Regulog Purine - Clostridiaceae

Properties
Regulator type:	RNA regulatory element
Name:	Purine
RFAM:	RF00167
Regulation mode:
Biological process:	Purine metabolism
Effector:	Adenine; Guanine
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Clostridiaceae
By RNA motif - Purine
By effector - Adenine
By effector - Guanine
By pathway - Purine metabolism

Statistics of regulated genes
Genome	Genes	Operons
Clostridium kluyveri DSM 555	10	3
Clostridium sp. SS2/1
Clostridium cellulolyticum H10	1	1
Clostridium phytofermentans ISDg
Clostridium tetani E88	2	1
Clostridium acetobutylicum ATCC 824	5	3
Clostridium botulinum A str. ATCC 3502	16	6
Clostridium novyi NT	5	4
Clostridium perfringens ATCC 13124	5	4
Clostridium difficile 630	5	4
Clostridium beijerincki NCIMB 8052	6	4
Clostridium sp. OhILAs	3	2
Clostridium sp. L2-50
Clostridium scindens ATCC 35704	1	1
Clostridium nexile DSM 1787
Clostridium leptum DSM 753
Clostridium hiranonis DSM 13275	1	1
Clostridium butyricum 5521	5	3
Clostridium bolteae ATCC BAA-613	2	2
Clostridium bartlettii DSM 16795	3	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																					Function

CRON 1.
purE	* Clostridium kluyveri DSM 555 Site: position = -304 score = 70.93 sequence = TATCATAAACAAATA... Gene: CKL_2689: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium sp. SS2/1 Gene: CLOSS21_00744: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium cellulolyticum H10 Gene: Ccel_2185: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium phytofermentans ISDg Gene: null: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium tetani E88 Gene: CTC01966: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium acetobutylicum ATCC 824 Gene: CAC1390: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	* Clostridium botulinum A str. ATCC 3502 Site: position = -193 score = 83.14 sequence = TAAAACAAATGAATA... Gene: CBO2878: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium novyi NT Gene: NT01CX_2424: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium perfringens ATCC 13124 Gene: CPF_0672: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium difficile 630 Gene: CD0218: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1054: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium sp. OhILAs Gene: Clos_0537: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium sp. L2-50 Gene: CLOL250_02947: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium scindens ATCC 35704 Gene: CLOSCI_04066: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium nexile DSM 1787 Gene: CLONEX_02821: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium leptum DSM 753 Gene: CLOLEP_02076: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_02250: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium butyricum 5521 Gene: CBY_1021: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03532: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00624: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
purC	Clostridium kluyveri DSM 555 Gene: CKL_2688: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium tetani E88 Gene: CTC01170: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium acetobutylicum ATCC 824 Gene: CAC1391: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2877: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium novyi NT Gene: NT01CX_2423: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium perfringens ATCC 13124 Gene: CPF_0673: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium difficile 630 Gene: CD0219: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1055: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium sp. OhILAs Gene: Clos_2697: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00781: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium nexile DSM 1787 Gene: CLONEX_03856: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium leptum DSM 753 Gene: CLOLEP_03230: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_01780: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium butyricum 5521 Gene: CBY_1022: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_04162: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00623: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
purF	Clostridium kluyveri DSM 555 Gene: CKL_2687: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium sp. SS2/1 Gene: CLOSS21_02136: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium cellulolyticum H10 Gene: Ccel_2184: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium phytofermentans ISDg Gene: null: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium tetani E88 Gene: CTC01965: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium acetobutylicum ATCC 824 Gene: CAC1392: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2876: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium novyi NT Gene: NT01CX_2422: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium perfringens ATCC 13124 Gene: CPF_0674: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium difficile 630 Gene: CD0220: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1056: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium sp. OhILAs Gene: Clos_0538: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium sp. L2-50 Gene: CLOL250_00660: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium scindens ATCC 35704 Gene: CLOSCI_00780: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium nexile DSM 1787	2 Clostridium leptum DSM 753 Gene: CLOLEP_02077: Amidophosphoribosyltransferase (EC 2.4.2.14) Gene: CLOLEP_03229: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_02251: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium butyricum 5521 Gene: CBY_1023: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_04161: Amidophosphoribosyltransferase (EC 2.4.2.14)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00622: Amidophosphoribosyltransferase (EC 2.4.2.14)	Amidophosphoribosyltransferase (EC 2.4.2.14)
purM	Clostridium kluyveri DSM 555 Gene: CKL_2686: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium sp. SS2/1 Gene: CLOSS21_00742: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium cellulolyticum H10 Gene: Ccel_2183: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium phytofermentans ISDg Gene: null: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium tetani E88 Gene: CTC01964: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium acetobutylicum ATCC 824 Gene: CAC1393: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2875: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium novyi NT Gene: NT01CX_2421: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium perfringens ATCC 13124 Gene: CPF_0675: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium difficile 630 Gene: CD0221: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1057: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium sp. OhILAs Gene: Clos_0539: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	2 Clostridium sp. L2-50 Gene: CLOL250_02270: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) Gene: CLOL250_02937: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium scindens ATCC 35704 Gene: CLOSCI_04067: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium nexile DSM 1787 Gene: CLONEX_02822: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium leptum DSM 753 Gene: CLOLEP_02078: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_02252: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium butyricum 5521 Gene: CBY_1024: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03531: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00621: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
purN	Clostridium kluyveri DSM 555 Gene: CKL_2685: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium sp. SS2/1 Gene: CLOSS21_00741: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium cellulolyticum H10 Gene: Ccel_2182: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium phytofermentans ISDg Gene: null: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium tetani E88 Gene: CTC01963: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium acetobutylicum ATCC 824 Gene: CAC1394: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2874: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium novyi NT Gene: NT01CX_2420: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium perfringens ATCC 13124 Gene: CPF_0676: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium difficile 630 Gene: CD0222: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1058: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium sp. OhILAs Gene: Clos_0540: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium sp. L2-50 Gene: CLOL250_02936: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium scindens ATCC 35704 Gene: CLOSCI_04068: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium nexile DSM 1787 Gene: CLONEX_02823: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium leptum DSM 753 Gene: CLOLEP_02079: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_02253: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium butyricum 5521 Gene: CBY_1025: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03530: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00620: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
purH	Clostridium kluyveri DSM 555 Gene: CKL_2684: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium sp. SS2/1 Gene: CLOSS21_00320: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium cellulolyticum H10 Gene: Ccel_2181: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium phytofermentans ISDg Gene: null: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium tetani E88 Gene: CTC01962: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium acetobutylicum ATCC 824 Gene: CAC1395: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2873: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium novyi NT Gene: NT01CX_2419: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium perfringens ATCC 13124 Gene: CPF_0677: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	2 Clostridium difficile 630 Gene: CD0841: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10) Gene: CD0223: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1059: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium sp. OhILAs Gene: Clos_0541: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium sp. L2-50 Gene: CLOL250_00135: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium scindens ATCC 35704 Gene: CLOSCI_04002: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium nexile DSM 1787 Gene: CLONEX_04124: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium leptum DSM 753 Gene: CLOLEP_02082: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_02254: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium butyricum 5521 Gene: CBY_1026: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_04669: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00132: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)	Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10)
purD	Clostridium kluyveri DSM 555 Gene: CKL_2683: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium sp. SS2/1 Gene: CLOSS21_00740: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium cellulolyticum H10 Gene: Ccel_2180: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium phytofermentans ISDg Gene: null: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium tetani E88 Gene: CTC01961: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium acetobutylicum ATCC 824 Gene: CAC1396: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2872: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_0678: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium difficile 630 Gene: CD0224: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1060: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium sp. OhILAs Gene: Clos_0542: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium sp. L2-50 Gene: CLOL250_02935: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium scindens ATCC 35704 Gene: CLOSCI_04069: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium nexile DSM 1787 Gene: CLONEX_02824: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium leptum DSM 753 Gene: CLOLEP_02083: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_02255: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium butyricum 5521 Gene: CBY_1027: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03529: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00619: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Phosphoribosylamine--glycine ligase (EC 6.3.4.13)

CRON 2.
pbuX	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	* Clostridium acetobutylicum ATCC 824 Site: position = -473 score = 70.91 sequence = ATATAAAAAACTAAA... Gene: CAC0872: Uracil-xanthine permease	* Clostridium botulinum A str. ATCC 3502 Site: position = -277 score = 82.54 sequence = CATATATCATATAAA... Gene: CBO0316: Uracil-xanthine permease	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -361 score = 75.7 sequence = ATAAGTGTATTAAAT... Gene: CPF_0385: Uracil-xanthine permease	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -245 score = 69.49 sequence = AACAGTTCATACAAA... Gene: Cbei_2426: Uracil-xanthine permease	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -340 score = 70.64 sequence = CTGAGACGATAACAC... Gene: CBY_1905: Uracil-xanthine permease	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Uracil-xanthine permease
xpt	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1 Gene: CLOSS21_00668: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	* Clostridium cellulolyticum H10 Site: position = -279 score = 78.82 sequence = TAAATTATGGAAAAG... Gene: Ccel_1405: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium phytofermentans ISDg Gene: null: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium tetani E88 Gene: CTC02386: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium acetobutylicum ATCC 824 Gene: CAC0873: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	2 Clostridium botulinum A str. ATCC 3502 Gene: CBO1139: Xanthine phosphoribosyltransferase (EC 2.4.2.22) Gene: CBO0317: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	* Clostridium novyi NT Site: position = -255 score = 75.6 sequence = AATTAAATAATGTTC... Gene: NT01CX_0402: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	2 Clostridium perfringens ATCC 13124* Gene: CPF_1498: Xanthine phosphoribosyltransferase (EC 2.4.2.22) Site: position = -339 score = 70.71 sequence = TATGTACTTATATAA... Gene: CPF_0319: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	* Clostridium difficile 630 Site: position = -285 score = 69.91 sequence = GGAATAAATTAATAT... Gene: CD2330: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2427: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_01934: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01698: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium nexile DSM 1787 Gene: CLONEX_03048: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00172: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium butyricum 5521 Gene: CBY_1904: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_00033: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02110: Xanthine phosphoribosyltransferase (EC 2.4.2.22)	Xanthine phosphoribosyltransferase (EC 2.4.2.22)

CRON 3.
guaB	* Clostridium kluyveri DSM 555 Site: position = -197 score = 21.59 sequence = AATAAGTTCTTTATT... Gene: CKL_0465: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	2 Clostridium sp. SS2/1 Gene: CLOSS21_02649: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Gene: CLOSS21_00765: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg Gene: null: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	* Clostridium tetani E88 Site: position = -190 score = 66.87 sequence = GCTCTATAATAAATT... Gene: CTC02410: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	* Clostridium acetobutylicum ATCC 824 Site: position = -229 score = 61.72 sequence = TAATCGTTAATATAG... Gene: CAC2701: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	2 Clostridium botulinum A str. ATCC 3502* Site: position = -185 score = 66.02 sequence = ATCAATATTTTCAAA... Gene: CBO3296: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Gene: CBO3605: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	* Clostridium novyi NT Site: position = -243 score = 67.37 sequence = CGCAGAGAAATAAAA... Gene: NT01CX_0460: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	* Clostridium perfringens ATCC 13124 Site: position = -286 score = 69.03 sequence = CAAAACGGAATATAA... Gene: CPF_2558: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -244 score = 65.74 sequence = ATATAGCACATTTGA... Gene: Cbei_0331: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	* Clostridium sp. OhILAs Site: position = -325 score = 87.25 sequence = ATTTAAAAACGAATA... Gene: Clos_0533: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	2 Clostridium sp. L2-50 Gene: CLOL250_01453: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Gene: CLOL250_02329: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	2 Clostridium scindens ATCC 35704 Gene: CLOSCI_00052: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Gene: CLOSCI_02499: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	Clostridium nexile DSM 1787 Gene: CLONEX_00412: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	2 Clostridium leptum DSM 753 Gene: CLOLEP_01281: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Gene: CLOLEP_03116: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	Clostridium hiranonis DSM 13275	* Clostridium butyricum 5521 Site: position = -246 score = 67.86 sequence = ATACGGCACATTAAA... Gene: CBY_3053: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_06625: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	* Clostridium bartlettii DSM 16795 Site: position = -357 score = 88.8 sequence = AAAAGATAATTAATA... Gene: CLOBAR_00656: Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)	Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)
guaA	Clostridium kluyveri DSM 555 Gene: CKL_0466: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium sp. SS2/1 Gene: CLOSS21_02054: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium cellulolyticum H10 Gene: Ccel_2202: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium phytofermentans ISDg Gene: null: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium tetani E88 Gene: CTC02409: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium acetobutylicum ATCC 824 Gene: CAC2700: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3295: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium novyi NT Gene: NT01CX_0459: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium perfringens ATCC 13124 Gene: CPF_2557: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	* Clostridium difficile 630 Site: position = -321 score = 91.19 sequence = ATATAAAATATAAAC... Gene: CD0198: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0332: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium sp. OhILAs Gene: Clos_0534: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium sp. L2-50 Gene: CLOL250_02428: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	2 Clostridium scindens ATCC 35704 Gene: CLOSCI_03505: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Gene: CLOSCI_03102: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium nexile DSM 1787 Gene: CLONEX_00833: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium leptum DSM 753 Gene: CLOLEP_03225: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	2 Clostridium hiranonis DSM 13275 Gene: CLOHIR_00057: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Gene: CLOHIR_00058: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium butyricum 5521 Gene: CBY_3054: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	2 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_04441: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Gene: CLOBOL_01078: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00655: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2)

CRON 4.
pbuO	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	* Clostridium botulinum A str. ATCC 3502 Site: position = -169 score = 79.07 sequence = TACAAAATAAAATAT... Gene: CBO2006: Guanine-hypoxanthine permease	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Guanine-hypoxanthine permease
xpt	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO2005: Adenine phosphoribosyltransferase (EC 2.4.2.7)	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753 Gene: CLOLEP_01895: Adenine phosphoribosyltransferase (EC 2.4.2.7)	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Adenine phosphoribosyltransferase (EC 2.4.2.7)

CRON 5.
COG2509	Clostridium kluyveri DSM 555 Gene: CKL_0086: NAD(FAD)-utilizing dehydrogenase	Clostridium sp. SS2/1 Gene: CLOSS21_03163: NAD(FAD)-utilizing dehydrogenase	Clostridium cellulolyticum H10 Gene: Ccel_1403: NAD(FAD)-utilizing dehydrogenase	Clostridium phytofermentans ISDg Gene: null: NAD(FAD)-utilizing dehydrogenase	2 Clostridium tetani E88 Gene: CTC00118: NAD(FAD)-utilizing dehydrogenase Gene: CTC01317: NAD(FAD)-utilizing dehydrogenase	Clostridium acetobutylicum ATCC 824 Gene: CAC3595: NAD(FAD)-utilizing dehydrogenase	Clostridium botulinum A str. ATCC 3502 Gene: CBO3617: NAD(FAD)-utilizing dehydrogenase	Clostridium novyi NT Gene: NT01CX_0904: NAD(FAD)-utilizing dehydrogenase	Clostridium perfringens ATCC 13124	Clostridium difficile 630	* Clostridium beijerincki NCIMB 8052 Site: position = -130 score = 65.42 sequence = AAAAGTTAATAATAT... Gene: Cbei_1910: NAD(FAD)-utilizing dehydrogenase	Clostridium sp. OhILAs	Clostridium sp. L2-50 Gene: CLOL250_01615: NAD(FAD)-utilizing dehydrogenase	Clostridium scindens ATCC 35704 Gene: CLOSCI_04008: NAD(FAD)-utilizing dehydrogenase	Clostridium nexile DSM 1787	Clostridium leptum DSM 753 Gene: CLOLEP_01066: NAD(FAD)-utilizing dehydrogenase	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	* Clostridium bolteae ATCC BAA-613 Site: position = -153 score = 46.47 sequence = ACTATAACCGTTGTG... Gene: CLOBOL_04589: NAD(FAD)-utilizing dehydrogenase	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01145: NAD(FAD)-utilizing dehydrogenase	NAD(FAD)-utilizing dehydrogenase

CRON 6.
pbuO	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC2820: Xanthine permease	* Clostridium botulinum A str. ATCC 3502 Site: position = -224 score = 76.96 sequence = AGACATAATTAAATA... Gene: CBO2189: Xanthine permease	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium difficile 630 Site: position = -173 score = 69.47 sequence = AAAAACAAATAGAAA... Gene: CD2704: Xanthine permease	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_03162: Xanthine permease	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	3 Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_03651: Xanthine permease Gene: CLOBOL_01253: Xanthine permease Gene: CLOBOL_06968: Xanthine permease	Clostridium bartlettii DSM 16795	Xanthine permease
guaD	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824	Clostridium botulinum A str. ATCC 3502 Gene: CBO2188: Pyrimidine deaminase archaeal predicted (EC 3.5.4.26) type 2	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD2705: Pyrimidine deaminase archaeal predicted (EC 3.5.4.26) type 2	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Pyrimidine deaminase archaeal predicted (EC 3.5.4.26) type 2

CRON 7.
add	Clostridium kluyveri DSM 555 Gene: CKL_0833: Adenosine deaminase (EC 3.5.4.4)	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC3005: Adenosine deaminase (EC 3.5.4.4)	Clostridium botulinum A str. ATCC 3502 Gene: CBO0991: Adenosine deaminase (EC 3.5.4.4)	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -213 score = 77.19 sequence = AAATAAAAAATAAAT... Gene: CPF_2829: Adenosine deaminase (EC 3.5.4.4)	Clostridium difficile 630 Gene: CD1747: Adenosine deaminase (EC 3.5.4.4)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	Clostridium scindens ATCC 35704 Gene: CLOSCI_00020: Adenosine deaminase (EC 3.5.4.4)	Clostridium nexile DSM 1787 Gene: CLONEX_02397: Adenosine deaminase (EC 3.5.4.4)	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275 Gene: CLOHIR_01530: Adenosine deaminase (EC 3.5.4.4)	* Clostridium butyricum 5521 Site: position = -156 score = 66.51 sequence = ATTTAAATTAATAAA... Gene: CBY_3122: Adenosine deaminase (EC 3.5.4.4)	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795	Adenosine deaminase (EC 3.5.4.4)

CRON 8.
guaD	Clostridium kluyveri DSM 555	Clostridium sp. SS2/1	Clostridium cellulolyticum H10	Clostridium phytofermentans ISDg	Clostridium tetani E88	Clostridium acetobutylicum ATCC 824 Gene: CAC0282: Guanine deaminase (EC 3.5.4.3)	Clostridium botulinum A str. ATCC 3502	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium difficile 630 Gene: CD1663: Guanine deaminase (EC 3.5.4.3)	Clostridium beijerincki NCIMB 8052	Clostridium sp. OhILAs	Clostridium sp. L2-50	* Clostridium scindens ATCC 35704 Site: position = -139 score = 43.03 sequence = AAAAATGAAATAACT... Gene: CLOSCI_02894: Guanine deaminase (EC 3.5.4.3)	Clostridium nexile DSM 1787 Gene: CLONEX_01616: Guanine deaminase (EC 3.5.4.3)	Clostridium leptum DSM 753	Clostridium hiranonis DSM 13275	Clostridium butyricum 5521	* Clostridium bolteae ATCC BAA-613 Site: position = -253 score = 57.42 sequence = AGAAGTATAAGTATT... Gene: CLOBOL_03369: Guanine deaminase (EC 3.5.4.3)	* Clostridium bartlettii DSM 16795 Site: position = -140 score = 50.64 sequence = ATATTATAATACAGA... Gene: CLOBAR_02435: Guanine deaminase (EC 3.5.4.3)	Guanine deaminase (EC 3.5.4.3)

CRON 9.
pbuO	* Clostridium kluyveri DSM 555 Site: position = -178 score = 72.22 sequence = CTAAATTTTTCGATA... Gene: CKL_2693: xanthine/uracil permease family protein	Clostridium sp. SS2/1	Clostridium cellulolyticum H10 Gene: Ccel_0209: xanthine/uracil permease family protein	Clostridium phytofermentans ISDg Gene: null: xanthine/uracil permease family protein	Clostridium tetani E88 Gene: CTC01973: xanthine/uracil permease family protein	* Clostridium acetobutylicum ATCC 824 Site: position = -418 score = 83.74 sequence = TGAAAAGTAATAACA... Gene: CAC2772: xanthine/uracil permease family protein	* Clostridium botulinum A str. ATCC 3502 Site: position = -185 score = 80.22 sequence = AAGTTAAGTGAATAG... Gene: CBO2901: xanthine/uracil permease family protein	2 Clostridium novyi NT* Site: position = -169 score = 79.16 sequence = AACAGAATATTAATC... Gene: NT01CX_2252: xanthine/uracil permease family protein Site: position = -282 score = 75.65 sequence = TTAAATACGTTATTA... Gene: NT01CX_2417: xanthine/uracil permease family protein	Clostridium perfringens ATCC 13124 Gene: CPF_2004: xanthine/uracil permease family protein	* Clostridium difficile 630 Site: position = -175 score = 66.63 sequence = ACATATAATTTTGAC... Gene: CD2107: xanthine/uracil permease family protein	2 Clostridium beijerincki NCIMB 8052* Site: position = -325 score = 84.77 sequence = ATATAAATAATGAAA... Gene: Cbei_4067: xanthine/uracil permease family protein Gene: Cbei_1974: xanthine/uracil permease family protein	* Clostridium sp. OhILAs Site: position = -274 score = 80.41 sequence = GTGAATATGGATTTT... Gene: Clos_0535: xanthine/uracil permease family protein	Clostridium sp. L2-50	Clostridium scindens ATCC 35704	Clostridium nexile DSM 1787	Clostridium leptum DSM 753 Gene: CLOLEP_03737: xanthine/uracil permease family protein	* Clostridium hiranonis DSM 13275 Site: position = -169 score = 67.97 sequence = ATAAAAATTAATAAT... Gene: CLOHIR_00437: xanthine/uracil permease family protein	Clostridium butyricum 5521	Clostridium bolteae ATCC BAA-613	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01999: xanthine/uracil permease family protein	xanthine/uracil permease family protein