Regulog SiaR - Enterobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	RpiR
Regulation mode:	repressor (activator)
Biological process:	Sialic acid utilization
Effector:	Glucosamine-6-phosphate
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 14 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - SiaR
By TF family - RpiR
By effector - Glucosamine-6-phosphate
By pathway - Sialic acid utilization

Statistics of regulated genes
Genome	Genes	Operons
Escherichia coli str. K-12 substr. MG1655
Salmonella typhimurium LT2	5	2
Citrobacter koseri ATCC BAA-895
Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Enterobacter sp. 638
Erwinia amylovora ATCC 49946
Yersinia pestis KIM	7	3
Serratia proteamaculans 568
Erwinia carotovora subsp. atroseptica SCRI1043
Edwardsiella tarda EIB202	6	3
Proteus mirabilis HI4320	6	2
Photorhabdus luminescens subsp. laumondii TTO1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
nanM	Escherichia coli str. K-12 substr. MG1655	* Salmonella typhimurium LT2 Site: position = -32 score = 5.04759 sequence = GATGAAGCTTTACTCCAAT Gene: STM1130: Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	* Edwardsiella tarda EIB202 Site: position = -98 score = 4.52564 sequence = AATGGAGCAATACTACAAC Site: position = -128 score = 5.22575 sequence = ATTGAAGTGTAACTCCAAA Gene: ETAE_0932: Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase
nanC	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2 Gene: STM1131: N-acetylneuraminic acid outer membrane channel protein NanC	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_03267: N-acetylneuraminic acid outer membrane channel protein NanC	Enterobacter sp. 638 Gene: Ent638_3298: N-acetylneuraminic acid outer membrane channel protein NanC	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202 Gene: ETAE_0931: N-acetylneuraminic acid outer membrane channel protein NanC	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	N-acetylneuraminic acid outer membrane channel protein NanC

CRON 2.
nanT	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	* Yersinia pestis KIM Site: position = -188 score = 5.47447 sequence = AATGGAGTTTTACTCCTTT Gene: y1465: Sialic acid transporter (permease) NanT	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	Sialic acid transporter (permease) NanT

CRON 3.
nanE	Escherichia coli str. K-12 substr. MG1655	* Salmonella typhimurium LT2 Site: position = -37 score = 4.90074 sequence = AACGGAGCAAAACTTCAAA Gene: STM1129: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Citrobacter koseri ATCC BAA-895 Gene: CKO_04626: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_03626: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	* Yersinia pestis KIM Site: position = -46 score = 5.91664 sequence = AATGGAGTTAAACTTCATT Gene: y1459: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	* Edwardsiella tarda EIB202 Site: position = -40 score = 4.32862 sequence = TATGGAGTTCAATTCTAAA Site: position = -70 score = 5.05494 sequence = GATGGAGTATTGCTCCATA Gene: ETAE_0521: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	* Proteus mirabilis HI4320 Site: position = -41 score = 4.47207 sequence = TTCGGAGTTACATTTCAAA Site: position = -71 score = 4.48166 sequence = TGAGAAATAAAACTCCGTA Gene: PMI2978: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Photorhabdus luminescens subsp. laumondii TTO1	N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)
nanK	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_04625: N-acetylmannosamine kinase (EC 2.7.1.60)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	* Yersinia pestis KIM Site: position = -111 score = 5.43783 sequence = AAAGGAGTTTAACTCCAAA Gene: y1461: N-acetylmannosamine kinase (EC 2.7.1.60)	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202 Gene: ETAE_0520: N-acetylmannosamine kinase (EC 2.7.1.60)	Proteus mirabilis HI4320 Gene: PMI2977: N-acetylmannosamine kinase (EC 2.7.1.60)	Photorhabdus luminescens subsp. laumondii TTO1	N-acetylmannosamine kinase (EC 2.7.1.60)
nanP	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2 Gene: STM1128: Predicted sialic acid transporter	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202 Gene: ETAE_0930: Predicted sialic acid transporter	Proteus mirabilis HI4320 Gene: PMI2976: Predicted sialic acid transporter	Photorhabdus luminescens subsp. laumondii TTO1	Predicted sialic acid transporter
yhcH	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895 Gene: CKO_04624: Uncharacterized protein yhcH	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM Gene: y1462: Uncharacterized protein yhcH	Serratia proteamaculans 568 Gene: Spro_1482: Uncharacterized protein yhcH	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202 Gene: ETAE_0519: Uncharacterized protein yhcH	Proteus mirabilis HI4320 Gene: PMI2975: Uncharacterized protein yhcH	Photorhabdus luminescens subsp. laumondii TTO1	Uncharacterized protein yhcH
siaR	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2 Gene: STM1127: Sialic acid utilization regulator, RpiR family	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM Gene: y1464: Sialic acid utilization regulator, RpiR family	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202 Gene: ETAE_0929: Sialic acid utilization regulator, RpiR family	Proteus mirabilis HI4320 Gene: PMI2974: Sialic acid utilization regulator, RpiR family	Photorhabdus luminescens subsp. laumondii TTO1	Sialic acid utilization regulator, RpiR family
y1463	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM Gene: y1463: hypothetical protein	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	Edwardsiella tarda EIB202	Proteus mirabilis HI4320	Photorhabdus luminescens subsp. laumondii TTO1	hypothetical protein
nanA	Escherichia coli str. K-12 substr. MG1655	Salmonella typhimurium LT2	Citrobacter koseri ATCC BAA-895	Klebsiella pneumoniae subsp. pneumoniae MGH 78578	Enterobacter sp. 638	Erwinia amylovora ATCC 49946	Yersinia pestis KIM Gene: y1458: N-acetylneuraminate lyase (EC 4.1.3.3)	Serratia proteamaculans 568	Erwinia carotovora subsp. atroseptica SCRI1043	* Edwardsiella tarda EIB202 Site: position = -61 score = 4.98094 sequence = AATGGAGCCAAACTCCATA Gene: ETAE_0928: N-acetylneuraminate lyase (EC 4.1.3.3)	* Proteus mirabilis HI4320 Site: position = -29 score = 4.84438 sequence = AAAGAAATTAATCTCCATA Site: position = -59 score = 5.37928 sequence = TATAGAGTTAAACTCCATA Gene: PMI2973: N-acetylneuraminate lyase (EC 4.1.3.3)	Photorhabdus luminescens subsp. laumondii TTO1	N-acetylneuraminate lyase (EC 4.1.3.3)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog SiaR - Enterobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --