Regulog Cobalamin - Mycobacteriaceae
| Regulator type: | RNA regulatory element |
| Name: | Cobalamin |
| RFAM: | RF00174 |
| Regulation mode: | |
| Biological process: | Cobalamin biosynthesis |
| Effector: | Adenosylcobalamin |
| Phylum: | Actinobacteria |
Member of regulog collections
- By taxonomy - Mycobacteriaceae
- By RNA motif - Cobalamin
- By effector - Adenosylcobalamin
- By pathway - Cobalamin biosynthesis
| Genome | Genes | Operons |
|---|---|---|
| Mycobacterium tuberculosis H37Rv | 4 | 2 |
| Mycobacterium leprae TN | 2 | 2 |
| Mycobacterium marinum M | 5 | 3 |
| Mycobacterium avium 104 | 5 | 3 |
| Mycobacterium sp. JLS | 3 | 1 |
| Mycobacterium vanbaalenii PYR-1 | 3 | 1 |
| Mycobacterium flavescens PYR-GCK | 6 | 2 |
| Mycobacterium smegmatis str. MC2 155 | 12 | 5 |
| Mycobacterium abscessus ATCC 19977 | 4 | 2 |
| Genes | Function | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CRON 1. | ||||||||||
| btuC3 |
|
|
|
|
|
|
|
|
*
Mycobacterium abscessus ATCC 19977 Site: position = -325 score = 98.07 sequence = ATAGTTTTGGCGCCG... Gene: MAB_0549c: Vitamin B12 ABC transporter, permease component |
Vitamin B12 ABC transporter, permease component |
| btuD3 |
|
|
|
|
|
|
|
|
Gene: MAB_0548c: Vitamin B12 ABC transporter, ATPase component |
Vitamin B12 ABC transporter, ATPase component |
| btuF3 |
|
|
|
|
|
|
|
|
Gene: MAB_0547c: Vitamin B12 ABC transporter, B12-binding component |
Vitamin B12 ABC transporter, B12-binding component |
| CRON 2. | ||||||||||
| metE |
*
Mycobacterium tuberculosis H37Rv Site: position = -305 score = 68.17 sequence = GAGAGGGAACCTGGT... Gene: Rv1133c: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
*
Mycobacterium leprae TN Site: position = -392 score = 80.07 sequence = TAACCTGAATGATGC... Gene: ML0961: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
*
Mycobacterium marinum M Site: position = -306 score = 77.35 sequence = AAGAGGGAATCCGGT... Gene: MMAR_4328: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
*
Mycobacterium avium 104 Site: position = -378 score = 65.61 sequence = CATCGAGCGAAGCAA... Gene: MAV_1262: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
|
|
|
*
Mycobacterium smegmatis str. MC2 155 Site: position = -287 score = 75.54 sequence = AGTTCCGTGTGCTGT... Gene: MSMEG_6638: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
*
Mycobacterium abscessus ATCC 19977 Site: position = -350 score = 85.74 sequence = GCCGTTGTCAGCATC... Gene: MAB_4623c: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) |
| CRON 3. | ||||||||||
| cbtG |
*
Mycobacterium tuberculosis H37Rv Site: position = -336 score = 81.37 sequence = CGCTCAACGTGCAAA... Gene: Rv0256c: Predicted cobalt transporter |
*
Mycobacterium leprae TN Site: position = -298 score = 90.94 sequence = TGTACTATATGCGAC... Gene: ML1828: Predicted cobalt transporter |
*
Mycobacterium marinum M Site: position = -433 score = 72.15 sequence = GTTGTCGGCATCAAG... Gene: MMAR_2944: Predicted cobalt transporter |
*
Mycobacterium avium 104 Site: position = -307 score = 77.49 sequence = ATGTCACCCGTAAGG... Gene: MAV_1329: Predicted cobalt transporter |
|
|
|
|
|
Predicted cobalt transporter |
| cbiP |
Gene: Rv0255c: Cobyric acid synthase |
|
Gene: MMAR_3838: Cobyric acid synthase |
Gene: MAV_3720: Cobyric acid synthase |
Gene: Mjls_2034: Cobyric acid synthase |
Gene: Mvan_0377: Cobyric acid synthase |
Gene: Mflv_0360: Cobyric acid synthase |
Gene: MSMEG_2588: Cobyric acid synthase |
Gene: MAB_3163c: Cobyric acid synthase |
Cobyric acid synthase |
| cobU |
Gene: Rv0254c: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
|
Gene: MMAR_3251: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: MAV_2284: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Mjls_3315: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Mvan_0379: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Mflv_0355: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: MSMEG_4274: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: MAB_1954c: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
| CRON 4. | ||||||||||
| btuF |
|
|
|
|
|
|
*
Mycobacterium flavescens PYR-GCK Site: position = -170 score = 75.39 sequence = GGAAGCCGGTGTGAA... Gene: Mflv_3882: Vitamin B12 ABC transporter, B12-binding component |
*
Mycobacterium smegmatis str. MC2 155 Site: position = -177 score = 46.41 sequence = CGTGCGGTATGACAC... Gene: MSMEG_6064: Vitamin B12 ABC transporter, B12-binding component |
|
Vitamin B12 ABC transporter, B12-binding component |
| btuC |
|
|
|
|
|
|
Gene: Mflv_3883: Vitamin B12 ABC transporter, permease component |
Gene: MSMEG_6063: Vitamin B12 ABC transporter, permease component |
|
Vitamin B12 ABC transporter, permease component |
| btuD |
|
|
|
|
|
|
Gene: Mflv_3884: Vitamin B12 ABC transporter, ATPase component |
Gene: MSMEG_6062: Vitamin B12 ABC transporter, ATPase component |
|
Vitamin B12 ABC transporter, ATPase component |
| CRON 5. | ||||||||||
| btuF2 |
|
|
|
|
|
|
|
*2
Mycobacterium smegmatis str. MC2 155 Site: position = -130 score = 38.51 sequence = CAGGGGAATCCGGTG... Gene: MSMEG_4561: Vitamin B12 ABC transporter, B12-binding component Gene: MSMEG_4560: Vitamin B12 ABC transporter, B12-binding component |
|
Vitamin B12 ABC transporter, B12-binding component |
| btuC2 |
|
|
|
|
|
|
|
Gene: MSMEG_4559: Vitamin B12 ABC transporter, permease component |
|
Vitamin B12 ABC transporter, permease component |
| btuD2 |
|
|
|
|
|
|
|
Gene: MSMEG_4557: Vitamin B12 ABC transporter, ATPase component |
|
Vitamin B12 ABC transporter, ATPase component |
| CRON 6. | ||||||||||
| MSMEG_6649 |
|
|
|
|
|
|
|
*
Mycobacterium smegmatis str. MC2 155 Site: position = -292 score = 74.16 sequence = TAGGAAGCCGGTGTG... Gene: MSMEG_6649: Hypothetical protein |
|
Hypothetical protein |
| CRON 7. | ||||||||||
| Mjls_5141 |
|
|
*
Mycobacterium marinum M Site: position = -147 score = 24.64 sequence = GTTTACACTGGCCGG... Gene: MMAR_5098: Hypothetical protein |
*
Mycobacterium avium 104 Site: position = -100 score = 19.63 sequence = GAATTTGGTGAAACT... Gene: MAV_0557: Hypothetical protein |
*
Mycobacterium sp. JLS Site: position = -101 score = 25.1 sequence = AGGAATCTGGTGAGA... Gene: Mjls_5141: Hypothetical protein |
*
Mycobacterium vanbaalenii PYR-1 Site: position = -101 score = 22.15 sequence = CGGAATCTGGTGAGA... Gene: Mvan_5356: Hypothetical protein |
*
Mycobacterium flavescens PYR-GCK Site: position = -136 score = 26.61 sequence = TTGGCTTACGATGCT... Gene: Mflv_1431: Hypothetical protein |
*
Mycobacterium smegmatis str. MC2 155 Site: position = -105 score = 25.06 sequence = CGGAATCTGGTGAGA... Gene: MSMEG_6090: Hypothetical protein |
|
Hypothetical protein |
| cbtA |
|
|
Gene: MMAR_5097: Predicted cobalt transporter CbtA |
Gene: MAV_0558: Predicted cobalt transporter CbtA |
Gene: Mjls_5140: Predicted cobalt transporter CbtA |
Gene: Mvan_5355: Predicted cobalt transporter CbtA |
Gene: Mflv_1432: Predicted cobalt transporter CbtA |
Gene: MSMEG_6089: Predicted cobalt transporter CbtA |
|
Predicted cobalt transporter CbtA |
| phoE |
|
|
Gene: MMAR_5096: Probable phosphoglycerate mutase |
Gene: MAV_0559: Probable phosphoglycerate mutase |
Gene: Mjls_5139: Probable phosphoglycerate mutase |
Gene: Mvan_5354: Probable phosphoglycerate mutase |
Gene: Mflv_1433: Probable phosphoglycerate mutase |
Gene: MSMEG_6088: Probable phosphoglycerate mutase |
|
Probable phosphoglycerate mutase |
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
|
Regulated Genes | [ Tab delimited format ] | DOWNLOAD |
|
Regulatory Sites | [ FASTA format ] | DOWNLOAD |