Regulog HexR - Comamonadaceae

Properties
Regulator type:	Transcription factor
Regulator family:	RpiR
Regulation mode:	repressor (activator)
Biological process:	Central carbohydrate metabolism
Effector:	2-keto-3-deoxy-6-phosphogluconate
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 28 sites [see more]

Member of regulog collections

By taxonomy - Comamonadaceae
By trascription factor - HexR
By TF family - RpiR
By effector - 2-keto-3-deoxy-6-phosphogluconate
By pathway - Central carbohydrate metabolism

Statistics of regulated genes
Genome	Genes	Operons
Acidovorax avenae subsp. citrulli AAC00-1	2	2
Acidovorax sp. JS42	3	2
Comamonas testosteroni KF-1	2	2
Delftia acidovorans SPH-1	4	4
Polaromonas naphthalenivorans CJ2	5	3
Polaromonas sp. JS666	6	4
Rhodoferax ferrireducens DSM 15236	7	4
Variovorax paradoxus S110
Verminephrobacter eiseniae EF01-2	3	3
Methylibium petroleiphilum PM1
Leptothrix cholodnii SP-6	6	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
pykA	* Acidovorax avenae subsp. citrulli AAC00-1 Site: position = -47 score = 5.56091 sequence = TTGAAACCCGATTACAT Gene: Aave_4581: Pyruvate kinase (EC 2.7.1.40)	* Acidovorax sp. JS42 Site: position = -38 score = 5.41716 sequence = TCGAAACTCGATTACAT Gene: Ajs_3956: Pyruvate kinase (EC 2.7.1.40)	* Comamonas testosteroni KF-1 Site: position = -39 score = 5.56091 sequence = TTGAAACCCGATTACAT Gene: CtesDRAFT_3719: Pyruvate kinase (EC 2.7.1.40)	* Delftia acidovorans SPH-1 Site: position = -38 score = 5.51609 sequence = TTGAAACCCGATTACAA Gene: Daci_0930: Pyruvate kinase (EC 2.7.1.40)	* Polaromonas naphthalenivorans CJ2 Site: position = -30 score = 5.48223 sequence = CGGAAACTAAATTACAA Gene: Pnap_3873: Pyruvate kinase (EC 2.7.1.40)	* Polaromonas sp. JS666 Site: position = -26 score = 5.00446 sequence = CGGGAACTAAATTACAG Gene: Bpro_4634: Pyruvate kinase (EC 2.7.1.40)	* Rhodoferax ferrireducens DSM 15236 Site: position = -29 score = 5.29927 sequence = TGGAAACTTGATTACAA Gene: Rfer_0205: Pyruvate kinase (EC 2.7.1.40)	Variovorax paradoxus S110 Gene: Vapar_5100: Pyruvate kinase (EC 2.7.1.40)	Verminephrobacter eiseniae EF01-2 Gene: Veis_0196: Pyruvate kinase (EC 2.7.1.40)	Methylibium petroleiphilum PM1 Gene: Mpe_A0290: Pyruvate kinase (EC 2.7.1.40)	Leptothrix cholodnii SP-6 Gene: Lcho_0360: Pyruvate kinase (EC 2.7.1.40)	Pyruvate kinase (EC 2.7.1.40)

CRON 2.
edd	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_2793: Phosphogluconate dehydratase (EC 4.2.1.12)	Acidovorax sp. JS42 Gene: Ajs_2049: Phosphogluconate dehydratase (EC 4.2.1.12)	Comamonas testosteroni KF-1 Gene: CtesDRAFT_0557: Phosphogluconate dehydratase (EC 4.2.1.12)	Delftia acidovorans SPH-1 Gene: Daci_3765: Phosphogluconate dehydratase (EC 4.2.1.12)	* Polaromonas naphthalenivorans CJ2 Site: position = -54 score = 4.71759 sequence = CCGTAATAAAGTTACAT Gene: Pnap_2986: Phosphogluconate dehydratase (EC 4.2.1.12)	* Polaromonas sp. JS666 Site: position = -34 score = 4.71759 sequence = CCGTAATAAAGTTACAT Gene: Bpro_3551: Phosphogluconate dehydratase (EC 4.2.1.12)	* Rhodoferax ferrireducens DSM 15236 Site: position = -32 score = 4.91055 sequence = ATGTAATTAAGTTACCA Gene: Rfer_2060: Phosphogluconate dehydratase (EC 4.2.1.12)	Variovorax paradoxus S110 Gene: Vapar_3708: Phosphogluconate dehydratase (EC 4.2.1.12)	Verminephrobacter eiseniae EF01-2 Gene: Veis_2570: Phosphogluconate dehydratase (EC 4.2.1.12)	Methylibium petroleiphilum PM1	* Leptothrix cholodnii SP-6 Site: position = -94 score = 4.35267 sequence = ATGTAACTTAGTTTCGG Gene: Lcho_2919: Phosphogluconate dehydratase (EC 4.2.1.12)	Phosphogluconate dehydratase (EC 4.2.1.12)
eda	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_2792: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Acidovorax sp. JS42 Gene: Ajs_2048: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Comamonas testosteroni KF-1 Gene: CtesDRAFT_0556: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Delftia acidovorans SPH-1 Gene: Daci_3766: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Polaromonas naphthalenivorans CJ2 Gene: Pnap_2985: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Polaromonas sp. JS666 Gene: Bpro_3550: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Rhodoferax ferrireducens DSM 15236 Gene: Rfer_2061: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Variovorax paradoxus S110 Gene: Vapar_3707: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Verminephrobacter eiseniae EF01-2 Gene: Veis_2569: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6 Gene: Lcho_2918: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

CRON 3.
tal	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_0943: Transaldolase (EC 2.2.1.2)	Acidovorax sp. JS42 Gene: Ajs_0696: Transaldolase (EC 2.2.1.2)	Comamonas testosteroni KF-1 Gene: CtesDRAFT_4623: Transaldolase (EC 2.2.1.2)	Delftia acidovorans SPH-1 Gene: Daci_5675: Transaldolase (EC 2.2.1.2)	Polaromonas naphthalenivorans CJ2 Gene: Pnap_0654: Transaldolase (EC 2.2.1.2)	2 Polaromonas sp. JS666* Site: position = -95 score = 4.14114 sequence = TTGTAATTTAGTTTCAC Gene: Bpro_0752: Transaldolase (EC 2.2.1.2) Gene: Bpro_4350: Transaldolase (EC 2.2.1.2)	* Rhodoferax ferrireducens DSM 15236 Site: position = -108 score = 4.91128 sequence = ATGTAACTTAGTTTCAT Gene: Rfer_1126: Transaldolase (EC 2.2.1.2)	Variovorax paradoxus S110 Gene: Vapar_1102: Transaldolase (EC 2.2.1.2)	Verminephrobacter eiseniae EF01-2 Gene: Veis_1779: Transaldolase (EC 2.2.1.2)	Methylibium petroleiphilum PM1 Gene: Mpe_A3095: Transaldolase (EC 2.2.1.2)	* Leptothrix cholodnii SP-6 Site: position = -221 score = 4.63706 sequence = CTGTAACTGAGTTTCAG Gene: Lcho_3386: Transaldolase (EC 2.2.1.2)	Transaldolase (EC 2.2.1.2)
pgi	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_0944: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Acidovorax sp. JS42 Gene: Ajs_0697: Glucose-6-phosphate isomerase (EC 5.3.1.9)	3 Comamonas testosteroni KF-1 Gene: CtesDRAFT_4622: Glucose-6-phosphate isomerase (EC 5.3.1.9) Gene: CtesDRAFT_1226: Glucose-6-phosphate isomerase (EC 5.3.1.9) Gene: CtesDRAFT_2676: Glucose-6-phosphate isomerase (EC 5.3.1.9)	2 Delftia acidovorans SPH-1* Gene: Daci_5674: Glucose-6-phosphate isomerase (EC 5.3.1.9) Site: position = -24 score = 4.30025 sequence = TGGTAATCAGATTACTT Site: position = -109 score = 4.79061 sequence = TGGTAACTTGGTTACCA Gene: Daci_5598: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Polaromonas naphthalenivorans CJ2 Gene: Pnap_0655: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Polaromonas sp. JS666 Gene: Bpro_0753: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Rhodoferax ferrireducens DSM 15236 Gene: Rfer_1127: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Variovorax paradoxus S110 Gene: Vapar_1103: Glucose-6-phosphate isomerase (EC 5.3.1.9)	* Verminephrobacter eiseniae EF01-2 Site: position = -67 score = 4.51857 sequence = TCGTAATCAAGTTACCA Gene: Veis_4222: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Methylibium petroleiphilum PM1 Gene: Mpe_A3094: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Leptothrix cholodnii SP-6 Gene: Lcho_3385: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Glucose-6-phosphate isomerase (EC 5.3.1.9)

CRON 4.
zwf	* Acidovorax avenae subsp. citrulli AAC00-1 Site: position = -105 score = 5.07009 sequence = GTGAAACTCGGTAACAT Gene: Aave_0942: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Acidovorax sp. JS42 Site: position = -93 score = 5.29906 sequence = ATGAAACTCGATAACAT Gene: Ajs_0695: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Comamonas testosteroni KF-1	* Delftia acidovorans SPH-1 Site: position = -47 score = 4.82245 sequence = TGGTAACCAAGTTACCA Gene: Daci_5599: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Polaromonas naphthalenivorans CJ2 Site: position = 13 score = 4.92284 sequence = ATGAAACTTTATTACCT Gene: Pnap_0653: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Polaromonas sp. JS666 Site: position = -74 score = 5.49989 sequence = GTGAAACTAAATTACAA Gene: Bpro_0751: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Rhodoferax ferrireducens DSM 15236 Site: position = -123 score = 5.66911 sequence = ATGAAACTAAGTTACAT Gene: Rfer_1125: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Variovorax paradoxus S110 Gene: Vapar_1096: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Verminephrobacter eiseniae EF01-2 Site: position = -44 score = 4.97714 sequence = ATGTAACGTGATTACAA Gene: Veis_4223: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Methylibium petroleiphilum PM1	* Leptothrix cholodnii SP-6 Site: position = -47 score = 5.5929 sequence = CTGAAACTCAGTTACAG Gene: Lcho_3387: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
hexR	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_0941: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Acidovorax sp. JS42 Gene: Ajs_0694: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Comamonas testosteroni KF-1 Gene: CtesDRAFT_4624: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Delftia acidovorans SPH-1 Gene: Daci_5676: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Polaromonas naphthalenivorans CJ2 Gene: Pnap_0652: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Polaromonas sp. JS666 Gene: Bpro_0750: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Rhodoferax ferrireducens DSM 15236 Gene: Rfer_1124: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Variovorax paradoxus S110	* Verminephrobacter eiseniae EF01-2 Site: position = -44 score = 4.61831 sequence = TGCAAACCCGGTTACAT Gene: Veis_1778: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6 Gene: Lcho_3388: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Central carbohydrate metabolism transcription regulator HexR, RpiR family

CRON 5.
pgk	Acidovorax avenae subsp. citrulli AAC00-1 Gene: Aave_4693: Phosphoglycerate kinase (EC 2.7.2.3)	Acidovorax sp. JS42 Gene: Ajs_4056: Phosphoglycerate kinase (EC 2.7.2.3)	* Comamonas testosteroni KF-1 Site: position = -157 score = 5.21141 sequence = CTGAAATCCAGTTACAG Gene: CtesDRAFT_3819: Phosphoglycerate kinase (EC 2.7.2.3)	* Delftia acidovorans SPH-1 Site: position = -27 score = 5.1671 sequence = CTGAAACCGGATTACAG Gene: Daci_0828: Phosphoglycerate kinase (EC 2.7.2.3)	2 Polaromonas naphthalenivorans CJ2 Gene: Pnap_1987: Phosphoglycerate kinase (EC 2.7.2.3) Gene: Pnap_3874: Phosphoglycerate kinase (EC 2.7.2.3)	Polaromonas sp. JS666 Gene: Bpro_4635: Phosphoglycerate kinase (EC 2.7.2.3)	Rhodoferax ferrireducens DSM 15236 Gene: Rfer_3690: Phosphoglycerate kinase (EC 2.7.2.3)	2 Variovorax paradoxus S110 Gene: Vapar_5101: Phosphoglycerate kinase (EC 2.7.2.3) Gene: Vapar_3023: Phosphoglycerate kinase (EC 2.7.2.3)	Verminephrobacter eiseniae EF01-2 Gene: Veis_4078: Phosphoglycerate kinase (EC 2.7.2.3)	2 Methylibium petroleiphilum PM1 Gene: Mpe_A0289: Phosphoglycerate kinase (EC 2.7.2.3) Gene: Mpe_A2792: Phosphoglycerate kinase (EC 2.7.2.3)	Leptothrix cholodnii SP-6 Gene: Lcho_0355: Phosphoglycerate kinase (EC 2.7.2.3)	Phosphoglycerate kinase (EC 2.7.2.3)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HexR - Comamonadaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --