Propagated regulons of Staphylococcus aureus subsp. aureus MRSA252
|
Type |
Regulator |
Effector |
Pathway |
Genes |
Sites |
TF |
ArcR |
Arginine |
Arginine degradation |
1 |
1 |
TF |
ArgR |
Arginine |
Arginine biosynthesis; Arginine degradation |
7 |
47 |
TF |
ArsR |
Arsenate; Arsenite |
Arsenic resistance |
2 |
3 |
TF |
BglR |
Beta-glucoside-6-phosphate |
Beta-glucosides utilization |
2 |
2 |
TF |
BirA |
Biotin |
Biotin biosynthesis |
2 |
2 |
TF |
BlaI |
BlaR, sensor histidine kinase (beta-lactam antibiotics) |
Beta-lactam resistance |
2 |
2 |
TF |
CcpA |
HPr, phosphocarrier protein; Fructose-1,6-diphosphate |
Carbon catabolism |
72 |
91 |
TF |
CggR |
Fructose-1,6-diphosphate |
Glycolysis |
1 |
1 |
TF |
CodY |
Branched-chain amino acids |
Amino acid metabolism |
70 |
142 |
TF |
CymR |
O-acetyl-L-serine; CysK, cysteine synthetase |
Cysteine metabolism |
11 |
14 |
TF |
CzrA |
Zinc ion, (Zn2+) |
Zinc resistance |
1 |
1 |
TF |
FapR |
Malonyl-CoA; Malonyl-ACP |
Fatty acid biosynthesis |
4 |
4 |
TF |
FruR |
Fructose-6-phosphate |
Fructose utilization |
1 |
3 |
TF |
Fur |
Iron ion, (Fe2+) |
Iron homeostasis |
18 |
30 |
TF |
GlnR |
Feedback-inhibited GlnA, glutamine synthetase |
Nitrogen assimilation |
2 |
2 |
TF |
GltC |
2-oxoglutarate; Glutamate |
Glutamate metabolism |
2 |
2 |
TF |
GlvR |
Maltose-6-phosphate |
Maltose utilization |
1 |
1 |
TF |
GntR |
Gluconate |
Gluconate utilization |
1 |
1 |
TF |
HisR |
Histidine |
Histidine biosynthesis |
5 |
6 |
TF |
HrcA |
Heat shock |
Heat shock response |
2 |
2 |
TF |
HutR |
Histidine |
Histidine utilization |
3 |
4 |
TF |
IcaR |
|
Intercellular adhesion |
2 |
2 |
TF |
LexA |
DNA damage |
SOS response |
9 |
12 |
TF |
MalR |
Maltose |
Maltose utilization; Maltodextrin utilization |
2 |
2 |
TF |
MecI |
Penicillin G; Methicillin |
Penicillin and methicillin resistance |
2 |
4 |
TF |
MepR |
Bis-indoles; Distamycin |
Multidrug resistance |
2 |
2 |
TF |
MntR |
Manganese ion, (Mn2+) |
Manganese homeostasis |
2 |
2 |
TF |
MurR |
N-acetylmuramate-6-phosphate |
N-acetylmuramate utilization |
1 |
1 |
TF |
NanR |
N-acetylmannosamine-6-phosphate |
Sialic acid utilization; N-acetylglucosamine utilization |
5 |
5 |
TF |
NrdR |
Deoxyribonucleotides |
Deoxyribonucleotide biosynthesis |
2 |
3 |
TF |
NreC |
NreB, sensor histidine kinase (Nitrate, Nitrite) |
Nitrate and nitrite respiration |
3 |
3 |
TF |
PerR |
Hydrogen peroxide; Manganese ion, (Mn2+); Iron ion, (Fe2+) |
Oxidative stress response |
9 |
13 |
TF |
Rex |
NADH |
Energy metabolism |
15 |
17 |
TF |
SaeR |
SaeS, sensor histidine kinase |
Virulence |
15 |
17 |
TF |
ScrR |
Sucrose-6-phosphate |
Sucrose utilization |
1 |
2 |
TF |
Zur |
Zinc ion, (Zn2+) |
Zinc homeostasis |
8 |
8 |