Propagation of CmbR regulog to Streptococcus mutans UA159
| Source regulog: | CmbR - Streptococcaceae |
| Regulator type: | Transcription factor |
| Regulator family: | LysR |
| Regulation mode: | repressor (activator) |
| Biological process: | Cysteine metabolism |
| Effector: | O-acetyl-L-serine |
| Phylum: | Firmicutes |
| Propagated regulon: | |
| Target genome | Streptococcus mutans UA159 |
| Orthologous TF(s) | SMU.1225, SMU.852 |
| Regulated genes | 10 |
| Locus tag | Position | Score | Sequence | |
|---|---|---|---|---|
|
Position: -102
Score: 5.8 Sequence: GTGATAGAAAAATATTATCAC
Position: -80
Score: 5 Sequence: GTGATAGGAAAAAACTATTAT
Locus tag: SMU.459
|
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| SMU.459 | -102 | 5.8 | GTGATAGAAAAATATTATCAC | |
| -80 | 5 | GTGATAGGAAAAAACTATTAT | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: tcyA | ||||
| Ortholog function: Cystine ABC transporter, substrate-binding protein | ||||
| Lactococcus lactis subsp. cremoris SK11 | LACR_1009 | -77 | 5.1 | GCTATAAGTTTTTTTTATGGC |
| Lactococcus lactis subsp. lactis Il1403 | L162009 | -77 | 5.1 | GCTATAAGTTTTTTTTATGGC |
| Streptococcus agalactiae 2603V/R | SAG0290 | -96 | 5.5 | TTGATATAAAATCTTTATCAC |
| -75 | 4.7 | CTGATAAGGAAATACTATTAT | ||
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_1582 | -98 | 4.7 | TTGATACTATTTTCTTATTGC |
| -76 | 4.2 | TTGATAGAGAAATGATATTAT | ||
| Streptococcus gallolyticus UCN34 | GALLO_0414 | -100 | 5.2 | CTGATAGTTTTTTCTTATCAA |
| Streptococcus mutans UA159 | SMU.459 | -102 | 5.8 | GTGATAGAAAAATATTATCAC |
| -80 | 5 | GTGATAGGAAAAAACTATTAT | ||
| Streptococcus uberis 0140J | SUB1416 | -98 | 4.5 | GTCATATAAATAGCTAATTAC |
| -76 | 4.2 | TTGATAGAAAAATGGTATTAT | ||
|
Position: -77
Score: 5 Sequence: GTGATAAATAATTTATATTTT
Locus tag: SMU.496
|
||||
| SMU.496 | -77 | 5 | GTGATAAATAATTTATATTTT | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: cysK | ||||
| Ortholog function: Cysteine synthase (EC 2.5.1.47) | ||||
| Lactococcus lactis subsp. lactis Il1403 | L0089 | -79 | 5.3 | GCTATAAAAAAATCTTATAGC |
| Lactococcus lactis subsp. lactis Il1403 | L0088 | -87 | 4.5 | ATCATAAATTTTTTTTAGAGC |
| Streptococcus mitis B6 | smi_2060 | -98 | 5.3 | GATATAAAAAAATCCTATCAC |
| Streptococcus thermophilus CNRZ1066 | str0366 | -16 | 5.2 | ATGATAAAATTTTTTTATGGA |
| Streptococcus uberis 0140J | SUB1379 | -104 | 5.1 | ATGATAAGCCTTTCCTATCAC |
|
Position: -188
Score: 4.6 Sequence: GTTATAGATGAAAACTATAAC
Position: -100
Score: 4 Sequence: TTAATAAGGATTATCTAGTAT
Locus tag: SMU.873
|
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| SMU.873 | -188 | 4.6 | GTTATAGATGAAAACTATAAC | |
| -100 | 4 | TTAATAAGGATTATCTAGTAT | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metE | ||||
| Ortholog function: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) | ||||
| Lactococcus lactis subsp. cremoris SK11 | LACR_1368 | -39 | 4.7 | TTGATAAGATAGACCTATTAA |
| Lactococcus lactis subsp. lactis Il1403 | L0100 | -76 | 4.1 | ATCATATTAAAAATGTATTAT |
| -39 | 4.7 | TTGATAAGATAGACCTATTAA | ||
| Streptococcus agalactiae 2603V/R | SAG2049 | -109 | 4.1 | GCTAAAAATATAAAATATTAA |
| Streptococcus gallolyticus UCN34 | GALLO_1316 | -221 | 4.2 | ATAATAAATTTTATTAATCTA |
| -172 | 4.6 | GTTATAGTTAAAAACTATAAT | ||
| Streptococcus gordonii str. Challis substr. CH1 | SGO_0310 | -182 | 4.2 | GTTATAGTTTTTGATTATACC |
| Streptococcus mutans UA159 | SMU.873 | -188 | 4.6 | GTTATAGATGAAAACTATAAC |
| Streptococcus pneumoniae TIGR4 | SP_0585 | -218 | 4.9 | CTTATAAGAATTACTAATAAC |
| Streptococcus sanguinis SK36 | SSA_0416 | -182 | 4.3 | GTCATAATTTCTACCTATAGC |
| Streptococcus suis 05ZYH33 | SSU05_1774 | -237 | 4.3 | TTCATAGATAAAATCTATACC |
| Streptococcus thermophilus CNRZ1066 | str0785 | -119 | 4.2 | GCTATACAAATATCTAATTAA |
|
Position: -175
Score: 5.3 Sequence: GCTATAAATTTTATTTATGAC
Locus tag: SMU.930c
|
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| SMU.930c | -175 | 5.3 | GCTATAAATTTTATTTATGAC | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: homR | ||||
| Ortholog function: Homocysteine biosynthesis transcriptional regulato HomR, LysR family | ||||
| Streptococcus gallolyticus UCN34 | GALLO_1277 | -175 | 4.4 | ATAATCTAAATTTTTTATTAT |
| -113 | 5.9 | GTTATAAAAAAATCTTATCAC | ||
| Streptococcus mutans UA159 | SMU.930c | -175 | 5.3 | GCTATAAATTTTATTTATGAC |
| -110 | 5 | GCCATAAGAAAAAGTTATCAC | ||
| Streptococcus thermophilus CNRZ1066 | str0452 | -108 | 5.3 | TTTATAAAAATTTCATATCAG |
|
Position: -168
Score: 5 Sequence: GTGATAACTTTTTCTTATGGC
Position: -103
Score: 5.3 Sequence: GTCATAAATAAAATTTATAGC
Locus tag: SMU.932
|
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| SMU.932 | -168 | 5 | GTGATAACTTTTTCTTATGGC | |
| -103 | 5.3 | GTCATAAATAAAATTTATAGC | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: tcyD | ||||
| Ortholog function: Predicted uroporphyrinogen-III decarboxylase | ||||
| Streptococcus gallolyticus UCN34 | GALLO_1275 | -104 | 4.9 | GCTATAAGCAAATCTTATGGC |
| Streptococcus mutans UA159 | SMU.932 | -168 | 5 | GTGATAACTTTTTCTTATGGC |
| -103 | 5.3 | GTCATAAATAAAATTTATAGC | ||
| Streptococcus sanguinis SK36 | SSA_2105 | -194 | 5.3 | TTGATAAAAATTACCTATCTC |
| -59 | 5.1 | TTGATAAATATTTTTAATCAG | ||
| Streptococcus sanguinis SK36 | SSA_2102 | -194 | 5.3 | TTGATAAAAATTACCTATCTC |
| -59 | 5.1 | TTGATAAATATTTTTAATCAG | ||
|
Position: -110
Score: 4.3 Sequence: CTTATAGTTTCTTTTTATAGC
Locus tag: SMU.1675
|
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| SMU.1675 | -110 | 4.3 | CTTATAGTTTCTTTTTATAGC | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metB1 | ||||
| Ortholog function: Cystathionine gamma-synthase (EC 2.5.1.48) | ||||
| Lactococcus lactis subsp. lactis Il1403 | L0102 | -132 | 4.3 | GCCATAGGCAAGTTTTATTAT |
| Streptococcus gallolyticus UCN34 | GALLO_1768 | -142 | 5 | GTTATAGTTTTTACTTATAGC |
| Streptococcus mutans UA159 | SMU.1675 | -110 | 4.3 | CTTATAGTTTCTTTTTATAGC |
| Streptococcus suis 05ZYH33 | SSU05_1562 | -120 | 5.1 | GTTATAAAGAAAAACTATAAC |
| Streptococcus thermophilus CNRZ1066 | str0352 | -132 | 4.5 | GTTATAGTAATAAACTATATC |
|
Position: -98
Score: 6 Sequence: GTGATAGAATTTTCTTATCAC
Position: -76
Score: 4.6 Sequence: GTGATAGAAATTATATAATAG
Locus tag: SMU.1942c
|
||||
| SMU.1942c | -98 | 6 | GTGATAGAATTTTCTTATCAC | |
| -76 | 4.6 | GTGATAGAAATTATATAATAG | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: gshT | ||||
| Ortholog function: Predicted glutathione ABC transporter, substrate-binding protein | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_0381 | -75 | 5 | TTGATAGGAATTAATTATTAG |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_1680 | -41 | 5 | ATGATAAACTAATCTTATGAA |
| Streptococcus gallolyticus UCN34 | GALLO_1845 | -122 | 6 | GTGATAAGTTTTATTTATCAC |
| Streptococcus mitis B6 | smi_1945 | -99 | 5.1 | GCCATAAAGAAAACCTATCAC |
| Streptococcus mutans UA159 | SMU.1942c | -98 | 6 | GTGATAGAATTTTCTTATCAC |
| -76 | 4.6 | GTGATAGAAATTATATAATAG | ||
| Streptococcus pyogenes M1 GAS | SPy0317 | -75 | 4.5 | TTGATAGGAATCAATTATTAG |
| Streptococcus thermophilus CNRZ1066 | str0296 | -98 | 5.7 | GTGATAGTATTTTCTTATCAC |
| Streptococcus uberis 0140J | SUB0365 | -93 | 4.9 | GTGATAGAGAACTATTATCAT |
| -71 | 4.2 | GCGATAGTGAATCACTATTAG | ||