Regulon of FruR in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Properties
Regulator type:	Transcription factor
TF locus tag:	KPN_00084
Regulator family:	LacI
Regulation mode:	activator (repressor)
Biological process:	Central carbohydrate metabolism
Effector:	Fructose-1-phosphate; Fructose-1,6-diphosphate
Regulog:	FruR - Enterobacteriales
Statistics of regulated genes:
- Genes	51
- Operons	22
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 213 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - FruR
By TF family - LacI
By effector - Fructose-1-phosphate
By effector - Fructose-1,6-diphosphate
By pathway - Central carbohydrate metabolism

Regulated operons
	Locus Tag	Name	Function
Position: -286 Score: 4.5 Sequence: GTTGAATCGATTTTCC Locus tag: KPN_03773 Name: pckA Funciton: Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49)
	KPN_03773	pckA	Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49)
Position: -35 Score: 5.3 Sequence: GCTGAAACGATTCAAT Locus tag: KPN_02600 Name: fruB Funciton: Fructose-specific phosphocarrier protein HPr (EC 2.7.1.69) / PTS system, fructose-specific IIA component (EC 2.7.1.69) Locus tag: KPN_02599 Name: fruK Funciton: 1-phosphofructokinase (EC 2.7.1.56) Locus tag: KPN_02598 Name: fruA Funciton: PTS system, fructose-specific IIB component (EC 2.7.1.69) / PTS system, fructose-specific IIC component (EC 2.7.1.69)
	KPN_02600	fruB	Fructose-specific phosphocarrier protein HPr (EC 2.7.1.69) / PTS system, fructose-specific IIA component (EC 2.7.1.69)
	KPN_02599	fruK	1-phosphofructokinase (EC 2.7.1.56)
	KPN_02598	fruA	PTS system, fructose-specific IIB component (EC 2.7.1.69) / PTS system, fructose-specific IIC component (EC 2.7.1.69)
Position: -119 Score: 5.1 Sequence: CCTGAATCAATTCAGC Locus tag: KPN_04223 Name: pfkA Funciton: 6-phosphofructokinase (EC 2.7.1.11)
	KPN_04223	pfkA	6-phosphofructokinase (EC 2.7.1.11)
Position: -221 Score: 4.9 Sequence: CTTGAATGGTTTCAGC Locus tag: KPN_02133 Name: pykF Funciton: Pyruvate kinase (EC 2.7.1.40)
	KPN_02133	pykF	Pyruvate kinase (EC 2.7.1.40)
Position: -108 Score: 4.6 Sequence: GCTTGAACGATTCACC Locus tag: KPN_02160 Name: ppsA Funciton: Phosphoenolpyruvate synthase (EC 2.7.9.2)
	KPN_02160	ppsA	Phosphoenolpyruvate synthase (EC 2.7.9.2)
Position: -193 Score: 4.9 Sequence: GCTGAAACGATAAAGT Locus tag: KPN_02738 Name: glk Funciton: Glucokinase (EC 2.7.1.2)
	KPN_02738	glk	Glucokinase (EC 2.7.1.2)
Position: -47 Score: 4.6 Sequence: GCTGAATCGTTAAGGT Locus tag: KPN_03752 Name: nirB Funciton: Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4) Locus tag: KPN_03753 Name: nirD Funciton: Nitrite reductase [NAD(P)H] small subunit (EC 1.7.1.4) Locus tag: KPN_03754 Name: cysG Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
	KPN_03752	nirB	Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4)
	KPN_03753	nirD	Nitrite reductase [NAD(P)H] small subunit (EC 1.7.1.4)
	KPN_03754	cysG	Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
Position: -81 Score: 4.5 Sequence: ACTGAATCGATTTTGT Locus tag: KPN_02333 Name: manX Funciton: PTS system, mannose-specific IIA component (EC 2.7.1.69) / PTS system, mannose-specific IIB component (EC 2.7.1.69) Locus tag: KPN_02334 Name: manY Funciton: PTS system, mannose-specific IIC component (EC 2.7.1.69) Locus tag: KPN_02335 Name: manZ Funciton: PTS system, mannose-specific IID component (EC 2.7.1.69)
	KPN_02333	manX	PTS system, mannose-specific IIA component (EC 2.7.1.69) / PTS system, mannose-specific IIB component (EC 2.7.1.69)
	KPN_02334	manY	PTS system, mannose-specific IIC component (EC 2.7.1.69)
	KPN_02335	manZ	PTS system, mannose-specific IID component (EC 2.7.1.69)
Position: -137 Score: 5.4 Sequence: GCTGAAGCGTTTCAGT Locus tag: KPN_03356 Name: epd Funciton: D-erythrose-4-phosphate dehydrogenase (EC 1.2.1.72) Locus tag: KPN_03355 Name: pgk Funciton: Phosphoglycerate kinase (EC 2.7.2.3) Locus tag: KPN_03354 Name: fbaA Funciton: Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
	KPN_03356	epd	D-erythrose-4-phosphate dehydrogenase (EC 1.2.1.72)
	KPN_03355	pgk	Phosphoglycerate kinase (EC 2.7.2.3)
	KPN_03354	fbaA	Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
Position: -216 Score: 4.7 Sequence: GCTGAATCGATTTTAT Locus tag: KPN_02762 Name: ptsH Funciton: PTS family, Hpr protein, phosphohistidinoprotein-hexose phosphotransferase Locus tag: KPN_02763 Name: ptsI Funciton: Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Locus tag: KPN_02764 Name: crr Funciton: PTS system, glucose-specific IIA component (EC 2.7.1.69)
	KPN_02762	ptsH	PTS family, Hpr protein, phosphohistidinoprotein-hexose phosphotransferase
	KPN_02763	ptsI	Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)
	KPN_02764	crr	PTS system, glucose-specific IIA component (EC 2.7.1.69)
Position: -125 Score: 3.7 Sequence: AGCTAAACGATTCAGT Locus tag: KPN_03942 Name: mtlA Funciton: mannitol-specific PTS system, IIABC components Locus tag: KPN_03943 Name: mtlD Funciton: mannitol-1-phosphate 5-dehydrogenase Locus tag: KPN_03944 Name: mtlR Funciton: Mannitol operon repressor
	KPN_03942	mtlA	mannitol-specific PTS system, IIABC components
	KPN_03943	mtlD	mannitol-1-phosphate 5-dehydrogenase
	KPN_03944	mtlR	Mannitol operon repressor
Position: -224 Score: 4.3 Sequence: GCTGAAGCGAGACACC Locus tag: KPN_03743 Name: crp Funciton: Catabolite gene activator (cAMP receptor protein), CRP family
	KPN_03743	crp	Catabolite gene activator (cAMP receptor protein), CRP family
Position: -408 Score: 4.4 Sequence: TCTGAACCGATTCAAC Locus tag: KPN_00116 Name: aroP Funciton: Aromatic amino acid transport protein AroP
	KPN_00116	aroP	Aromatic amino acid transport protein AroP
Position: -109 Score: 4.4 Sequence: GCTGAAGCGATTTCGC Locus tag: KPN_04245 Name: ppc Funciton: Phosphoenolpyruvate carboxylase (EC 4.1.1.31)
	KPN_04245	ppc	Phosphoenolpyruvate carboxylase (EC 4.1.1.31)
Position: -242 Score: 4.8 Sequence: CCTAAAGCGTTTCAGC Locus tag: KPN_04395 Name: aceB Funciton: Malate synthase (EC 2.3.3.9) Locus tag: KPN_04396 Name: aceA Funciton: Isocitrate lyase (EC 4.1.3.1) Locus tag: KPN_04397 Name: aceK Funciton: Isocitrate dehydrogenase phosphatase (EC 2.7.11.5)/kinase (EC 3.1.3.-)
	KPN_04395	aceB	Malate synthase (EC 2.3.3.9)
	KPN_04396	aceA	Isocitrate lyase (EC 4.1.3.1)
	KPN_04397	aceK	Isocitrate dehydrogenase phosphatase (EC 2.7.11.5)/kinase (EC 3.1.3.-)
Position: -260 Score: 4.5 Sequence: GCTGAAAGGTATCAGC Locus tag: KPN_02199 Name: adhE Funciton: Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)
	KPN_02199	adhE	Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)
Position: -91 Score: 4.3 Sequence: GCTGGCGCGATTCACC Locus tag: KPN_04626 Name: fbp Funciton: Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11)
	KPN_04626	fbp	Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11)
Position: -375 Score: 3.6 Sequence: aCgGAcaCGATTCAaC Locus tag: KPN_02678 Name: nuoA Funciton: NADH dehydrogenase I chain A Locus tag: KPN_02677 Name: nuoB Funciton: NADH dehydrogenase I chain B Locus tag: KPN_02676 Name: nuoD Funciton: NADH dehydrogenase I chain C,D Locus tag: KPN_02675 Name: nuoE Funciton: NADH dehydrogenase I chain E Locus tag: KPN_02674 Name: nuoF Funciton: NADH dehydrogenase I chain F Locus tag: KPN_02673 Name: nuoG Funciton: NADH dehydrogenase I chain G Locus tag: KPN_02672 Name: nuoH Funciton: NADH dehydrogenase I chain H Locus tag: KPN_02671 Name: nuoI Funciton: NADH dehydrogenase I chain I Locus tag: KPN_02670 Name: nuoJ Funciton: NADH dehydrogenase I chain J Locus tag: KPN_02669 Name: nuoK Funciton: NADH dehydrogenase I chain K Locus tag: KPN_02668 Name: nuoL Funciton: NADH dehydrogenase I chain L Locus tag: KPN_02667 Name: nuoM Funciton: NADH dehydrogenase I chain M Locus tag: KPN_02666 Name: nuoN Funciton: NADH dehydrogenase I chain N
	KPN_02678	nuoA	NADH dehydrogenase I chain A
	KPN_02677	nuoB	NADH dehydrogenase I chain B
	KPN_02676	nuoD	NADH dehydrogenase I chain C,D
	KPN_02675	nuoE	NADH dehydrogenase I chain E
	KPN_02674	nuoF	NADH dehydrogenase I chain F
	KPN_02673	nuoG	NADH dehydrogenase I chain G
	KPN_02672	nuoH	NADH dehydrogenase I chain H
	KPN_02671	nuoI	NADH dehydrogenase I chain I
	KPN_02670	nuoJ	NADH dehydrogenase I chain J
	KPN_02669	nuoK	NADH dehydrogenase I chain K
	KPN_02668	nuoL	NADH dehydrogenase I chain L
	KPN_02667	nuoM	NADH dehydrogenase I chain M
	KPN_02666	nuoN	NADH dehydrogenase I chain N
Position: -181 Score: 4.2 Sequence: ATTGAACCGATTAAGC Locus tag: KPN_04005 Name: tpiA Funciton: Triosephosphate isomerase (EC 5.3.1.1)
	KPN_04005	tpiA	Triosephosphate isomerase (EC 5.3.1.1)
Position: -251 Score: 4.5 Sequence: GTTGAATCGGTTCAGA Locus tag: KPN_00117 Name: pdhR Funciton: Transcriptional repressor for pyruvate dehydrogenase, GntR family Locus tag: KPN_00118 Name: aceE Funciton: Pyruvate dehydrogenase E1 component (EC 1.2.4.1) Locus tag: KPN_00119 Name: aceF Funciton: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)
	KPN_00117	pdhR	Transcriptional repressor for pyruvate dehydrogenase, GntR family
	KPN_00118	aceE	Pyruvate dehydrogenase E1 component (EC 1.2.4.1)
	KPN_00119	aceF	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)
Position: -87 Score: 3.7 Sequence: ATTGACACGATTCCGC Locus tag: KPN_01197 Name: gapA Funciton: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Locus tag: KPN_01196 Name: yeaD Funciton: Aldose 1-epimerase family protein YeaD
	KPN_01197	gapA	NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
	KPN_01196	yeaD	Aldose 1-epimerase family protein YeaD
Position: -86 Score: 4.6 Sequence: ATTTAAACGATTCAGC Locus tag: KPN_03956 Name: gpmM Funciton: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)
	KPN_03956	gpmM	2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of FruR in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --