Regulog LldR - Corynebacteriaceae

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	repressor
Biological process:	Lactate utilization
Effector:	L-lactate
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 12 sites [see more]

Member of regulog collections

By taxonomy - Corynebacteriaceae
By trascription factor - LldR
By TF family - GntR/Others
By effector - L-lactate
By pathway - Lactate utilization

Statistics of regulated genes
Genome	Genes	Operons
Corynebacterium amycolatum SK46
Corynebacterium aurimucosum ATCC 700975
Corynebacterium diphtheriae NCTC 13129	5	3
Corynebacterium efficiens YS-314	8	3
Corynebacterium glutamicum ATCC 13032	12	4
Corynebacterium jeikeium K411
Corynebacterium kroppenstedtii DSM 44385
Corynebacterium urealyticum DSM 7109

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
lldE	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1042: Predicted L-lactate dehydrogenase, Fe-S oxidoreductase subunit YkgE	* Corynebacterium diphtheriae NCTC 13129 Site: position = -332 score = 3.9019 sequence = TTTGGGTGGACCACA Gene: DIP1032: Predicted L-lactate dehydrogenase, Fe-S oxidoreductase subunit YkgE	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1293: Predicted L-lactate dehydrogenase, Fe-S oxidoreductase subunit YkgE	Corynebacterium urealyticum DSM 7109	Predicted L-lactate dehydrogenase, Fe-S oxidoreductase subunit YkgE
lldF	Corynebacterium amycolatum SK46 Gene: CORAM0001_0634: Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1041: Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF	Corynebacterium diphtheriae NCTC 13129 Gene: DIP1031: Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1294: Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF	Corynebacterium urealyticum DSM 7109	Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF
lldG	Corynebacterium amycolatum SK46 Gene: CORAM0001_0633: Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1040: Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG	Corynebacterium diphtheriae NCTC 13129 Gene: DIP1030: Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1295: Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG	Corynebacterium urealyticum DSM 7109	Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG

CRON 2.
ldhA	Corynebacterium amycolatum SK46 Gene: CORAM0001_2074: L-lactate dehydrogenase (EC 1.1.1.27)	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_2403: L-lactate dehydrogenase (EC 1.1.1.27)	Corynebacterium diphtheriae NCTC 13129 Gene: DIP2255: L-lactate dehydrogenase (EC 1.1.1.27)	* Corynebacterium efficiens YS-314 Site: position = -119 score = 4.82966 sequence = AGTGGTCCGGCCAGA Gene: CE2753: L-lactate dehydrogenase (EC 1.1.1.27)	* Corynebacterium glutamicum ATCC 13032 Site: position = -137 score = 5.37601 sequence = CTTGGTCTGACCACA Gene: cg3219: L-lactate dehydrogenase (EC 1.1.1.27)	Corynebacterium jeikeium K411 Gene: jk0113: L-lactate dehydrogenase (EC 1.1.1.27)	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0111: L-lactate dehydrogenase (EC 1.1.1.27)	Corynebacterium urealyticum DSM 7109	L-lactate dehydrogenase (EC 1.1.1.27)

CRON 3.
cg3226	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	* Corynebacterium efficiens YS-314 Site: position = -14 score = 5.08265 sequence = CATGGCCTGACCACA Site: position = -27 score = 5.959 sequence = TGTGGTCTGACCACA Gene: CE2761: L-lactate permease, PF00083 family	* Corynebacterium glutamicum ATCC 13032 Site: position = -77 score = 5.29164 sequence = TGTGGTCTGACCATG Gene: cg3226: L-lactate permease, PF00083 family	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	L-lactate permease, PF00083 family
lldD	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_0795: L-lactate dehydrogenase (EC 1.1.2.3)	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2762: L-lactate dehydrogenase (EC 1.1.2.3)	Corynebacterium glutamicum ATCC 13032 Gene: cg3227: L-lactate dehydrogenase (EC 1.1.2.3)	Corynebacterium jeikeium K411 Gene: jk1705: L-lactate dehydrogenase (EC 1.1.2.3)	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0013: L-lactate dehydrogenase (EC 1.1.2.3)	Corynebacterium urealyticum DSM 7109	L-lactate dehydrogenase (EC 1.1.2.3)

CRON 4.
lldP	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1046: L-lactate permease	2 Corynebacterium diphtheriae NCTC 13129* Site: position = -122 score = 5.37601 sequence = TGTGGTCTTACCACT Site: position = -108 score = 5.1022 sequence = TGTGGTCAGACCAAC Gene: DIP0012: L-lactate permease Site: position = -120 score = 4.95395 sequence = TGTGGTCCACCCAAA Gene: DIP1033: L-lactate permease	Corynebacterium efficiens YS-314	Corynebacterium glutamicum ATCC 13032	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_0014: L-lactate permease	Corynebacterium urealyticum DSM 7109	L-lactate permease

CRON 5.
CE2754	Corynebacterium amycolatum SK46 Gene: CORAM0001_2075: conserved membrane-spanning protein	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_2404: conserved membrane-spanning protein	Corynebacterium diphtheriae NCTC 13129	* Corynebacterium efficiens YS-314 Site: position = -75 score = 3.9659 sequence = TCTGGCCGGACCACT Gene: CE2754: conserved membrane-spanning protein	* Corynebacterium glutamicum ATCC 13032 Site: position = -106 score = 5.1022 sequence = TGTGGTCAGACCAAG Gene: cg3220: conserved membrane-spanning protein	Corynebacterium jeikeium K411 Gene: jk0028: conserved membrane-spanning protein	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	conserved membrane-spanning protein
CE2755	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_0021: phosphoglycolate phosphatase	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2755: phosphoglycolate phosphatase	Corynebacterium glutamicum ATCC 13032 Gene: cg3221: phosphoglycolate phosphatase	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	phosphoglycolate phosphatase
CE2756	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2756: NADPH-dependent FMN reductase	Corynebacterium glutamicum ATCC 13032 Gene: cg3223: NADPH-dependent FMN reductase	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	NADPH-dependent FMN reductase
lldR	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2757: Lactate-responsive regulator LldR in Actinobacteria, GntR family	Corynebacterium glutamicum ATCC 13032 Gene: cg3224: Lactate-responsive regulator LldR in Actinobacteria, GntR family	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	Lactate-responsive regulator LldR in Actinobacteria, GntR family
CE2758	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE2758: hypothetical protein	Corynebacterium glutamicum ATCC 13032 Gene: cg3225: hypothetical protein	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	hypothetical protein

CRON 6.
fruR	Corynebacterium amycolatum SK46	Corynebacterium aurimucosum ATCC 700975	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE1827: Fructose utilization transcriptional regulator FruR, DeoR family	* Corynebacterium glutamicum ATCC 13032 Site: position = -110 score = 4.20305 sequence = TACGGTTCTTCCACA Gene: cg2118: Fructose utilization transcriptional regulator FruR, DeoR family	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385	Corynebacterium urealyticum DSM 7109	Fructose utilization transcriptional regulator FruR, DeoR family
pfkB	Corynebacterium amycolatum SK46 Gene: CORAM0001_0855: 1-phosphofructokinase	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1480: 1-phosphofructokinase	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE1828: 1-phosphofructokinase	Corynebacterium glutamicum ATCC 13032 Gene: cg2119: 1-phosphofructokinase	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1091: 1-phosphofructokinase	Corynebacterium urealyticum DSM 7109	1-phosphofructokinase
ptsF	Corynebacterium amycolatum SK46 Gene: CORAM0001_0854: Fructose-specific PTS, IIABC component	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1481: Fructose-specific PTS, IIABC component	Corynebacterium diphtheriae NCTC 13129	Corynebacterium efficiens YS-314 Gene: CE1829: Fructose-specific PTS, IIABC component	Corynebacterium glutamicum ATCC 13032 Gene: cg2120: Fructose-specific PTS, IIABC component	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1092: Fructose-specific PTS, IIABC component	Corynebacterium urealyticum DSM 7109	Fructose-specific PTS, IIABC component
ptsH	Corynebacterium amycolatum SK46 Gene: CORAM0001_0853: Phosphocarrier protein of PTS system	Corynebacterium aurimucosum ATCC 700975 Gene: cauri_1482: Phosphocarrier protein of PTS system	Corynebacterium diphtheriae NCTC 13129 Gene: DIP1435: Phosphocarrier protein of PTS system	Corynebacterium efficiens YS-314 Gene: CE1830: Phosphocarrier protein of PTS system	Corynebacterium glutamicum ATCC 13032 Gene: cg2121: Phosphocarrier protein of PTS system	Corynebacterium jeikeium K411	Corynebacterium kroppenstedtii DSM 44385 Gene: ckrop_1094: Phosphocarrier protein of PTS system	Corynebacterium urealyticum DSM 7109	Phosphocarrier protein of PTS system

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog LldR - Corynebacteriaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --