Regulog T-box(Leu) - Clostridiaceae

Properties
Regulator type:	RNA regulatory element
Name:	T-box
RFAM:	RF00230
Regulation mode:
Biological process:	Amino acid metabolism
Effector:	Leu-tRNA
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Clostridiaceae
By RNA motif - T-box
By effector - Leu-tRNA
By pathway - Amino acid metabolism

Statistics of regulated genes
Genome	Genes	Operons
Clostridium kluyveri DSM 555	9	5
Clostridium sp. SS2/1	1	1
Clostridium cellulolyticum H10	6	2
Clostridium phytofermentans ISDg	2	2
Clostridium tetani E88	1	1
Clostridium acetobutylicum ATCC 824	2	2
Clostridium botulinum A str. ATCC 3502	1	1
Clostridium novyi NT	2	2
Clostridium perfringens ATCC 13124	1	1
Clostridium difficile 630	5	2
Clostridium beijerincki NCIMB 8052	1	1
Clostridium sp. OhILAs	1	1
Clostridium sp. L2-50	1	1
Clostridium scindens ATCC 35704	1	1
Clostridium nexile DSM 1787	1	1
Clostridium leptum DSM 753	1	1
Clostridium hiranonis DSM 13275	1	1
Clostridium butyricum 5521	3	2
Clostridium bolteae ATCC BAA-613	1	1
Clostridium bartlettii DSM 16795	1	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																					Function

CRON 1.
leuS	* Clostridium kluyveri DSM 555 Site: position = -371 score = 118.75 sequence = ACTTAGCTTTGAAGA... Gene: CKL_3605: Leucyl-tRNA synthetase (EC 6.1.1.4)	Clostridium sp. SS2/1 Gene: CLOSS21_01939: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium cellulolyticum H10 Site: position = -258 score = 104.98 sequence = TTAAAGTTATGAAGC... Gene: Ccel_3454: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium phytofermentans ISDg Site: position = -266 score = 127.58 sequence = AAAAAGTTATGATTA... Gene: null: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium tetani E88 Site: position = -218 score = 123.16 sequence = ATGAAAAGCTATGAG... Gene: CTC00337: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium acetobutylicum ATCC 824 Site: position = -244 score = 129.12 sequence = TTTAAAAGCTTTGAA... Gene: CAC0646: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium botulinum A str. ATCC 3502 Site: position = -308 score = 134.44 sequence = ATTAAAGGCTTTGAA... Gene: CBO0186: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium novyi NT Site: position = -270 score = 124.94 sequence = TGTTATTGCTTTGAA... Gene: NT01CX_1372: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium perfringens ATCC 13124 Site: position = -297 score = 138.51 sequence = ATTAAAAGCTTTGAT... Gene: CPF_0657: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium difficile 630 Site: position = -302 score = 78.6 sequence = TTGAATAGACTAGAG... Gene: CD2521: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium beijerincki NCIMB 8052 Site: position = -382 score = 106.02 sequence = ATTGTGCGATGAATA... Gene: Cbei_4590: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium sp. OhILAs Site: position = -301 score = 104.31 sequence = AAAAGTTGCTGTGAA... Gene: Clos_2587: Leucyl-tRNA synthetase (EC 6.1.1.4)	Clostridium sp. L2-50 Gene: CLOL250_02927: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium scindens ATCC 35704 Site: position = -198 score = 109.61 sequence = TAGAAACGAAGAAGA... Gene: CLOSCI_03648: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium nexile DSM 1787 Site: position = -419 score = 96.97 sequence = TCAAAAAACATAGAT... Gene: CLONEX_03143: Leucyl-tRNA synthetase (EC 6.1.1.4)	Clostridium leptum DSM 753 Gene: CLOLEP_03285: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium hiranonis DSM 13275 Site: position = -285 score = 92.59 sequence = AGACAGTCTGAAGTA... Gene: CLOHIR_01984: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium butyricum 5521 Site: position = -379 score = 122.73 sequence = ATATTAAGCTATGAG... Gene: CBY_1582: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium bolteae ATCC BAA-613 Site: position = -364 score = 98.06 sequence = TGCAAATACGCAGAT... Gene: CLOBOL_01934: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Clostridium bartlettii DSM 16795 Site: position = -299 score = 87.43 sequence = CAAATAAACTAAAGT... Gene: CLOBAR_01473: Leucyl-tRNA synthetase (EC 6.1.1.4)	Leucyl-tRNA synthetase (EC 6.1.1.4)

CRON 2.
brnQ1	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	* Clostridium novyi NT Site: position = -381 score = 71.14 sequence = TCAAGACATTGACGG... Gene: NT01CX_2428: branched-chain amino acid transport system II carrier protein	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	branched-chain amino acid transport system II carrier protein

CRON 3.
leuA1	* Clostridium kluyveri DSM 555 Site: position = -332 score = 57.43 sequence = TAAAGGATATGAAAA... Gene: CKL_0047: 2-isopropylmalate synthase (EC 2.3.3.13)	* Clostridium sp. SS2/1 Site: position = -306 score = 142.75 sequence = TTTAAATACAATGAT... Gene: CLOSS21_00446: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2175: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium sp. OhILAs	* Clostridium sp. L2-50 Site: position = -284 score = 119.05 sequence = ATAATACGATGAAGA... Gene: CLOL250_00490: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01346: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium nexile DSM 1787 Gene: CLONEX_02947: 2-isopropylmalate synthase (EC 2.3.3.13)	* Clostridium leptum DSM 753 Site: position = -281 score = 110.24 sequence = TAAATACGATGAAGA... Gene: CLOLEP_01755: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	2-isopropylmalate synthase (EC 2.3.3.13)

CRON 4.
ilvB	* Clostridium kluyveri DSM 555 Site: position = -306 score = 102.99 sequence = TATAAAAGCTATGAT... Gene: CKL_1618: Acetolactate synthase large subunit (EC 2.2.1.6)	Clostridium sp. SS2/1	* Clostridium cellulolyticum H10 Site: position = -327 score = 86.73 sequence = TATACAGCTTATGAT... Gene: Ccel_3437: Acetolactate synthase large subunit (EC 2.2.1.6)	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -461 score = 56.75 sequence = TTACAAGTATGACAA... Gene: CBY_1194: Acetolactate synthase large subunit (EC 2.2.1.6)	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Acetolactate synthase large subunit (EC 2.2.1.6)
ilvH	Clostridium kluyveri DSM 555 Gene: CKL_1617: Acetolactate synthase small subunit (EC 2.2.1.6)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_3436: Acetolactate synthase small subunit (EC 2.2.1.6)	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Acetolactate synthase small subunit (EC 2.2.1.6)
ilvC	* Clostridium kluyveri DSM 555 Site: position = -253 score = 104.84 sequence = TAAAAACTGAGACAG... Gene: CKL_1089: Ketol-acid reductoisomerase (EC 1.1.1.86)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_3435: Ketol-acid reductoisomerase (EC 1.1.1.86)	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Ketol-acid reductoisomerase (EC 1.1.1.86)
leuA2	* Clostridium kluyveri DSM 555 Site: position = -244 score = 112.64 sequence = TGTAAAAACTATGAT... Gene: CKL_2160: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_3434: 2-isopropylmalate synthase (EC 2.3.3.13)	* Clostridium phytofermentans ISDg Site: position = -421 score = 109.86 sequence = GAAAAATACTTGGAA... Gene: Cphy_3171: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	2-isopropylmalate synthase (EC 2.3.3.13)
leuA	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_3433: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium phytofermentans ISDg	Clostridium tetani E88	* Clostridium acetobutylicum ATCC 824 Site: position = -310 score = 123.39 sequence = ATATTGCTATGAACA... Gene: CAC0273: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium difficile 630 Site: position = -369 score = 116.48 sequence = AAAAAGTGATGAATA... Gene: CD0989: 2-isopropylmalate synthase (EC 2.3.3.13)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	2-isopropylmalate synthase (EC 2.3.3.13)
leuC	Clostridium kluyveri DSM 555 Gene: CKL_2159: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD0990: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
leuD	Clostridium kluyveri DSM 555 Gene: CKL_2158: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD0991: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
leuB	Clostridium kluyveri DSM 555 Gene: CKL_2157: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD0992: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	3-isopropylmalate dehydrogenase (EC 1.1.1.85)
ilvH1	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521 Gene: CBY_1195: Acetolactate synthase small subunit (EC 2.2.1.6)	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Acetolactate synthase small subunit (EC 2.2.1.6)