96 score = 7.48093 sequence = TTTGGCACAGACAACTGTGCCAAA Gene: LSEI_2888: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -104 score = 6.66462 sequence = TGTGGCACAGTTTCCTGTGCCACG Gene: lp_0230: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Lactobacillus reuteri JCM 1112	* Lactobacillus rhamnosus GG Site: position = -96 score = 7.23981 sequence = TTTGGCACAACTAACTGTGCCAAA Gene: LGG_02912: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Lactobacillus sakei subsp. sakei 23K	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -110 score = 6.90296 sequence = TTTGACACTGACAACTGTGCCAAA Gene: LSL_1620: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)
mtlR	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_2887: Mannitol utilization transcription activator MtlR, BglG family	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0231: Mannitol utilization transcription activator MtlR, BglG family	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_02911: Mannitol utilization transcription activator MtlR, BglG family	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1628: Mannitol utilization transcription activator MtlR, BglG family	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Mannitol utilization transcription activator MtlR, BglG family
mtlF	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_2886: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0232: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_02910: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1619: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	PTS system, mannitol-specific IIA component (EC 2.7.1.69)
mtlD	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_2885: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0233: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_02909: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1618: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog MtlR - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --