Regulog Cobalamin - Cyanobacteria

Properties
Regulator type:	RNA regulatory element
Name:	Cobalamin
RFAM:	RF00174
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:	Adenosylcobalamin
Phylum:	Cyanobacteria

Member of regulog collections

By taxonomy - Cyanobacteria
By RNA motif - Cobalamin
By effector - Adenosylcobalamin
By pathway - Cobalamin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Synechococcus sp. PCC 7002	4	1
Synechocystis sp. PCC 6803
Cyanothece sp. ATCC 51142	3	2
Cyanothece sp. PCC 8801	1	1
Cyanothece sp. PCC 7425	2	2
Microcystis aeruginosa NIES-843
Nostoc sp. PCC 7120	13	3
Trichodesmium erythraeum IMS101
Synechococcus elongatus PCC 7942	6	2
Prochlorococcus marinus str. MIT 9313	1	1
Synechococcus sp. JA-3-3Ab	6	3
Synechococcus sp. WH 8102	2	1
Gloeobacter violaceus PCC 7421	3	2
Thermosynechococcus elongatus BP-1	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
hupE	Synechococcus sp. PCC 7002 Gene: SYNPCC7002_D0005: HupE-UreJ family cobalt transporter	Synechocystis sp. PCC 6803 Gene: slr2135: HupE-UreJ family cobalt transporter	* Cyanothece sp. ATCC 51142 Site: position = -217 score = 58.25 sequence = ATAATACTCAAGCTA... Gene: cce_0951: HupE-UreJ family cobalt transporter	* Cyanothece sp. PCC 8801 Site: position = -189 score = 59.98 sequence = ATTATACCGAGGCTA... Gene: PCC8801_2095: HupE-UreJ family cobalt transporter	* Cyanothece sp. PCC 7425 Site: position = -183 score = 40.86 sequence = TTGAACAATGTGTCA... Gene: Cyan7425_5052: HupE-UreJ family cobalt transporter	Microcystis aeruginosa NIES-843 Gene: MAE_17650: HupE-UreJ family cobalt transporter	Nostoc sp. PCC 7120 Gene: alr4717: HupE-UreJ family cobalt transporter	Trichodesmium erythraeum IMS101 Gene: Tery_1026: HupE-UreJ family cobalt transporter	* Synechococcus elongatus PCC 7942 Site: position = -166 score = 56.78 sequence = ATATAATCACTAGGC... Gene: Synpcc7942_1373: HupE-UreJ family cobalt transporter	* Prochlorococcus marinus str. MIT 9313 Site: position = -207 score = 53.19 sequence = ATGATTGAATCCATC... Gene: PMT0232: HupE-UreJ family cobalt transporter	Synechococcus sp. JA-3-3Ab Gene: CYA_1062: HupE-UreJ family cobalt transporter	* Synechococcus sp. WH 8102 Site: position = -75 score = 44.25 sequence = CCCTAGGGTTTGGGT... Gene: SYNW2127: HupE-UreJ family cobalt transporter	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	HupE-UreJ family cobalt transporter
som	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313 Gene: PMT0802: Possible S-layer porin	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102 Gene: SYNW2128: Possible S-layer porin	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Possible S-layer porin

CRON 2.
cobG	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	* Nostoc sp. PCC 7120 Site: position = -109 score = 33.01 sequence = TGGTAGATTACTAGA... Gene: all0456: Cobalamin biosynthesis protein CobG / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Trichodesmium erythraeum IMS101	* Synechococcus elongatus PCC 7942 Site: position = -235 score = 31.29 sequence = GCAGTGACCAGCCCC... Gene: Synpcc7942_1851: Cobalamin biosynthesis protein CobG	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Cobalamin biosynthesis protein CobG
cbiC	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843 Gene: MAE_02730: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101 Gene: Tery_1670: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Synechococcus elongatus PCC 7942 Gene: Synpcc7942_1852: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiL	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803 Gene: slr1879: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cyanothece sp. ATCC 51142 Gene: cce_0538: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cyanothece sp. PCC 8801 Gene: PCC8801_3100: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cyanothece sp. PCC 7425 Gene: Cyan7425_1032: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Microcystis aeruginosa NIES-843 Gene: MAE_02740: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Nostoc sp. PCC 7120 Gene: all0455: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Trichodesmium erythraeum IMS101 Gene: Tery_0768: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Synechococcus elongatus PCC 7942 Gene: Synpcc7942_1853: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab Gene: CYA_0903: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Synechococcus sp. WH 8102 Gene: SYNW0653: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Gloeobacter violaceus PCC 7421 Gene: gvip028: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Thermosynechococcus elongatus BP-1 Gene: null: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)	Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiGH	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843 Gene: MAE_42070: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase	Nostoc sp. PCC 7120 Gene: all0453: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942 Gene: Synpcc7942_1854: Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase
cbiA	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803 Gene: sll1501: Cobyrinic acid A,C-diamide synthase	Cyanothece sp. ATCC 51142 Gene: cce_4641: Cobyrinic acid A,C-diamide synthase	Cyanothece sp. PCC 8801 Gene: PCC8801_0431: Cobyrinic acid A,C-diamide synthase	Cyanothece sp. PCC 7425 Gene: Cyan7425_2994: Cobyrinic acid A,C-diamide synthase	Microcystis aeruginosa NIES-843 Gene: MAE_06120: Cobyrinic acid A,C-diamide synthase	Nostoc sp. PCC 7120 Gene: alr3934: Cobyrinic acid A,C-diamide synthase	Trichodesmium erythraeum IMS101 Gene: Tery_0517: Cobyrinic acid A,C-diamide synthase	Synechococcus elongatus PCC 7942 Gene: Synpcc7942_1855: Cobyrinic acid A,C-diamide synthase	Prochlorococcus marinus str. MIT 9313 Gene: PMT1104: Cobyrinic acid A,C-diamide synthase	Synechococcus sp. JA-3-3Ab Gene: CYA_1189: Cobyrinic acid A,C-diamide synthase	Synechococcus sp. WH 8102 Gene: SYNW0748: Cobyrinic acid A,C-diamide synthase	Gloeobacter violaceus PCC 7421 Gene: gvip500: Cobyrinic acid A,C-diamide synthase	Thermosynechococcus elongatus BP-1 Gene: null: Cobyrinic acid A,C-diamide synthase	Cobyrinic acid A,C-diamide synthase
all0454	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120 Gene: all0454: Putative ATP-binding protein	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Putative ATP-binding protein

CRON 3.
cbiX	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803 Gene: sll0037: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Cyanothece sp. ATCC 51142 Gene: cce_4308: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Cyanothece sp. PCC 8801 Gene: PCC8801_3840: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	* Cyanothece sp. PCC 7425 Site: position = -201 score = 25.57 sequence = TAAGATAACCACGTA... Gene: Cyan7425_1197: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101 Gene: Tery_4741: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313 Gene: PMT0901: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	* Synechococcus sp. JA-3-3Ab Site: position = -172 score = 38.13 sequence = GGGCTTGGTGAACGG... Gene: CYA_2373: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Synechococcus sp. WH 8102 Gene: SYNW0837: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	* Gloeobacter violaceus PCC 7421 Site: position = -122 score = 30.27 sequence = CCCGCGCCTTGCAGC... Gene: gll4193: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	* Thermosynechococcus elongatus BP-1 Site: position = -156 score = 29.71 sequence = ATTGGCGACGTTCAC... Gene: null: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)	Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)

CRON 4.
cce_4820	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	* Cyanothece sp. ATCC 51142 Site: position = -298 score = 55.27 sequence = ACAATGCAAAAAATA... Gene: cce_4820: Hypothetical protein	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101 Gene: Tery_0843: Hypothetical protein	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Hypothetical protein
metE	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142 Gene: cce_4821: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101 Gene: Tery_0847: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	2 Synechococcus sp. JA-3-3Ab* Site: position = -612 score = 45.85 sequence = TAGGATAAAGTCTAC... Gene: CYA_0167: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Gene: CYA_0148: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	* Thermosynechococcus elongatus BP-1 Site: position = -418 score = 52.29 sequence = GGTTGGCTTAGTTGC... Gene: tlr1090: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)

CRON 5.
cfrX	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	4 Nostoc sp. PCC 7120* Site: position = -546 score = 61.66 sequence = TTTTTCAATATCAAC... Gene: alr4027: Predicted cobalamin biosynthesis-related protein Site: position = -195 score = 34.41 sequence = TACCATTAAATAAAT... Gene: all1781: Predicted cobalamin biosynthesis-related protein Gene: all2156: Predicted cobalamin biosynthesis-related protein Gene: alr2594: Predicted cobalamin biosynthesis-related protein	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab Gene: CYA_1107: Predicted cobalamin biosynthesis-related protein	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Predicted cobalamin biosynthesis-related protein
btuB	* Synechococcus sp. PCC 7002 Site: position = -512 score = 62.13 sequence = ATATAATTAGACTCT... Gene: SYNPCC7002_A0637: Outer membrane vitamin B12 receptor BtuB	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	2 Nostoc sp. PCC 7120 Gene: alr4028: Outer membrane vitamin B12 receptor BtuB Gene: alr4029: Outer membrane vitamin B12 receptor BtuB	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	* Synechococcus sp. JA-3-3Ab Site: position = -182 score = 46.66 sequence = GAGGAAAGCCGTGCC... Gene: CYA_1108: Outer membrane vitamin B12 receptor BtuB	Synechococcus sp. WH 8102	* Gloeobacter violaceus PCC 7421 Site: position = 15 score = 41.91 sequence = ACAATCGAATGGCTT... Gene: glr1973: Outer membrane vitamin B12 receptor BtuB	Thermosynechococcus elongatus BP-1	Outer membrane vitamin B12 receptor BtuB
cbiW	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120 Gene: alr4030: Putative ferredoxin	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab Gene: CYA_1106: Putative ferredoxin	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421 Gene: glr1974: Putative ferredoxin	Thermosynechococcus elongatus BP-1	Putative ferredoxin
btuF1	Synechococcus sp. PCC 7002 Gene: SYNPCC7002_A0635: Vitamin B12 ABC transporter, B12-binding component BtuF1	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120 Gene: alr4031: Vitamin B12 ABC transporter, B12-binding component BtuF1	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Vitamin B12 ABC transporter, B12-binding component BtuF1
btuC1	Synechococcus sp. PCC 7002 Gene: SYNPCC7002_A0634: Vitamin B12 ABC transporter, permease component BtuC1	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120 Gene: alr4032: Vitamin B12 ABC transporter, permease component BtuC1	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Vitamin B12 ABC transporter, permease component BtuC1
btuD1	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120 Gene: alr4033: Vitamin B12 ABC transporter, ATPase component BtuD1	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Vitamin B12 ABC transporter, ATPase component BtuD1
CYA_1105	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab Gene: CYA_1105: Hypothetical protein	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Hypothetical protein
cpdA	Synechococcus sp. PCC 7002 Gene: SYNPCC7002_A0636: Metallo-dependent phosphatases	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Metallo-dependent phosphatases
cbiJ	Synechococcus sp. PCC 7002	Synechocystis sp. PCC 6803	Cyanothece sp. ATCC 51142	Cyanothece sp. PCC 8801	Cyanothece sp. PCC 7425	Microcystis aeruginosa NIES-843	Nostoc sp. PCC 7120 Gene: all1780: Cobalt-precorrin-6x reductase (EC 1.3.1.54)	Trichodesmium erythraeum IMS101	Synechococcus elongatus PCC 7942	Prochlorococcus marinus str. MIT 9313	Synechococcus sp. JA-3-3Ab	Synechococcus sp. WH 8102	Gloeobacter violaceus PCC 7421	Thermosynechococcus elongatus BP-1	Cobalt-precorrin-6x reductase (EC 1.3.1.54)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Cobalamin - Cyanobacteria

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --