Statistics of regulated genes

Genome	Genes	Operons
Mycobacterium tuberculosis H37Rv	4	2
Mycobacterium leprae TN	2	2
Mycobacterium marinum M	5	3
Mycobacterium avium 104	5	3
Mycobacterium sp. JLS	3	1
Mycobacterium vanbaalenii PYR-1	3	1
Mycobacterium flavescens PYR-GCK	6	2
Mycobacterium smegmatis str. MC2 155	12	5
Mycobacterium abscessus ATCC 19977	4	2

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes										Function
CRON 1.
btuC3	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	Mycobacterium smegmatis str. MC2 155	* Mycobacterium abscessus ATCC 19977 Site: position = -325 score = 98.07 sequence = ATAGTTTTGGCGCCG... Gene: MAB_0549c: Vitamin B12 ABC transporter, permease component	Vitamin B12 ABC transporter, permease component
btuD3	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	Mycobacterium smegmatis str. MC2 155	Mycobacterium abscessus ATCC 19977 Gene: MAB_0548c: Vitamin B12 ABC transporter, ATPase component	Vitamin B12 ABC transporter, ATPase component
btuF3	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	Mycobacterium smegmatis str. MC2 155	Mycobacterium abscessus ATCC 19977 Gene: MAB_0547c: Vitamin B12 ABC transporter, B12-binding component	Vitamin B12 ABC transporter, B12-binding component
CRON 2.
metE	* Mycobacterium tuberculosis H37Rv Site: position = -305 score = 68.17 sequence = GAGAGGGAACCTGGT... Gene: Rv1133c: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Mycobacterium leprae TN Site: position = -392 score = 80.07 sequence = TAACCTGAATGATGC... Gene: ML0961: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Mycobacterium marinum M Site: position = -306 score = 77.35 sequence = AAGAGGGAATCCGGT... Gene: MMAR_4328: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Mycobacterium avium 104 Site: position = -378 score = 65.61 sequence = CATCGAGCGAAGCAA... Gene: MAV_1262: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	* Mycobacterium smegmatis str. MC2 155 Site: position = -287 score = 75.54 sequence = AGTTCCGTGTGCTGT... Gene: MSMEG_6638: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Mycobacterium abscessus ATCC 19977 Site: position = -350 score = 85.74 sequence = GCCGTTGTCAGCATC... Gene: MAB_4623c: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
CRON 3.
cbtG	* Mycobacterium tuberculosis H37Rv Site: position = -336 score = 81.37 sequence = CGCTCAACGTGCAAA... Gene: Rv0256c: Predicted cobalt transporter	* Mycobacterium leprae TN Site: position = -298 score = 90.94 sequence = TGTACTATATGCGAC... Gene: ML1828: Predicted cobalt transporter	* Mycobacterium marinum M Site: position = -433 score = 72.15 sequence = GTTGTCGGCATCAAG... Gene: MMAR_2944: Predicted cobalt transporter	* Mycobacterium avium 104 Site: position = -307 score = 77.49 sequence = ATGTCACCCGTAAGG... Gene: MAV_1329: Predicted cobalt transporter	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	Mycobacterium smegmatis str. MC2 155	Mycobacterium abscessus ATCC 19977	Predicted cobalt transporter
cbiP	Mycobacterium tuberculosis H37Rv Gene: Rv0255c: Cobyric acid synthase	Mycobacterium leprae TN	Mycobacterium marinum M Gene: MMAR_3838: Cobyric acid synthase	Mycobacterium avium 104 Gene: MAV_3720: Cobyric acid synthase	Mycobacterium sp. JLS Gene: Mjls_2034: Cobyric acid synthase	Mycobacterium vanbaalenii PYR-1 Gene: Mvan_0377: Cobyric acid synthase	Mycobacterium flavescens PYR-GCK Gene: Mflv_0360: Cobyric acid synthase	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_2588: Cobyric acid synthase	Mycobacterium abscessus ATCC 19977 Gene: MAB_3163c: Cobyric acid synthase	Cobyric acid synthase
cobU	Mycobacterium tuberculosis H37Rv Gene: Rv0254c: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium leprae TN	Mycobacterium marinum M Gene: MMAR_3251: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium avium 104 Gene: MAV_2284: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium sp. JLS Gene: Mjls_3315: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium vanbaalenii PYR-1 Gene: Mvan_0379: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium flavescens PYR-GCK Gene: Mflv_0355: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_4274: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Mycobacterium abscessus ATCC 19977 Gene: MAB_1954c: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
CRON 4.
btuF	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	* Mycobacterium flavescens PYR-GCK Site: position = -170 score = 75.39 sequence = GGAAGCCGGTGTGAA... Gene: Mflv_3882: Vitamin B12 ABC transporter, B12-binding component	* Mycobacterium smegmatis str. MC2 155 Site: position = -177 score = 46.41 sequence = CGTGCGGTATGACAC... Gene: MSMEG_6064: Vitamin B12 ABC transporter, B12-binding component	Mycobacterium abscessus ATCC 19977	Vitamin B12 ABC transporter, B12-binding component
btuC	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK Gene: Mflv_3883: Vitamin B12 ABC transporter, permease component	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_6063: Vitamin B12 ABC transporter, permease component	Mycobacterium abscessus ATCC 19977	Vitamin B12 ABC transporter, permease component
btuD	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK Gene: Mflv_3884: Vitamin B12 ABC transporter, ATPase component	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_6062: Vitamin B12 ABC transporter, ATPase component	Mycobacterium abscessus ATCC 19977	Vitamin B12 ABC transporter, ATPase component
CRON 5.
btuF2	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	*2 Mycobacterium smegmatis str. MC2 155 Site: position = -130 score = 38.51 sequence = CAGGGGAATCCGGTG... Gene: MSMEG_4561: Vitamin B12 ABC transporter, B12-binding component Gene: MSMEG_4560: Vitamin B12 ABC transporter, B12-binding component	Mycobacterium abscessus ATCC 19977	Vitamin B12 ABC transporter, B12-binding component
btuC2	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_4559: Vitamin B12 ABC transporter, permease component	Mycobacterium abscessus ATCC 19977	Vitamin B12 ABC transporter, permease component
btuD2	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_4557: Vitamin B12 ABC transporter, ATPase component	Mycobacterium abscessus ATCC 19977	Vitamin B12 ABC transporter, ATPase component
CRON 6.
MSMEG_6649	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M	Mycobacterium avium 104	Mycobacterium sp. JLS	Mycobacterium vanbaalenii PYR-1	Mycobacterium flavescens PYR-GCK	* Mycobacterium smegmatis str. MC2 155 Site: position = -292 score = 74.16 sequence = TAGGAAGCCGGTGTG... Gene: MSMEG_6649: Hypothetical protein	Mycobacterium abscessus ATCC 19977	Hypothetical protein
CRON 7.
Mjls_5141	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	* Mycobacterium marinum M Site: position = -147 score = 24.64 sequence = GTTTACACTGGCCGG... Gene: MMAR_5098: Hypothetical protein	* Mycobacterium avium 104 Site: position = -100 score = 19.63 sequence = GAATTTGGTGAAACT... Gene: MAV_0557: Hypothetical protein	* Mycobacterium sp. JLS Site: position = -101 score = 25.1 sequence = AGGAATCTGGTGAGA... Gene: Mjls_5141: Hypothetical protein	* Mycobacterium vanbaalenii PYR-1 Site: position = -101 score = 22.15 sequence = CGGAATCTGGTGAGA... Gene: Mvan_5356: Hypothetical protein	* Mycobacterium flavescens PYR-GCK Site: position = -136 score = 26.61 sequence = TTGGCTTACGATGCT... Gene: Mflv_1431: Hypothetical protein	* Mycobacterium smegmatis str. MC2 155 Site: position = -105 score = 25.06 sequence = CGGAATCTGGTGAGA... Gene: MSMEG_6090: Hypothetical protein	Mycobacterium abscessus ATCC 19977	Hypothetical protein
cbtA	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M Gene: MMAR_5097: Predicted cobalt transporter CbtA	Mycobacterium avium 104 Gene: MAV_0558: Predicted cobalt transporter CbtA	Mycobacterium sp. JLS Gene: Mjls_5140: Predicted cobalt transporter CbtA	Mycobacterium vanbaalenii PYR-1 Gene: Mvan_5355: Predicted cobalt transporter CbtA	Mycobacterium flavescens PYR-GCK Gene: Mflv_1432: Predicted cobalt transporter CbtA	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_6089: Predicted cobalt transporter CbtA	Mycobacterium abscessus ATCC 19977	Predicted cobalt transporter CbtA
phoE	Mycobacterium tuberculosis H37Rv	Mycobacterium leprae TN	Mycobacterium marinum M Gene: MMAR_5096: Probable phosphoglycerate mutase	Mycobacterium avium 104 Gene: MAV_0559: Probable phosphoglycerate mutase	Mycobacterium sp. JLS Gene: Mjls_5139: Probable phosphoglycerate mutase	Mycobacterium vanbaalenii PYR-1 Gene: Mvan_5354: Probable phosphoglycerate mutase	Mycobacterium flavescens PYR-GCK Gene: Mflv_1433: Probable phosphoglycerate mutase	Mycobacterium smegmatis str. MC2 155 Gene: MSMEG_6088: Probable phosphoglycerate mutase	Mycobacterium abscessus ATCC 19977	Probable phosphoglycerate mutase

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