Regulog CtsR - Bacillales

Properties
Regulator type:	Transcription factor
Regulator family:	CtsR
Regulation mode:	repressor
Biological process:	Heat shock response
Effector:	Heat shock
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 41 sites [see more]

Member of regulog collections

By taxonomy - Bacillales
By TF family - CtsR
By effector - Heat shock
By pathway - Heat shock response

Statistics of regulated genes
Genome	Genes	Operons
Bacillus subtilis subsp. subtilis str. 168	8	3
Bacillus amyloliquefaciens FZB42	9	4
Bacillus pumilus SAFR-032	9	4
Bacillus licheniformis DSM 13	10	5
Anoxybacillus flavithermus WK1	8	4
Geobacillus kaustophilus HTA426	8	4
Bacillus cereus ATCC 14579	10	5
Bacillus halodurans C-125	9	4
Bacillus clausii KSM-K16	8	3
Oceanobacillus iheyensis HTE831	7	3
Paenibacillus sp. JDR-2	7	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
clpE	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -84 score = 8.42687 sequence = AGTCAAA-(3)-GGTCAAA Gene: BSU13700: ATP-dependent Clp protease (class III stress gene)	* Bacillus amyloliquefaciens FZB42 Site: position = -85 score = 7.73477 sequence = AATCAAA-(3)-GGTCAAA Gene: RBAM_013460: ATP-dependent Clp protease (class III stress gene)	* Bacillus pumilus SAFR-032 Site: position = -89 score = 8.42687 sequence = AGTCAAA-(3)-GGTCAAA Gene: BPUM_1261: ATP-dependent Clp protease (class III stress gene)	* Bacillus licheniformis DSM 13 Site: position = -84 score = 7.52948 sequence = AGTCAGA-(3)-GGTCAAA Gene: BLi01525: ATP-dependent Clp protease (class III stress gene)	* Anoxybacillus flavithermus WK1 Site: position = 5 score = 8.42687 sequence = AGTCAAA-(3)-GGTCAAA Gene: Aflv_1984: ATP-dependent Clp protease (class III stress gene)	* Geobacillus kaustophilus HTA426 Site: position = -87 score = 8.42687 sequence = AGTCAAA-(3)-GGTCAAA Gene: GK0968: ATP-dependent Clp protease (class III stress gene)	Bacillus cereus ATCC 14579	* Bacillus halodurans C-125 Site: position = -86 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: BH2179: ATP-dependent Clp protease (class III stress gene)	* Bacillus clausii KSM-K16 Site: position = -60 score = 8.42687 sequence = GGTCAAA-(3)-AGTCAAA Gene: ABC3449: ATP-dependent Clp protease (class III stress gene)	* Oceanobacillus iheyensis HTE831 Site: position = -106 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: OB0881: ATP-dependent Clp protease (class III stress gene)	Paenibacillus sp. JDR-2	ATP-dependent Clp protease (class III stress gene)

CRON 2.
clpB	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	* Anoxybacillus flavithermus WK1 Site: position = -34 score = 8.42687 sequence = GGTCAAA-(3)-AGTCAAA Gene: Aflv_2144: Class III stress response-related ATPase	* Geobacillus kaustophilus HTA426 Site: position = -30 score = 8.42687 sequence = AGTCAAA-(3)-GGTCAAA Gene: GK0799: Class III stress response-related ATPase	* Bacillus cereus ATCC 14579 Site: position = -36 score = 8.42687 sequence = GGTCAAA-(3)-AGTCAAA Gene: BC1168: Class III stress response-related ATPase	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Class III stress response-related ATPase

CRON 3.
gs14	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU35990: General stress protein 14	* Bacillus amyloliquefaciens FZB42 Site: position = -27 score = 7.52948 sequence = GGTAAAA-(3)-AGTCAAA Gene: RBAM_033150: General stress protein 14	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi03696: General stress protein 14	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	General stress protein 14

CRON 4.
BLi03709	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	* Bacillus pumilus SAFR-032 Site: position = -175 score = 7.97067 sequence = GGTCAAT-(3)-GGTCAAA Gene: BPUM_3100: TM2 domain containing protein	* Bacillus licheniformis DSM 13 Site: position = -187 score = 7.97067 sequence = GGTCAAT-(3)-GGTCAAA Gene: BLi03709: TM2 domain containing protein	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1115: TM2 domain containing protein	TM2 domain containing protein

CRON 5.
ctsR	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -38 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: BSU00830: Transcriptional repressor of class III stress genes, CtdR fsmily	* Bacillus amyloliquefaciens FZB42 Site: position = -38 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: RBAM_001080: Transcriptional repressor of class III stress genes, CtdR fsmily	* Bacillus pumilus SAFR-032 Site: position = -38 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: BPUM_0068: Transcriptional repressor of class III stress genes, CtdR fsmily	* Bacillus licheniformis DSM 13 Site: position = -39 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: BLi00101: Transcriptional repressor of class III stress genes, CtdR fsmily	* Anoxybacillus flavithermus WK1 Site: position = -41 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: Aflv_0074: Transcriptional repressor of class III stress genes, CtdR fsmily	* Geobacillus kaustophilus HTA426 Site: position = -100 score = 8.42687 sequence = GGTCAAA-(3)-AGTCAAA Gene: GK0075: Transcriptional repressor of class III stress genes, CtdR fsmily	* Bacillus cereus ATCC 14579 Site: position = -38 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: BC0099: Transcriptional repressor of class III stress genes, CtdR fsmily	* Bacillus halodurans C-125 Site: position = -86 score = 8.42687 sequence = GGTCAAA-(3)-AGTCAAA Gene: BH0100: Transcriptional repressor of class III stress genes, CtdR fsmily	* Bacillus clausii KSM-K16 Site: position = -90 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: ABC0118: Transcriptional repressor of class III stress genes, CtdR fsmily	* Oceanobacillus iheyensis HTE831 Site: position = -61 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: OB0090: Transcriptional repressor of class III stress genes, CtdR fsmily	* Paenibacillus sp. JDR-2 Site: position = -80 score = 8.45821 sequence = AGTCAAA-(3)-AGTCAAA Gene: Pjdr2_5718: Transcriptional repressor of class III stress genes, CtdR fsmily	Transcriptional repressor of class III stress genes, CtdR fsmily
mcsA	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU00840: Modulator of heat shock repressor CtsR, McsA	Bacillus amyloliquefaciens FZB42 Gene: RBAM_001090: Modulator of heat shock repressor CtsR, McsA	Bacillus pumilus SAFR-032 Gene: BPUM_0069: Modulator of heat shock repressor CtsR, McsA	Bacillus licheniformis DSM 13 Gene: BLi00102: Modulator of heat shock repressor CtsR, McsA	Anoxybacillus flavithermus WK1 Gene: Aflv_0075: Modulator of heat shock repressor CtsR, McsA	Geobacillus kaustophilus HTA426 Gene: GK0076: Modulator of heat shock repressor CtsR, McsA	Bacillus cereus ATCC 14579 Gene: BC0100: Modulator of heat shock repressor CtsR, McsA	Bacillus halodurans C-125 Gene: BH0101: Modulator of heat shock repressor CtsR, McsA	Bacillus clausii KSM-K16 Gene: ABC0119: Modulator of heat shock repressor CtsR, McsA	Oceanobacillus iheyensis HTE831 Gene: OB0091: Modulator of heat shock repressor CtsR, McsA	Paenibacillus sp. JDR-2 Gene: Pjdr2_5717: Modulator of heat shock repressor CtsR, McsA	Modulator of heat shock repressor CtsR, McsA
mcsB	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU00850: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Bacillus amyloliquefaciens FZB42 Gene: RBAM_001100: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Bacillus pumilus SAFR-032 Gene: BPUM_0070: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Bacillus licheniformis DSM 13 Gene: BLi00103: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Anoxybacillus flavithermus WK1 Gene: Aflv_0076: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Geobacillus kaustophilus HTA426 Gene: GK0077: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Bacillus cereus ATCC 14579 Gene: BC0101: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Bacillus halodurans C-125 Gene: BH0102: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Bacillus clausii KSM-K16 Gene: ABC0120: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Oceanobacillus iheyensis HTE831 Gene: OB0092: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Paenibacillus sp. JDR-2 Gene: Pjdr2_5716: Tyrosine kinase McSB, modulator of heat shock repressor CtsR	Tyrosine kinase McSB, modulator of heat shock repressor CtsR
clpC	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU00860: class III stress response-related ATPase, AAA+ superfamily	Bacillus amyloliquefaciens FZB42 Gene: RBAM_001110: class III stress response-related ATPase, AAA+ superfamily	Bacillus pumilus SAFR-032 Gene: BPUM_0071: class III stress response-related ATPase, AAA+ superfamily	Bacillus licheniformis DSM 13 Gene: BLi00104: class III stress response-related ATPase, AAA+ superfamily	Anoxybacillus flavithermus WK1 Gene: Aflv_0077: class III stress response-related ATPase, AAA+ superfamily	Geobacillus kaustophilus HTA426 Gene: GK0078: class III stress response-related ATPase, AAA+ superfamily	Bacillus cereus ATCC 14579 Gene: BC0102: class III stress response-related ATPase, AAA+ superfamily	Bacillus halodurans C-125 Gene: BH0103: class III stress response-related ATPase, AAA+ superfamily	Bacillus clausii KSM-K16 Gene: ABC0121: class III stress response-related ATPase, AAA+ superfamily	Oceanobacillus iheyensis HTE831 Gene: OB0093: class III stress response-related ATPase, AAA+ superfamily	Paenibacillus sp. JDR-2 Gene: Pjdr2_5715: class III stress response-related ATPase, AAA+ superfamily	class III stress response-related ATPase, AAA+ superfamily
radA	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU00870: DNA repair protein RadA	Bacillus amyloliquefaciens FZB42 Gene: RBAM_001120: DNA repair protein RadA	Bacillus pumilus SAFR-032 Gene: BPUM_0072: DNA repair protein RadA	Bacillus licheniformis DSM 13 Gene: BLi00105: DNA repair protein RadA	Anoxybacillus flavithermus WK1 Gene: Aflv_0078: DNA repair protein RadA	Geobacillus kaustophilus HTA426 Gene: GK0079: DNA repair protein RadA	Bacillus cereus ATCC 14579 Gene: BC0103: DNA repair protein RadA	Bacillus halodurans C-125 Gene: BH0104: DNA repair protein RadA	Bacillus clausii KSM-K16 Gene: ABC0122: DNA repair protein RadA	Oceanobacillus iheyensis HTE831 Gene: OB0094: DNA repair protein RadA	Paenibacillus sp. JDR-2 Gene: Pjdr2_5713: DNA repair protein RadA	DNA repair protein RadA
yacK	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU00880: DNA integrity scanning protein DisA	Bacillus amyloliquefaciens FZB42 Gene: RBAM_001130: DNA integrity scanning protein DisA	Bacillus pumilus SAFR-032 Gene: BPUM_0073: DNA integrity scanning protein DisA	Bacillus licheniformis DSM 13 Gene: BLi00106: DNA integrity scanning protein DisA	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC0104: DNA integrity scanning protein DisA	Bacillus halodurans C-125 Gene: BH0105: DNA integrity scanning protein DisA	Bacillus clausii KSM-K16 Gene: ABC0123: DNA integrity scanning protein DisA	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_5712: DNA integrity scanning protein DisA	DNA integrity scanning protein DisA

CRON 6.
BC2214	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	* Bacillus cereus ATCC 14579 Site: position = -104 score = 6.98729 sequence = CATCAAA-(3)-GGTCAAA Gene: BC2214: Small heat shock protein	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Small heat shock protein

CRON 7.
clpP	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -69 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: BSU34540: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Bacillus amyloliquefaciens FZB42 Site: position = -69 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: RBAM_031850: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Bacillus pumilus SAFR-032 Site: position = -69 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: BPUM_3102: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Bacillus licheniformis DSM 13 Site: position = -70 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: BLi03710: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Anoxybacillus flavithermus WK1 Site: position = -70 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: Aflv_2522: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Geobacillus kaustophilus HTA426 Site: position = -77 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: GK3062: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Bacillus cereus ATCC 14579 Site: position = -65 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: BC5152: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Bacillus halodurans C-125 Site: position = -93 score = -0.130742 sequence = TTTGACC-(3)-TTTGACC Gene: BH3564: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Bacillus clausii KSM-K16 Site: position = -87 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: ABC3026: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Oceanobacillus iheyensis HTE831 Site: position = -89 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: OB2456: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Paenibacillus sp. JDR-2 Site: position = -85 score = 0.745489 sequence = TTTGACT-(3)-TTTGACT Gene: Pjdr2_0175: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)

CRON 8.
BC4452	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	* Bacillus cereus ATCC 14579 Site: position = -179 score = 0.616734 sequence = TTTGACC-(3)-ATTGACC Gene: BC4452: Hypothetical protein	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Hypothetical protein

CRON 9.
sspI	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28660: Small acid-soluble spore protein SspI	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025730: Small acid-soluble spore protein SspI	Bacillus pumilus SAFR-032 Gene: BPUM_2524: Small acid-soluble spore protein SspI	* Bacillus licheniformis DSM 13 Site: position = -112 score = -0.151907 sequence = TTTGACT-(3)-TTTGTCT Gene: BLi03018: Small acid-soluble spore protein SspI	Anoxybacillus flavithermus WK1 Gene: Aflv_0539: Small acid-soluble spore protein SspI	Geobacillus kaustophilus HTA426 Gene: GK2712: Small acid-soluble spore protein SspI	Bacillus cereus ATCC 14579 Gene: BC4563: Small acid-soluble spore protein SspI	* Bacillus halodurans C-125 Site: position = -165 score = 0.272958 sequence = TTTTCCA-(3)-TTTGACT Gene: BH3113: Small acid-soluble spore protein SspI	Bacillus clausii KSM-K16 Gene: ABC2682: Small acid-soluble spore protein SspI	Oceanobacillus iheyensis HTE831 Gene: OB2133: Small acid-soluble spore protein SspI	Paenibacillus sp. JDR-2 Gene: Pjdr2_1121: Small acid-soluble spore protein SspI	Small acid-soluble spore protein SspI

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CtsR - Bacillales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --