Regulon of PurR in Lactobacillus acidophilus NCFM

Properties
Regulator type:	Transcription factor
TF locus tag:	LBA0218
Regulator family:	PurR
Regulation mode:	repressor
Biological process:	Purine metabolism
Effector:	5-phosphoribosyl 1-pyrophosphate
Regulog:	PurR - Lactobacillaceae
Statistics of regulated genes:
- Genes	19
- Operons	7
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 76 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - PurR
By effector - 5-phosphoribosyl 1-pyrophosphate
By pathway - Purine metabolism

Regulated operons
	Locus Tag	Name	Function
Position: -120 Score: 4.4 Sequence: AAAACCGAATTAT Locus tag: LBA1893 Name: guaC Funciton: GMP reductase (EC 1.7.1.7)
	LBA1893	guaC	GMP reductase (EC 1.7.1.7)
Position: -151 Score: 5.3 Sequence: AAACACGAACGAT Locus tag: LBA1559 Name: purC Funciton: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) Locus tag: LBA1558 Name: purS Funciton: Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3) Locus tag: LBA1557 Name: purQ Funciton: Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3) Locus tag: LBA1556 Name: purL Funciton: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) Locus tag: LBA1555 Name: purF Funciton: Amidophosphoribosyltransferase (EC 2.4.2.14) Locus tag: LBA1554 Name: purM Funciton: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) Locus tag: LBA1553 Name: purN Funciton: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) Locus tag: LBA1552 Name: purH Funciton: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) Locus tag: LBA1551 Name: purD Funciton: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
	LBA1559	purC	Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
	LBA1558	purS	Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
	LBA1557	purQ	Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
	LBA1556	purL	Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)
	LBA1555	purF	Amidophosphoribosyltransferase (EC 2.4.2.14)
	LBA1554	purM	Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
	LBA1553	purN	Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
	LBA1552	purH	IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
	LBA1551	purD	Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
Position: -59 Score: 4.4 Sequence: ATATAAGAACAAT Locus tag: LBA1562 Name: fhs Funciton: Formate--tetrahydrofolate ligase (EC 6.3.4.3) Locus tag: LBA1561 Name: purE Funciton: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21) Locus tag: LBA1560 Name: purK Funciton: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
	LBA1562	fhs	Formate--tetrahydrofolate ligase (EC 6.3.4.3)
	LBA1561	purE	Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
	LBA1560	purK	Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
Position: -123 Score: 4.9 Sequence: AAAATCGAACTAT Locus tag: LBA1892 Name: purA Funciton: Adenylosuccinate synthetase (EC 6.3.4.4) Locus tag: LBA1891 Name: purB Funciton: Adenylosuccinate lyase (EC 4.3.2.2)
	LBA1892	purA	Adenylosuccinate synthetase (EC 6.3.4.4)
	LBA1891	purB	Adenylosuccinate lyase (EC 4.3.2.2)
Position: 29 Score: 4.4 Sequence: AAAGGAGAACAAT Locus tag: LBA1956 Name: pbuO Funciton: Guanine/hypoxanthine permease
	LBA1956	pbuO	Guanine/hypoxanthine permease
Position: -27 Score: 4.8 Sequence: AAAACCAAACATT Locus tag: LBA0218 Name: purR Funciton: Purine metabolism transcriptional regulator PurR, PurR family Locus tag: LBA0219 Name: glmU Funciton: N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)
	LBA0218	purR	Purine metabolism transcriptional regulator PurR, PurR family
	LBA0219	glmU	N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)
Position: -30 Score: 5.6 Sequence: AAACACGAACAAT Locus tag: LBA1952 Name: pbuO Funciton: Guanine/hypoxanthine permease
	LBA1952	pbuO	Guanine/hypoxanthine permease

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of PurR in Lactobacillus acidophilus NCFM

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --