Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog TPP - Mycobacteriaceae

Properties
Regulator type: RNA regulatory element
Name: TPP
RFAM: RF00059
Regulation mode:
Biological process: Thiamine biosynthesis
Effector: Thiamine pyrophosphate
Phylum: Actinobacteria
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Mycobacterium tuberculosis H37Rv 5 2
Mycobacterium leprae TN 5 2
Mycobacterium marinum M 5 2
Mycobacterium avium 104 5 2
Mycobacterium sp. JLS 7 3
Mycobacterium vanbaalenii PYR-1 5 2
Mycobacterium flavescens PYR-GCK 8 4
Mycobacterium smegmatis str. MC2 155 8 3
Mycobacterium abscessus ATCC 19977 5 2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
ykoE
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
*
Mycobacterium sp. JLS

Site:
position = -102
score = 53.32
sequence = CGATAACCCACGCGG...

Gene: Mjls_5653: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium vanbaalenii PYR-1
*
Mycobacterium flavescens PYR-GCK

Site:
position = -101
score = 47.57
sequence = TGGACGCACACGGGA...

Gene: Mflv_0970: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -105
score = 58.69
sequence = GAACAACCCACGCGG...

Gene: MSMEG_6726: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium abscessus ATCC 19977
Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoD
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS

Gene: Mjls_5652: ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_0971: ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_6725: ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium abscessus ATCC 19977
ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoC
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS

Gene: Mjls_5651: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_0972: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_6724: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Mycobacterium abscessus ATCC 19977
Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
CRON 2.
thiC
*
Mycobacterium tuberculosis H37Rv

Site:
position = -102
score = 54.53
sequence = GGGGTACCCACGCGG...

Gene: Rv0423c: Thiamin biosynthesis protein ThiC
*
Mycobacterium leprae TN

Site:
position = -101
score = 55.4
sequence = AAAAACCACGCGGGA...

Gene: ML0294: Thiamin biosynthesis protein ThiC
*
Mycobacterium marinum M

Site:
position = -113
score = 50.11
sequence = AATTAACGCACGCGG...

Gene: MMAR_0735: Thiamin biosynthesis protein ThiC
*
Mycobacterium avium 104

Site:
position = -102
score = 48.22
sequence = TCCATCAGACGCGGG...

Gene: MAV_4731: Thiamin biosynthesis protein ThiC
 
Mycobacterium sp. JLS
*
Mycobacterium vanbaalenii PYR-1

Site:
position = -98
score = 47.42
sequence = CACTAACGCGGGAGC...

Gene: Mvan_0725: Thiamin biosynthesis protein ThiC
*
Mycobacterium flavescens PYR-GCK

Site:
position = -105
score = 49.55
sequence = GTCGACCACTCGCGG...

Gene: Mflv_0754: Thiamin biosynthesis protein ThiC
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -163
score = 51.8
sequence = CAGAGAAAACCGCGG...

Gene: MSMEG_0826: Thiamin biosynthesis protein ThiC
*
Mycobacterium abscessus ATCC 19977

Site:
position = -103
score = 55.71
sequence = CCCACAAACACGGGA...

Gene: MAB_4196: Thiamin biosynthesis protein ThiC
Thiamin biosynthesis protein ThiC
thiD
 
Mycobacterium tuberculosis H37Rv

Gene: Rv0422c: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Mycobacterium leprae TN

Gene: ML0295: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Mycobacterium marinum M

Gene: MMAR_0734: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Mycobacterium avium 104

Gene: MAV_4732: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
*
Mycobacterium sp. JLS

Site:
position = -100
score = 54.1
sequence = CCACCGACCACGCGG...

Gene: Mjls_0554: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_0724: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
*
Mycobacterium flavescens PYR-GCK

Site:
position = -96
score = 41.21
sequence = AACACGCGGGAGCGC...

Gene: Mflv_0181: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_0825: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_4197: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
CRON 3.
thiO
*
Mycobacterium tuberculosis H37Rv

Site:
position = -100
score = 45.59
sequence = CCTGTAGACACGGGA...

Gene: Rv0415: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium leprae TN

Site:
position = -130
score = 41.1
sequence = AACTTCAGTACACGG...

Gene: ML0299: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium marinum M

Site:
position = -120
score = 40.88
sequence = CTGAAGAACACGGGA...

Gene: MMAR_0718: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium avium 104

Site:
position = -102
score = 43.3
sequence = TCGTTTTAGACACGG...

Gene: MAV_4746: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium sp. JLS

Site:
position = -105
score = 43.74
sequence = TGATGGCCGACACGG...

Gene: Mjls_0535: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium vanbaalenii PYR-1

Site:
position = -91
score = 40.41
sequence = ACGGGAGTCCCGGGT...

Gene: Mvan_0708: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium flavescens PYR-GCK

Site:
position = -92
score = 41.2
sequence = CACACGGGAGTCCCG...

Gene: Mflv_0197: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -102
score = 46.81
sequence = ACGGGCAACACGGGA...

Gene: MSMEG_0791: Glycine oxidase ThiO (EC 1.4.3.19)
*
Mycobacterium abscessus ATCC 19977

Site:
position = -113
score = 55.11
sequence = GTGTAAGTAACGCGG...

Gene: MAB_4218c: Glycine oxidase ThiO (EC 1.4.3.19)
Glycine oxidase ThiO (EC 1.4.3.19)
thiS
 
Mycobacterium tuberculosis H37Rv

Gene: Rv0416: Sulfur carrier protein ThiS
 
Mycobacterium leprae TN

Gene: ML0298: Sulfur carrier protein ThiS
 
Mycobacterium marinum M

Gene: MMAR_0719: Sulfur carrier protein ThiS
 
Mycobacterium avium 104

Gene: MAV_4745: Sulfur carrier protein ThiS
 
Mycobacterium sp. JLS

Gene: Mjls_0536: Sulfur carrier protein ThiS
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_0709: Sulfur carrier protein ThiS
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_0196: Sulfur carrier protein ThiS
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_0792: Sulfur carrier protein ThiS
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_4217c: Sulfur carrier protein ThiS
Sulfur carrier protein ThiS
thiG
 
Mycobacterium tuberculosis H37Rv

Gene: Rv0417: Thiazole biosynthesis protein ThiG
 
Mycobacterium leprae TN

Gene: ML0297: Thiazole biosynthesis protein ThiG
 
Mycobacterium marinum M

Gene: MMAR_0720: Thiazole biosynthesis protein ThiG
 
Mycobacterium avium 104

Gene: MAV_4744: Thiazole biosynthesis protein ThiG
 
Mycobacterium sp. JLS

Gene: Mjls_0537: Thiazole biosynthesis protein ThiG
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_0710: Thiazole biosynthesis protein ThiG
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_0195: Thiazole biosynthesis protein ThiG
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_0793: Thiazole biosynthesis protein ThiG
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_4216c: Thiazole biosynthesis protein ThiG
Thiazole biosynthesis protein ThiG
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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